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1. 发明申请

US20200375900A1 MAGNETIC ASSISTED DRUG DELIVERY 审中-公开
公开(公告)号：US20200375900A1
公开(公告)日：2020-12-03
申请号：US16888355
申请日：2020-05-29
申请人： Hao SHANG
发明人： Hao SHANG
IPC分类号： A61K9/14 , A61M25/00 , A61K9/00 , A61K45/06
摘要： A method of delivering magnetic particles to a target site, including inserting a magnet catheter into a blood vessel; advancing the magnet catheter to a position downstream from the target site; and releasing magnetic particles into the blood vessel upstream of the target site; in which a first portion of the magnetic particles embolize in the blood vessel is disclosed. A system is also disclosed.

2. 发明申请

US20070172426A1 POLYMER COATED MICROPARTICLES 有权
标题翻译：聚合物包衣微胶囊
公开(公告)号：US20070172426A1
公开(公告)日：2007-07-26
申请号：US11552324
申请日：2006-10-24
申请人： Gil Lee , Hao Shang , Won-Suk Chang
发明人： Gil Lee , Hao Shang , Won-Suk Chang
IPC分类号： A61K49/10 , B05D3/00
CPC分类号： B01J2/06 , A61K41/0028 , A61K41/0052 , A61K49/1887 , B01J13/12 , B01J13/14 , B82Y5/00 , B82Y25/00 , H01F1/0054
摘要： Methods for preparing uniformly sized microparticles, with an optional polymeric coating generally include: 1) providing nanoparticles, preferably having a size of between 1 nm and 100 nm; 2) adding a hydrophobic surface layer to the nanoparticles; 3) making a suspension of the hydrophobic nanoparticles and a polymerization initiator in an hydrophobic solvent; 4) dissolving a monomer in the hydrophobic solvent; 5) making an emulsion by dispersing droplets of the hydrophobic solvent in a continuous aqueous phase with an emulsifier; 6) sizing the first emulsion to provide a second emulsion of the same basic components but in which the droplets are substantially uniform and between 2 and 20 μm in size; 7) evaporating at least a substantial portion of the dispersed hydrophobic droplets to assemble nanoparticles to form microparticles suspended now in the aqueous phase; 8) optionally replacing the first surfactant with a second surfactant, which is preferably a polymerizable surfactant; 9) optionally adding a polymerizable monomer to the aqueous phase and allowing it to adsorb into the microparticle; 10) polymerizing the monomer(s) to provide a polymer layer on the microparticles; and 11) functionalizing the polymer surface layer of the microparticles with one or more polymer, nanoparticle or biological macromolecular layers. In a related method the nanoparticles are provided with a hydrophilic surface layer, and the emulsion is made by dispersing the aqueous nanoparticles in a continuous hydrophobic phase. The microparticles have a polymeric coating and a magnetic core that comprises in excess of 50% of the particle's mass. The polymeric shell may contain one or more functional groups capable of forming chemical bonds useful in managing a variety of separations.
摘要翻译：用任选的聚合物涂层制备均匀尺寸的微粒的方法通常包括：1）提供优选具有1nm至100nm尺寸的纳米颗粒; 2）向纳米颗粒中加入疏水表面层; 3）使疏水性纳米粒子和聚合引发剂在疏水性溶剂中的悬浮液; 4）将单体溶解在疏水溶剂中; 5）通过将疏水性溶剂的液滴与乳化剂分散在连续的水相中来制备乳液; 6）调整第一乳液的尺寸以提供相同基本组分的第二乳液，但其中液滴基本均匀且尺寸在2至20μm之间; 7）蒸发至少大部分分散的疏水液滴以组装纳米颗粒以形成现在悬浮在水相中的微粒; 8）任选地用第二表面活性剂替代第一表面活性剂，第二表面活性剂优选为可聚合表面活 9）任选地将可聚合单体加入到水相中并使其吸附到微粒中; 10）聚合单体以在微粒上提供聚合物层; 和11）用一种或多种聚合物，纳米颗粒或生物大分子层官能化微粒的聚合物表面层。在相关方法中，纳米颗粒设置有亲水表面层，并且通过将水性纳米颗粒分散在连续的疏水相中来制备乳液。微粒具有聚合物涂层和包含超过颗粒质量的50％的磁芯。聚合物壳可以含有一个或多个能够形成用于管理各种分离的化学键的官能团。

