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1. 发明专利

MX171315B 未知
公开(公告)号：MX171315B
公开(公告)日：1993-10-18
申请号：MX1682789
申请日：1989-07-17
申请人： HAIM AVIV Y SHABTAY DISTEIN
发明人： AVIV HAIM , DIKSTEIN SHABTAY
IPC分类号： A23J1/04 , A23J7/00 , A61K9/56

2. 发明专利

IT8948185D0 未知
公开(公告)号：IT8948185D0
公开(公告)日：1989-07-13
申请号：IT4818589
申请日：1989-07-13
申请人： HAIM AVIV , DIKSTEIN SHABTAY
发明人： AVIV HAIM , DIKSTEIN SHABTAY
IPC分类号： A23D20060101

3. 发明专利

IL218398D0 NUTRITIONAL COMPOSITIONS COMPRISING CITRUS FIBERS 未知
公开(公告)号：IL218398D0
公开(公告)日：2012-04-30
申请号：IL21839812
申请日：2012-02-29
申请人： HERBAMED LTD , HAIM AVIV , SOLOMON ANAT
IPC分类号： A61K20060101

4. 发明专利

IT1231478B Palatable edible prods. providing dosed amts. of fish oils 未知
公开(公告)号：IT1231478B
公开(公告)日：1991-12-07
申请号：IT4818589
申请日：1989-07-13
申请人： HAIM AVIV , DIKSTEIN SHABTAY
发明人： AVIV HAIM , DIKSTEIN SHABTAY
IPC分类号： A23D20060101 , A23D
摘要： Edible prods. with an acceptable taste in the form of dosage units providing at least one third of the daily requirement of unsatd. acids of the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) type comprising a chocolate-like core filling comprising unsatd. acids of the EPA- and DHA-type in the form of enriched fish oil or in prepd. form, lecithin and chocolate-forming components, coated with a palatable outer layer.

5. 发明专利

IL85121A EDIBLE FISH-OIL PRODUCT AND METHOD OF MAKING SAME 未知
公开(公告)号：IL85121A
公开(公告)日：1991-11-21
申请号：IL8512188
申请日：1988-01-18
申请人： HAIM AVIV AND ASSOCIATES LTD
IPC分类号： A23G3/00 , A23G3/36 , A23L1/30 , A61K35/60 , A23D9/04 , A23L1/327

6. 发明专利

IL85121D0 EDIBLE FISH-OIL PRODUCT AND METHOD OF MAKING SAME 未知
公开(公告)号：IL85121D0
公开(公告)日：1988-06-30
申请号：IL8512188
申请日：1988-01-18
申请人： HAIM AVIV AND ASSOCIATES LTD
IPC分类号： A23G3/00 , A23G3/36 , A23L1/30 , A61K35/60 , A23D

7. 发明授权

US5961970A Submicron emulsions as vaccine adjuvants 失效
标题翻译：亚微米乳剂作为疫苗佐剂
公开(公告)号：US5961970A
公开(公告)日：1999-10-05
申请号：US637756
申请日：1996-04-29
申请人： George H. Lowell , Shimon Amselem , Doron Friedman , Haim Aviv
发明人： George H. Lowell , Shimon Amselem , Doron Friedman , Haim Aviv
IPC分类号： A61K9/00 , A61K9/107 , A61K39/008 , A61K39/02 , A61K39/085 , A61K39/095 , A61K39/21 , A61K39/39 , A61P31/04 , A61P37/02 , A61P37/04 , A61K39/00 , A61K9/127 , A61K9/58 , A01N63/00
CPC分类号： A61K39/39 , A61K39/008 , A61K39/085 , A61K39/12 , A61K39/21 , A61K9/1075 , B82Y5/00 , A61K2039/54 , A61K2039/541 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55544 , A61K2039/55555 , A61K2039/55566 , A61K2039/57 , A61K2039/6037 , A61K2039/6068 , C12N2740/16134 , Y10S977/906 , Y10S977/907 , Y10S977/915 , Y10S977/917 , Y10S977/918
摘要： A vaccine adjuvant composition of an oil-in-water submicron emulsion that has about 0.5 to 50% of a first component of an oil, about 0.1 to 10% of a second component of an emulsifier, about 0.05 to 5% of a nonionic surfactant, about 0.00001 to 1% of an immunogen, and an aqueous continuous phase. This submicron emulsion has a mean droplet size in the range of between about 0.03 and 0.5 .mu.m, and preferably 0.05 and 0.2 .mu.m.
摘要翻译： PCT No.PCT / US93 / 10402 Sec。 371日期：1996年4月29日 102（e）日期1996年4月29日PCT提交1993年10月29日PCT公布。公开号WO95 / 11700 日期1995年5月4日一种水包油亚微米乳剂的疫苗佐剂组合物，其具有约0.5至50％的第一组分油，约0.1至10重量％的第二组分乳化剂，约0.05至5重量％的非离子表面活性剂，约0.00001至1％的免疫原和水性连续相。该亚微米乳液的平均液滴尺寸范围为约0.03至0.5μm，优选为0.05至0.2μm。

