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1. 发明授权

US07741317B2 LXR modulators 有权
标题翻译： LXR调制剂
公开(公告)号：US07741317B2
公开(公告)日：2010-06-22
申请号：US11582673
申请日：2006-10-18
申请人： Hannguang J. Chao , Huji Tuerdi , Ellen K. Kick , Wu Yang
发明人： Hannguang J. Chao , Huji Tuerdi , Ellen K. Kick , Wu Yang
IPC分类号： A01N43/00 , A61K31/55 , C07D223/14
CPC分类号： C07D417/06 , C07D279/16 , C07D281/10
摘要： A compound of formula I wherein A, X, q, R1, R2a, R2b, R2c, R3a, and R3b are defined herein.
摘要翻译：其中A，X，q，R 1，R 2a，R 2b，R 2c，R 3a和R 3b在本文中定义的式I化合物。

2. 发明授权

US07674828B2 Urea antagonists of P2Y1receptor useful in the treatment of thrombotic conditions 有权
标题翻译： P2Y1受体的尿素拮抗剂可用于治疗血栓形成
公开(公告)号：US07674828B2
公开(公告)日：2010-03-09
申请号：US12117005
申请日：2008-05-08
申请人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Y. Roberge , Yalei Liu , Michael R. Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy C. Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
发明人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Y. Roberge , Yalei Liu , Michael R. Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy C. Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
IPC分类号： A61K31/155 , C07C275/28
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译：本发明提供了作为人P2Y1受体的选择性抑制剂的新颖的吡啶基或苯基脲及其类似物。本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。

3. 发明授权

US07388021B2 Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译： P2Y1受体的尿素拮抗剂可用于治疗血栓形成
公开(公告)号：US07388021B2
公开(公告)日：2008-06-17
申请号：US11126915
申请日：2005-05-10
申请人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
发明人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jacques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
IPC分类号： A61K31/4412 , A61K31/444 , C07D213/60 , C07D213/72
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译：本发明提供了新的吡啶基或苯基脲及其类似物，它们是人P2Y 1受体的选择性抑制剂。本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。

4. 发明授权

US07816382B2 Linear urea mimics antagonists of P2Y1 receptor useful in the treatment of thrombotic condition 有权
标题翻译：线性尿素模拟P2Y1受体拮抗剂可用于治疗血栓形成
公开(公告)号：US07816382B2
公开(公告)日：2010-10-19
申请号：US11474900
申请日：2006-06-26
申请人： Hannguang J. Chao , R. Michael Lawrence , Rejean Ruel , James C. Sutton
发明人： Hannguang J. Chao , R. Michael Lawrence , Rejean Ruel , James C. Sutton
IPC分类号： A61K31/44 , C07D213/643 , C07D213/75
CPC分类号： C07D213/75 , C07D213/76 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
摘要： The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.
摘要翻译：本发明提供新的尿素模拟物和式（I）的类似物：或其立体异构体，互变异构体，药学上可接受的盐或溶剂化物形式，其中变量A，B，W和R6如本文所定义。这些化合物是可用作药物的人P2Y1受体的选择性抑制剂。

5. 发明授权

US07550499B2 Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
标题翻译： P2Y1受体的尿素拮抗剂可用于治疗血栓形成
公开(公告)号：US07550499B2
公开(公告)日：2009-06-23
申请号：US11126567
申请日：2005-05-10
申请人： Huji Tuerdi , Hannguang J. Chao , Jennifer X. Qiao , Tammy C. Wang , Timur Gungor
发明人： Huji Tuerdi , Hannguang J. Chao , Jennifer X. Qiao , Tammy C. Wang , Timur Gungor
IPC分类号： A01N43/38 , A61K31/40 , A61K31/405 , C07D207/00 , C07D209/00 , C07D295/00
CPC分类号： C07D409/04 , C07D209/08 , C07D209/14 , C07D209/96 , C07D215/06 , C07D241/42 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/10
摘要： The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译：本发明提供了含有N-芳基或N-杂芳基取代的杂环及其类似物的新型尿素，它们是人P2Y1受体的选择性抑制剂。本发明还提供了相同的各种药物组合物以及治疗对P2Y1受体活性调节作用的疾病的方法。