3. 发明申请

US20050103404A1 Low nickel containing chromim-nickel-mananese-copper austenitic stainless steel 审中-公开
标题翻译：低镍含铬铬镍锰锰铜奥氏体不锈钢
公开(公告)号：US20050103404A1
公开(公告)日：2005-05-19
申请号：US10993674
申请日：2004-11-19
申请人： Meng-Hsin Hsieh , Yi-Cheng Wu , Pei-Te Huang , Hao-Shang Liu
发明人： Meng-Hsin Hsieh , Yi-Cheng Wu , Pei-Te Huang , Hao-Shang Liu
IPC分类号： C22C38/42
CPC分类号： C22C38/42 , C22C38/001 , C22C38/02 , C22C38/58
摘要： An austenitic stainless steel includes (a) 0.03 wt % to 0.12 wt % of C, (b) 0.2 wt % to 1.0 wt % of Si, (c) 7.5 wt % to 10.5 wt % of Mn, (d) 14.0 wt % to 16.0 wt % of Cr, (e) 4.05 wt % to 4.31 wt % of Ni, (f) 0.04 wt % to 0.07 wt % of N, (g) 1.0 wt % to 3.5 wt % of Cu, (h) trace amount of Mo, and the balance being Fe and incidental impurities. The austenitic stainless steel has a δ-ferrite content less than 8.5 and equal to 6.77[(d)+(h)+1.5(b)]−4.85[(e)+30(a)+30(f)+0.5(c)+0.3(g)]−52.75.
摘要翻译：奥氏体不锈钢包括（a）0.03重量％至0.12重量％的C，（b）0.2重量％至1.0重量％的Si，（c）7.5重量％至10.5重量％的Mn，（d）14.0重量％至6.0重量％的Cr，（e）4.05重量％至4.31重量％的Ni，（f）0.04重量％至0.07重量％的N，（g）1.0重量％至3.5重量％的Cu，（h）痕量 Mo量，余量为Fe和杂质。奥氏体不锈钢的δ-铁素体含量小于8.5，等于6.77 [（d）+（h）+1.5（b）] - 4.85 [（e）+30（a）+30（f）+0.5（ c）+0.3（g）] - 52.75。

4. 发明授权

US08715739B2 Polymer coated microparticles 有权
标题翻译：聚合物涂层微粒
公开(公告)号：US08715739B2
公开(公告)日：2014-05-06
申请号：US11552324
申请日：2006-10-24
申请人： Gil U. Lee , Hao Shang , Won-Suk Chang
发明人： Gil U. Lee , Hao Shang , Won-Suk Chang
IPC分类号： A61K9/50
CPC分类号： B01J2/06 , A61K41/0028 , A61K41/0052 , A61K49/1887 , B01J13/12 , B01J13/14 , B82Y5/00 , B82Y25/00 , H01F1/0054
摘要： Methods for preparing uniformly sized micropanicles, with an optional polymeric coating generally include: 1) providing nanoparticles, preferably having a size of between 1 nm and 100 nm; 2) adding a hydrophobic surface layer to the nanoparticles; 3) making a suspension of the hydrophobic nanoparticles and a polymerization initiator in an hydrophobic solvent; 4) dissolving a monomer in the hydrophobic solvent; 5) making an emulsion by dispersing droplets of the hydrophobic solvent in a continuous aqueous phase with an emulsifier; 6) sizing the first emulsion to provide a second emulsion of the same components in which the droplets are substantially uniform and between 2 and 20 um in size; 7) evaporating at least a substantial portion of the dispersed hydrophobic droplets to assemble nanoparticles to form micropanicles suspended now in the aqueous phase; 8) replacing the first surfactant with a second surfactant, which is preferably a polymerizable surfactant; 9) adding a polymerizable monomer to the aqueous phase and allowing it to adsorb into the microparticle; 10) polymerizing the monomer(s) to provide a polymer layer on the micropanicles; and 11) functionalizing the polymer surface layer erf the micropanicles with one or more polymer, nanoparticle or biological macromolecular layers.
摘要翻译：用任选的聚合物涂层制备均匀尺寸的微粒子的方法通常包括：1）提供优选具有1nm至100nm尺寸的纳米颗粒; 2）向纳米颗粒中加入疏水表面层; 3）使疏水性纳米粒子和聚合引发剂在疏水性溶剂中的悬浮液; 4）将单体溶解在疏水溶剂中; 5）通过将疏水性溶剂的液滴与乳化剂分散在连续的水相中来制备乳液; 6）调整第一乳液的尺寸以提供相同组分的第二乳液，其中液滴基本上均匀且尺寸在2-20μm之间; 7）蒸发至少大部分分散的疏水液滴以组装纳米颗粒以形成现在悬浮于水相中的微球; 8）用优选可聚合表面活性剂的第二表面活性剂代替第一表面活性剂; 9）向水相中加入可聚合单体并使其吸附到微粒中; 10）聚合单体以在微粒上提供聚合物层; 和11）使用一种或多种聚合物，纳米颗粒或生物大分子层对聚合物表面层进行功能化。

