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1. 发明授权

US08309072B2 Irreversibly-inactivated pepsinogen fragments for modulating immune function 有权
标题翻译：不可逆失活的胃蛋白酶原片段用于调节免疫功能
公开(公告)号：US08309072B2
公开(公告)日：2012-11-13
申请号：US12487637
申请日：2009-06-18
申请人： Harry H. Zhabilov
发明人： Harry H. Zhabilov
IPC分类号： A01N63/00 , A61K38/00
CPC分类号： A61K38/488 , A61K38/2013 , A61K39/39 , A61K2300/00
摘要： Isolated anti-cancer peptides are disclosed which are characterized by the amino acid sequences TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG (SEQ ID NO: 1); TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP (SEQ ID NO: 2); CCATSGPCGAVMILTPHLTA (SEQ ID NO: 5); MTLTTGSGAIAPAMPPGLPPHTGAIHAPM (SEQ ID NO: 4); and NXVPVSVEGYXQITLDSITX (SEQ ID NO: 3) and a significant in vitro binding affinity for gp96. The peptides exhibit anti-tumor, anti-cancer activity in vivo. Also disclosed is an isolated antiviral peptide characterized by the amino acid sequence GDEPLENYLDTEYF (SEQ ID NO: 6) and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41, and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activity.
摘要翻译：公开了分离的抗癌肽，其特征在于氨基酸序列TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG（SEQ ID NO：1）; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP（SEQ ID NO：2）; CCATSGPCGAVMILTPHLTA（SEQ ID NO：5）; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM（SEQ ID NO：4）; 和NXVPVSVEGYXQITLDSITX（SEQ ID NO：3）和对gp96的显着体外结合亲和力。肽在体内表现出抗肿瘤，抗癌活性。还公开了以氨基酸序列GDEPLENYLDTEYF（SEQ ID NO：6）为特征的分离的抗病毒肽和对HIV-1 gp120和gp41以及人CD4细胞的显着体外结合亲和力。肽在体内表现出抗逆转录病毒活性，特别是抗HIV-1活性。

2. 发明授权

US08067531B2 Inactivated pepsin fragments for modulating immune system activity against human malignant tumor cells 有权
标题翻译：用于调节针对人恶性肿瘤细胞的免疫系统活性的失活的胃蛋白酶片段
公开(公告)号：US08067531B2
公开(公告)日：2011-11-29
申请号：US12315441
申请日：2008-12-02
申请人： Harry H. Zhabilov
发明人： Harry H. Zhabilov
IPC分类号： C07K5/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/55533 , C07K14/47 , C12N2740/16111 , G01N2333/16
摘要： Isolated anti-cancer peptides are disclosed which are characterized by the amino acid sequences TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP; CCATSGPCGAVMILTPHLTA; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM; and NXVPVSVEGYXQITLDSITX and a significant in vitro binding affinity for gp96. The peptides exhibit anti-tumor, anti-cancer activity in vivo. Also disclosed is an isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41, and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activity.
摘要翻译：公开了分离的抗癌肽，其特征在于氨基酸序列TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP; CCATSGPCGAVMILTPHLTA; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM; 和NXVPVSVEGYXQITLDSITX和对gp96的显着体外结合亲和力。肽在体内表现出抗肿瘤，抗癌活性。还公开了分离的抗病毒肽的特征在于氨基酸序列GDEPLENYLDTEYF和对HIV-1gp120和gp41以及人CD4细胞的显着体外结合亲和力。肽在体内表现出抗逆转录病毒活性，特别是抗HIV-1活性。

3. 发明申请

US20100143291A1 Inactivated pepsin fragments for modulating immune system activity against human malignant tumor cells 有权
标题翻译：用于调节针对人恶性肿瘤细胞的免疫系统活性的失活的胃蛋白酶片段
公开(公告)号：US20100143291A1
公开(公告)日：2010-06-10
申请号：US12315441
申请日：2008-12-02
申请人： Harry H. Zhabilov
发明人： Harry H. Zhabilov
IPC分类号： A61K38/48 , C12N9/50 , A61P35/00
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/55533 , C07K14/47 , C12N2740/16111 , G01N2333/16
摘要： Isolated anti-cancer peptides are disclosed which are characterized by the amino acid sequences TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP; CCATSGPCGAVMILTPHLTA; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM; and NXVPVSVEGYXQITLDSITX and a significant in vitro binding affinity for gp96. The peptides exhibit anti-tumor, anti-cancer activity in vivo. Also disclosed is an isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41, and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activity.
摘要翻译：公开了分离的抗癌肽，其特征在于氨基酸序列TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP; CCATSGPCGAVMILTPHLTA; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM; 和NXVPVSVEGYXQITLDSITX和对gp96的显着体外结合亲和力。肽在体内表现出抗肿瘤，抗癌活性。还公开了分离的抗病毒肽的特征在于氨基酸序列GDEPLENYLDTEYF和对HIV-1gp120和gp41以及人CD4细胞的显着体外结合亲和力。肽在体内表现出抗逆转录病毒活性，特别是抗HIV-1活性。