8. 发明授权

US5496811A Submicron emulsions as ocular drug delivery vehicles 失效
标题翻译：亚微米乳剂作为眼药物递送载体
公开(公告)号：US5496811A
公开(公告)日：1996-03-05
申请号：US854
申请日：1993-01-05
申请人： Haim Aviv , Doron Friedman , Amir Bar-Ilan , Micha Vered
发明人： Haim Aviv , Doron Friedman , Amir Bar-Ilan , Micha Vered
IPC分类号： A61K9/00 , A61K9/107 , A61K31/685 , A61K31/22 , A61K31/225 , A61K31/66
CPC分类号： A61K9/0048 , A61K9/1075 , Y10S514/912
摘要： An ocular drug delivery vehicle of an oil-in-water submicron emulsion comprising about 0.5 to 50% of a first component of an oil, about 0.1 to 10% of a second component of an emulsifier, about 0.05 to 5% of a non-ionic surfactant and an aqueous component, with the mean droplet size being in the submicron range, i.e., below about 0.5 .mu.m and preferably between about 0.1 and 0.3 .mu.m. Also, topical pharmaceutical compositions containing a drug such as an anti-glaucoma drug, beta adrenergic blocker or other autonomic system drug, a local anesthetic, a steroid, a non-steroidal anti-inflammatory drug, an antibiotic drug, an antifungal drug, an antiviral drug or combinations thereof and the vehicle described above. Methods of administering such vehicles or compositions to the eye of a patient while reducing irritation thereof and providing increased bioavailability of the drug.
摘要翻译：一种水包油亚微米乳剂的眼药物递送载体，其包含约0.5至50％的第一组分油，约0.1至10重量％的第二组分的乳化剂，约0.05至5重量％离子表面活性剂和水性组分，平均液滴尺寸在亚微米范围内，即低于约0.5μm，优选在约0.1和0.3μm之间。此外，含有药物如抗青光眼药物，β-肾上腺素能阻滞剂或其他自主神经系统药物的局部药物组合物，局部麻醉剂，类固醇，非甾体抗炎药，抗生素药物，抗真菌药物抗病毒药物或其组合和上述载体。将这些载体或组合物施用于患者的眼睛同时减少其刺激并提供药物的增加的生物利用度的方法。

9. 发明授权

US5162217A Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof 失效
标题翻译：用于表达含有λPL启动子的人超氧化物歧化酶（SOD）类似物用于代替核糖体结合位点的工程化限制性位点的质粒及其使用方法
公开(公告)号：US5162217A
公开(公告)日：1992-11-10
申请号：US449125
申请日：1989-12-08
申请人： Jacob R. Hartman , Amos B. Oppenheim , Marian Gorecki , Haim Aviv , Rachel Oren
发明人： Jacob R. Hartman , Amos B. Oppenheim , Marian Gorecki , Haim Aviv , Rachel Oren
IPC分类号： A23K1/165 , A61K38/44 , C07K14/61 , C07K14/775 , C12N9/02 , C12N15/53 , C12N15/69 , C12N15/73
CPC分类号： C12N9/0089 , A23K20/168 , A61K38/446 , C07K14/61 , C07K14/775 , C12N15/69 , C12N15/73 , Y10S514/886
摘要： An improved plasmid for the production of superoxide dismutase which upon introduction into a host containing the thermolabile repressor C.sub.I renders the host capable of effecting expression of a gene encoding superoxide dismutase. The plasmid which includes in 5' to 3' order the following: the promoter and operator P.sub.L O.sub.L from lambda bacteriophage; the N utilization site; a first restriction enzyme site permitting replacement of the ribosomal binding site which follows thereafter; a ribosomal binding site; an ATG initiation codon; a second restriction enzyme site; a gene encoding superoxide dismutase; an origin of replication and a gene associated with a selectable or identifiable phenotypic trait manifested when the plasmid is present in the host. The distance between the 3' end of P.sub.L O.sub.L and the 5' end of the N utilization site is less than about 80 base pairs. The distance between the 3' end of the N utilization site and the 5' end of the ribosomal binding site is less than about 300 base pairs.Host vector systems have been constructed from these plasmids and used to produce human superoxide dismutase and analogs thereof. Such SOD or analogs may be used to catalyze the reduction of superoxide radicals, reduce reperfusion injury, prolong the survival time of isolated organs and reduce spinal cord injury.
摘要翻译：用于生产超氧化物歧化酶的改良质粒，其在引入含有不耐热阻遏物CI的宿主中时，使宿主能够实现编码超氧化物歧化酶的基因的表达。包含5'至3'的质粒命名如下：来自λ噬菌体的启动子和操纵子PLOL; N利用场所; 第一限制性内切酶位点，其允许置换随后的核糖体结合位点; 核糖体结合位点; ATG起始密码子; 第二限制酶位点; 编码超氧化物歧化酶的基因; 复制起点和当质粒存在于宿主中时显示的与可选择或可鉴定的表型性状相关的基因。 PLOL的3'端与N利用位点的5'端之间的距离小于约80个碱基对。 N利用位点的3'末端与核糖体结合位点的5'末端之间的距离小于约300个碱基对。宿主载体系统已经由这些质粒构建并用于产生人超氧化物歧化酶及其类似物。这种SOD或类似物可用于催化超氧自由基的减少，减少再灌注损伤，延长分离器官的存活时间并减少脊髓损伤。

