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1. 发明授权

US07749517B2 Anthrax antitoxins 失效
标题翻译：炭疽毒素
公开(公告)号：US07749517B2
公开(公告)日：2010-07-06
申请号：US11340424
申请日：2006-01-26
申请人： John A. Young , Heather M. Scobie , G. Jonah A. Rainey , Kenneth A. Bradley
发明人： John A. Young , Heather M. Scobie , G. Jonah A. Rainey , Kenneth A. Bradley
IPC分类号： A61K39/07 , C07H21/04
CPC分类号： C07K16/1278 , A61K38/00 , C07K14/705 , C07K14/78
摘要： The present invention provides compositions useful in preparing and/or serving as antitoxins against Bacillus anthracis, the causative agent of anthrax. The present invention also provides polypeptides and polynucleotides relating to the capillary morphogenisis gene 2 (CMG-2), vectors containing the polynucleotides and polypeptides, and host cells containing related polynucleotide molecules, all used in association with the treatment of, or the research and development of treatments for anthrax. The present invention also relates to methods for identifying molecules that bind CMG-2 and molecules that reduce the toxicity of anthrax toxin. Finally, the present invention provides methods for treating human and non-human animals suffering from anthrax.
摘要翻译：本发明提供了可用于制备和/或用作抗炭疽杆菌（Anthracis）的抗毒素的组合物，炭疽芽孢杆菌的致病因子。本发明还提供了与毛细血管形成形成发生基因2（CMG-2）相关的多肽和多核苷酸，含有多核苷酸和多肽的载体以及含有相关多核苷酸分子的宿主细胞，所有这些都与治疗或研究和开发相结合的炭疽治疗。本发明还涉及用于鉴定结合CMG-2的分子和降低炭疽毒素毒性的分子的方法。最后，本发明提供了治疗患有炭疽的人类和非人类动物的方法。

2. 发明授权

US07998487B2 Antitoxin and vaccine platform based on nodavirus VLPs 失效
标题翻译：基于转染病毒VLP的抗毒素和疫苗平台
公开(公告)号：US07998487B2
公开(公告)日：2011-08-16
申请号：US12070384
申请日：2008-02-14
申请人： John Young , Anette Schneemann , Marianne Manchester , Kelly Dryden , John M. Marlett , Darly Joseph Manayani , Godfrey Jonah Anderson Rainey , Vijay Reddy , Marc E. Siladi , Heather M. Scobie , Diane Thomas , Mark Yeager
发明人： John Young , Anette Schneemann , Marianne Manchester , Kelly Dryden , John M. Marlett , Darly Joseph Manayani , Godfrey Jonah Anderson Rainey , Vijay Reddy , Marc E. Siladi , Heather M. Scobie , Diane Thomas , Mark Yeager
IPC分类号： A61K39/385 , A61K39/07 , A61K39/08 , A61K39/116 , A61K39/295
CPC分类号： A61K39/07 , A61K2039/5256 , A61K2039/5258 , C12N2710/14143 , C12N2770/30023
摘要： Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs are provided.
摘要翻译：提供了基于转染病毒VLP的抗毒素和疫苗组合物。提供炭疽毒素抗毒素和疫苗组合物。提供了使用基于VLP的抗毒素治疗毒素的方法。提供了用免疫原装饰的VLP提高免疫应答的方法。

3. 发明申请

US20080299148A1 Novel antitoxin and vaccine platform based on nodavirus VLPS 失效
标题翻译：基于诺如病毒VLPS的新型抗毒素和疫苗平台
公开(公告)号：US20080299148A1
公开(公告)日：2008-12-04
申请号：US12070384
申请日：2008-02-14
申请人： John Young , Anette Schneemann , Marianne Manchester , Kelly Dryden , John M. Marlett , Darly Joseph Manayani , Godfrey Jonah Anderson Rainey , Vijay Reddy , Marc E. Siladi , Heather M. Scobie , Diane Thomas , Mark Yeager
发明人： John Young , Anette Schneemann , Marianne Manchester , Kelly Dryden , John M. Marlett , Darly Joseph Manayani , Godfrey Jonah Anderson Rainey , Vijay Reddy , Marc E. Siladi , Heather M. Scobie , Diane Thomas , Mark Yeager
IPC分类号： A61K39/00 , A61P37/00
CPC分类号： A61K39/07 , A61K2039/5256 , A61K2039/5258 , C12N2710/14143 , C12N2770/30023
摘要： Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs are provided.
摘要翻译：提供了基于转染病毒VLP的抗毒素和疫苗组合物。提供炭疽毒素抗毒素和疫苗组合物。提供了使用基于VLP的抗毒素治疗毒素的方法。提供了用免疫原装饰的VLP提高免疫应答的方法。

