专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1046036A4 METHODS FOR OBTAINING PROBES OF PEPTIDE FUNCTION 失效
标题翻译：法探头用肽特性取得
公开(公告)号：EP1046036A4
公开(公告)日：2003-08-27
申请号：EP98939132
申请日：1998-07-29
申请人： HUSTON JAMES S , HUTCHENS T WILLIAM
发明人： HUSTON JAMES S , HUTCHENS T WILLIAM
IPC分类号： C07K16/00 , C12N15/10 , C12Q1/68 , C40B40/02 , B01J19/00 , C07K1/04 , G01N33/68
CPC分类号： C40B40/02 , C07K16/00 , C07K2317/55 , C07K2317/622 , C12N15/1037 , C12Q1/6811
摘要： Methods for obtaining probes of function for peptides are described. The methods include contacting an array of peptidic targets with a diverse library of binding partners, and identifying the binding partners which bind to the array of targets.

2. 发明公开

EP1046036A1 METHODS FOR OBTAINING PROBES OF PEPTIDE FUNCTION 失效
标题翻译：法探头用肽特性取得
公开(公告)号：EP1046036A1
公开(公告)日：2000-10-25
申请号：EP98939132.1
申请日：1998-07-29
申请人： Huston, James S. , Hutchens, T. William
发明人： Huston, James S. , Hutchens, T. William
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： C40B40/02 , C07K16/00 , C07K2317/55 , C07K2317/622 , C12N15/1037 , C12Q1/6811
摘要： Methods for obtaining probes of function for peptides are described. The methods include contacting an array of peptidic targets with a diverse library of binding partners, and identifying the binding partners which bind to the array of targets.

3. 发明申请

WO2017151971A2 METHODS RELATED TO ENGINEERED Fc CONSTRUCTS 审中-公开
标题翻译：与工程化Fc结构相关的方法
公开(公告)号：WO2017151971A2
公开(公告)日：2017-09-08
申请号：PCT/US2017/020519
申请日：2017-03-02
申请人： MOMENTA PHARMACEUTICALS, INC. , BOSQUES, Carlos, J. , HUSTON, James, S. , LANSING, Jonathan, C. , LING, Leona, E. , MEADOR, James , ORTIZ, Daniel , RUTITZKY, Laura , SCHULTES, Brigit C.
发明人： BOSQUES, Carlos, J. , HUSTON, James, S. , LANSING, Jonathan, C. , LING, Leona, E. , MEADOR, James , ORTIZ, Daniel , RUTITZKY, Laura , SCHULTES, Brigit C. , SCHULTES, Birgit, C.
IPC分类号： A61K39/00
摘要： The present invention relates to methods of using biologically active Fc domain-containing therapeutic constructs (Fc constructs) to induce immune cell activation of the immune response in a subject, and for example, to treat diseases such as cancers and infections in a subject. Such Fc constructs may include 5 or more Fc domains.
摘要翻译：本发明涉及使用具有生物学活性的含Fc结构域的治疗性构建体（Fc构建体）来诱导受试者免疫应答的免疫应答激活以及例如治疗疾病的方法，所述疾病例如癌症和感染。这种Fc构建体可以包含5个或更多个Fc结构域。

4. 发明申请

WO2014145159A3 CHARGE-ENGINEERED ANTIBODIES OR COMPOSITIONS OF PENETRATION-ENHANCED TARGETING PROTEINS AND METHODS OF USE 审中-公开
标题翻译：充电工程抗体或渗透增强的靶向蛋白的组合物及其使用方法
公开(公告)号：WO2014145159A3
公开(公告)日：2015-01-08
申请号：PCT/US2014029875
申请日：2014-03-14
申请人： PERMEON BIOLOG INC , BOWDISH KATHERINE S , HUSTON JAMES S , VOGAN ERIK M , COOKE HEATHER , ROSS JOHN , LIN KAI
发明人： BOWDISH KATHERINE S , HUSTON JAMES S , VOGAN ERIK M , COOKE HEATHER , ROSS JOHN , LIN KAI
IPC分类号： C07K19/00 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/44
CPC分类号： C07K16/28 , A61K47/6801 , A61K47/6849 , A61K47/6855 , A61K2039/505 , C07K16/00 , C07K16/2887 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3069 , C07K16/32 , C07K19/00 , C07K2317/14 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2318/10 , C07K2319/01 , C07K2319/30 , C07K2319/60 , C12N9/86 , C12Y305/02006
摘要： The disclosure relates to charge-engineered antibodies and penetration-enhanced targeted proteins and their uses for therapeutic treatment or therapeutics delivery.
摘要翻译：本公开涉及电荷工程抗体和渗透增强靶向蛋白及其用于治疗性治疗或治疗递送的用途。

