专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012114222A1 IMIDAZO[5,1-f][1,2,4]TRIAZINES FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：咪达唑[5,1-f] [1,2,4]治疗神经病的TRIAZINES
公开(公告)号：WO2012114222A1
公开(公告)日：2012-08-30
申请号：PCT/IB2012/050589
申请日：2012-02-09
申请人： PFIZER INC. , CHAPPIE, Thomas Allen , HUMPHREY, John Michael , VERHOEST, Patrick Robert , YANG, Eddie , HELAL, Christopher John
发明人： CHAPPIE, Thomas Allen , HUMPHREY, John Michael , VERHOEST, Patrick Robert , YANG, Eddie , HELAL, Christopher John
IPC分类号： C07D487/04 , A61K31/53 , A61P25/18
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds as a method for the treatment of a disease or condition selected from the group consisting of central nervous system disorders, cognitive disorders, schizophrenia, dementia and other disorders in a mammal.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐，用于制备用于制备中间体的方法和含有这些化合物的组合物以及这些化合物的用途，例如用于治疗疾病或病症，其选自哺乳动物中的中枢神经系统疾病，认知障碍，精神分裂症，痴呆和其他疾病。

2. 发明申请

WO2007085954A2 AMINOPHTHALAZINE DERIVATIVE COMPOUNDS 审中-公开
标题翻译：氨基嘌呤衍生化合物
公开(公告)号：WO2007085954A2
公开(公告)日：2007-08-02
申请号：PCT/IB2007/000197
申请日：2007-01-22
申请人： PFIZER PRODUCTS INC. , HUMPHREY, John, Michael
发明人： HUMPHREY, John, Michael
CPC分类号： C07D403/04 , C07D401/04 , C07D401/12 , C07D413/12 , C07D471/10 , C07D513/04
摘要： The invention pertains to new aminophthalazine compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE-10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom.
摘要翻译：本发明涉及用作有效磷酸二酯酶（PDE）抑制剂的新的氨基酞嗪化合物。本发明还涉及PDE-10的选择性抑制剂的化合物。本发明还涉及制备这些化合物的中间体; 包含这些化合物的药物组合物; 以及这些化合物在治疗某些中枢神经系统（CNS）或其他疾病的方法中的应用。本发明还涉及用于治疗神经变性和精神疾病的方法，例如包括缺乏认知作为症状的精神病和病症。

3. 发明申请

WO2007085954A3 AMINOPHTHALAZINE DERIVATIVE COMPOUNDS 审中-公开
标题翻译：氨基嘌呤衍生化合物
公开(公告)号：WO2007085954A3
公开(公告)日：2007-10-25
申请号：PCT/IB2007000197
申请日：2007-01-22
申请人： PFIZER PROD INC , HUMPHREY JOHN MICHAEL
发明人： HUMPHREY JOHN MICHAEL
IPC分类号： C07D401/04 , A61K31/495 , A61K31/502 , C07D401/14 , C07D413/14
CPC分类号： C07D403/04 , C07D401/04 , C07D401/12 , C07D413/12 , C07D471/10 , C07D513/04
摘要： The invention pertains to new aminophthalazine compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to. compounds that are selective inhibitors of PDE-10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders, The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom. The claimed compounds have following structure: or a pharmaceutically acceptable salt thereof, wherein ring A is a 5 or 6 membered heterocyclic ring substituted or not.
摘要翻译：本发明涉及用作有效磷酸二酯酶（PDE）抑制剂的新的氨基酞嗪化合物。本发明还涉及。作为PDE-10的选择性抑制剂的化合物。本发明还涉及制备这些化合物的中间体; 包含这些化合物的药物组合物; 以及这些化合物在治疗某些中枢神经系统（CNS）或其它疾病的方法中的用途。本发明还涉及用于治疗神经变性和精神疾病的方法，例如精神病和包括缺乏认知作为症状的病症。所要求保护的化合物具有以下结构：或其药学上可接受的盐，其中环A是取代或未取代的5或6元杂环。

4. 发明申请

WO2005082883A2 TETRAHYDROISOQUINOLINYL DERIVATIVES OF QUINAZOLINE AND ISOQUINOLINE 审中-公开
标题翻译：喹唑啉和异喹啉的四氢喹啉啉衍生物
公开(公告)号：WO2005082883A2
公开(公告)日：2005-09-09
申请号：PCT/IB2005/000307
申请日：2005-02-07
申请人： PFIZER PRODUCTS INC. , ALLEN, Martin, Patrick , CHAPPIE, Thomas, Allen , HUMPHREY, John, Michael , LIRAS, Spiros , WHALEN, William, Michael
发明人： ALLEN, Martin, Patrick , CHAPPIE, Thomas, Allen , HUMPHREY, John, Michael , LIRAS, Spiros , WHALEN, William, Michael
IPC分类号： C07D401/00
CPC分类号： C07D401/04 , C07D491/04
摘要： The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.
摘要翻译：本发明涉及用作有效磷酸二酯酶（PDE）抑制剂的取代喹唑啉和异喹啉化合物。特别地，本发明涉及作为PDE-10的选择性抑制剂的所述化合物。本发明还涉及制备所述化合物的中间体; 包含所述化合物的药物组合物; 以及所述化合物在治疗某些中枢神经系统（CNS）或其它疾病的方法中的用途。

