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1. 发明授权

US4058512A Synthetic peptides having growth promoting activity 失效
标题翻译：具有生长促进活性的合成肽
公开(公告)号：US4058512A
公开(公告)日：1977-11-15
申请号：US571995
申请日：1975-04-28
申请人： Hans Sievertsson , Ronny Hugo Loritz Lundin , Gertrud Elisabeth Westin Sjodahl
发明人： Hans Sievertsson , Ronny Hugo Loritz Lundin , Gertrud Elisabeth Westin Sjodahl
IPC分类号： A61K38/00 , C07K7/06 , C07K7/08 , C07K14/65 , C07C103/52 , A61K37/00
CPC分类号： C07K7/06 , C07K14/65 , C07K7/08 , A61K38/00 , Y10S435/811 , Y10S930/12 , Y10S930/26
摘要： Novel synthetic peptides of the general formula ##STR1## and the corresponding reduced, linear form. The cyclic form of the peptide is produced by oxidation of the corresponding linear compound thereby providing the divalent dithio group --S--S-- joining the beta carbon of each of the cysteine moieties. In the above formula X is serine (SER) or lysine (Lys), and Y is OH or Thr-Glu-Gly-Phe. The obtained synthetic peptides, in either form, are useful in promoting growth of cells of mammalian tissues.
摘要翻译：具有通式的新型合成肽和相应的还原型线性形式。通过氧化相应的线性化合物产生肽的环状，从而提供二价二硫基-S-S-连接每个半胱氨酸部分的β碳。在上式中，X是丝氨酸（SER）或赖氨酸（Lys），Y是OH或Thr-Glu-Gly-Phe。获得的任何形式的合成肽可用于促进哺乳动物组织细胞的生长。

2. 发明授权

US3974135A Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for producing the same 失效
标题翻译：具有促黄体激素释放激素活性的合成十肽及其制备方法
公开(公告)号：US3974135A
公开(公告)日：1976-08-10
申请号：US261007
申请日：1972-06-08
申请人： Karl Folkers , Hans Sievertsson
发明人： Karl Folkers , Hans Sievertsson
IPC分类号： A61K38/00 , C07K7/23 , C07C103/52 , C07G7/00
CPC分类号： C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13
摘要： A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide having the hormonal activity of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is provided by utilizing, as key starting materials, the amino acids, pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate protected forms, all of the remaining amino acids, individually or in combination, to the starting amino acid, or amino acid group or to the terminal amino acid resulting from combinations with one or more other amino acids, bound to a resin or carrier followed by release of the decapeptide from the carrier as the amide or other form which is converted to the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide.
摘要翻译：具有促黄体生成激素释放激素（LRH）的激素活性的合成十肽L- L-谷氨酰-L-组氨酰基-L-色氨酰-L-丝氨酰-L-酪氨酰 - 甘氨酰-L-赖氨酸-L-精氨酰-L-脯氨酰基 - 甘氨酰胺）作为关键原料，通过利用氨基酸，焦谷氨酸，组氨酸，色氨酸，丝氨酸，酪氨酸，甘氨酸，亮氨酸，精氨酸，脯氨酸来提供哺乳动物的下丘脑腺体。十肽的合成通过以适当的保护形式将所有残留的氨基酸单独或组合连接到起始氨基酸或氨基酸基团或与由一种或多种其它的组合产生的末端氨基酸氨基酸，结合到树脂或载体上，随后将十肽从载体中释放为酰胺或转化为酰胺的其它形式，L-谷氨酰-L-组氨酰-L-色氨酰-L-丝氨酰-L-酪氨酰基甘氨酰-L-赖氨酸-L-精氨酰-L-脯氨酰基 - 甘氨酰胺。

3. 发明授权

US3953416A Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same 失效
标题翻译：具有黄体激素释放激素活性的合成十肽及其制造方法
公开(公告)号：US3953416A
公开(公告)日：1976-04-27
申请号：US432903
申请日：1974-01-14
申请人： Karl Folkers , Bruce L. Currie , Jaw-Kang Chang , Hans Sievertsson , Conny Bogentoft
发明人： Karl Folkers , Bruce L. Currie , Jaw-Kang Chang , Hans Sievertsson , Conny Bogentoft
IPC分类号： A61K38/00 , C07K5/103 , C07K7/23 , C07C103/52 , C07G7/00
CPC分类号： C07K5/1005 , C07K7/23 , A61K38/00 , Y10S514/80 , Y10S930/13
摘要： A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucyl-L-arginyl-L-prolyl-glycinamide.
摘要翻译：具有黄体生成激素释放激素的激素活性的合成十肽L- L-谷氨酰-L-组氨酰-LL-色氨酰-L-丝氨酰-L-酪氨酰 - 甘氨酰-L-赖氨酸-L-精氨酰-L-脯氨酰甘氨酰胺通过利用氨基酸，谷氨酸或焦谷氨酸，组氨酸，色氨酸，丝氨酸，酪氨酸，甘氨酸，亮氨酸，精氨酸和脯氨酸的关键起始物质产生哺乳动物下丘脑的LRH）。十肽的合成通过以合适的保护形式的氨基酸的适当组合偶联，最后脱保护得到酰胺，L-谷氨酰基-L-组氨酰基-L-色氨酸-L-丝氨酰-L-酪氨酰 - 甘氨酰基 -L-赖氨酸-L-精氨酰-L-脯氨酰基 - 甘氨酰胺。

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