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1. 发明申请

WO2007032940A2 SYSTEM AND METHODS FOR GENERATING THREE-DIMENSIONAL IMAGES FROM TWO-DIMENSIONAL BIOLUMINESCENCE IMAGES AND VISUALIZING TUMOR SHAPES AND LOCATIONS 审中-公开
标题翻译：用于从二维生物荧光图像和可视化肿瘤形状和位置生成三维图像的系统和方法
公开(公告)号：WO2007032940A2
公开(公告)日：2007-03-22
申请号：PCT/US2006/034320
申请日：2006-08-31
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY OFFICE OF CORPORATE LIAISON AND TECHNOLOGY TRANSFER , METAXAS, Dimitris , BANERJEE, Debabrata , HUANG, Xiaolei
发明人： METAXAS, Dimitris , BANERJEE, Debabrata , HUANG, Xiaolei
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/593
摘要： A system and methods for generating 3D images from 2D bioluminescent images and visualizing tumor locations are provided. A plurality of 2D bioluminescent images of a subject are acquired during a complete revolution of an imaging system about a subject, using any suitable bioluminescent imaging system. After imaging, the 2D images are registered according to the rotation axis to align each image and to compensate for differences between adjacent images. After registration, corresponding features are identified between consecutive sets of 2D images. For each corresponding feature identified in each set of 2D images, an orthographic projection model is applied, such that rays are projected through each point in the feature. The intersection points of the rays are plotted in a 3D image space. All of the 2D images are processed in the same manner, such that a resulting 3D image of a tumor is generated. The 3D image can be registered with a reference image of the subject, so that the shape and location of the tumor can be precisely visualized with respect to the subject.
摘要翻译：提供了一种用于从2D生物发光图像生成3D图像并可视化肿瘤位置的系统和方法。使用任何合适的生物发光成像系统，在关于受试者的成像系统的完整旋转期间获取对象的多个2D生物发光图像。在成像之后，根据旋转轴记录2D图像以对准每个图像并补偿相邻图像之间的差异。在注册之后，在连续的2D图像集之间识别相应的特征。对于每组2D图像中识别的每个相应特征，应用正交投影模型，使得射线通过特征中的每个点投射。将光线的交点绘制在3D图像空间中。以相同的方式处理所有2D图像，使得产生肿瘤的所得3D图像。 3D图像可以与受试者的参考图像一起登记，使得可以相对于受试者精确地显现肿瘤的形状和位置。

2. 发明申请

WO2006049591A2 METHOD AND SYSTEM FOR HYBRID RIGID REGISTRATION BASED ON JOINT CORRESPONDENCES BETWEEN SCALE-INVARIANT SALIENT REGION FEATURES 审中-公开
标题翻译：基于尺度不变尺度区域特征的联合对应的混合刚性配准方法和系统
公开(公告)号：WO2006049591A2
公开(公告)日：2006-05-11
申请号：PCT/US2004031056
申请日：2004-09-22
申请人： SIEMENS MEDICAL SOLUTIONS , XU CHENYANG , HUANG XIAOLEI , SUN YIYONG , SAUER FRANK
发明人： XU CHENYANG , HUANG XIAOLEI , SUN YIYONG , SAUER FRANK
IPC分类号： G06T7/00 , G06K9/00 , G06K9/46 , G06K9/64 , G06T7/20
CPC分类号： G06K9/6211 , G06K9/6212 , G06K2009/6213 , G06T7/246 , G06T7/277 , G06T7/337 , G06T7/35 , G06T2207/30016
摘要： A method of aligning a pair of images includes providing a pair of images with a first image and a second image, wherein the images comprise a plurality of intensities corresponding to a domain of points in a D -dimensional space. Salient feature regions are identified (101 in both the first image and the second image, a correspondence between each pair of salient feature regions is hypothesized, wherein a first region of each pair is on the first image and a second region of each pair is on the second image, the likelihood of the hypothesized correspondence of each pair of feature regions is measured (102), and a joint correspondence is determined (103) from a set of pairs of feature regions with the greatest likelihood of correspondence.
摘要翻译：对准一对图像的方法包括提供具有第一图像和第二图像的一对图像，其中图像包括对应于D维空间中的点的域的多个强度。在第一图像和第二图像两者中识别出显着特征区域（101），假设每对显着特征区域之间的对应关系，其中每对的第一区域在第一图像上并且每一对的第二区域在第二区域上测量第二图像，每对特征区域的假设对应的可能性（102），并且从具有最大对应可能性的一组特征区域中确定（103）联合对应。