5. 发明申请

WO2004043908A1 PROCESS FOR CONVERTING A CIS-TRANS MIXTURE OF SUBSTITUTED BENZYLIDENE AMINES INTO THE PURE CIS ISOMER 审中-公开
标题翻译：将替代的苯并噻唑衍生物转化为独特异构体的方法
公开(公告)号：WO2004043908A1
公开(公告)日：2004-05-27
申请号：PCT/IB2003/004953
申请日：2003-11-03
申请人： PFIZER PRODUCTS INC. , HUMPHREY, John, Michael , TOM, Norma, Jacqueline
发明人： HUMPHREY, John, Michael , TOM, Norma, Jacqueline
IPC分类号： C07C251/24
CPC分类号： C07C251/24 , C07B2200/09 , C07C249/02
摘要： A process for interconverting a mixture of cis-trans erythro-threo isomers of a compound of formula I into the substantially pure cis isomer. Cis isomers of formula I are usefull intermediates in the synthesis of cis isomers of benzamide piperidine compounds which exhibit activity as NK-1 receptor antagonists.
摘要翻译：将式I化合物的顺式 - 反式 - 赤式 - 苏氨酸异构体的混合物相互转化为基本上纯的顺式异构体的方法。式I的顺式异构体在合成具有作为NK-1受体拮抗剂活性的苯甲酰胺哌啶化合物的顺式异构体中是有用的中间体。

6. 发明申请

WO0177100A3 BENZOAMIDE PIPERIDINE COMPOUNDS AS SUBSTANCE P ANTAGONISTS 审中-公开
标题翻译：苯甲酰胺哌啶化合物作为物质拮抗剂
公开(公告)号：WO0177100A3
公开(公告)日：2002-03-07
申请号：PCT/IB0100629
申请日：2001-04-06
申请人： PFIZER PROD INC , ARNOLD ERIC PLATT , CHAPPIE THOMAS ALLEN , HUANG JIANHUA , HUMPHREY JOHN MICHAEL , NAGEL ARTHUR ADAM , NEILL BRIAN THOMAS O , SOBOLOV JAYNES SUSAN BETH , VINCENT LAWRENCE ALBERT
发明人： ARNOLD ERIC PLATT , CHAPPIE THOMAS ALLEN , HUANG JIANHUA , HUMPHREY JOHN MICHAEL , NAGEL ARTHUR ADAM , O'NEILL BRIAN THOMAS , SOBOLOV-JAYNES SUSAN BETH , VINCENT LAWRENCE ALBERT
IPC分类号： A61K31/437 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/5415 , A61P1/00 , A61P1/04 , A61P1/14 , A61P1/16 , A61P3/04 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/02 , A61P13/10 , A61P17/04 , A61P17/06 , A61P17/16 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/36 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D401/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/04 , C07D471/10 , C07D491/10 , A61K31/5395
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to certain benzoamide piperidine containing compounds of formula I and related compounds that exhibit activity as NK-1 receptor antagonists, ( e.g. , substance P receptor antagonists), to pharmaceutical compositions containing them, and to their use in the treatment and prevention of central nervous system disorders, inflammatory disorders, cardiovascular disorders, ophthalmic disorders, gastrointestinal disorders, disorders caused by helicobacter pylori , disorders of the immune system, urinary incontinence, pain, migraine, emesis, angiogenesis and other disorders. (I)
摘要翻译：本发明涉及含有式I化合物的某些苯甲酰胺哌啶及其作为NK-1受体拮抗剂（例如，P物质受体拮抗剂）具有活性的相关化合物，含有它们的药物组合物，以及它们用于治疗和预防中枢神经系统疾病，炎症性疾病，心血管疾病，眼科疾病，胃肠道疾病，由幽门螺杆菌引起的疾病，免疫系统疾病，尿失禁，疼痛，偏头痛，呕吐，血管生成等疾病。（一世）

7. 发明申请

WO2006072828A2 HETEROAROMATIC QUINOLINE COMPOUNDS 审中-公开
标题翻译：异喹啉化合物
公开(公告)号：WO2006072828A2
公开(公告)日：2006-07-13
申请号：PCT/IB2005/003937
申请日：2005-12-22
申请人： PFIZER PRODUCTS INC. , VERHOEST, Patrick, Robert , HELAL, Christopher, John , HOOVER, Dennis, Jay , HUMPHREY, John, Michael
发明人： VERHOEST, Patrick, Robert , HELAL, Christopher, John , HOOVER, Dennis, Jay , HUMPHREY, John, Michael
CPC分类号： C07D401/14 , C07D413/14
摘要： The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.
摘要翻译：本发明涉及用作有效磷酸二酯酶（PDE）抑制剂的杂芳族化合物。特别地，本发明涉及作为PDE10的选择性抑制剂的所述化合物。本发明还涉及制备所述化合物的中间体; 包含所述化合物的药物组合物; 以及所述化合物在治疗某些中枢神经系统（CNS）或其它疾病的方法中的用途。

