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1. 发明申请

WO2006079119A3 MODULATION OF TH2 LINEAGE COMMITMENT BY T-BET 审中-公开
公开(公告)号：WO2006079119A3
公开(公告)日：2006-07-27
申请号：PCT/US2006/002917
申请日：2006-01-20
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , GLIMCHER, Laurie H. , SZABO, Susanne J. , HWANG, Eun Sook
发明人： GLIMCHER, Laurie H. , SZABO, Susanne J. , HWANG, Eun Sook
IPC分类号： G01N33/48 , G01N33/53 , G01N33/566 , A61K49/00 , A01N61/00 , A61K31/00
摘要： The instant invention is based, at least in part, on the identification of a mechanism by which T-bet directly modulates Th2 cytokine production. The present invention pertains to methods of identifying agents that modulate the Tec kinase- mediated interaction of T-bet with GAT A-3, as well as methods of use therefore.

2. 发明申请

WO2011030955A1 INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 审中-公开
标题翻译：茚尼酮衍生物和药物组合物
公开(公告)号：WO2011030955A1
公开(公告)日：2011-03-17
申请号：PCT/KR2009/006085
申请日：2009-10-21
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , HEO, Jung Nyoung , BAE, Myung-Ae , KIM, Nack Jeong , CHANG, Sung Youn , KANG, Namsook , YOO, Sung Eun , HWANG, Eun Sook
发明人： HEO, Jung Nyoung , BAE, Myung-Ae , KIM, Nack Jeong , CHANG, Sung Youn , KANG, Namsook , YOO, Sung Eun , HWANG, Eun Sook
IPC分类号： C07D265/33
CPC分类号： C07D213/50 , C07D213/89 , C07D239/26 , C07D241/12 , C07D295/088 , C07D333/22
摘要： An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.
摘要翻译：式（1）的茚酮酮衍生物对于增强成骨细胞的活性和抑制破骨细胞的骨吸收是有效的，并且包含茚酮酮衍生物或其药学上可接受的盐的药物组合物可用于预防或治疗诸如骨质疏松症。

3. 发明申请

WO2012011673A3 PHARMACEUTICAL COMPOSITION INCLUDING HESPERETIN AS AN ACTIVE INGREDIENT FOR PROMOTING MUSCLE CELL DIFFERENTIATION OR RENEWAL 审中-公开
标题翻译：药物组合物，包括半球菌素作为促进肌细胞分化或再生的活性成分
公开(公告)号：WO2012011673A3
公开(公告)日：2012-05-03
申请号：PCT/KR2011004560
申请日：2011-06-22
申请人： UNIV EWHA IND COLLABORATION , HWANG EUN SOOK
发明人： HWANG EUN SOOK
IPC分类号： A61K31/353 , A61K31/35 , A61P21/00 , A61P21/02
CPC分类号： A61K31/35 , A61K31/353
摘要： The present invention relates to a promoter of muscle cell differentiation or renewal, to a pharmaceutical composition for treating or preventing muscular impairment, and to a food composition for alleviating or preventing muscular impairment. The promoter of the present invention is effective for muscle cell differentiation and renewal, and the composition of the present invention is effective for the treatment (improvement) or prevention of muscular impairment.
摘要翻译：本发明涉及肌肉细胞分化或更新的启动子，用于治疗或预防肌肉损伤的药物组合物，以及用于减轻或预防肌肉损伤的食物组合物。本发明的促进剂对肌肉细胞分化和更新有效，本发明的组合物对于肌肉损伤的治疗（改善）或预防是有效的。

4. 发明申请

WO2007056422A2 MODULATION OF IL-2 PRODUCTION BY T-BET 审中-公开
标题翻译：通过T-BET调节IL-2生产
公开(公告)号：WO2007056422A2
公开(公告)日：2007-05-18
申请号：PCT/US2006/043429
申请日：2006-11-07
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , GLIMCHER, Laurie, H. , HWANG, Eun, Sook
发明人： GLIMCHER, Laurie, H. , HWANG, Eun, Sook
IPC分类号： C40B30/06 , C40B40/04 , C40B40/10
CPC分类号： C12Q1/485 , G01N2333/4706 , G01N2333/55 , G01N2500/02
摘要： The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that modulate the kinase-mediated interaction of T-bet with RelA, as well as methods of use therefore.
摘要翻译：本发明至少部分地基于T-bet调节IL2产生的机制的牙齿修复。本发明涉及鉴定调节T-bet与RelA的激酶介导的相互作用的试剂的方法以及因此使用的方法。