5. 发明专利

CA2338865A1 METHODS FOR OBTAINING PROBES OF PEPTIDE FUNCTION 未知
公开(公告)号：CA2338865A1
公开(公告)日：1999-02-11
申请号：CA2338865
申请日：1998-07-29
申请人： HUTCHENS T WILLIAM , HUSTON JAMES S
发明人： HUTCHENS T WILLIAM , HUSTON JAMES S
IPC分类号： C07K16/00 , C12N15/10 , C12Q1/68 , C40B40/02 , G01N33/53 , G01N33/566
摘要： Methods for obtaining probes of function for peptides are described. The methods include contacting an array of peptidic targets with a diverse libra ry of binding partners, and identifying the binding partners which bind to the array of targets.

6. 发明申请

WO2014145159A2 CHARGE-ENGINEERED ANTIBODIES OR COMPOSITIONS OF PENETRATION-ENHANCED TARGETING PROTEINS AND METHODS OF USE 审中-公开
标题翻译：充电工程抗体或渗透增强的靶向蛋白的组合物及其使用方法
公开(公告)号：WO2014145159A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/029875
申请日：2014-03-14
申请人： PERMEON BIOLOGICS, INC. , BOWDISH, Katherine, S. , HUSTON, James, S. , VOGAN, Erik, M. , COOKE, Heather , ROSS, John , LIN, Kai
发明人： BOWDISH, Katherine, S. , HUSTON, James, S. , VOGAN, Erik, M. , COOKE, Heather , ROSS, John , LIN, Kai
IPC分类号： C07K19/00
CPC分类号： C07K16/28 , A61K47/6801 , A61K47/6849 , A61K47/6855 , A61K2039/505 , C07K16/00 , C07K16/2887 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3069 , C07K16/32 , C07K19/00 , C07K2317/14 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/77 , C07K2317/92 , C07K2317/94 , C07K2318/10 , C07K2319/01 , C07K2319/30 , C07K2319/60 , C12N9/86 , C12Y305/02006
摘要： The disclosure relates to charge-engineered antibodies and penetration-enhanced targeted proteins and their uses for therapeutic treatment or therapeutics delivery.
摘要翻译：本公开涉及电荷工程化抗体和渗透增强靶向蛋白及其用于治疗性治疗或治疗递送的用途。

7. 发明申请

WO1996005228A1 METHOD OF PRODUCING SINGLE-CHAIN Fv MOLECULES 审中-公开
标题翻译：生产单链Fv分子的方法
公开(公告)号：WO1996005228A1
公开(公告)日：1996-02-22
申请号：PCT/US1995010348
申请日：1995-08-14
申请人： CREATIVE BIOMOLECULES, INC. , THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , JOST, Carolina, R. , SEGAL, David, M. , HUSTON, James, S.
发明人： CREATIVE BIOMOLECULES, INC. , THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： C07K16/00
CPC分类号： C07K16/44 , C07K16/00
摘要： The invention relates to a method of producing single-chain Fv molecules in eukaryotic cells, and to secretable sFv proteins having at least one non-naturally occurring glycosylation site. The single-chain Fv molecules produced by this method are biologically active and capable of being secreted from eukaryotic cells into the cell culture medium.
摘要翻译：本发明涉及在真核细胞中产生单链Fv分子的方法，以及具有至少一个非天然存在的糖基化位点的可分泌的sFv蛋白。通过该方法产生的单链Fv分子是生物活性的并且能够从真核细胞分泌到细胞培养基中。

