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1. 发明申请

WO1996000720A1 ARYL AND HETEROARYL ALKOXYNAPHTHALENE DERIVATIVES 审中-公开
标题翻译： ARYL和HETEROARYL ALKOXYNPHTHALENE DERIVATIVES
公开(公告)号：WO1996000720A1
公开(公告)日：1996-01-11
申请号：PCT/IB1995000381
申请日：1995-05-18
申请人： PFIZER INC. , CHENARD, Bertrand, L. , DESAI, Kishor, A. , HOWARD, Harry, R., Jr. , MACOR, John, E. , SHENK, Kevin, D.
发明人： PFIZER INC.
IPC分类号： C07C271/06
CPC分类号： C07D213/30 , C07D209/34 , C07D213/64 , C07D213/85 , C07D215/14 , C07D237/14 , C07D239/34 , C07D239/42 , C07D257/04 , C07D263/56 , C07D271/06 , C07D271/107 , C07D277/24 , C07D277/64 , C07D295/155 , C07D333/28 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula (I) wherein R , R , R , R , R , R and R are defined as in the specification. These compounds are useful psychotherapeutics and are potent serotonin (5-HT1) agonists and antagonists.
摘要翻译：其中R 1，R 2，R 4，R 23，R 24，R 25和R 26的式（I）化合物如说明书中所定义。这些化合物是有用的精神治疗药物，是有效的5-羟色胺（5-HT1）激动剂和拮抗剂。

2. 发明申请

WO1995018129A1 DIAZABICYCLIC NEUROKININ ANTAGONISTS 审中-公开
公开(公告)号：WO1995018129A1
公开(公告)日：1995-07-06
申请号：PCT/IB1994000352
申请日：1994-11-14
申请人： PFIZER INC. , HOWARD, Harry, R., Jr. , SHENK, Kevin, D.
发明人： PFIZER INC.
IPC分类号： C07D471/08
CPC分类号： C07D471/08
摘要： The present invention relates to diazabicyclic compounds and, specifically, to compounds of formula (I), wherein A, G, R , R , R , R , R , R , and R are as defined in the specification. The compounds of formula (I) are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
摘要翻译：本发明涉及二氮杂双环化合物，具体地涉及式（I）化合物，其中A，G，R 1，R 2，R 3，R 4，R 5，R 5， <6>和R 7如说明书中所定义。式（I）的化合物可用于治疗炎性和中枢神经系统疾病以及其它疾病。

3. 发明申请

WO1995007908A1 HETEROARYLAMINO AND HETEROARYLSULFONAMIDO SUBSTITUTED 3-BENZYLAMINOMETHYL PIPERIDINES AND RELATED COMPOUNDS 审中-公开
标题翻译：取代的三苯甲酰氨基哌啶及其相关化合物
公开(公告)号：WO1995007908A1
公开(公告)日：1995-03-23
申请号：PCT/IB1994000221
申请日：1994-07-18
申请人： PFIZER INC. , HOWARD, Harry, R., Jr.
发明人： PFIZER INC.
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： The present invention relates to novel heteroarylamino and heteroarylsulfonamido substituted 3-benzylaminomethylpiperidines and, specifically, to compounds of formula (I), wherein W, R , R , P and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula (I) are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
摘要翻译：本发明涉及新的杂芳基氨基和杂芳基磺酰氨基取代的3-苄基氨基甲基哌啶，具体地，涉及式（I）的化合物，其中W，R 1，R 3，P和A如说明书中所定义，用于合成这些化合物的中间体。式（I）的新型化合物可用于治疗炎性和中枢神经系统疾病以及其它疾病。

