专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

AU4620100A Oligonucleotide for detection and identification of mycobacteria 未知
公开(公告)号：AU4620100A
公开(公告)日：2000-12-18
申请号：AU4620100
申请日：2000-05-16
申请人： SJ HIGHTECH CO LTD , CHEOL MIN KIM , HEE KYUNG PARK
发明人： KIM CHEOL MIN , PARK HEE KYUNG , JANG HYUN JUNG
IPC分类号： C12N15/09 , C07K14/35 , C12N15/11
摘要： This invention relates to oligonucleotides sequence of probes or primers for detection or identication of Mycobacterium. In the claimed invention, oligonucleotide sequences of ITS (Internal Transcribing Spacer Region) from M. fortuitium, M. chelonae, M. abscessus, M. vaccae, M. flavescence, M. Asiaticum, M. porcinum, M. acapulcensis and M. diernhoferi have been identified. Using these ITS sequences, PCR primers or hybridization probes for detection or identication of Mycobacterium have been developed and presented as seq ID : 10 to seq ID : 241.

2. 发明授权

US08219151B2 Portable terminal and driving method of the same 有权
标题翻译：便携式终端和驱动方法相同
公开(公告)号：US08219151B2
公开(公告)日：2012-07-10
申请号：US12403138
申请日：2009-03-12
申请人： Hee Kyung Park , Jong Hwan Kim , Seon Hwi Cho
发明人： Hee Kyung Park , Jong Hwan Kim , Seon Hwi Cho
IPC分类号： H04M1/00 , G06F3/01 , G06F3/041
CPC分类号： H04M1/72583 , H04M1/72552 , H04M19/047 , H04M2250/22 , H04M2250/52
摘要： A portable terminal is provided that includes a vibration generator for vibrating the portable terminal, a receiving device for receiving input from a user and determining a coordinate value on a display screen based on the received input, and a controller for determining a vibration pattern corresponding to information on a display screen based on the determined coordinate value.
摘要翻译：提供一种便携式终端，其包括用于振动便携式终端的振动发生器，用于接收来自用户的输入并基于所接收的输入来确定显示屏上的坐标值的接收装置，以及用于确定对应于基于确定的坐标值在显示屏幕上的信息。

3. 发明授权

US08133985B2 Peptide nucleic acids conjugated with multi-amine linkers and nucleic acid detecting device using the same 有权
标题翻译：与多胺接头结合的肽核酸和使用其的核酸检测装置
公开(公告)号：US08133985B2
公开(公告)日：2012-03-13
申请号：US12300235
申请日：2007-12-14
申请人： Hyunil Lee , Hee Kyung Park , Bong Ho Um , Serka Kim , Jae Jin Choi , Jung Hyun Min , Hye Yeon Kim
发明人： Hyunil Lee , Hee Kyung Park , Bong Ho Um , Serka Kim , Jae Jin Choi , Jung Hyun Min , Hye Yeon Kim
IPC分类号： C07K2/00 , C07K1/00 , C40B80/00 , C40B40/06
CPC分类号： C07K14/003 , A61K47/641 , Y10S977/754
摘要： The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof. More specifically, the method is characterized by conjugating monomers having multi-amine functionality sequentially at a PNA terminal, and effectively immobilizing the PNA conjugated with multi-amine linkers on a solid surface. A PNA array prepared using the PNA conjugated with multi-amine linkers exhibits improved sensitivity and specificity of signals for detecting target nucleic acids as compared to a PNA array using PNA probes having only one amine group. The PNA conjugated with multi-amine linkers can be utilized in nucleic acid detecting devices or kits for gene diagnosis such as PNA microarrays, PNA chips, PNA field-effect transistors and impedance detectors.
摘要翻译：本发明涉及与多胺接头共轭的肽核酸（PNA）及其制备方法及应用。更具体地说，该方法的特征在于在PNA末端连续连接具有多胺官能团的单体，并有效地将与多胺接头共轭的PNA固定在固体表面上。使用与多胺接头共轭的PNA制备的PNA阵列与使用仅具有一个胺基团的PNA探针的PNA阵列相比，显示出用于检测靶核酸的信号的改善的灵敏度和特异性。与多胺接头结合的PNA可用于核酸检测装置或用于基因诊断的试剂盒，例如PNA微阵列，PNA芯片，PNA场效应晶体管和阻抗检测器。