10. 发明授权

US4997916A Method for recovering a purified animal growth hormone or polypeptide analog thereof from a bacterial cell 失效
标题翻译：从细菌细胞中回收纯化的动物生长激素或其多肽类似物的方法
公开(公告)号：US4997916A
公开(公告)日：1991-03-05
申请号：US320320
申请日：1989-03-07
申请人： Haim Aviv , Marian Gorecki , Avigdor Levanon , Amos Oppenheim , Tikva Vogel , Elisha Zeelon , Menachem Zeevi
发明人： Haim Aviv , Marian Gorecki , Avigdor Levanon , Amos Oppenheim , Tikva Vogel , Elisha Zeelon , Menachem Zeevi
IPC分类号： A61K38/00 , C07K14/61 , C12N15/73
CPC分类号： C07K14/61 , C12N15/73 , A61K38/00 , Y10S530/82 , Y10S530/825
摘要： A method is provided for recovering a purified animal growth hormone or a polypeptide analog thereof having substantially the same amino acid sequence as, and the biological activity of, the corresponding naturally-occurring animal growth hormone from a bacterial cell in which the animal growth hormone or polypeptide analog has been produced by means of expression of a plasmid encoding the hormone or polypeptide analog which comprises: (a) disrupting the cell wall of the bacterial cell in a buffered neutral pH solution so as to produce a lysate containing precipitated hormone or polypeptide analog; (b) recovering the resulting precipitated hormone or polypeptide analog; (c) suspending the precipitated hormone or polypeptide analog so recovered in distilled water; (d) treating the resulting precipitate-containing suspension with a sodium hydroxide solution having an alkaline pH of about 11.8 so as to solubilize the precipitate and thus the hormone or polypeptide analog contained therein; (e) separating the solubilized hormone or polypeptide analog from other soluble components by gel filtration chromatography; and (f) subjecting the hormone or polypeptide analog thus separated to ion exchange chromatography to purify the hormone or analog and thereby recover purified hormone or polypeptide analog.
摘要翻译：提供了一种用于从动物生长激素或细菌细胞的细菌细胞中回收纯化的动物生长激素或其多肽类似物，其具有与相应天然存在的动物生长激素基本上相同的氨基酸序列和生物学活性，已经通过表达编码激素或多肽类似物的质粒产生多肽类似物，其包括：（a）在缓冲的中性pH溶液中破坏细菌细胞的细胞壁，以产生含有沉淀激素或多肽类似物的裂解物 ; （b）回收所得沉淀的激素或多肽类似物; （c）将沉淀的激素或多肽类似物悬浮于蒸馏水中; （d）用碱性pH为约11.8的氢氧化钠溶液处理所得沉淀物的悬浮液，以溶解沉淀物，从而溶解其中所含的激素或多肽类似物; （e）通过凝胶过滤色谱法将溶解的激素或多肽类似物与其他可溶组分分离; 和（f）使由此分离的激素或多肽类似物经离子交换色谱纯化激素或类似物，从而回收纯化的激素或多肽类似物。

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