8. 发明申请

WO1988009344A1 TARGETED MULTIFUNCTIONAL PROTEINS 审中-公开
标题翻译：目标多功能蛋白
公开(公告)号：WO1988009344A1
公开(公告)日：1988-12-01
申请号：PCT/US1988001737
申请日：1988-05-19
申请人： CREATIVE BIOMOLECULES, INC. , HUSTON, James, S. , OPPERMANN, Hermann
发明人： CREATIVE BIOMOLECULES, INC.
IPC分类号： C07K13/00
CPC分类号： C07K16/18 , C07K16/00 , C07K16/464 , C07K16/468 , C07K2317/24 , C07K2317/622 , C07K2317/624 , C07K2319/00 , C07K2319/02 , C07K2319/705
摘要： Disclosed are a family of synthetic proteins having binding affinity for a preselected antigen, and multifunctional proteins having such affinity. The proteins are characterized by one or more sequences of amino acids constituting a region which behaves as a biosynthetic antibody binding site (BABS). The sites comprise VH-VL or VL-VH-like single chains wherein the VH and VL-like sequences are attached by a polypeptide linker, or individual VH or VL-like domains. The binding domains comprise linked CDR and FR regions, which may be derived from separate immunoglobulins. The proteins may also include other polypeptide sequences which function, e.g., as an enzyme, toxin, binding site, or site for attachment to an immobilization media or radioactive atom. Methods are disclosed for producing the proteins, for designing BABS having any specificity that can be elicited by in vivo generation of antibody, for producing analogs thereof, and for producing multifunctional synthetic proteins which are self-targeted by virtue of their binding site region.
摘要翻译：公开了对预选抗原具有结合亲和力的合成蛋白质家族，以及具有这种亲和力的多功能蛋白质。蛋白质的特征在于构成表现为生物合成抗体结合位点（BABS）的区域的一个或多个氨基酸序列。所述位点包含VH-VL或VL-VH样单链，其中VH和VL样序列通过多肽接头或单独的VH或VL样结构域连接。结合域包含连接的CDR和FR区，其可以衍生自单独的免疫球蛋白。蛋白质还可以包括其它多肽序列，其功能例如作为酶，毒素，结合位点或用于附着于固定化介质或放射性原子的位点。公开了用于制备蛋白质的方法，用于设计具有可通过体内产生抗体引起的任何特异性的BABS，用于产生其类似物，以及用于生产通过其结合位点区域自身靶向的多功能合成蛋白质。

9. 发明申请

WO2017151971A3 METHODS RELATED TO ENGINEERED Fc CONSTRUCTS 审中-公开
公开(公告)号：WO2017151971A3
公开(公告)日：2017-09-08
申请号：PCT/US2017/020519
申请日：2017-03-02
申请人： MOMENTA PHARMACEUTICALS, INC. , BOSQUES, Carlos, J. , HUSTON, James, S. , LANSING, Jonathan, C. , LING, Leona, E. , MEADOR, James , ORTIZ, Daniel , RUTITZKY, Laura , SCHULTES, Brigit C.
发明人： BOSQUES, Carlos, J. , HUSTON, James, S. , LANSING, Jonathan, C. , LING, Leona, E. , MEADOR, James , ORTIZ, Daniel , RUTITZKY, Laura , SCHULTES, Brigit C. , SCHULTES, Birgit, C.
IPC分类号： C12N9/00 , C12N9/96 , G01N33/53 , G01N33/574 , A61P37/04 , C07K16/28 , C07K16/46 , C07K16/08 , C07K16/12
摘要： The present invention relates to methods of using biologically active Fc domain-containing therapeutic constructs (Fc constructs) to induce immune cell activation of the immune response in a subject, and for example, to treat diseases such as cancers and infections in a subject. Such Fc constructs may include 5 or more Fc domains.

10. 发明申请

WO0200914A9 BIOENGINEERED VEHICLES FOR TARGETED NUCLEIC ACID DELIVERY 审中-公开
标题翻译：生物医药用于定向核酸递送
公开(公告)号：WO0200914A9
公开(公告)日：2003-03-06
申请号：PCT/US0120182
申请日：2001-06-25
申请人： HUSTON JAMES S , WILS PIERRE , ZHU QUAN , LAURENT OLIVIER , MARASCO WAYNE A , SCHERMAN DANIEL
发明人： HUSTON JAMES S , WILS PIERRE , ZHU QUAN , LAURENT OLIVIER , MARASCO WAYNE A , SCHERMAN DANIEL
IPC分类号： A61K48/00 , C07K16/32 , C12N15/87 , C12P21/08 , C07K1/00 , A01N43/04 , C07K16/00
CPC分类号： A61K48/00 , A61K2039/505 , C07K16/32 , C07K2317/622 , C07K2319/00 , C12N15/87
摘要： There is disclosed a gene-delivery compound comprising: a) a single-chain binding polypeptide having at least one effector segment which includes at least one cysteinyl residue; and b) a nucleic acid-binding moiety which is coupled to the polypeptide via the cysteinyl residue. There is disclosed also a gene-delivery compound comprising: a) a single-chain, binding polypeptide having at least one effector segment which includes at least one cysteinyl residue; b) a lipid-associating moiety which is coupled to the polypeptide via the cysteinyl residue. Additionally disclosed are compositions comprising the above-mentioned compounds and a nucleic acid.
摘要翻译：公开了一种基因递送化合物，其包含：a）具有至少一个效应子段的单链结合多肽，其包含至少一个半胱氨酰残基; 和b）通过半胱氨酰残基与多肽偶联的核酸结合部分。还公开了一种基因递送化合物，其包含：a）具有至少一个效应子区段的单链结合多肽，其包含至少一个半胱氨酰残基; b）通过半胱氨酰残基与多肽偶联的脂质缔合部分。另外公开的是包含上述化合物和核酸的组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式