4. 发明申请

US20120156237A1 Novel Antitoxin and Vaccine Platform Based on Nodavirus VLPS 失效
标题翻译：基于Nodavirus VLPS的新型抗毒素和疫苗平台
公开(公告)号：US20120156237A1
公开(公告)日：2012-06-21
申请号：US13167627
申请日：2011-06-23
申请人： JOHN YOUNG , ANETTE SCHNEEMANN , MARIANNE MANCHESTER , KELLY DRYDEN , JOHN M. MARLETT , DARLY JOSEPH MANAYANI , GODFREY JONAH ANDERSON RAINEY , VIJAY REDDY , MARC E. SILADI , HEATHER M. SCOBIE , DIANE THOMAS , MARK YEAGER
发明人： JOHN YOUNG , ANETTE SCHNEEMANN , MARIANNE MANCHESTER , KELLY DRYDEN , JOHN M. MARLETT , DARLY JOSEPH MANAYANI , GODFREY JONAH ANDERSON RAINEY , VIJAY REDDY , MARC E. SILADI , HEATHER M. SCOBIE , DIANE THOMAS , MARK YEAGER
IPC分类号： A61K39/385 , C07K17/02 , A61P31/04 , C07K19/00 , A61K38/16
CPC分类号： A61K39/07 , A61K2039/5256 , A61K2039/5258 , C12N2710/14143 , C12N2770/30023
摘要： Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs are provided.
摘要翻译：提供了基于转染病毒VLP的抗毒素和疫苗组合物。提供炭疽毒素抗毒素和疫苗组合物。提供了使用基于VLP的抗毒素治疗毒素的方法。提供了用免疫原装饰的VLP提高免疫应答的方法。

5. 发明授权

US08404247B2 Antitoxin and vaccine platform based on nodavirus VLPS 失效
标题翻译：基于诺塔病毒VLPS的抗毒素和疫苗平台
公开(公告)号：US08404247B2
公开(公告)日：2013-03-26
申请号：US13167627
申请日：2011-06-23
申请人： John Young , Anette Schneemann , Marianne Manchester , Kelly Dryden , John M. Marlett , Darly Joseph Manayani , Godfrey Jonah Anderson Rainey , Vijay Reddy , Marc E. Siladi , Heather M. Scobie , Diane Thomas , Mark Yeager
发明人： John Young , Anette Schneemann , Marianne Manchester , Kelly Dryden , John M. Marlett , Darly Joseph Manayani , Godfrey Jonah Anderson Rainey , Vijay Reddy , Marc E. Siladi , Heather M. Scobie , Diane Thomas , Mark Yeager
IPC分类号： A61K39/385 , A61K39/07 , A61K39/08 , A61K39/116 , A61K39/295
CPC分类号： A61K39/07 , A61K2039/5256 , A61K2039/5258 , C12N2710/14143 , C12N2770/30023
摘要： Antitoxin and vaccine compositions based on nodavirus VLPs are provided. Anthrax antitoxin and vaccine compositions are provided. Methods of treating toxins with VLP-based antitoxins are provided. Methods of raising an immune response with immunogen decorated VLPs are provided.
摘要翻译：提供了基于转染病毒VLP的抗毒素和疫苗组合物。提供炭疽毒素抗毒素和疫苗组合物。提供了使用基于VLP的抗毒素治疗毒素的方法。提供了用免疫原装饰的VLP提高免疫应答的方法。

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