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1. 发明授权

US08951567B2 Sol-gel phase-reversible hydrogel templates and uses thereof 有权
标题翻译：溶胶 - 凝胶相可逆水凝胶模板及其用途
公开(公告)号：US08951567B2
公开(公告)日：2015-02-10
申请号：US12286147
申请日：2008-09-27
申请人： Kinam Park , Ghanashyam Acharya , Haesun Park
发明人： Kinam Park , Ghanashyam Acharya , Haesun Park
IPC分类号： A61K9/14 , A61K9/50 , A61K31/00 , B82B1/00 , B82B3/00
CPC分类号： A61K9/1682 , A61K9/1647 , A61K9/5031 , A61K9/5089 , A61K31/00 , Y10S977/773 , Y10S977/887 , Y10S977/89 , Y10S977/906
摘要： Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template. The method of preparing microstructures based on hydrogel templates is simple and can easily produce large quantities of the microstructures.
摘要翻译：使用溶胶 - 凝胶相可逆水凝胶模板制备预定尺寸和形状的离散微结构。将水凝胶形成材料的水溶液覆盖在具有预定义的微特征（例如柱）的微制造硅晶片主模板上。通常通过降低温度形成水凝胶模板，并将形成的水凝胶模板从硅主模板剥离。在水凝胶模板上预定尺寸和形状的孔填充有水不溶性聚合物的溶液或糊剂，并除去溶剂以形成固体结构。通过在水中简单地熔化水凝胶模板，将形成的微结构从水凝胶模板中释放出来。通过离心收集微结构。通过该方法制造的微结构显示出与水凝胶模板的微孔完全对应的预定义的尺寸和形状。基于水凝胶模板制备微结构的方法简单，容易产生大量微结构。

2. 发明授权

US5750585A Super absorbent hydrogel foams 失效
标题翻译：超吸收性水凝胶泡沫
公开(公告)号：US5750585A
公开(公告)日：1998-05-12
申请号：US416269
申请日：1995-04-04
申请人： Kinam Park , Haesun Park
发明人： Kinam Park , Haesun Park
IPC分类号： A61K9/12 , A61K9/20 , A61L15/42 , A61L15/48 , A61L15/60 , C08F110/00 , A61F13/00
CPC分类号： A61L15/48 , A61K9/122 , A61K9/2027 , A61L15/425 , A61L15/60
摘要： A water swellable foam matrix formed as a macroporous solid comprising a foam stabilizing agent and a polymer or copolymer of a free radical polymerizable hydrophilic olefin monomer crosslinked with about 0.1 to about 10% by weight of a multiolefin-functional crosslinking agent is described. The foam matrix is characterized by rapid swelling and high water swelling ratios.
摘要翻译：描述了形成为大孔固体的水可膨胀泡沫基质，其包含泡沫稳定剂和与约0.1至约10重量％的多烯属官能交联剂交联的可自由基聚合的亲水烯烃单体的聚合物或共聚物。泡沫基质的特征在于快速溶胀和高的水溶胀比。

3. 发明授权

US06960617B2 Hydrogels having enhanced elasticity and mechanical strength properties 失效
标题翻译：水凝胶具有增强的弹性和机械强度性能
公开(公告)号：US06960617B2
公开(公告)日：2005-11-01
申请号：US10420323
申请日：2003-04-22
申请人： Hossein Omidian , Yong Qiu , Shicheng Yang , Dukjoon Kim , Haesun Park , Kinam Park
发明人： Hossein Omidian , Yong Qiu , Shicheng Yang , Dukjoon Kim , Haesun Park , Kinam Park
IPC分类号： A61K9/00 , C08F2/00 , C08F2/44 , C08F220/06 , C08F220/56 , C08F251/00 , C08F289/00 , C08F36/04
CPC分类号： A61K9/0065 , C08F2/44 , C08F220/06 , C08F220/56 , C08F251/00 , C08F289/00
摘要： Hydrogels having improved elasticity and mechanical strength properties are obtained by subjecting a hydrogel formulation containing a strengthening agent to chemical or physical crosslinking conditions subsequent to initial gel formation. Superporous hydrogels having improved elasticity and mechanical strength properties are similarly obtained whenever the hydrogel formulation is provided with a foaming agent. Interpenetrating networks of polymer chains comprised of primary polymer(s) and strengthening polymer(s) are thereby formed. The primary polymer affords capillary-based water sorption properties while the strengthening polymer imparts significantly enhanced mechanical strength and elasticity to the hydrogel or superporous hydrogel. Suitable strengthening agents can be natural or synthetic polymers, polyelectrolytes, or neutral, hydrophilic polymers.
摘要翻译：具有改善的弹性和机械强度性能的水凝胶是通过使含有强化剂的水凝胶制剂经历初始凝胶形成之后的化学或物理交联条件获得的。当水凝胶制剂设置有发泡剂时，类似地获得具有改善的弹性和机械强度性能的多孔水凝胶。从而形成由初级聚合物和强化聚合物构成的聚合物链的互穿网络。主要聚合物提供基于毛细管的水吸附性质，而强化聚合物赋予水凝胶或多孔水凝胶显着增强的机械强度和弹性。合适的增强剂可以是天然或合成聚合物，聚电解质或中性亲水聚合物。