4. 发明申请

US20100248980A1 Method for Selective Labeling and Detection of Target Nucleic Acids Using Immobilized Peptide Nucleic Acid Probes 审中-公开
标题翻译：使用固定化肽核酸探针选择性标记和检测靶核酸的方法
公开(公告)号：US20100248980A1
公开(公告)日：2010-09-30
申请号：US12745857
申请日：2008-12-04
申请人： Hee Kyung Park , Jae Jin Choi
发明人： Hee Kyung Park , Jae Jin Choi
IPC分类号： C40B30/04 , C40B50/18 , C40B70/00
CPC分类号： C12Q1/6837 , C12Q2525/107 , G01N33/532 , G01N2333/9015 , G01N2333/9127 , C12Q2565/537 , C12Q2521/131 , C12Q2521/501
摘要： Disclosed are a method for selective labeling of target nucleic acids on an array having nucleic acid analogue, e.g. PNA (peptide nucleic acid), probes immobilized on a support or supports, comprising adding to the array a detectable label and an agent for introducing the label into the target nucleic acids, after hybridization between the target nucleic acids and the nucleic acid analogue probes, and a method for detection of target nucleic acids using the same.
摘要翻译：公开了在具有核酸类似物的阵列上选择性标记靶核酸的方法，例如， PNA（肽核酸），固定在载体或载体上的探针，包括在靶核酸和核酸类似物探针杂交后，向阵列中加入可检测标记和引入标记物到靶核酸中的试剂，以及使用其的靶核酸的检测方法。

5. 发明申请

US20090312197A1 PEPTIDE NUCLEIC ACIDS CONJUGATED WITH MULTI-AMINE LINKERS AND NUCLEIC ACID DETECTING DEVICE USING THE SAME 有权
标题翻译：与多胺连接子和核酸检测装置相结合的肽核酸
公开(公告)号：US20090312197A1
公开(公告)日：2009-12-17
申请号：US12300235
申请日：2007-12-14
申请人： Hyunil Lee , Hee Kyung Park , Bong Ho Um , Serka Kim , Jae Jin Choi , Jung Hyun Min , Hye Yeon Kim
发明人： Hyunil Lee , Hee Kyung Park , Bong Ho Um , Serka Kim , Jae Jin Choi , Jung Hyun Min , Hye Yeon Kim
IPC分类号： C40B40/08 , C07K9/00 , C07K1/00 , C40B50/14
CPC分类号： C07K14/003 , A61K47/641 , Y10S977/754
摘要： The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof. More specifically, the method is characterized by conjugating monomers having multi-amine functionality sequentially at a PNA terminal, and effectively immobilizing the PNA conjugated with multi-amine linkers on a solid surface. A PNA array prepared using the PNA conjugated with multi-amine linkers exhibits improved sensitivity and specificity of signals for detecting target nucleic acids as compared to a PNA array using PNA probes having only one amine group. The PNA conjugated with multi-amine linkers can be utilized in nucleic acid detecting devices or kits for gene diagnosis such as PNA microarrays, PNA chips, PNA field-effect transistors and impedance detectors.
摘要翻译：本发明涉及与多胺接头共轭的肽核酸（PNA）及其制备方法及其应用。更具体地说，该方法的特征在于在PNA末端连续连接具有多胺官能团的单体，并有效地将与多胺接头共轭的PNA固定在固体表面上。使用与多胺接头共轭的PNA制备的PNA阵列与使用仅具有一个胺基团的PNA探针的PNA阵列相比，显示出用于检测靶核酸的信号的改善的灵敏度和特异性。与多胺接头结合的PNA可用于核酸检测装置或用于基因诊断的试剂盒，例如PNA微阵列，PNA芯片，PNA场效应晶体管和阻抗检测器。