4. 发明授权

US07625565B2 Antiviral compositions comprising lysine-rich histone fractions prepared by pepsin treatment of thymic cell nuclei 失效
$Antiviral compositions comprising lysine-rich histone fractions prepared by pepsin treatment of thymic cell nuclei$
标题翻译：包含通过胃蛋白酶处理胸腺细胞核制备的富含赖氨酸的组蛋白级分的抗病毒组合物
公开(公告)号：US07625565B2
公开(公告)日：2009-12-01
申请号：US10336512
申请日：2003-01-03
申请人： Harry P. Zhabilov , Jordanka Zhabilov, legal representative , Harry H. Zhabilov
发明人： Harry P. Zhabilov , Harry H. Zhabilov
IPC分类号： A61K39/38 , A61K35/26
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , G01N33/56988 , G01N33/68
摘要： This invention relates to the area of immunology and virology, and specifically relates to compositions obtainable from mammalian thymus cells which are useful as diagnostics, vaccines, and therapeutics for human immunodeficiency virus (HIV) infection and related diseases such as acquired immunodeficiency syndrome (AIDS) and AIDS-related complex (ARC). The diagnostic, vaccination, and therapeutic methods, and devices, using these compositions are also disclosed.
摘要翻译：本发明涉及免疫学和病毒学领域，具体涉及可从哺乳动物胸腺细胞获得的组合物，其可用作人类免疫缺陷病毒（HIV）感染和相关疾病如获得性免疫缺陷综合征（AIDS）的诊断，疫苗和治疗剂，和艾滋病相关综合症（ARC）。还公开了使用这些组合物的诊断，疫苗接种和治疗方法以及装置。

5. 发明申请

US20090285776A1 IRREVERSIBLY-INACTIVATED PEPSINOGEN FRAGMENTS FOR MODULATING IMMUNE FUNCTION 有权
标题翻译：用于调节免疫功能的不可逆灭活的PEPSINOGEN片段
公开(公告)号：US20090285776A1
公开(公告)日：2009-11-19
申请号：US12487637
申请日：2009-06-18
申请人： Harry H. Zhabilov
发明人： Harry H. Zhabilov
IPC分类号： A61K38/20 , A61K39/00 , A61K38/10
CPC分类号： A61K38/488 , A61K38/2013 , A61K39/39 , A61K2300/00
摘要： Isolated anti-cancer peptides are disclosed which are characterized by the amino acid sequences TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP; CCATSGPCGAVMILTPHLTA; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM; and NXVPVSVEGYXQITLDSITX and a significant in vitro binding affinity for gp96. The peptides exhibit anti-tumor, anti-cancer activity in vivo. Also disclosed is an isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41, and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activity.
摘要翻译：公开了分离的抗癌肽，其特征在于氨基酸序列TLTSGGGAIALPPSMAAPPLGPVAPLTGAIHAPTXG; TLSTATGGAIPPVAAMPPGLVAPTHGPAIHP; CCATSGPCGAVMILTPHLTA; MTLTTGSGAIAPAMPPGLPPHTGAIHAPM; 和NXVPVSVEGYXQITLDSITX和对gp96的显着体外结合亲和力。肽在体内表现出抗肿瘤，抗癌活性。还公开了分离的抗病毒肽的特征在于氨基酸序列GDEPLENYLDTEYF和对HIV-1gp120和gp41以及人CD4细胞的显着体外结合亲和力。肽在体内表现出抗逆转录病毒活性，特别是抗HIV-1活性。

6. 发明授权

US08066982B2 Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing and treating HIV 有权
标题翻译：不可逆灭活的胃蛋白酶原片段和包含其的药物组合物用于检测，预防和治疗HIV
公开(公告)号：US08066982B2
公开(公告)日：2011-11-29
申请号：US12321262
申请日：2009-01-16
申请人： Harry H. Zhabilov
发明人： Harry H. Zhabilov
IPC分类号： A61K48/00 , C07K5/00
CPC分类号： C07K7/06 , A61K38/10 , C07K14/47 , G01N2333/16
摘要： An isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41 and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activity.
摘要翻译：分离的抗病毒肽的特征在于氨基酸序列GDEPLENYLDTEYF和对HIV-1gp120和gp41和人CD4细胞的显着体外结合亲和力。肽在体内表现出抗逆转录病毒活性，特别是抗HIV-1活性。

7. 发明申请

US20100204133A1 Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing and treating HIV 有权
标题翻译：不可逆灭活的胃蛋白酶原片段和包含其的药物组合物用于检测，预防和治疗HIV
公开(公告)号：US20100204133A1
公开(公告)日：2010-08-12
申请号：US12321262
申请日：2009-01-16
申请人： Harry H. Zhabilov
发明人： Harry H. Zhabilov
IPC分类号： A61K38/10 , C12N5/071 , A61P31/18
CPC分类号： C07K7/06 , A61K38/10 , C07K14/47 , G01N2333/16
摘要： An isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41 and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activity.
摘要翻译：分离的抗病毒肽的特征在于氨基酸序列GDEPLENYLDTEYF和对HIV-1gp120和gp41和人CD4细胞的显着体外结合亲和力。肽在体内表现出抗逆转录病毒活性，特别是抗HIV-1活性。

8. 发明授权

US07479538B2 Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing, and treating HIV 有权
标题翻译：不可逆灭活的胃蛋白酶原片段和包含其的用于检测，预防和治疗HIV的药物组合物
公开(公告)号：US07479538B2
公开(公告)日：2009-01-20
申请号：US11177427
申请日：2005-07-11
申请人： Harry H. Zhabilov
发明人： Harry H. Zhabilov
IPC分类号： A61K38/04 , A61K38/10 , A61K38/17 , C07K7/04 , C07K7/08 , G01N33/53
CPC分类号： C07K7/06 , A61K38/10 , C07K14/47 , G01N2333/16
摘要： An isolated antiviral peptide is characterized by the amino acid sequence GDEPLENYLDTEYF and a significant in vitro binding affinity for HIV-1 gp 120 and gp 41, and human CD4 cells. The peptide exhibits anti-retroviral activity in vivo, particularly anti-HIV-1 activity.
摘要翻译：分离的抗病毒肽的特征在于氨基酸序列GDEPLENYLDTEYF和对HIV-1gp120和gp41以及人CD4细胞的显着体外结合亲和力。肽在体内表现出抗逆转录病毒活性，特别是抗HIV-1活性。

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