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1. 发明专利

CA218092A POCKET IRON FOR BILLIARD TABLES 未知
公开(公告)号：CA218092A
公开(公告)日：1922-05-02
申请号：CA218092D
申请人： BRUBACKER HAROLD CHAPMAN
发明人： BRUBACKER HAROLD CHAPMAN

2. 发明申请

US20050095248A1 Suppression of immune response via inhibition of cathepsin S 失效
公开(公告)号：US20050095248A1
公开(公告)日：2005-05-05
申请号：US10913045
申请日：2004-08-05
申请人： Hidde Ploegh , Harold Chapman , Richard Riese , Paula Bryant , Matthew Bogyo
发明人： Hidde Ploegh , Harold Chapman , Richard Riese , Paula Bryant , Matthew Bogyo
IPC分类号： C12N9/99 , A61K31/00 , A61K38/00 , A61K38/55 , A61K45/00 , A61P1/00 , A61P1/02 , A61P3/00 , A61P3/10 , A61P5/00 , A61P21/00 , A61P25/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/093 , A61K39/395 , A61K38/17
CPC分类号： C07K5/06113 , A61K38/55 , C07K5/06043 , C07K5/06095 , C07K5/0819 , Y10S424/81 , Y10S514/885
摘要： Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reducing the competency of class II MHC molecules for binding antigenic peptides, reducing presentation of antigenic peptides by class II MHC molecules, and suppressing immune responses. The methods may be employed in the treatment of autoimmune diseases, allergic responses, and organ or tissue graft rejection. Pharmaceutical and therapeutic compositions which are peptide based inhibitors of cathepsin S are also described.

3. 发明申请

US20050080010A1 Suppression of immune response via inhibition of cathepsin S 审中-公开
标题翻译：通过抑制组织蛋白酶S抑制免疫反应
公开(公告)号：US20050080010A1
公开(公告)日：2005-04-14
申请号：US10641872
申请日：2003-08-14
申请人： Hidde Ploegh , Harold Chapman , Richard Riese , Paula Bryant , Matthew Bogyo
发明人： Hidde Ploegh , Harold Chapman , Richard Riese , Paula Bryant , Matthew Bogyo
IPC分类号： C12N9/99 , A61K31/00 , A61K38/00 , A61K38/55 , A61K45/00 , A61P1/00 , A61P1/02 , A61P3/00 , A61P3/10 , A61P5/00 , A61P21/00 , A61P25/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07K5/06 , C07K5/072 , C07K5/08 , C07K5/093 , A61K38/17
CPC分类号： C07K5/06113 , A61K38/55 , C07K5/06043 , C07K5/06095 , C07K5/0819 , Y10S424/81 , Y10S514/885
摘要： Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reducing the competency of class II MHC molecules for binding antigenic peptides, reducing presentation of antigenic peptides by class II MHC molecules, and suppressing immune responses. The methods may be employed in the treatment of autoimmune diseases, allergic responses, and organ or tissue graft rejection. Pharmaceutical and therapeutic compositions which are peptide based inhibitors of cathepsin S are also described.
摘要翻译：描述了用于抑制哺乳动物或哺乳动物细胞中II类MHC限制性免疫应答的方法和产品。该方法取决于来自II类MHC /不变链复合物的组织蛋白酶S的不变链蛋白酶解，从而降低II类MHC分子与抗原肽结合的能力，减少II类MHC分子呈递抗原肽，抑制免疫应答。该方法可用于治疗自身免疫疾病，过敏反应和器官或组织移植物排斥。还描述了作为组织蛋白酶S的基于肽的抑制剂的药物和治疗组合物。

4. 发明授权

US5830850A Methods for the treatment of bone resorption disorders, including osteoporosis 失效
标题翻译：治疗骨吸收障碍的方法，包括骨质疏松症
公开(公告)号：US5830850A
公开(公告)日：1998-11-03
申请号：US704473
申请日：1996-08-28
申请人： Bruce D. Gelb , Harold Chapman , Robert J. Desnick
发明人： Bruce D. Gelb , Harold Chapman , Robert J. Desnick
IPC分类号： A61K45/00 , A61K31/00 , A61P19/08 , A61P19/10 , A61P43/00 , A61K48/00
CPC分类号： A61K31/00
摘要： The present invention relates to methods and compositions for the amelioration of symptoms caused by bone resorption disorders, including but not limited to osteoporosis, arthritides and periodontal disease, and damage caused by macrophage-mediated inflammatory processes. In one embodiment, the methods and compositions of the invention include methods and compositions for the specific inhibition of cathepsin K activity. In an additional embodiment, the methods and compositions of the invention include methods and compositions for the specific inhibition of cathepsin K activity coupled with specific inhibition of at least a second activity involved in the bone resorption and/or macrophage-mediated inflammatory processes. In a particular embodiment, the methods and compositions of the invention include methods and compositions for the specific inhibition of cathepsin K and cathepsin S activity.
摘要翻译：本发明涉及用于改善由骨吸收障碍引起的症状的方法和组合物，包括但不限于骨质疏松症，关节炎和牙周病以及由巨噬细胞介导的炎性过程引起的损伤。在一个实施方案中，本发明的方法和组合物包括用于特异性抑制组织蛋白酶K活性的方法和组合物。在另外的实施方案中，本发明的方法和组合物包括用于特异性抑制组织蛋白酶K活性的方法和组合物，以及参与骨吸收和/或巨噬细胞介导的炎症过程的至少第二活性的特异性抑制。在一个具体实施方案中，本发明的方法和组合物包括用于特异性抑制组织蛋白酶K和组织蛋白酶S活性的方法和组合物。

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