5. 发明授权

US07780908B2 Low nickel containing chromium-nickel-manganese- copper austenitic stainless steel 有权
标题翻译：低镍含铬镍锰铜奥氏体不锈钢
公开(公告)号：US07780908B2
公开(公告)日：2010-08-24
申请号：US11866869
申请日：2007-10-03
申请人： Meng-Hsin Hsieh , Yi-Cheng Wu , Pei-Te Huang , Hao-Shang Liu
发明人： Meng-Hsin Hsieh , Yi-Cheng Wu , Pei-Te Huang , Hao-Shang Liu
IPC分类号： C22C38/58
CPC分类号： C22C38/42 , C22C38/001 , C22C38/02 , C22C38/58
摘要： An austenitic stainless steel includes (a) 0.03 wt % to 0.12 wt % of C, (b) 0.2 wt % to 1.0 wt % of Si, (c) 8.55 wt % to 10.12 wt % of Mn, (d) 14.0 wt % to 16.0 wt % of Cr, (e) 4.05 wt % to 4.31 wt % of Ni, (f) 0.04 wt % to 0.07 wt % of N, (g) 1.0 wt % to 3.5 wt % of Cu, (h) trace amount of Mo, and the balance being Fe and incidental impurities. The austenitic stainless steel has a δ-ferrite content less than 8.5 and equal to 6.77[(d)+(h)+1.5(b)]−4.85[(e)+30(a)+30(f)+0.5(c)+0.3(g)]−52.75.
摘要翻译：奥氏体不锈钢包括（a）0.03重量％至0.12重量％的C，（b）0.2重量％至1.0重量％的Si，（c）8.55重量％至10.12重量％的Mn，（d）14.0重量％至6.0重量％的Cr，（e）4.05重量％至4.31重量％的Ni，（f）0.04重量％至0.07重量％的N，（g）1.0重量％至3.5重量％的Cu，（h）痕量 Mo量，余量为Fe和杂质。奥氏体不锈钢的δ-铁素体含量小于8.5，等于6.77 [（d）+（h）+1.5（b）] - 4.85 [（e）+30（a）+30（f）+0.5（ c）+0.3（g）] - 52.75。

6. 发明申请

US20080075623A1 LOW NICKEL CONTAINING CHROMIUM-NICKEL-MANGANESE- COPPER AUSTENITIC STAINLESS STEEL 有权
标题翻译：低镍含铬铬锰锰铜奥氏体不锈钢
公开(公告)号：US20080075623A1
公开(公告)日：2008-03-27
申请号：US11866869
申请日：2007-10-03
申请人： Meng-Hsin Hsieh , Yi-Cheng Wu , Pei-Te Huang , Hao-Shang Liu
发明人： Meng-Hsin Hsieh , Yi-Cheng Wu , Pei-Te Huang , Hao-Shang Liu
IPC分类号： C22C38/58
CPC分类号： C22C38/42 , C22C38/001 , C22C38/02 , C22C38/58
摘要： An austenitic stainless steel includes (a) 0.03 wt % to 0.12 wt % of C, (b) 0.2 wt % to 1.0 wt % of Si, (c) 8.55 wt % to 10.12 wt % of Mn, (d) 14.0 wt % to 16.0 wt % of Cr, (e) 4.05 wt % to 4.31 wt % of Ni, (f) 0.04 wt % to 0.07 wt % of N, (g) 1.0 wt % to 3.5 wt % of Cu, (h) trace amount of Mo, and the balance being Fe and incidental impurities. The austenitic stainless steel has a δ-ferrite content less than 8.5 and equal to 6.77[(d)+(h)+1.5(b)]−4.85[(e)+30(a)+30(f)+0.5(c)+0.3(g)]−52.75.
摘要翻译：奥氏体不锈钢包括（a）0.03重量％至0.12重量％的C，（b）0.2重量％至1.0重量％的Si，（c）8.55重量％至10.12重量％的Mn，（d）14.0重量％至6.0重量％的Cr，（e）4.05重量％至4.31重量％的Ni，（f）0.04重量％至0.07重量％的N，（g）1.0重量％至3.5重量％的Cu，（h）痕量 Mo量，余量为Fe和杂质。奥氏体不锈钢的δ-铁素体含量小于8.5，等于6.77 [（d）+（h）+1.5（b）] - 4.85 [（e）+30（a）+30（f）+0.5（ c）+0.3（g）] - 52.75。

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