4. 发明申请

US20090136583A1 Sol-Gel phase-reversible hydrogel templates and uses thereof 有权
标题翻译：溶胶 - 凝胶相可逆水凝胶模板及其用途
公开(公告)号：US20090136583A1
公开(公告)日：2009-05-28
申请号：US12286147
申请日：2008-09-27
申请人： Kinam Park , Ghanashyam Acharya , Haesun Park
发明人： Kinam Park , Ghanashyam Acharya , Haesun Park
IPC分类号： A61K9/14 , C40B50/14 , B05D1/00 , B82B1/00 , B82B3/00
CPC分类号： A61K9/1682 , A61K9/1647 , A61K9/5031 , A61K9/5089 , A61K31/00 , Y10S977/773 , Y10S977/887 , Y10S977/89 , Y10S977/906
摘要： Discrete microstructures of predefined size and shape are prepared using sol-gel phase-reversible hydrogel templates. An aqueous solution of hydrogel-forming material is covered onto a microfabricated silicon wafer master template having predefined microfeatures, such as pillars. A hydrogel template is formed, usually by lowering the temperature, and the formed hydrogel template is peeled away from the silicon master template. The wells of predefined size and shape on the hydrogel template are filled with a solution or a paste of a water-insoluble polymer, and the solvent is removed to form solid structures. The formed microstructures are released from the hydrogel template by simply melting the hydrogel template in water. The microstructures are collected by centrifugation. The microstructures fabricated by this method exhibit pre-defined size and shape that exactly correspond to the microwells of the hydrogel template. The method of preparing microstructures based on hydrogel templates is simple and can easily produce large quantities of the microstructures.
摘要翻译：使用溶胶 - 凝胶相可逆水凝胶模板制备预定尺寸和形状的离散微结构。将水凝胶形成材料的水溶液覆盖在具有预定义的微特征（例如柱）的微制造硅晶片主模板上。通常通过降低温度形成水凝胶模板，并将形成的水凝胶模板从硅主模板剥离。在水凝胶模板上预定尺寸和形状的孔填充有水不溶性聚合物的溶液或糊剂，并除去溶剂以形成固体结构。通过在水中简单地熔化水凝胶模板，将形成的微结构从水凝胶模板中释放出来。通过离心收集微结构。通过该方法制造的微结构显示出与水凝胶模板的微孔完全对应的预定义的尺寸和形状。基于水凝胶模板制备微结构的方法简单，容易产生大量微结构。

5. 发明授权

US06271278B1 Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties 失效
标题翻译：水凝胶复合材料和具有快速溶胀，高机械强度和超吸收性能的多孔水凝胶复合材料
公开(公告)号：US06271278B1
公开(公告)日：2001-08-07
申请号：US08855499
申请日：1997-05-13
申请人： Kinam Park , Jun Chen , Haesun Park
发明人： Kinam Park , Jun Chen , Haesun Park
IPC分类号： C08F3604
CPC分类号： A61L15/60 , C08F251/00 , C08F291/00
摘要： A superporous hydrogel composite is formed by polymerizing one or more ethylenically-unsaturated monomers, and a multiolefinic crosslinking agent, in the presence of particles of a disintegrant and a blowing agent. The disintegrant, which rapidly absorbs water, serves to greatly increase the mechanical strength of the superporous hydrogel and significantly shorten the time required to absorb water and swell. Superporous hydrogel composites prepared by this method have an average pore size in the range of 10 &mgr;m to 3,000 &mgr;m. Preferred particles of disintegrant include natural and synthetic charged polymers, such as crosslinked sodium carboxymethylcellulose, crosslinked sodium starch glycolate, and crosslinked polyvinylpyrrolidone. The blowing agent is preferably a compound that releases gas bubbles upon acidification, such as NaHCO3. Improved hydrogel composites formed without a blowing agent are also provided.
摘要翻译：通过在崩解剂和发泡剂的颗粒存在下聚合一种或多种烯属不饱和单体和多烯属交联剂来形成多孔水凝胶复合物。迅速吸收水分的崩解剂大大增加了多孔水凝胶的机械强度，显着缩短了吸收水分和膨胀所需的时间。通过该方法制备的多孔水凝胶复合材料的平均孔径在10〜3000μm的范围内。优选的崩解剂颗粒包括天然和合成的带电聚合物，例如交联的羧甲基纤维素钠，交联的羟基乙酸淀粉钠和交联的聚乙烯吡咯烷酮。发泡剂优选是在酸化时释放气泡的化合物，例如NaHCO 3。还提供了没有发泡剂形成的改进的水凝胶复合材料。

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