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1. 发明申请

US20110020401A1 TISSUE TARGETED ANTIGENIC ACTIVATION OF THE IMMUNE RESPONSE TO TREAT CANCERS 有权
标题翻译：组织针对治疗癌症的免疫应答的针对性抗原激活
公开(公告)号：US20110020401A1
公开(公告)日：2011-01-27
申请号：US12843296
申请日：2010-07-26
申请人： Harold David GUNN
发明人： Harold David GUNN
IPC分类号： A61K39/02 , C12Q1/06 , A61K39/00 , A61P37/04
CPC分类号： A61K39/0258 , A61K39/0011 , A61K45/06 , A61K2039/521 , A61K2039/5252 , G01N33/5011 , G01N33/5047 , G01N33/5082 , G01N2333/24 , G01N2333/31 , A61K2300/00
摘要： The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The formulations of the invention thereby facilitate activation of an immune response to a cancer in a particular tissue or organ. The compositions may for example include killed or attenuated microbial pathogens, such as whole killed bacterial cells, and may be administered at sites distant from the cancer, for example the skin. In some embodiments, microbial species of endogenous flora that are known to cause infection in the relevant organ or tissue may be used in the formulation of the antigenic compositions. In alternative embodiments, exogenous microbial pathogens that are known to cause infection in the relevant organ or tissue may be used in the formulation of the antigenic compositions. The administration of the immunogenic compositions may be repeated relatively frequently over a relatively long period of time. In embodiments for intradermal or subcutaneous injection, dosages may be adjusted so that injections reproduce a consistent, visible, delayed inflammatory immune reaction at the successive site or sites of administration.
摘要翻译：本发明部分地通过给予在癌症所在的特定器官或组织中具有致病性的一种或多种微生物具有抗原性特异性的组合物来治疗特定器官或组织的癌症的方法。因此，本发明的制剂有助于激活对特定组织或器官中的癌症的免疫应答。组合物可以例如包括灭活或减毒的微生物病原体，例如完全杀死的细菌细胞，并且可以在远离癌症的位置（例如皮肤）施用。在一些实施方案中，已知在相关器官或组织中引起感染的内源性菌群的微生物物种可用于抗原组合物的制剂中。在替代实施方案中，已知在相关器官或组织中引起感染的外源微生物病原体可用于抗原组合物的制剂中。免疫原性组合物的施用可以在相当长的时间内相对频繁地重复。在皮内注射或皮下注射的实施方案中，可以调整剂量，使得注射在连续的施用位点或再生部位再现一致的，可见的，延迟的炎性免疫反应。

2. 发明授权

US08034359B2 Tissue targeted antigenic activation of the immune response to cancers 有权
标题翻译：组织靶向抗原激活对癌症的免疫反应
公开(公告)号：US08034359B2
公开(公告)日：2011-10-11
申请号：US12234569
申请日：2008-09-19
申请人： Harold David Gunn
发明人： Harold David Gunn
IPC分类号： A61K39/108
CPC分类号： A61K39/0011 , A61K2039/521 , A61K2039/5252 , A61K2300/00
摘要： The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The formulations of the invention thereby facilitate activation of a treatment response to a cancer in a particular tissue or organ. The compositions may for example include killed or attenuated microbial pathogens, and may be administered at sites distant from the cancer, for example the skin. In some embodiments, microbial species of endogenous flora that are known to cause infection in the relevant organ or tissue may be used in the formulation of the antigenic compositions. In alternative embodiments, exogenous microbial pathogens that are known to cause infection in the relevant organ or tissue may be used in the formulation of the antigenic compositions. The administration of the immunogenic compositions may be repeated relatively frequently over a relatively long period of time. In embodiments for intradermal or subcutaneous injection, dosages may be adjusted so that injections reproduce a consistent visible delayed inflammatory immune reaction at the successive site or sites of administration.
摘要翻译：本发明部分地通过给予在癌症所在的特定器官或组织中具有致病性的一种或多种微生物具有抗原性特异性的组合物来治疗特定器官或组织的癌症的方法。因此，本发明的制剂有助于激活对特定组织或器官中的癌症的治疗反应。组合物可以例如包括杀死或减毒的微生物病原体，并且可以在远离癌症的位置（例如皮肤）施用。在一些实施方案中，已知在相关器官或组织中引起感染的内源性菌群的微生物物种可用于抗原组合物的制剂中。在替代实施方案中，已知在相关器官或组织中引起感染的外源微生物病原体可用于抗原组合物的制剂中。免疫原性组合物的施用可以在相当长的时间内相对频繁地重复。在皮内注射或皮下注射的实施方案中，可以调节剂量，使得注射在连续的施用部位或再现部位再现一致的可见延迟炎症免疫反应。