6. 发明授权

US07338954B2 Compounds useful as motilin agonists and method 有权
标题翻译：可用作胃动素激动剂和方法的化合物
公开(公告)号：US07338954B2
公开(公告)日：2008-03-04
申请号：US10940241
申请日：2004-09-14
申请人： James J. Li , Hannguang J. Chao , Joseph A. Tino , William R. Ewing
发明人： James J. Li , Hannguang J. Chao , Joseph A. Tino , William R. Ewing
IPC分类号： A01N43/58 , C07D237/00
CPC分类号： C07D471/20 , A61K31/503
摘要： A method is provided for treating disorders of gastrointestinal motility which include the steps of administering to a patient in need of treatment of a compound having the structure or a pharmaceutically acceptable salt thereof, a prodrug ester thereof, and all stereoisomers thereof, wherein R1 is selected from alkyl, aryl, cycloalkyl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or heterocycloalkyl; Z is selected from —CON(R4)R4a, —SO2N(R4)R4a, —CN, and R4 and R4a are the same or different and are independently selected from hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl or R4 and R4a can be joined together to form a heterocycle; R4b is selected from hydrogen, halogen, hydroxyl, CN, OCF3, CF3, CONH2, SONH2, SO2CH3, NHCOCH3 or NHCO2CH3; and Q is a substituted bicyclic heterocycle. New compounds for use in treating disorders of gastrointestinal motility are also provided.
摘要翻译：提供了一种用于治疗胃肠蠕动障碍的方法，其包括对需要治疗具有其结构的化合物或其药学上可接受的盐，其前药酯及其所有立体异构体的患者施用的步骤，其中R _{3 Q是取代的双环杂环。还提供了用于治疗胃肠蠕动障碍的新化合物。}

7. 发明申请

US20080280905A1 UREA ANTAGONISTS OF P2Y1 RECEPTOR USEFUL IN THE TREATMENT OF THROMBOTIC CONDITIONS 有权
标题翻译： P2Y1受体的尿素拮抗剂用于治疗血栓病症
公开(公告)号：US20080280905A1
公开(公告)日：2008-11-13
申请号：US12117005
申请日：2008-05-08
申请人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jaques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
发明人： Hannguang J. Chao , Huji Tuerdi , Timothy F. Herpin , Jaques Yves Roberge , Yalei Liu , R. Michael Lawrence , Robert P. Rehfuss , Charles G. Clark , Jennifer X. Qiao , Timur Gungor , Patrick Y. S. Lam , Tammy Wang , Rejean Ruel , Alexandre L'Heureux , Carl Thibeault , Gilles Bouthillier , Dora M. Schnur
IPC分类号： A61K31/5377 , C07D213/72 , C07D413/12 , A61K31/4412 , A61K31/4439 , A61K31/4709 , A61P7/00 , A61P9/00 , A61K31/4725 , A61K31/444 , A61K31/4545 , A61K31/496 , C07D401/12
CPC分类号： C07D409/14 , C07C275/30 , C07C275/32 , C07D213/40 , C07D213/75 , C07D213/89 , C07D231/40 , C07D231/50 , C07D237/22 , C07D333/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity.
摘要翻译：本发明提供了新的吡啶基或苯基脲及其类似物，它们是人P2Y 1受体的选择性抑制剂。本发明还提供了相同的各种药物组合物以及治疗对P2Y受体活性的调节作用的疾病的方法。

8. 发明授权

US07262195B2 Compounds useful as motilin agonists and method 有权
标题翻译：可用作胃动素激动剂和方法的化合物
公开(公告)号：US07262195B2
公开(公告)日：2007-08-28
申请号：US10940240
申请日：2004-09-14
申请人： James J. Li , Hannguang J. Chao , Joseph A. Tino , William R. Ewing
发明人： James J. Li , Hannguang J. Chao , Joseph A. Tino , William R. Ewing
IPC分类号： A61K31/50 , C07D237/00 , C07D487/00
CPC分类号： C07D471/20 , A61K31/495 , A61K31/50
摘要： Compounds are provided which are useful in treating disorders of gastrointestinal motility and which have the structure or a pharmaceutically acceptable salt thereof, a prodrug ester thereof, and all stereoisomers thereof, wherein R1 and R2 are the same or different and are independently selected from hydrogen, alkyl, aryl, cycloalkyl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or heterocycloalkyl; Z is selected from —CON(R4)R4a, —CO2R4, —SO2N(R4)R4a, —SO2R4, CN, and R4 and R4a are the same or different and are independently selected from hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl or R4 and R4a can be joined together to form a heterocycle. R4b is selected from hydrogen, halogen, hydroxyl, CN, OCF3, CF3, CONH2, SONH2, SO2CH3, NHCOCH3 or NHCO2CH3; and Q is a substituted bicyclic heterocycle. A method for using such compounds for treating disorders of gastrointestinal motility is also provided.
摘要翻译：提供了可用于治疗胃肠蠕动障碍并且具有其结构或其药学上可接受的盐，其前药酯及其所有立体异构体的化合物，其中R 1和R 2 独立地选自氢，烷基，芳基，环烷基，烯基，炔基，芳基烷基，杂芳基，杂芳基烷基或杂环烷基; Z选自-CON（R 4 S）R 4a，-CO 2 R 4，-SO 3， N 2（R 4）R 4a，-SO 2 R 4，CN R 4a和R 4a相同或不同并且独立地选自氢，烷基，环烷基，芳基，芳基烷基，杂芳基或杂芳基烷基或R 1， 4和R 4a可以连接在一起形成杂环。 R 4b选自氢，卤素，羟基，CN，OCF 3，CF 3，CONH 2， SO 2 H 2，CH 2 CH 3，NHCOCH 3或NHCO 2 CH 3， SUB> 3 Q是取代的双环杂环。还提供了使用这些化合物治疗胃肠蠕动障碍的方法。

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