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    • 6. 发明申请
    • VACCINATION AGAINST MALIGNANT MELANOMA USING BCG AND/OR VACCINIA
    • 使用卡介苗和/或疫苗接种恶性黑质素疫苗
    • WO2005099750A1
    • 2005-10-27
    • PCT/EP2005/004050
    • 2005-04-15
    • GEORG-AUGUST-UNIVERSITÄT GÖTTINGENKRONE, BerndHUNSMANN, Gerhard
    • KRONE, BerndHUNSMANN, Gerhard
    • A61K39/02
    • A61K39/02A61K39/002A61K2039/545Y02A50/388Y02A50/487Y02A50/491
    • The present invention relates to a vaccination which reduces the risk to contract melanoma to about half to third and moreover, within a five year period post diagnosis of malignant melanoma the risk to die is reduced to about half as compared to the non-vaccinated individuals. Beyond its effect on melanoma, the vaccination of the invention also may have protective effects against some other malignancies such as cancers of bladder, breast, esophagus, and kidney, against sarcomas and lymphomas, and against a multitude of micro-organisms which can induce severe and lethal infections or allergies. The present invention relates also to the use the yellow fever vaccine for the prophylactic vaccination against a malignancy, in particular melanoma, to the use of some other licensed vaccinations for the prophylactic vaccination against a malignancy, in particular melanoma, and to new synthetic vaccines which use the identified antigenic motifs.
    • 本发明涉及将接种黑素瘤的风险降低到约半数至三分之一的疫苗接种,此外,在恶性黑素瘤诊断后的五年内,与非接种个体相比,死亡风险降低至约一半。 除了其对黑素瘤的作用之外,本发明的疫苗接种还可以对一些其它恶性肿瘤(例如膀胱,乳腺,食道和肾脏的癌症)针对肉瘤和淋巴瘤以及针对可诱导严重的多种微生物具有保护作用 和致命的感染或过敏。 本发明还涉及将黄热病疫苗用于预防性接种恶性肿瘤,特别是黑素瘤的用途,以使用一些其他许可的接种疫苗来预防性接种恶性肿瘤,特别是黑素瘤,以及新的合成疫苗,其中 使用确定的抗原基序。