3. 发明申请

WO2007032940A3 SYSTEM AND METHODS FOR GENERATING THREE-DIMENSIONAL IMAGES FROM TWO-DIMENSIONAL BIOLUMINESCENCE IMAGES AND VISUALIZING TUMOR SHAPES AND LOCATIONS 审中-公开
标题翻译：用于从二维生物荧光图像和可视化肿瘤形状和位置生成三维图像的系统和方法
公开(公告)号：WO2007032940A3
公开(公告)日：2007-06-07
申请号：PCT/US2006034320
申请日：2006-08-31
申请人： UNIV RUTGERS , METAXAS DIMITRIS , BANERJEE DEBABRATA , HUANG XIAOLEI
发明人： METAXAS DIMITRIS , BANERJEE DEBABRATA , HUANG XIAOLEI
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/593
摘要： A system and methods for generating 3D images (24) from 2D bioluminescent images (22) and visualizing tumor locations are provided. A plurality of 2D bioluminescent images of a subject are acquired during a complete revolution of an imaging system about a subject, using any suitable bioluminescent imaging system. After imaging, the 2D images are registered (20) according to the rotation axis to align each image and to compensate for differences between adjacent images. After registration (20), corresponding features are identified between consecutive sets of 2D image (22). For each corresponding feature identified in each set of 2D images an orthographic projection model (24) is applied, such that rays are progjected through each point in the feature. The intersectin point of the rays are plotted in a 3D image of a tumor is generated. The 3D image can be registered with a reference image of the subject, so that the shape and location of the tumor can be precisely visualized with respect to the subject .
摘要翻译：提供了用于从2D生物发光图像（22）生成3D图像（24）并且可视化肿瘤位置的系统和方法。使用任何合适的生物发光成像系统，在关于受试者的成像系统的完整旋转期间获取对象的多个2D生物发光图像。在成像之后，根据旋转轴记录（20）2D图像以对准每个图像并补偿相邻图像之间的差异。在注册（20）之后，在连续的2D图像组（22）之间识别相应的特征。对于在每组2D图像中识别的每个相应特征，应用正投影模型（24），使得射线通过特征中的每个点进行。光线的相交点被绘制在产生肿瘤的3D图像中。 3D图像可以与受试者的参考图像一起登记，使得可以相对于受试者精确地显现肿瘤的形状和位置。

4. 发明申请

WO2007044508A2 SYSTEM AND METHOD FOR WHOLE BODY LANDMARK DETECTION, SEGMENTATION AND CHANGE QUANTIFICATION IN DIGITAL IMAGES 审中-公开
标题翻译：用于数字图像中整体地标检测，分割和改变量化的系统和方法
公开(公告)号：WO2007044508A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/039109
申请日：2006-10-05
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , HUANG, Xiaolei , ZHOU, Xiang , JEREBKO, Anna , KRISHNAN, Arun , GUAN, Haiying , KUBOTA, Toshiro , POTESIL, Vaclav
发明人： HUANG, Xiaolei , ZHOU, Xiang , JEREBKO, Anna , KRISHNAN, Arun , GUAN, Haiying , KUBOTA, Toshiro , POTESIL, Vaclav
IPC分类号： G06T7/00
CPC分类号： G06T7/174 , G06T7/155 , G06T7/33 , G06T7/38 , G06T2207/10072 , G06T2207/20016 , G06T2207/20081 , G06T2207/20164 , G06T2207/30004 , G06T2207/30204
摘要： A method for segmenting digitized images includes providing (11) a training set comprising a plurality of digitized whole-body images, providing labels (12) on anatomical landmarks in each image of said training set, aligning (13) each said training set image, generating (14) positive and negative training examples for each landmark by cropping the aligned training volumes into one or more cropping windows of different spatial scales, and using said positive and negative examples to train (15) a detector for each landmark at one or more spatial scales ranging from a coarse resolution to a fine resolution, wherein the spatial relationship between a cropping windows of a coarse resolution detector and a fine resolution detector is recorded.
摘要翻译：用于分割数字化图像的方法包括提供（11）包括多个数字化全身图像的训练集，在所述训练集的每个图像中的解剖标志上提供标签（12），对齐（ 13）每个所述训练集图像，通过将所述对齐的训练体裁剪成不同空间尺度的一个或多个裁剪窗口来生成（14）每个地标的正面和负面训练示例，并且使用所述正面和反面示例来训练（15）检测器，用于从粗分辨率到高分辨率的一个或多个空间尺度范围内的每个界标，其中记录粗分辨率检测器的裁剪窗口和精细分辨率检测器之间的空间关系。