5. 发明申请

WO2006079119A2 MODULATION OF TH2 LINEAGE COMMITMENT BY T-BET 审中-公开
标题翻译：通过T-BET调整TH2线路承诺
公开(公告)号：WO2006079119A2
公开(公告)日：2006-07-27
申请号：PCT/US2006002917
申请日：2006-01-20
申请人： HARVARD COLLEGE , GLIMCHER LAURIE H , SZABO SUSANNE J , HWANG EUN SOOK
发明人： GLIMCHER LAURIE H , SZABO SUSANNE J , HWANG EUN SOOK
IPC分类号： C40B40/10
CPC分类号： G01N33/505 , A61K49/0008 , G01N2333/4706 , G01N2500/02
摘要： The instant invention is based, at least in part, on the identification of a mechanism by which T-bet directly modulates Th2 cytokine production. The present invention pertains to methods of identifying agents that modulate the Tec kinase- mediated interaction of T-bet with GAT A-3, as well as methods of use therefore.
摘要翻译：本发明至少部分地基于T-bet直接调节Th2细胞因子产生的机制的鉴定。本发明涉及鉴定调节Tec激动剂介导的T-bet与GAT A-3的相互作用的试剂的方法以及因此使用的方法。

6. 发明申请

WO2006079119A9 MODULATION OF TH2 LINEAGE COMMITMENT BY T-BET 审中-公开
标题翻译：用T-BET法调制TH2线图
公开(公告)号：WO2006079119A9
公开(公告)日：2007-05-18
申请号：PCT/US2006002917
申请日：2006-01-20
申请人： HARVARD COLLEGE , GLIMCHER LAURIE H , SZABO SUSANNE J , HWANG EUN SOOK
发明人： GLIMCHER LAURIE H , SZABO SUSANNE J , HWANG EUN SOOK
IPC分类号： G01N33/48 , A01N61/00 , A61K31/00 , A61K49/00 , G01N33/53 , G01N33/566
CPC分类号： G01N33/505 , A61K49/0008 , G01N2333/4706 , G01N2500/02
摘要： The instant invention is based, at least in part, on the identification of a mechanism by which T-bet directly modulates Th2 cytokine production. The present invention pertains to methods of identifying agents that modulate the Tec kinase- mediated interaction of T-bet with GAT A-3, as well as methods of use therefore.
摘要翻译：本发明至少部分基于鉴定T-bet直接调节Th2细胞因子产生的机制。本发明涉及鉴定调节T-bet与GAT A-3的Tec激酶介导的相互作用的试剂的方法，以及因此使用的方法。

7. 发明申请

WO2013002485A3 PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING KIDNEY DISORDERS, CONTAINING INHIBITOR FOR PHOSPHORYLATION OF TAZ TYROSINE AS ACTIVE INGREDIENT FOR ACTIVATION OF NFAT5/TONEBP 审中-公开
标题翻译：用于预防和治疗肾病的药物组合物，含有作为活化NFAT5 / TONEBP活性成分的TAZ酪氨酸的磷酸化抑制剂
公开(公告)号：WO2013002485A3
公开(公告)日：2013-02-21
申请号：PCT/KR2012003249
申请日：2012-04-26
申请人： UNIV EWHA IND COLLABORATION , HWANG EUN SOOK
发明人： HWANG EUN SOOK
IPC分类号： A61K38/16 , A61K31/7088 , A61K38/17 , A61K39/395 , A61P13/12
CPC分类号： A61K38/1703
摘要： The present invention relates to a pharmaceutical composition for preventing and treating kidney disorders caused by osmotic stress, containing an inhibitor for the phosphorylation of TAZ tyrosine as an active ingredient. More specifically, it has been ascertained that TAZ inhibits the activity of NFAT5/TonEBP, the activity of c-Abl is required for the interaction between TAZ and NFAT5/TonEBP, phosphorylated TAZ inhibits the binding activity of NFAT5/TonEBP, and the inhibition of TAZ maximizes the expression of a target gene and the activity of NFAT5/TonEBP for relieving the influence of a hypertonic stimulus under in vivo hypertonic conditions caused by dehydration, and thus the inhibitor for phosphorylation of TAZ tyrosine can be useful for preventing or treating kidney disorders caused by osmotic stress.
摘要翻译：本发明涉及用于预防和治疗由渗透压引起的肾病的药物组合物，其含有作为活性成分的TAZ酪氨酸磷酸化抑制剂。更具体地说，已经确定TAZ抑制NFAT5 / TonEBP的活性，c-Abl的活性对于TAZ和NFAT5 / TonEBP之间的相互作用是必需的，磷酸化的TAZ抑制NFAT5 / TonEBP的结合活性， TAZ最大化目标基因的表达和NFAT5 / TonEBP的活性以减轻脱水引起的体内高渗性条件下高渗刺激的影响，因此TAZ酪氨酸磷酸化抑制剂可用于预防或治疗肾病由渗透压引起。

