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1. 发明申请

WO2011014816A1 WD REPEAT 79 PROTEIN TARGETED THERAPY 审中-公开
标题翻译： WD REPEAT 79蛋白指导治疗
公开(公告)号：WO2011014816A1
公开(公告)日：2011-02-03
申请号：PCT/US2010/043986
申请日：2010-07-30
申请人： NEW YORK BLOOD CENTER, INC. , CHEN, Ying , HUANG, Cheng-han , YE, Mao
发明人： CHEN, Ying , HUANG, Cheng-han , YE, Mao
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/713
CPC分类号： C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12Y207/07049 , C12Y301/02015
摘要： Methods and compositions are disclosed for inhibiting cell proliferation and diagnosing and treating cancer comprising antagonists or inhibitors of the WDR79 protein. Also disclosed are methods for screening compounds for WDR79 inhibitory or antagonist activity.
摘要翻译：公开了用于抑制细胞增殖并诊断和治疗包含WDR79蛋白质的拮抗剂或抑制剂的癌症的方法和组合物。还公开了筛选化合物用于WDR79抑制或拮抗剂活性的方法。

2. 发明申请

WO2011150400A1 NUCLEAR SCAFFOLD PROTEIN STIP/TFIP11 TARGET FOR CANCER THERAPY 审中-公开
标题翻译：核糖体蛋白STIP / TFIP11癌症治疗目标
公开(公告)号：WO2011150400A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038447
申请日：2011-05-27
申请人： NEW YORK BLOOD CENTER, INC. , YE, Mao , CHEN, Ying , HUANG, Cheng-Han
发明人： YE, Mao , CHEN, Ying , HUANG, Cheng-Han
IPC分类号： C12Q1/68
CPC分类号： G01N33/5011 , C12Q2600/106 , C12Q2600/158
摘要： Disclosed herein are methods of inhibiting tumor cell proliferation by exposing to a subject, a cell population or a tissue an effective amount of an antagonist or inhibitor of STIP expression and methods of identifying compounds which have anti-cancer activity and/or modulate USP7 or STIP in a cell or tissue.
摘要翻译：本文公开了通过暴露于受试者，细胞群体或组织有效量的STIP表达的拮抗剂或抑制剂来抑制肿瘤细胞增殖的方法以及鉴定具有抗癌活性和/或调节USP7或STIP的化合物的方法在细胞或组织中。

3. 发明申请

WO0216396A9 MAMMALIAN RH TYPE B GLYCOPROTEIN ION TRANSPORTER 审中-公开
公开(公告)号：WO0216396A9
公开(公告)日：2002-09-26
申请号：PCT/US0125881
申请日：2001-08-17
申请人： NEW YORK BLOOD CT INC , HUANG CHENG-HAN , LIU ZHI
发明人： HUANG CHENG-HAN , LIU ZHI
IPC分类号： C07K14/705 , C12N15/12 , C07K
CPC分类号： C07K14/705 , C07K2319/00
摘要： The present invention provides nucleic acid sequences encoding novel mammalian nonerythroid Rh glycoprotein homologues, Rhbg including the human homologue RhBG. These RhBG, Rhbg glycoproteins are polytypic transporter-type proteins with 12 transmembrane domains and are predominantly expressed as a single major form in kidney, and as multiple forms in liver, skin and ovaries. Also provided are recombinant vectors and host vector systems containing these nucleic acid sequences, as well as fusion proteins incorporating Rhbg, RhBG or fragments of each. The invention further provides methods of detection of Rhbg and RhBG glycoproteins and also methods of detecting nucleic acids encoding Rhbg and RhBG.