3. 发明申请

US20130177593A1 PERSONALIZED SITE-SPECIFIC IMMUNOMODULATION 有权
标题翻译：个性化网站特异性免疫调节
公开(公告)号：US20130177593A1
公开(公告)日：2013-07-11
申请号：US13560892
申请日：2012-07-27
申请人： Harold David Gunn , Salim Dhanji , Brett Anthony Premack , Michael Tak Huai Chow
发明人： Harold David Gunn , Salim Dhanji , Brett Anthony Premack , Michael Tak Huai Chow
IPC分类号： A61K39/108
CPC分类号： A61K39/0258 , A61K39/0008 , A61K39/0011 , A61K39/0266 , A61K39/0275 , A61K39/05 , A61K39/085 , A61K39/092 , A61K39/095 , A61K39/102 , A61K2039/521 , A61K2039/5252 , A61K2039/542 , A61K2039/545 , A61K2039/58 , A61K2039/585 , A61K2039/70 , Y02A50/474 , Y02A50/482 , Y10S514/867 , A61K2300/00
摘要： The invention provides methods of treating inflammation in a specific organ or tissue of an individual. The method involves determining whether the individual has previously been infected with at least one pathogen that is pathogenic in the specific organ or tissue; and administering to the individual an anti-inflammatory composition comprising antigenic determinants, the antigenic determinants selected or formulated so that together they are specific for the at least one pathogen. The pathogen may be an endogenous or exogenous pathogen, and may further be a bacterial pathogen, a viral pathogen, a fungal pathogen, a protozoan pathogen, or a helminth pathogen.
摘要翻译：本发明提供了治疗个体的特定器官或组织中的炎症的方法。该方法包括确定个体以前是否已经感染了至少一种在特定器官或组织中致病的病原体; 以及向个体施用包含抗原决定簇的抗炎组合物，选择或配制的抗原决定簇，使得它们一起对于至少一种病原体是特异性的。病原体可以是内源性或外源性病原体，并且可能是细菌病原体，病毒病原体，真菌病原体，原生动物病原体或蠕虫病原体。

4. 发明申请

US20110195093A1 Tissue Targeted Antigenic Activation of the Immune Response to Treat Cancers 有权
标题翻译：组织靶向抗原激活免疫反应治疗癌症
公开(公告)号：US20110195093A1
公开(公告)日：2011-08-11
申请号：US13019208
申请日：2011-02-01
申请人： Harold David Gunn
发明人： Harold David Gunn
IPC分类号： A61K39/085 , A61P35/00
CPC分类号： A61K39/235 , A61K31/192 , A61K31/405 , A61K31/635 , A61K33/24 , A61K39/0011 , A61K39/0241 , A61K39/0258 , A61K39/0266 , A61K39/0275 , A61K39/085 , A61K39/092 , A61K39/102 , A61K39/1045 , A61K39/145 , A61K39/155 , A61K2039/521 , A61K2039/522 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , A61K2039/575 , A61K2039/585 , A61K2039/70 , C12N2710/10032 , C12N2760/16032 , C12N2760/18532 , C12N2760/18632 , C12R1/445 , G01N33/5055 , G01N33/5088 , Y02A50/474 , Y02A50/482 , A61K2300/00
摘要： The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated.
摘要翻译：本发明部分地通过给予在癌症所在的特定器官或组织中具有致病性的一种或多种微生物具有抗原性特异性的组合物来治疗特定器官或组织的癌症的方法。

5. 发明授权

US07921361B2 Data entry for personal computing devices 失效
标题翻译：个人计算设备的数据输入
公开(公告)号：US07921361B2
公开(公告)日：2011-04-05
申请号：US11871887
申请日：2007-10-12
申请人： Harold David Gunn , John Chapman
发明人： Harold David Gunn , John Chapman
IPC分类号： G06F17/00
CPC分类号： G06F3/04883 , G06F3/0236 , G06F3/0237 , G06F3/04886
摘要： In one aspect, a method, apparatus, computer-readable medium and system is provided for facilitating user text generation and entry. In some illustrative embodiments, user input received from a digital keyboard and search list is used to retrieve completion candidates likely intended by the user or containing at least a portion of the user's intended text. Completion candidates may be selected using a pointing device (for example, a touch-sensitive screen) with a pointing operation that includes a gesture. A completion candidate may be used to search for more relevant completion candidates.
摘要翻译：在一个方面，提供了一种用于促进用户文本生成和输入的方法，装置，计算机可读介质和系统。在一些说明性实施例中，从数字键盘和搜索列表接收的用户输入用于检索可能由用户预期的或包含用户期望文本的至少一部分的完成候选。可以使用包括手势的指向操作的指点设备（例如，触敏屏幕）来选择完成候选。完成候选人可用于搜索更多相关的完成候选人。