4. 发明申请

WO1994004496A1 SUBSTITUTED BENZYLAMINO NITROGEN CONTAINING NON-AROMATIC HETEROCYCLES 审中-公开
标题翻译：取代的苯甲酰胺含有非芳香杂环的氮
公开(公告)号：WO1994004496A1
公开(公告)日：1994-03-03
申请号：PCT/US1993004063
申请日：1993-05-05
申请人： PFIZER INC. , HOWARD, Harry, R., Jr. , IKUNAKA, Masaya , ITO, Fumitaka , LOWE, John, A., III , NAKANE, Masami , O'NEILL, Brian, T. , ROSEN, Terry, R. , SATAKE, Kunio
发明人： PFIZER INC.
IPC分类号： C07D211/56
CPC分类号： C07D401/12 , C07D211/56 , C07D417/12 , C07D453/02 , C07D487/08
摘要： The present invention relates to novel substituted benzylamino nitrogen containing non-aromatic heterocycles and, specifically, to compounds of formula (I) wherein W, R1, R2, R3 and A are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula (I) are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
摘要翻译：本发明涉及新的取代的苄基氨基氮的非芳族杂环，具体地说，涉及式（I）的化合物，其中W，R 1，R 2，R 3和A如说明书中所定义，以及用于合成这样的化合物。式（I）的新型化合物可用于治疗炎性和中枢神经系统疾病以及其它疾病。

5. 发明申请

WO1993012786A1 INDOLINONE DERIVATIVES 审中-公开
标题翻译：吲哚啉酮衍生物
公开(公告)号：WO1993012786A1
公开(公告)日：1993-07-08
申请号：PCT/US1986001429
申请日：1986-07-10
申请人： HOWARD, Harry, R., Jr. , SARGES, Reinhard
IPC分类号： A61K31/40
CPC分类号： C07D209/34 , C07D209/96
摘要： A series of novel 3-mono(substituted methyl)- and 3,3-di(substituted methyl)-2-oxo-indoline-1-alkanoic acid compounds have been prepared, including their lower alkyl esters and unsubstituted amide derivatives, as well as the base salts of said acids with pharmacologically acceptable cations. These compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Typical members include those compounds derived from 2-oxo-indoline-1-acetic acid wherein a 3,4-dichloro-benzyl or 3,4-dichloro- alpha -methylbenzyl moiety is substituted at 3-position of the molecule. Preferred member compounds include 3-(3,4-dichlorobenzyl)-2-oxo-indoline-1-acetic acid, 5-chloro-3-(3,4-dichloro-benzyl)-2-oxo-indoline-1-acetic acid, 3-(3,4-dichloro-benzyl)-6-methoxy-2-oxo-indoline-1-acetic acid, 3-(3,4-dichlorobenzyl)-6-hydroxy-2-oxo-indoline-1-acetic acid and 3-(3,4-dichloro- alpha -methylbenzyl)-2-oxo-indoline-1-acetic acid. Methods for preparing these compounds from known starting materials are provided.
摘要翻译：已经制备了一系列新的3-单（取代的甲基） - 和3,3-二（取代的甲基）-2-氧代 - 二氢吲哚-1-链烷酸化合物，包括其低级烷基酯和未取代的酰胺衍生物，以及作为所述酸与药理学上可接受的阳离子的碱式盐。这些化合物可用于治疗某些慢性糖尿病并发症的醛糖还原酶抑制剂。典型的成员包括衍生自2-氧代 - 二氢吲哚-1-乙酸的那些化合物，其中3,4-二氯苄基或3,4-二氯-α-甲基苄基部分在分子的3位被取代。优选的成员化合物包括3-（3,4-二氯苄基）-2-氧代 - 二氢吲哚-1-乙酸，5-氯-3-（3,4-二氯 - 苄基）-2-氧代 - 二氢吲哚-1-乙酸酸，3-（3,4-二氯 - 苄基）-6-甲氧基-2-氧代 - 二氢吲哚-1-乙酸，3-（3,4-二氯苄基）-6-羟基-2-氧代 - 二氢吲哚-1 - 乙酸和3-（3,4-二氯-α-甲基苄基）-2-氧代 - 二氢吲哚-1-乙酸。提供了从已知原料制备这些化合物的方法。

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