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1. 发明授权

US08377710B2 Lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same 有权
公开(公告)号：US08377710B2
公开(公告)日：2013-02-19
申请号：US12425121
申请日：2009-04-16
申请人： George M. Whitesides , Scott T. Phillips , Andres W. Martinez , Manish J. Butte , Amy Wong , Samuel W. Thomas , Hayat Sindi , Sarah J. Vella , Emanuel Carrilho , Katherine A. Mirica , Yanyan Liu
发明人： George M. Whitesides , Scott T. Phillips , Andres W. Martinez , Manish J. Butte , Amy Wong , Samuel W. Thomas , Hayat Sindi , Sarah J. Vella , Emanuel Carrilho , Katherine A. Mirica , Yanyan Liu
IPC分类号： G01N21/77
CPC分类号： G01N33/558 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/12 , B01L2300/06 , B01L2300/0848 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , C12Q1/48 , G01N21/77 , G01N33/523 , G01N33/526 , G01N33/54386 , G06F3/005
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.

2. 发明申请

US20090298191A1 Lateral Flow and Flow-through Bioassay Devices Based On Patterned Porous Media, Methods of Making Same, and Methods of Using Same 有权
标题翻译：基于图案化多孔介质的横向流动和流通生物测定装置，制备方法及其使用方法
公开(公告)号：US20090298191A1
公开(公告)日：2009-12-03
申请号：US12425121
申请日：2009-04-16
申请人： George M. WHITESIDES , Scott T. PHILLIPS , Andres W. MARTINEZ , Manish J. BUTTE , Amy WONG , Samuel W. THOMAS , Hayat SINDI , Sarah J. VELLA , Emanuel CARRILHO , Katherine A. MIRICA , Yanyan LIU
发明人： George M. WHITESIDES , Scott T. PHILLIPS , Andres W. MARTINEZ , Manish J. BUTTE , Amy WONG , Samuel W. THOMAS , Hayat SINDI , Sarah J. VELLA , Emanuel CARRILHO , Katherine A. MIRICA , Yanyan LIU
IPC分类号： G01N21/00 , G01N31/22 , B01L3/00 , G03F7/20 , B29C59/00 , B05D1/28
CPC分类号： G01N33/558 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L2200/12 , B01L2300/06 , B01L2300/0848 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , C12Q1/48 , G01N21/77 , G01N33/523 , G01N33/526 , G01N33/54386 , G06F3/005
摘要： Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
摘要翻译：本发明的实施方案提供了基于图案化多孔介质的横向流动和流通生物测定装置，其制备方法及其使用方法。在一个方面，测定装置包括多孔亲水介质; 包含聚合的光致抗蚀剂的流体不透过屏障，所述屏障基本上渗透所述多孔亲水介质的厚度，并且限定所述多孔亲水介质内的测定区域的边界; 和测定区域中的测定试剂。

3. 发明授权

US07740803B2 Biochemical sensor with thermoelastic probes 失效
标题翻译：具有热弹性探针的生化传感器
公开(公告)号：US07740803B2
公开(公告)日：2010-06-22
申请号：US10528554
申请日：2003-09-22
申请人： Hayat Sindi
发明人： Hayat Sindi
IPC分类号： G01N33/00 , G01N15/06 , G01N33/48
CPC分类号： G01N21/253 , G01N21/1702 , Y10T436/205831
摘要： The thermoelastic response of certain materials to an incident electromagnetic excitation beam is highly sensitive to physical conditions existing at the surface of the material. Probe structures carrying probe materials are used as sensors in the analysis and investigation of biochemical molecules. Each probe structure is adapted to undergo a thermoelastic response when excited by temporally varying electromagnetic radiation, characteristics of the thermoelastic response being a function of physical properties of material binding to the surface of the probe structure. An electromagnetic excitation means directs electromagnetic energy at a selected one of the probe structures in order to elicit the excitation response. A detection means determines change in excitation response of the probe structures resulting from the binding of molecules thereto.
摘要翻译：某些材料对入射电磁激发光束的热弹性响应对材料表面存在的物理条件非常敏感。携带探针材料的探针结构在生化分子的分析和调查中被用作传感器。每个探针结构适于在通过时间变化的电磁辐射激发时经历热弹性响应，热弹性响应的特征是结合到探针结构表面的材料的物理性质的函数。电磁激励装置在所选择的一个探针结构中引导电磁能，以便引发激发响应。检测装置确定由分子与其结合而产生的探针结构的激发响应的变化。

4. 发明申请

US20060148092A1 Biochemical sensor with thermoelastic probes 失效
标题翻译：具有热弹性探针的生化传感器
公开(公告)号：US20060148092A1
公开(公告)日：2006-07-06
申请号：US10528554
申请日：2003-09-22
申请人： Hayat Sindi
发明人： Hayat Sindi
IPC分类号： G01N33/00
CPC分类号： G01N21/253 , G01N21/1702 , Y10T436/205831
摘要： The thermoelastic response of certain materials to an incident electromagnetic excitation beam is highly sensitive to physical conditions existing at the surface of the material. Probe structures carrying probe materials are used as sensors in the analysis and investigation of biochemical molecules. Each probe structure is adapted to undergo a thermoelastic response when excited by temporally varying electromagnetic radiation, characteristics of the thermoelastic response being a function of physical properties of material binding to the surface of the probe structure. An electromagnetic excitation means directs electromagnetic energy at a selected one of the probe structures in order to elicit the excitation response. A detection means determines change in excitation response of the probe structures resulting from the binding of molecules thereto.
摘要翻译：某些材料对入射电磁激发光束的热弹性响应对材料表面存在的物理条件非常敏感。携带探针材料的探针结构在生化分子的分析和调查中被用作传感器。每个探针结构适于在通过时间变化的电磁辐射激发时经历热弹性响应，热弹性响应的特性是结合到探针结构表面的材料的物理性质的函数。电磁激励装置在所选择的一个探针结构中引导电磁能，以便引发激发响应。检测装置确定由分子与其结合而产生的探针结构的激发响应的变化。

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