5. 发明申请

WO2006049591A3 METHOD AND SYSTEM FOR HYBRID RIGID REGISTRATION BASED ON JOINT CORRESPONDENCES BETWEEN SCALE-INVARIANT SALIENT REGION FEATURES 审中-公开
公开(公告)号：WO2006049591A3
公开(公告)日：2006-05-11
申请号：PCT/US2004/031056
申请日：2004-09-22
申请人： SIEMENS MEDICAL SOLUTIONS USA, INC. , XU, Chenyang , HUANG, Xiaolei , SUN, Yiyong , SAUER, Frank
发明人： XU, Chenyang , HUANG, Xiaolei , SUN, Yiyong , SAUER, Frank
IPC分类号： G06T7/00
摘要： A method of aligning a pair of images includes providing a pair of images with a first image and a second image, wherein the images comprise a plurality of intensities corresponding to a domain of points in a D -dimensional space. Salient feature regions are identified (101 in both the first image and the second image, a correspondence between each pair of salient feature regions is hypothesized, wherein a first region of each pair is on the first image and a second region of each pair is on the second image, the likelihood of the hypothesized correspondence of each pair of feature regions is measured (102), and a joint correspondence is determined (103) from a set of pairs of feature regions with the greatest likelihood of correspondence.

6. 发明申请

WO2007044508A3 SYSTEM AND METHOD FOR WHOLE BODY LANDMARK DETECTION, SEGMENTATION AND CHANGE QUANTIFICATION IN DIGITAL IMAGES 审中-公开
标题翻译：系统和方法，用于数字图像全身体检测，分段和更改量化
公开(公告)号：WO2007044508A3
公开(公告)日：2007-08-02
申请号：PCT/US2006039109
申请日：2006-10-05
申请人： SIEMENS MEDICAL SOLUTIONS , HUANG XIAOLEI , ZHOU XIANG , JEREBKO ANNA , KRISHNAN ARUN , GUAN HAIYING , KUBOTA TOSHIRO , POTESIL VACLAV
发明人： HUANG XIAOLEI , ZHOU XIANG , JEREBKO ANNA , KRISHNAN ARUN , GUAN HAIYING , KUBOTA TOSHIRO , POTESIL VACLAV
IPC分类号： G06T7/00
CPC分类号： G06T7/174 , G06T7/155 , G06T7/33 , G06T7/38 , G06T2207/10072 , G06T2207/20016 , G06T2207/20081 , G06T2207/20164 , G06T2207/30004 , G06T2207/30204
摘要： A method for segmenting digitized images includes providing (11) a training set comprising a plurality of digitized whole-body images, providing labels (12) on anatomical landmarks in each image of said training set, aligning (13) each said training set image, generating (14) positive and negative training examples for each landmark by cropping the aligned training volumes into one or more cropping windows of different spatial scales, and using said positive and negative examples to train (15) a detector for each landmark at one or more spatial scales ranging from a coarse resolution to a fine resolution, wherein the spatial relationship between a cropping windows of a coarse resolution detector and a fine resolution detector is recorded.
摘要翻译：用于分割数字化图像的方法包括提供（11）包括多个数字化全身图像的训练集合，在所述训练集合的每个图像中的解剖学标志上提供标签（12），对准（13）每个所述训练集合图像，通过将对准的训练量裁剪成不同空间尺度的一个或多个裁剪窗口来生成（14）每个地标的正和负训练示例，并且使用所述正和负的示例来训练（15）每个地标的检测器在一个或多个记录从粗分辨率到精细分辨率的空间刻度，其中记录粗分辨率检测器的裁剪窗与精细分辨率检测器之间的空间关系。

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