6. 发明申请

US20080233557A1 PNA Probes, Kits, and Methods for Detecting Lamivudine-Resistant Hepatitis B Viruses 审中-公开
标题翻译： PNA探针，试剂盒和检测拉米夫定耐药乙型肝炎病毒的方法
公开(公告)号：US20080233557A1
公开(公告)日：2008-09-25
申请号：US11860983
申请日：2007-09-25
申请人： Hee Kyung PARK , Hyunil LEE , Jae Jin CHOI , Serka KIM
发明人： Hee Kyung PARK , Hyunil LEE , Jae Jin CHOI , Serka KIM
IPC分类号： C12Q1/70 , C07H21/04
CPC分类号： C12Q1/706 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： Disclosed are peptide nucleic acid (PNA) probes to detect lamivudine resistant mutants of hepatitis B virus (HBV), which causes acute and chronic hepatitis, kits for detecting lamivudine resistant HBV comprising the PNA probes, and methods for detecting lamivudine resistant HBV by using the kits. They can accurately detect mutations of rtL180M, rtM204V, rtM204I and rtV2071 within B and C domains of HBV DNA polymerase gene, the main cause of lamivudine resistance, as well as mixed mutants of more than one mutant. They can detect lamivudine resistant HBV with high specificity and sensitivity.
摘要翻译：公开了用于检测引起急性和慢性肝炎的乙型肝炎病毒（HBV）的拉米夫定抗性突变体的肽核酸（PNA）探针，用于检测包含PNA探针的拉米夫定耐药性HBV的试剂盒，以及通过使用工具包他们可以准确检测HBV DNA聚合酶基因的B和C结构域中rtL180M，rtM204V，rtM204I和rtV2071的突变，这是拉米夫定耐药的主要原因，以及多个突变体的混合突变体。他们可以检测出具有高特异性和灵敏度的拉米夫定耐药HBV。

7. 发明申请

US20100240058A1 MicroRNA Antisense PNAs, Compositions Comprising the Same, and Methods for Using and Evaluating the Same 审中-公开
标题翻译： MicroRNA反义PNAs，组合物及其使用和评价方法
公开(公告)号：US20100240058A1
公开(公告)日：2010-09-23
申请号：US12741413
申请日：2008-11-24
申请人： Hee Kyung Park , Su Young Oh
发明人： Hee Kyung Park , Su Young Oh
IPC分类号： C12Q1/68 , C07K9/00 , C12N5/02
CPC分类号： C07K14/003 , C12N15/113 , C12N2310/113 , C12N2310/3181 , C12N2310/3513 , C12Q1/6897 , C12Q2525/207
摘要： Disclosed are a microRNA antisense PNA capable of inhibiting the activity or function of microRNA, a composition for inhibiting the activity or function of microRNA containing the same, a method for inhibiting the activity or function of microRNA using the same, and a method for evaluating the effectiveness thereof.
摘要翻译：公开了能够抑制微小RNA的活性或功能的微小RNA反义PNA，用于抑制其含有的微小RNA的活性或功能的组合物，使用其的微小RNA的抑制活性或功能的方法，以及评估方法有效性。

8. 发明申请

US20100004028A1 PORTABLE TERMINAL AND DRIVING METHOD OF THE SAME 有权
标题翻译：终端的便携式和驱动方法
公开(公告)号：US20100004028A1
公开(公告)日：2010-01-07
申请号：US12403138
申请日：2009-03-12
申请人： Hee Kyung Park , Jong Hwan Kim , Seon Hwi Cho
发明人： Hee Kyung Park , Jong Hwan Kim , Seon Hwi Cho
IPC分类号： H04M1/00
CPC分类号： H04M1/72583 , H04M1/72552 , H04M19/047 , H04M2250/22 , H04M2250/52
摘要： A portable terminal is provided that includes a vibration generator for vibrating the portable terminal, a receiving device for receiving input from a user and determining a coordinate value on a display screen based on the received input, and a controller for determining a vibration pattern corresponding to information on a display screen based on the determined coordinate value.
摘要翻译：提供一种便携式终端，其包括用于振动便携式终端的振动发生器，用于接收来自用户的输入并基于所接收的输入来确定显示屏上的坐标值的接收装置，以及用于确定对应于基于确定的坐标值在显示屏幕上的信息。

