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1. 发明申请

WO2006124095A2 SAMPLE HANDLING MECHANISMS AND METHODS FOR MASS SPECTROMETRY 审中-公开
标题翻译：样品处理机理和质谱方法
公开(公告)号：WO2006124095A2
公开(公告)日：2006-11-23
申请号：PCT/US2006/007889
申请日：2006-03-07
申请人： APPLERA CORPORATION , MDS, INC. , CYGAN, Thomas, R. , TSANG, Vincent , BURKE, Raymond, P. , GILL, Richard , MARTIN, Roy , HUTCHINS, Timothy, E.
发明人： CYGAN, Thomas, R. , TSANG, Vincent , BURKE, Raymond, P. , GILL, Richard , MARTIN, Roy , HUTCHINS, Timothy, E.
IPC分类号： H01J49/04
CPC分类号： H01J49/0495
摘要： In various aspects, the present teaching provide systems for providing sample ions, methods for providing sample ions, and sample support handling mechanisms. The sample support handling mechanisms of the present teachings comprising a sample support transfer mechanism portion and a sample support changing mechanism portion, where the sample support changing mechanism portion is disposed in a vacuum lock chamber. In various embodiments, the sample support handling mechanism facilitates providing consistent positioning of a sample support for subsequent ion generation by MALDI.
摘要翻译：在各个方面，本教导提供用于提供样品离子的系统，用于提供样品离子的方法和样品支持处理机构。本发明的样品支持处理机构包括样品支承转移机构部分和样品支撑体改变机构部分，其中样品支撑体改变机构部分设置在真空锁定室中。在各种实施方案中，样品支持处理机制有助于提供样品载体的一致的定位，以便随后通过MALDI产生离子。

2. 发明申请

WO2006124095A3 SAMPLE HANDLING MECHANISMS AND METHODS FOR MASS SPECTROMETRY 审中-公开
标题翻译：样品处理机理和质谱方法
公开(公告)号：WO2006124095A3
公开(公告)日：2008-01-10
申请号：PCT/US2006007889
申请日：2006-03-07
申请人： APPLERA CORP , MDS INC , CYGAN THOMAS R , TSANG VINCENT , BURKE RAYMOND P , GILL RICHARD , MARTIN ROY , HUTCHINS TIMOTHY E
发明人： CYGAN THOMAS R , TSANG VINCENT , BURKE RAYMOND P , GILL RICHARD , MARTIN ROY , HUTCHINS TIMOTHY E
IPC分类号： H01J49/04 , G01J1/00 , G06F19/00 , H01J31/26
CPC分类号： H01J49/0495
摘要： In various aspects, the present teaching provide systems for providing sample ions, methods for providing sample ions, and sample support handling mechanisms. The sample support handling mechanisms of the present teachings comprising a sample support transfer mechanism portion and a sample support changing mechanism portion, where the sample support changing mechanism portion is disposed in a vacuum lock chamber. In various embodiments, the sample support handling mechanism facilitates providing consistent positioning of a sample support for subsequent ion generation by MALDI.
摘要翻译：在各个方面，本教导提供用于提供样品离子的系统，用于提供样品离子的方法和样品支持处理机构。本发明的样品支持处理机构包括样品支承转移机构部分和样品支撑体改变机构部分，其中样品支撑体改变机构部分设置在真空锁定室中。在各种实施方案中，样品支持处理机制有助于提供样品载体的一致的定位，以便随后通过MALDI产生离子。

3. 发明申请

WO2005061111A3 MALDI PLATE CONSTRUCTION WITH GRID 审中-公开
标题翻译： MALDI板结构与网格
公开(公告)号：WO2005061111A3
公开(公告)日：2006-06-29
申请号：PCT/US2004041382
申请日：2004-12-10
申请人： APPLERA CORP , VESTAL MARVIN L , HUTCHINS TIMOTHY E
发明人： VESTAL MARVIN L , HUTCHINS TIMOTHY E
IPC分类号： H01J49/16 , B01L20060101 , H01J49/04
CPC分类号： H01J49/0418
摘要： A MALDI plate construction is provided to support a sample in a manner to effect mass spectrometry of the sample. The plate construction comprises a sample receiving surface, a plate holder for retaining the sample receiving surface and an electrically conductive grid positioned adjacent to the sample receiving surface and in electrical contact with the plate holder.
摘要翻译：提供了MALDI板结构以支持样品以进行样品的质谱分析。板结构包括样品接收表面，用于保持样品接收表面的板保持器和邻近样品接收表面定位并与板保持器电接触的导电栅格。