8. 发明申请

WO2006070284A1 PYRROLIDYL DERIVATIVES OF HETEROAROMATIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：作为磷酸酯酶抑制剂的异佛尔酮化合物的吡咯烷衍生物
公开(公告)号：WO2006070284A1
公开(公告)日：2006-07-06
申请号：PCT/IB2005/003989
申请日：2005-12-19
申请人： PFIZER PRODUCTS INC. , CHAPPIE, Thomas, Allen , HUMPHREY, John, Michael
发明人： CHAPPIE, Thomas, Allen , HUMPHREY, John, Michael
IPC分类号： C07D403/14 , A61K31/517 , A61K31/502 , A61P25/00 , C07D403/12 , C07D403/04 , C07D401/14 , C07D401/12 , C07D207/12
CPC分类号： C07D403/12 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14
摘要： The invention pertains to new pyrrolidyl derivatives of benzo-fused aza heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE-IO. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom. Formula (I).
摘要翻译：本发明涉及用作有效磷酸二酯酶（PDE）抑制剂的苯并稠合氮杂杂芳族化合物的新吡咯烷基衍生物。本发明还涉及作为PDE-10的选择性抑制剂的化合物。本发明还涉及制备这些化合物的中间体; 包含这些化合物的药物组合物; 以及这些化合物在治疗某些中枢神经系统（CNS）或其他疾病的方法中的应用。本发明还涉及用于治疗神经变性和精神疾病的方法，例如包括缺乏认知作为症状的精神病和病症。式（I）。

9. 发明申请

WO2006011040A1 QUINAZOLIN-4-YL- PIPERIDINE AND CINNOLIN-4-YL- PIPERIDINE DERIVATIVES AS PDE10 INHIBITORS FOR THE TREATMENT OF CNS DISORDERS 审中-公开
标题翻译：喹诺酮-4-YL-哌啶和CINNOLIN-4-YL-哌啶衍生物作为治疗CNS疾病的PDE10抑制剂
公开(公告)号：WO2006011040A1
公开(公告)日：2006-02-02
申请号：PCT/IB2005/002177
申请日：2005-07-11
申请人： PFIZER PRODUCTS INC. , CHAPPIE, Thomas, Allen , HUMPHREY, John, Michael , LIRAS, Spiros
发明人： CHAPPIE, Thomas, Allen , HUMPHREY, John, Michael , LIRAS, Spiros
IPC分类号： C07D401/04
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D491/04
摘要： The invention pertains to new piperidyl-substituted quinazoline and isoquínoline derivatives of formula (I) that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders.
摘要翻译：本发明涉及用作有效磷酸二酯酶（PDE）抑制剂的式（I）的新的哌啶基取代的喹唑啉和异喹啉衍生物。本发明还涉及作为PDE10的选择性抑制剂的化合物。本发明还涉及制备这些化合物的中间体; 包含这些化合物的药物组合物; 以及这些化合物在治疗某些中枢神经系统（CNS）或其他疾病的方法中的应用。

10. 发明申请

WO2007096743A1 SUBSTITUTED QUINAZOLINES AS PDE10 INHIBITORS 审中-公开
标题翻译：替代喹诺酮作为PDE10抑制剂
公开(公告)号：WO2007096743A1
公开(公告)日：2007-08-30
申请号：PCT/IB2007/000411
申请日：2007-02-09
申请人： PFIZER PRODUCTS INC. , ALLEN, Martin, Patrick , CHAPPIE, Thomas, Allen , HUMPHREY, John, Michael , LIRAS, Spiros
发明人： ALLEN, Martin, Patrick , CHAPPIE, Thomas, Allen , HUMPHREY, John, Michael , LIRAS, Spiros
IPC分类号： C07D471/04 , C07D471/14 , A61K31/437 , A61K31/4375 , A61K31/519 , A61P25/24 , A61P25/28
CPC分类号： C07D471/04 , C07D471/14
摘要： The invention pertains to substituted quinazoline compounds of structures (I) and (II) that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds which are selective inhibitors of PDE-10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom. (I, II).
摘要翻译：本发明涉及用作有效磷酸二酯酶（PDE）抑制剂的结构（I）和（II）的取代喹唑啉化合物。本发明还涉及作为PDE-10的选择性抑制剂的化合物。本发明还涉及制备这些化合物的中间体; 包含这些化合物的药物组合物; 以及这些化合物在治疗某些中枢神经系统（CNS）或其他疾病的方法中的应用。本发明还涉及用于治疗神经变性和精神疾病的方法，例如包括缺乏认知作为症状的精神病和病症。（一，二）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式