4. 发明申请

WO2010096813A1 KRÜPPEL-LIKE FACTORS AND FAT REGULATION 审中-公开
标题翻译： KRÜPPEL-LIKE因子和脂肪调节
公开(公告)号：WO2010096813A1
公开(公告)日：2010-08-26
申请号：PCT/US2010/025062
申请日：2010-02-23
申请人： NEW YORK BLOOD CENTER , HASHMI, Sarwar , YANG, Chuan , ZHANG, Jun , HUANG, Cheng-Han
发明人： HASHMI, Sarwar , YANG, Chuan , ZHANG, Jun , HUANG, Cheng-Han
IPC分类号： A61K38/17 , G01N33/68 , A61P33/04 , A61P3/06
CPC分类号： A61K38/1709 , C07K14/4702 , C12N15/113 , C12N2310/14
摘要： Disclosed herein are methods and cell lines used in fat regulation. The methods and cell lines incorporate Krϋppel-like factors including, without limitation, klf-1 and klf-3 .
摘要翻译：本文公开了用于脂肪调节的方法和细胞系。方法和细胞系包括Krβppel样因子，包括但不限于klf-1和klf-3。

5. 发明申请

WO0216396A8 MAMMALIAN RH TYPE B GLYCOPROTEIN ION TRANSPORTER 审中-公开
标题翻译：哺乳动物RH型B型糖蛋白离子转运体
公开(公告)号：WO0216396A8
公开(公告)日：2002-08-29
申请号：PCT/US0125881
申请日：2001-08-17
申请人： NEW YORK BLOOD CT INC , HUANG CHENG-HAN , LIU ZHI
发明人： HUANG CHENG-HAN , LIU ZHI
IPC分类号： C07K14/705 , C12N15/12 , C07K
CPC分类号： C07K14/705 , C07K2319/00
摘要： The present invention provides nucleic acid sequences encoding novel mammalian nonerythroid Rh glycoprotein homologues, Rhbg including the human homologue RhBG. These RhBG, Rhbg glycoproteins are polytypic transporter-type proteins with 12 transmembrane domains and are predominantly expressed as a single major form in kidney, and as multiple forms in liver, skin and ovaries. Also provided are recombinant vectors and host vector systems containing these nucleic acid sequences, as well as fusion proteins incorporating Rhbg, RhBG or fragments of each. The invention further provides methods of detection of Rhbg and RhBG glycoproteins and also methods of detecting nucleic acids encoding Rhbg and RhBG.
摘要翻译：本发明提供了编码新型哺乳动物非红细胞体Rh糖蛋白同系物的核酸序列，Rhbg包括人类同系物RhBG。这些RhBG，Rhbg糖蛋白是具有12个跨膜结构域的多型转运蛋白型蛋白质，并且主要在肾中表达为单一主要形式，并且在肝脏，皮肤和卵巢中以多种形式表达。还提供了含有这些核酸序列的重组载体和宿主载体系统，以及融合了Rhbg，RhBG或其片段的融合蛋白。本发明进一步提供了检测Rhbg和RhBG糖蛋白的方法以及检测编码Rhbg和RhBG的核酸的方法。

6. 发明申请

WO2002016396A3 MAMMALIAN RH TYPE B GLYCOPROTEIN ION TRANSPORTER 审中-公开
公开(公告)号：WO2002016396A3
公开(公告)日：2002-02-28
申请号：PCT/US2001/025881
申请日：2001-08-17
申请人： THE NEW YORK BLOOD CENTER, INC. , HUANG, Cheng-Han , LIU, Zhi
发明人： HUANG, Cheng-Han , LIU, Zhi
IPC分类号： C12N5/10
摘要： The present invention provides nucleic acid sequences encoding novel mammalian nonerythroid Rh glycoprotein homologues, Rhbg including the human homologue RhBG. These RhBG, Rhbg glycoproteins are polytypic transporter-type proteins with 12 transmembrane domains and are predominantly expressed as a single major form in kidney, and as multiple forms in liver, skin and ovaries. Also provided are recombinant vectors and host vector systems containing these nucleic acid sequences, as well as fusion proteins incorporating Rhbg, RhBG or fragments of each. The invention further provides methods of detection of Rhbg and RhBG glycoproteins and also methods of detecting nucleic acids encoding Rhbg and RhBG.

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