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1. 发明申请

WO2005089164A2 INDUCING CELLULAR IMMUNE RESPONSES TO HUMAN PAPILLOMAVIRUS USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS 审中-公开
标题翻译：使用肽和核酸组合物诱导对人乳头瘤病毒的细胞免疫应答
公开(公告)号：WO2005089164A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/000077
申请日：2005-01-03
申请人： EPIMMUNE INC. , INNOGENETICS N.V. , CHESNUT, Robert , NEWMAN, Mark, J. , MOTHE, Bianca , BAKER, Denise , SOUTHWOOD, Scott , BABE, Lilia, Maria , CHEN, Yiyou , DEYOUNG, Lawrence, M. , HUANG, Manley, T., F. , POWER, Scott, D.
发明人： CHESNUT, Robert , NEWMAN, Mark, J. , MOTHE, Bianca , BAKER, Denise , SOUTHWOOD, Scott , BABE, Lilia, Maria , CHEN, Yiyou , DEYOUNG, Lawrence, M. , HUANG, Manley, T., F. , POWER, Scott, D.
IPC分类号： A61K39/00 , A61K39/12 , C07K14/025
CPC分类号： A61K39/0011 , A61K39/00 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/545 , A61K2039/57 , A61K2039/645 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20034
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
摘要翻译：本发明使用我们对抗原被T细胞识别并制备人乳头状瘤病毒（HPV）表位的机制的知识，并开发针对HPV的基于表位的疫苗。更具体地说，本申请介绍了我们在预防和治疗HPV感染中的药物组合物和使用方法的发现。

2. 发明申请

WO2004105681A2 CD4+ HUMAN PAPILLOMAVIRUS (HPV) EPITOPES 审中-公开
标题翻译： CD4 +人乳头瘤病毒（HPV）病毒
公开(公告)号：WO2004105681A2
公开(公告)日：2004-12-09
申请号：PCT/US2004/012650
申请日：2004-04-23
申请人： INNOGENETICS N.V. , BABE, Lilia, M. , DE YOUNG, Lawrence, M. , HARDING, Fiona, A , HUANG, Manley, T., F. , POWER, Scott, D. , STICKLER, Marcia
发明人： BABE, Lilia, M. , DE YOUNG, Lawrence, M. , HARDING, Fiona, A , HUANG, Manley, T., F. , POWER, Scott, D. , STICKLER, Marcia
IPC分类号： A61K
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/57 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , G01N33/505 , G01N2333/025 , G01N2333/70514 , G01N2333/70517
摘要： The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
摘要翻译：本发明提供来自人乳头瘤病毒（HPV）的各种菌株的E6，E7和E2蛋白中的CD4 + T细胞表位。在一些优选实施方案中，本发明提供用于开发HPV疫苗，特别是用于预防高危HPV病毒感染的多价疫苗的方法。在另外的实施方案中，本发明提供了用于开发针对预防感染个体中良性和/或恶性肿瘤发展的高风险HPV类型的治疗性疫苗的手段。本发明还提供了适用于预防和治疗疫苗的表位。

3. 发明申请

WO2004098497A2 CD4+ HUMAN PAPILLOMAVIRUS (HPV) EPITOPES 审中-公开
标题翻译： CD4 +人类乳头状瘤病毒（HPV）表位
公开(公告)号：WO2004098497A2
公开(公告)日：2004-11-18
申请号：PCT/US2004012652
申请日：2004-04-23
申请人： BABE LILIA M , DE YOUNG LAWRENCE M , HARDING FIONA A , HUANG MANLEY T F , POWER SCOTT D , STICKLER MARCIA , GENENCOR INT
发明人： BABE LILIA M , DE YOUNG LAWRENCE M , HARDING FIONA A , HUANG MANLEY T F , POWER SCOTT D , STICKLER MARCIA
IPC分类号： A61K20060101 , A61K39/12 , A61K39/295 , C07K14/025 , C12N15/37 , C12Q1/68 , G01N33/50 , A61K
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/57 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , G01N33/505 , G01N2333/025 , G01N2333/70514 , G01N2333/70517
摘要： The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
摘要翻译：本发明提供了来自人乳头瘤病毒（HPV）的各种菌株的E6，E7和E2蛋白中的CD4 + T细胞表位。在一些优选的实施方案中，本发明提供了开发HPV疫苗的手段，特别是用于预防高风险HPV毒株感染的多价疫苗。在另外的实施方案中，本发明提供了用于开发针对高风险HPV类型的治疗性疫苗的手段，所述高风险HPV类型阻止感染个体发展良性和/或恶性肿瘤。本发明还提供了适用于预防性和治疗性疫苗的表位。