8. 发明申请

WO2012096436A3 LUNG INJURY MODEL ANIMAL CAUSED BY HYPEROXIA EXPOSURE, AND KIT FOR DIAGNOSING LUNG INJURY CAUSED BY HYPEROXIA EXPOSURE USING A TAZ MARKER 审中-公开
标题翻译：由超氧化物歧化酶引起的肺损伤模型动物，以及使用TAZ标记诊断由超氧化物歧化引起的肺损伤的药盒
公开(公告)号：WO2012096436A3
公开(公告)日：2012-09-07
申请号：PCT/KR2011008808
申请日：2011-11-17
申请人： UNIV EWHA IND COLLABORATION , HWANG EUN SOOK , HONG JEONG HO
发明人： HWANG EUN SOOK , HONG JEONG HO
IPC分类号： A01K67/027 , C12N15/85 , G01N33/15 , G01N33/53
CPC分类号： G01N33/5088 , A01K67/0276 , A01K2207/35 , A01K2217/075 , A01K2227/105 , A01K2267/03
摘要： The present invention relates to a lung injury model animal caused by hyperoxia exposure, and a kit for diagnosing lung injury caused by hyperoxia exposure using a TAZ marker. Serous fibroid lung was induced in TAZ-deficient (TAZ-/-) mice, and this was similar to fibroid lung occurring in the lungs of mice in a normal group which were exposed to hyperoxia. TAZ suppresses signal molecules by affecting a signal path related to oxidative stress, enabling the homeostasis of lungs to be controlled. Therefore, TAZ-deficient (TAZ-/-) mice can be usefully used as fibroid lung model mice caused by hyperoxia exposure, and also used for the preparation of fibroid lung model mice caused by hyperoxia exposure, and as screening of candidate substances for treating agents using the mice. Further, the TAZ-deficient (TAZ-/-) mice can be used for diagnosing fibroid lung caused by hyperoxia exposure and a diagnosis kit therefor, by confirming the expression of TAZ gene or protein.
摘要翻译：本发明涉及由高氧暴露引起的肺损伤模型动物，以及用于使用TAZ标记物诊断由高氧暴露引起的肺损伤的试剂盒。在TAZ缺陷型（TAZ - / - ）小鼠中诱导浆液性纤维瘤肺，这与在暴露于高氧的正常组中的小鼠肺中发生的纤维瘤肺相似。 TAZ通过影响与氧化应激相关的信号通路来抑制信号分子，使得能够控制肺的体内平衡。因此，TAZ缺陷型（TAZ - / - ）小鼠可以有效地用作由高氧暴露引起的纤维瘤肺模型小鼠，也可用于由高氧暴露引起的肌瘤肺模型小鼠的制备，以及作为候选物质的筛选使用老鼠的药剂此外，TAZ缺陷型（TAZ - / - ）小鼠可用于诊断由高氧暴露引起的纤维瘤肺及其诊断试剂盒，通过确认TAZ基因或蛋白质的表达。

9. 发明申请

WO2010120029A1 COMPOSITION COMPRISING THE EXTRACT OF ANEMARRHENA ASPHODELOIDES BUNGE OR THE COMPOUNDS ISOLATED FROM THE SAME FOR PREVENTING AND TREATING LIPID METABOLISM DISORDER 审中-公开
标题翻译：组合物包含非甾体类抗坏血酸的提取物或从其分离的化合物，用于预防和治疗脂质代谢紊乱
公开(公告)号：WO2010120029A1
公开(公告)日：2010-10-21
申请号：PCT/KR2009/007327
申请日：2009-12-08
申请人： EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION , SEO, Eun Kyoung , HWANG, Eun Sook , YOUN, Ui Joung , NAM, Joo Won
发明人： SEO, Eun Kyoung , HWANG, Eun Sook , YOUN, Ui Joung , NAM, Joo Won
IPC分类号： C07D311/74 , C07D311/48 , A61K31/37 , A61K36/8964 , A61P3/04 , A61P3/10
CPC分类号： C07D311/64 , A23L33/105 , A61K31/37 , C07C49/835 , C07D311/58
摘要： The present invention relates to a composition comprising an extract of Anemarrhena asphodeloides Bunge or the compounds isolated from the same, as an active ingredient. In particular, the extract and compounds have the excellent inhibitory effects on adipocyte differentiation, and thus can be used in a pharmaceutical composition and functional food for the prevention and treatment of lipid metabolism disorders.
摘要翻译：本发明涉及包含Anemarrhena asphodeloides Bunge的提取物或从其分离的化合物作为活性成分的组合物。特别地，提取物和化合物对脂肪细胞分化具有优异的抑制作用，因此可用于药物组合物和功能性食品中以预防和治疗脂质代谢紊乱。

10. 发明申请

WO2007056422A3 MODULATION OF IL-2 PRODUCTION BY T-BET 审中-公开
标题翻译：通过T-BET调节IL-2产生
公开(公告)号：WO2007056422A3
公开(公告)日：2007-11-22
申请号：PCT/US2006043429
申请日：2006-11-07
申请人： HARVARD COLLEGE , GLIMCHER LAURIE H , HWANG EUN SOOK
发明人： GLIMCHER LAURIE H , HWANG EUN SOOK
IPC分类号： C12P1/00 , A61K38/00 , C12N9/12
CPC分类号： C12Q1/485 , G01N2333/4706 , G01N2333/55 , G01N2500/02
摘要： The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that modulate the kinase-mediated interaction of T-bet with RelA, as well as methods of use therefore.
摘要翻译：本发明至少部分基于T-bet调节IL2产生的机制的鉴定。本发明涉及鉴定调节T-bet与RelA的激酶介导的相互作用的试剂的方法，以及因此使用的方法。

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