6. 发明授权

US07293231B1 Data entry for personal computing devices 有权
标题翻译：个人计算设备的数据输入
公开(公告)号：US07293231B1
公开(公告)日：2007-11-06
申请号：US09631101
申请日：2000-08-01
申请人： Harold David Gunn , John Chapman
发明人： Harold David Gunn , John Chapman
IPC分类号： G06F17/00
CPC分类号： G06F3/04883 , G06F3/0236 , G06F3/0237 , G06F3/04886
摘要： In one aspect of the invention, the user can rapidly enter and search for text through a combination of entering one or more characters (a partial text entry) on a digitally displayed keyboard with a pointing device and using a search list to display a list of selectable completion candidates based on the partial text entry. The user can select one of the completion candidates in the search list to replace the partial text entry which the user is currently entering. Alternatively, the user can select a completion candidate to be the basis of a search for a refined list of completion candidates. The user can also deactivate the interactive search list, and immediately continue adding to or modifying the current partial text entry, and may re-invoke the search list to further search for completion candidates based on the modified partial text entry.
摘要翻译：在本发明的一个方面，用户可以通过在数字显示的键盘上与定点设备输入一个或多个字符（部分文本输入）的组合来快速地输入和搜索文本，并且使用搜索列表来显示列表基于部分文本输入的可选择的完成候选。用户可以选择搜索列表中的一个完成候选来替换用户当前正在进入的部分文本条目。或者，用户可以选择完成候选作为搜索完成候选的精简列表的基础。用户还可以停用交互式搜索列表，并且立即继续添加或修改当前的部分文本条目，并且可以重新调用搜索列表以进一步基于修改的部分文本条目搜索完成候选。

7. 发明授权

US09107864B2 Tissue targeted antigenic activation of the immune response to treat cancers 有权
标题翻译：组织靶向抗原激活治疗癌症的免疫反应
公开(公告)号：US09107864B2
公开(公告)日：2015-08-18
申请号：US13019208
申请日：2011-02-01
申请人： Harold David Gunn
发明人： Harold David Gunn
IPC分类号： A61K39/085 , A61K39/00 , A61K39/108 , A61K39/112 , A61K39/09 , A61K39/104 , C12R1/445
CPC分类号： A61K39/235 , A61K31/192 , A61K31/405 , A61K31/635 , A61K33/24 , A61K39/0011 , A61K39/0241 , A61K39/0258 , A61K39/0266 , A61K39/0275 , A61K39/085 , A61K39/092 , A61K39/102 , A61K39/1045 , A61K39/145 , A61K39/155 , A61K2039/521 , A61K2039/522 , A61K2039/5252 , A61K2039/5254 , A61K2039/545 , A61K2039/575 , A61K2039/585 , A61K2039/70 , C12N2710/10032 , C12N2760/16032 , C12N2760/18532 , C12N2760/18632 , C12R1/445 , G01N33/5055 , G01N33/5088 , Y02A50/474 , Y02A50/482 , A61K2300/00
摘要： The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated.
摘要翻译：本发明部分地通过给予在癌症所在的特定器官或组织中具有致病性的一种或多种微生物具有抗原性特异性的组合物来治疗特定器官或组织的癌症的方法。