4. 发明申请

WO2005089164A3 INDUCING CELLULAR IMMUNE RESPONSES TO HUMAN PAPILLOMAVIRUS USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS 审中-公开
标题翻译：用肽和核酸组合物诱导人乳头瘤病毒的细胞免疫应答
公开(公告)号：WO2005089164A3
公开(公告)日：2005-12-01
申请号：PCT/US2005000077
申请日：2005-01-03
申请人： EPIMMUNE INC , INNOGENETICS NV , CHESNUT ROBERT , NEWMAN MARK J , MOTHE BIANCA , BAKER DENISE , SOUTHWOOD SCOTT , BABE LILIA MARIA , CHEN YIYOU , DEYOUNG LAWRENCE M , HUANG MANLEY T F , POWER SCOTT D
发明人： CHESNUT ROBERT , NEWMAN MARK J , MOTHE BIANCA , BAKER DENISE , SOUTHWOOD SCOTT , BABE LILIA MARIA , CHEN YIYOU , DEYOUNG LAWRENCE M , HUANG MANLEY T F , POWER SCOTT D
IPC分类号： A61K39/00 , A61K39/12 , C07K14/025
CPC分类号： A61K39/0011 , A61K39/00 , A61K39/12 , A61K2039/5158 , A61K2039/53 , A61K2039/545 , A61K2039/57 , A61K2039/645 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20034
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines directed towards HPV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HPV infection.
摘要翻译：本发明使用我们关于T细胞识别和制备人乳头瘤病毒（HPV）表位以及开发针对HPV的基于表位的疫苗的机制的知识。更具体地说，该应用传达了我们对药物组合物的发现和用于预防和治疗HPV感染的方法。

5. 发明申请

WO1998016250A1 STABLE PROTEIN AND NUCLEIC ACID FORMULATIONS USING NON-AQUEOUS, ANHYDROUS, APROTIC, HYDROPHOBIC, NON-POLAR VEHICLES WITH LOW REACTIVITY 审中-公开
标题翻译：稳定的蛋白质和核酸制剂使用非水，无机，无机，非极性反应性非极性车辆
公开(公告)号：WO1998016250A1
公开(公告)日：1998-04-23
申请号：PCT/US1997018575
申请日：1997-10-15
申请人： ALZA CORPORATION , KNEPP, Victoria, Marie , PRESTRELSKI, Steven, J. , SMITH, Jessica, G. , HUANG, Manley, T., F.
发明人： ALZA CORPORATION
IPC分类号： A61K47/06
CPC分类号： A61K9/0019 , A61K9/0014 , A61K9/0024 , A61K9/0026 , A61K9/10 , A61K38/212 , A61K38/38 , A61K38/4826 , A61K38/4846 , A61K47/06 , A61K48/00
摘要： This invention relates to stable non-aqueous formulations which are suspensions of proteinaceous substances or nucleic acids in non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity. More specifically, the present invention relates to stable protein or nucleic acid formulations wherein the compound remains in stable, dry powder form, yet the formulation is flowable and, therefore amenable to delivery to an animal via injection, transdermal administration, oral delivery or using an implantable device for sustained delivery. These stable formulations may be stored at elevated temperatures (e.g., 37 DEG C) for long periods of time and are especially useful as flowable formulations which can be shipped and/or stored at high temperatures or in implantable delivery devices for long term delivery (e.g., 1-12 months or longer) of drug.
摘要翻译：本发明涉及稳定的非水性制剂，其是蛋白质物质或核酸在具有低反应性的非水，无水，非质子，疏水，非极性载体中的悬浮液。更具体地，本发明涉及稳定的蛋白质或核酸制剂，其中所述化合物保持稳定的干燥粉末形式，但是所述制剂是可流动的，并且因此适于通过注射，透皮给药，口服递送或使用用于持续输送的可植入装置。这些稳定的制剂可以在升高的温度（例如37℃）下长时间储存，并且特别适用于可在高温下运输和/或储存的可流动制剂或用于长期输送的可植入递送装置（例如，，1-12个月以上）药物。