9. 发明申请

US20080248461A1 PNA Probes, Kits, and Methods for Detecting Genotypes of Human Papillomavirus 审中-公开
标题翻译： PNA探针，试剂盒和检测人乳头瘤病毒基因型的方法
公开(公告)号：US20080248461A1
公开(公告)日：2008-10-09
申请号：US11851581
申请日：2007-09-07
申请人： Hee Kyung Park , Hyunil Lee , Jae Jin Choi , Serka Kim
发明人： Hee Kyung Park , Hyunil Lee , Jae Jin Choi , Serka Kim
IPC分类号： C12Q1/70 , C07H21/00
CPC分类号： C12Q1/708 , C12Q2525/107
摘要： Disclosed are PNA probes capable of genotype specifically binding with Human Paillomavirus (HPV) DNA, kits for detecting HPV genotypes comprising the probes, and methods for detecting HPV genotypes by using the kits, which enables the accurate detection of all 24 genotypes of HPV found in cervix, diagnosis of combined infection with more than one HPV genotype, and detection of HPV genotypes with high specificity and sensitivity.
摘要翻译：公开了能够基因型与人类苍蝇病毒（HPV）DNA特异性结合的PNA探针，用于检测包含探针的HPV基因型的试剂盒，以及通过使用试剂盒检测HPV基因型的方法，其能够精确检测所有24种HPV基因型子宫颈，联合感染多种HPV基因型的诊断，以及具有高特异性和敏感性的HPV基因型的检测。

10. 发明申请

US20060134792A1 Microarray comprising probes for drug-resistant hepatitis b virus detection, quality control and negative control, and method for detecting drug-resistant hepatitis b virus using the same 审中-公开
标题翻译：包括用于耐药性乙型肝炎病毒检测，质量控制和阴性对照的探针的微阵列以及使用该检测的耐药性乙型肝炎病毒的检测方法
公开(公告)号：US20060134792A1
公开(公告)日：2006-06-22
申请号：US10567072
申请日：2004-08-02
申请人： Cheol-Min Kim , Hee-Kyung Park , Mong Cho , Hyun-Jung Jang , Jeong Heo
发明人： Cheol-Min Kim , Hee-Kyung Park , Mong Cho , Hyun-Jung Jang , Jeong Heo
IPC分类号： C12Q1/00
CPC分类号： C12Q1/706 , C12Q1/6837 , C12Q2545/113
摘要： Provided are a microarray manufactured using a mixture of target probes for drug-resistant HBV detection, quality control probes for controlling quality in probe hybridization and fabrication of microarrays, and negative control probes for determining the presence and ratio of more than one type, i.e., a wild type and a mutant in a codon, measuring a background of non-specific cross-hybridization, and discriminating homozygotes and heterozygotes, and a method of detecting a drug-resistant HBV, controlling the quality of a microarray, determining the presence and ratio of more than one type, and determining positive and false positive probes at the same time using the microarray. The microarray, which includes the target probes for drug-resistant HBV detection, the QC probes, and the negative control probes, can detect a drug-resistant HBV, control quality in fabrication of microarrays and hybridization, determine the presence and ratio of more than one type, i.e., a wild type and a mutant, determine positive and false positive probes by measuring a background of non-specific cross-hybridization, and discriminate homozygotes and heterozygotes. When a plurality of sets of probes, each set containing target probes, QC probes, and negative control probes, are immobilized on a support of the microarray, detection of resistance in HBV to multiple drugs, quality control, and determination as to the presence and ratio of a wild type and a mutant and whether each probe is positive or false positive can be rapidly and accurately performed.
摘要翻译：提供了使用用于耐药HBV检测的靶探针混合物制造的微阵列，用于控制探针杂交质量的控制探针和微阵列的制造以及用于确定多于一种类型的存在和比例的阴性对照探针，密码子中的野生型和突变体，测量非特异性交叉杂交的背景，以及鉴别纯合子和杂合子，以及检测耐药性HBV的方法，控制微阵列的质量，确定存在和比例的多种类型，并使用微阵列同时确定阳性和假阳性探针。包括用于耐药HBV检测的目标探针，QC探针和阴性对照探针的微阵列可以检测耐药性HBV，控制微阵列和杂交的制备质量，确定多于一个的存在和比例一种类型，即野生型和突变体，通过测量非特异性交叉杂交的背景，并鉴别纯合子和杂合子来确定阳性和假阳性探针。当将包含目标探针，QC探针和阴性对照探针的多组探针固定在微阵列的载体上时，检测HBV对多种药物的耐药性，质量控制和确定存在和野生型和突变体的比例以及每种探针是阳性还是假阳性可以快速和准确地进行。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式