8. 发明申请

US20120258135A1 IMMUNOGENIC ANTI-INFLAMMATORY COMPOSITIONS 审中-公开
标题翻译：免疫组化抗炎组合物
公开(公告)号：US20120258135A1
公开(公告)日：2012-10-11
申请号：US13359441
申请日：2012-01-26
申请人： Harold David Gunn , Salim Dhanji , Brett Anthony Premack , Michael Tak Huai Chow
发明人： Harold David Gunn , Salim Dhanji , Brett Anthony Premack , Michael Tak Huai Chow
IPC分类号： A61K39/00 , A61K39/12 , A61K39/085 , A61K39/04 , A61K39/09 , A61K39/104 , A61K39/095 , A61K39/112 , A61K39/108 , A61K39/10 , A61K39/145 , A61K39/29 , A61K39/21 , A61K39/165 , A61P37/04 , A61P19/02 , A61K39/02
CPC分类号： A61K39/0011 , A61K39/0008 , A61K39/0258 , A61K39/0266 , A61K39/0275 , A61K39/05 , A61K39/085 , A61K39/092 , A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/5252 , A61K2039/542 , A61K2039/545 , A61K2039/58 , A61K2039/585 , A61K2039/70 , G01N33/569 , Y02A50/474 , Y02A50/478 , Y02A50/482 , A61K2300/00
摘要： The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue. In embodiments of the invention the pathogen may be an endogenous pathogen, such as an endogenous bacterial pathogen. The pathogen may be an exogenous pathogen, such as a bacterial pathogen, viral pathogen, a fungal pathogen, or a helminth pathogen.
摘要翻译：本发明提供配制用于治疗特定器官或组织中的炎性病症的抗炎组合物的方法。该方法包括选择至少一种在特定器官或组织中致病的病原体; 产生包含抗原决定簇的抗原组合物，其一起对病原体是特异性的; 并配制作为能够在特定器官或组织中引发抗炎反应的抗炎组合物给药的抗原组合物。在本发明的实施方案中，病原体可以是内源性病原体，例如内源性细菌病原体。病原体可以是外源性病原体，例如细菌病原体，病毒病原体，真菌病原体或蠕虫病原体。

9. 发明授权

US10130692B2 Immunogenic anti-inflammatory compositions 有权
公开(公告)号：US10130692B2
公开(公告)日：2018-11-20
申请号：US13359441
申请日：2012-01-26
申请人： Harold David Gunn , Salim Dhanji , Brett Anthony Premack , Michael Tak Huai Chow
发明人： Harold David Gunn , Salim Dhanji , Brett Anthony Premack , Michael Tak Huai Chow
IPC分类号： A61K39/05 , A61K39/00 , A61K39/108 , A61K39/112 , A61K39/085 , A61K39/09 , G01N33/569 , A61K39/095 , A61K39/102 , A61K39/104
摘要： The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue. In embodiments of the invention the pathogen may be an endogenous pathogen, such as an endogenous bacterial pathogen. The pathogen may be an exogenous pathogen, such as a bacterial pathogen, viral pathogen, a fungal pathogen, or a helminth pathogen.

10. 发明授权

US08980279B2 Personalized site-specific immunomodulation 有权
标题翻译：个性化的位点特异性免疫调节
公开(公告)号：US08980279B2
公开(公告)日：2015-03-17
申请号：US13560892
申请日：2012-07-27
申请人： Harold David Gunn , Salim Dhanji , Brett Anthony Premack , Michael Tak Huai Chow
发明人： Harold David Gunn , Salim Dhanji , Brett Anthony Premack , Michael Tak Huai Chow
IPC分类号： A61K39/108 , A61K39/00 , A61K39/112 , A61K39/085 , A61K39/09 , A61K39/05 , A61K39/095 , A61K39/102
CPC分类号： A61K39/0258 , A61K39/0008 , A61K39/0011 , A61K39/0266 , A61K39/0275 , A61K39/05 , A61K39/085 , A61K39/092 , A61K39/095 , A61K39/102 , A61K2039/521 , A61K2039/5252 , A61K2039/542 , A61K2039/545 , A61K2039/58 , A61K2039/585 , A61K2039/70 , Y02A50/474 , Y02A50/482 , Y10S514/867 , A61K2300/00
摘要： The invention provides methods of treating inflammation in a specific organ or tissue of an individual. The method involves determining whether the individual has previously been infected with at least one pathogen that is pathogenic in the specific organ or tissue; and administering to the individual an anti-inflammatory composition comprising antigenic determinants, the antigenic determinants selected or formulated so that together they are specific for the at least one pathogen. The pathogen may be an endogenous or exogenous pathogen, and may further be a bacterial pathogen, a viral pathogen, a fungal pathogen, a protozoan pathogen, or a helminth pathogen.
摘要翻译：本发明提供了治疗个体的特定器官或组织中的炎症的方法。该方法包括确定个体以前是否已经感染了至少一种在特定器官或组织中致病的病原体; 以及向个体施用包含抗原决定簇的抗炎组合物，选择或配制的抗原决定簇，使得它们一起对于至少一种病原体是特异性的。病原体可以是内源性或外源性病原体，并且可能是细菌病原体，病毒病原体，真菌病原体，原生动物病原体或蠕虫病原体。

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