6. 发明申请

WO2004105681A3 CD4+ HUMAN PAPILLOMAVIRUS (HPV) EPITOPES 审中-公开
标题翻译： CD4 +人乳头瘤病毒（HPV）病毒
公开(公告)号：WO2004105681A3
公开(公告)日：2005-03-24
申请号：PCT/US2004012650
申请日：2004-04-23
申请人： INNOGENETICS NV , BABE LILIA M , DE YOUNG LAWRENCE M , HARDING FIONA A , HUANG MANLEY T F , POWER SCOTT D , STICKLER MARCIA
发明人： BABE LILIA M , DE YOUNG LAWRENCE M , HARDING FIONA A , HUANG MANLEY T F , POWER SCOTT D , STICKLER MARCIA
IPC分类号： A61K20060101 , A61K39/12 , A61K39/295 , C07K14/025 , C12N15/37 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K2039/57 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , G01N33/505 , G01N2333/025 , G01N2333/70514 , G01N2333/70517
摘要： The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.
摘要翻译：本发明提供来自人乳头瘤病毒（HPV）的各种菌株的E6，E7和E2蛋白中的CD4 + T细胞表位。在一些优选实施方案中，本发明提供用于开发HPV疫苗，特别是用于预防高危HPV病毒感染的多价疫苗的方法。在另外的实施方案中，本发明提供了用于开发针对预防感染个体中良性和/或恶性肿瘤发展的高风险HPV类型的治疗性疫苗的手段。本发明还提供了适用于预防和治疗疫苗的表位。

7. 发明申请

WO1992022645A1 TRANSGENIC IMMUNODEFICIENT NON-HUMAN ANIMALS 审中-公开
标题翻译：转基因免疫非人类动物
公开(公告)号：WO1992022645A1
公开(公告)日：1992-12-23
申请号：PCT/US1992004823
申请日：1992-06-15
申请人： GENPHARM INTERNATIONAL , TERHORST, Cornelis, P. , HUANG, Manley, T., F.
发明人： GENPHARM INTERNATIONAL
IPC分类号： C12N15/00
CPC分类号： C12N15/8509 , A01K67/0271 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2217/30 , A01K2227/105 , A01K2267/0381 , C07K14/34 , C07K14/7051
摘要： Transgenic non-human animals having genotypes comprising a first DNA sequence encoding an expression regulation sequence for a lymphoid gene operably linked to DNA encoding a lethal polypeptide. Also included are transgenic animals having genotypes comprising the substitution, deletion or insertion of one or more nucleotides in at least one endogenous allele of a CD3-type gene. The transgenic non-human animals have phenotypes characterized by immunodeficiency in at least one function of a lymphoid cell. Such phenotypes include depletion of one or more lymphoid cell types such as T-cells, NK cells, large granular lymphocytes, and/or B-cells. The invention also provides transgenic immunodeficient animals containing a xenograft characterized by a phenotype wherein the animal has an enhanced ability to maintain the xenograft as compared to the maintenance of the xenograft in the species from which the transgenic animal is derived.
摘要翻译：具有基因型的转基因非人动物包含编码与编码致死多肽的DNA可操作地连接的淋巴样基因的表达调控序列的第一DNA序列。还包括具有基因型的转基因动物，其包含在CD3型基因的至少一个内源等位基因中取代，缺失或插入一个或多个核苷酸。转基因非人动物具有以淋巴细胞的至少一种功能为特征的免疫缺陷表型。这种表型包括一种或多种淋巴细胞类型的消耗，例如T细胞，NK细胞，大颗粒淋巴细胞和/或B细胞。本发明还提供了转基因免疫缺陷动物，其含有特征在于表型的异种移植物，其中与在转基因动物得到的物种中的异种移植物的维持相比，该动物具有增强的维持异种移植物的能力。

8. 发明申请

WO2004098497A3 CD4+ HUMAN PAPILLOMAVIRUS (HPV) EPITOPES 审中-公开
公开(公告)号：WO2004098497A3
公开(公告)日：2004-11-18
申请号：PCT/US2004/012652
申请日：2004-04-23
申请人： GENENCOR INTERNATIONAL, INC. , BABE, Lilia, M. , DE YOUNG, Lawrence, M. , HARDING, Fiona, A , HUANG, Manley, T., F. , POWER, Scott, D. , STICKLER, Marcia
发明人： BABE, Lilia, M. , DE YOUNG, Lawrence, M. , HARDING, Fiona, A , HUANG, Manley, T., F. , POWER, Scott, D. , STICKLER, Marcia
IPC分类号： C12Q1/68
摘要： The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional embodiments, the present invention provides means for the development of therapeutic vaccines against high-risk HPV types that prevent the development of benign and/or malignant tumors in infected individuals. The present invention further provides epitopes suitable for use in prophylactic and therapeutic vaccines.

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