4. 发明申请

WO2005037435A1 MALDI PLATE WITH REMOVABLE INSERT 审中-公开
标题翻译：具有可移除插件的MALDI板
公开(公告)号：WO2005037435A1
公开(公告)日：2005-04-28
申请号：PCT/US2004/032993
申请日：2004-10-07
申请人： APPLERA CORPORATION , HUTCHINS, Timothy, E. , TOMLINSON, Andrew, J. , SAVICKAS, Philip, J.
发明人： HUTCHINS, Timothy, E. , TOMLINSON, Andrew, J. , SAVICKAS, Philip, J.
IPC分类号： B01L3/00
CPC分类号： H01J49/0418 , B01L9/52 , B01L2200/025 , B01L2300/0819 , B01L2300/0822
摘要： A sample plate structure is provided including a retainer plate having a central opening, a sample insert plate which fits into the opening, an optional pressure plate and a handle. The handle applies pressure to the sample insert plate to retain it within the retainer plate. The sample insert plate is provided with a peripheral configuration, which assures that the sample insert is properly oriented within the sample plate support structure and is held flat. While the sample insert plate can be a consumable, the remaining portion of the apparatus can be reused.
摘要翻译：提供了样品板结构，其包括具有中心开口的保持板，装配到开口中的样品插入板，可选的压力板和手柄。手柄向样品插入板施加压力以将其保持在保持板内。样品插入板设置有周边构造，其确保样品插入件在样品板支撑结构内适当地取向并保持平坦。当样品插入板可以是消耗品时，装置的剩余部分可以重复使用。

5. 发明申请

WO2005061111A2 MALDI PLATE CONSTRUCTION WITH GRID 审中-公开
标题翻译： MALDI板结构与网格
公开(公告)号：WO2005061111A2
公开(公告)日：2005-07-07
申请号：PCT/US2004/041382
申请日：2004-12-10
申请人： APPLERA CORPORATION , VESTAL, Marvin, L. , HUTCHINS, Timothy, E.
发明人： VESTAL, Marvin, L. , HUTCHINS, Timothy, E.
IPC分类号： B01L
CPC分类号： H01J49/0418
摘要： A MALDI plate construction is provided to support a sample in a manner to effect mass spectrometry of the sample. The plate construction comprises a sample receiving surface, a plate holder for retaining the sample receiving surface and an electrically conductive grid positioned adjacent to the sample receiving surface and in electrical contact with the plate holder.
摘要翻译：提供了MALDI板结构以支持样品以进行样品的质谱分析。板结构包括样品接收表面，用于保持样品接收表面的板保持器和邻近样品接收表面定位并与板保持器电接触的导电栅格。

6. 发明申请

WO2005037434A1 MALDI PLATE WITH REMOVABLE MAGNETIC INSERT 审中-公开
标题翻译：具有可拆卸磁性插件的MALDI板
公开(公告)号：WO2005037434A1
公开(公告)日：2005-04-28
申请号：PCT/US2004/032992
申请日：2004-10-07
申请人： APPLERA CORPORATION , MCCARTHY, Robert, D. , HAYDEN, Kevin, M. , HUTCHINS, Timothy, E. , SAVICKAS, Philip, J. , CRANSHAW, Peter, C.
发明人： MCCARTHY, Robert, D. , HAYDEN, Kevin, M. , HUTCHINS, Timothy, E. , SAVICKAS, Philip, J. , CRANSHAW, Peter, C.
IPC分类号： B01L3/00
CPC分类号： B01L9/523 , B01L2200/04 , B01L2300/0829 , H01J49/0418
摘要： A sample plate structure (10) is provided including a retainer plate (11) having a central recess (12) with a trough (13) along its periphery, a sample insert plate (14) which fits into and rests on contact surface of the recess, and a magnet (16) that is held below the contact surface. A portion of the bottom surface (15) of the insert is formed of a magnetic material. The magnet (16) provides sufficient force to retain the insert plate (14) in the retainer plate (11) during MALDI MS analysis. The sample insert plate 814) is provided with a peripheral configuration, which assures that the sample insert plate is properly oriented within the sample plate support structure and is held flat. A hole (18) for a protrusion allows easy insert installation and alignment against the orientation feature in the recess as well as easy removal of the insert simply by pushing up from underneath the retainer plate. While the insert sample plate (14) can be a consumable, the remaining portion of the apparatus can be reused.
摘要翻译：一种样品板结构（10），其包括具有沿着其周边具有槽（13）的中心凹部（12）的保持板（11），样品插入板（14）凹部，以及保持在接触表面下方的磁体（16）。插入件的底表面（15）的一部分由磁性材料形成。在MALDI MS分析期间，磁体（16）提供足够的力以将插入板（14）保持在保持板（11）中。样品插入板814）设置有周边结构，其确保样品插入板在样品板支撑结构内被适当地取向并保持平坦。用于突起的孔（18）允许容易地插入安装和对准凹部中的取向特征，并且简单地通过从保持板的下面向上推动来容易地移除插入件。当插入样品板（14）可以是消耗品时，装置的剩余部分可以被重新使用。

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