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1. 发明申请

WO03050283A2 A STRUCTURE FOR PRESENTING DESIRED PEPTIDE SEQUENCES 审中-公开
标题翻译：用于提供所需的肽序列的结构
公开(公告)号：WO03050283A2
公开(公告)日：2003-06-19
申请号：PCT/NL0200810
申请日：2002-12-10
申请人： CATCHMABS B V , HOUTZAGER ERWIN , VIJN IRMA MARIA CAECILIA , SIJMONS PETER CHRISTIAAN
发明人： HOUTZAGER ERWIN , VIJN IRMA MARIA CAECILIA , SIJMONS PETER CHRISTIAAN
IPC分类号： C12N15/09 , A61K39/395 , A61K47/48 , C07K1/14 , C07K1/22 , C07K16/00 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/10 , C12N15/12 , C12P21/02 , G01N33/50
CPC分类号： C07K16/00 , C07K2317/22
摘要： Provided are means, methods for generating binding peptide associated with a suitable core region, the resulting proteinaceous molecule and uses thereof. The invention provides a solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of use such as extreme temperatures or pH. Alternatively, binding molecules can be designed to respond to very subtle changes in the environment.
摘要翻译：提供了用于产生与合适的核心区域相关联的结合肽的方法，所得到的蛋白质分子及其用途。本发明提供了在整个使用范围内与使用结合分子相关的问题的解决方案。结合分子可以设计成适应极端的使用条件，如极端的温度或pH值。或者，可以设计结合分子以响应环境中非常微妙的变化。

2. 发明申请

WO2004108749A3 BINDING PEPTIDES: METHODS FOR THEIR GENERATION AND USE 审中-公开
标题翻译： BINDING PEPTIDES：METHODS FOR THE GENERATION AND USE
公开(公告)号：WO2004108749A3
公开(公告)日：2005-02-24
申请号：PCT/NL2004000407
申请日：2004-06-09
申请人： CATCHMABS B V , HOUTZAGER ERWIN , WILLEBRANDS WIETSE , DE ROO GUY , FRANCOIJS KEESJAN , VIJN IRMA MARIA CAECILIA
发明人： HOUTZAGER ERWIN , WILLEBRANDS WIETSE , DE ROO GUY , FRANCOIJS KEESJAN , VIJN IRMA MARIA CAECILIA
IPC分类号： C07K1/00 , C07K1/107 , C07K1/22 , G01N33/537 , G01N33/543
CPC分类号： C07K1/107 , G01N33/5375
摘要： Provided are means, methods for generating binding peptide associated with a suitable core region, the resulting proteinaceous molecule and uses thereof. The invention provides a solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of use such as extreme temperatures or pH. Alternatively, binding molecules can be designed to respond to very subtle changes in the environment.
摘要翻译：提供了用于产生与合适的核心区域相关联的结合肽的方法，所得到的蛋白质分子及其用途。本发明提供了在整个使用范围内与使用结合分子相关的问题的解决方案。结合分子可以设计成适应极端的使用条件，如极端的温度或pH值。或者，可以设计结合分子以响应环境中非常微妙的变化。

3. 发明申请

WO2003050283A3 A STRUCTURE FOR PRESENTING DESIRED PEPTIDE SEQUENCES 审中-公开
公开(公告)号：WO2003050283A3
公开(公告)日：2003-06-19
申请号：PCT/NL2002/000810
申请日：2002-12-10
申请人： CATCHMABS B.V. , HOUTZAGER, Erwin , VIJN, Irma, Maria, Caecilia , SIJMONS, Peter, Christiaan
发明人： HOUTZAGER, Erwin , VIJN, Irma, Maria, Caecilia , SIJMONS, Peter, Christiaan
IPC分类号： C12N15/12
摘要： Provided are means, methods for generating binding peptide associated with a suitable core region, the resulting proteinaceous molecule and uses thereof. The invention provides a solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of use such as extreme temperatures or pH. Alternatively, binding molecules can be designed to respond to very subtle changes in the environment.

4. 发明申请

WO2009157771A3 ANTIBODY PRODUCING NON-HUMAN MAMMALS 审中-公开
标题翻译：抗生素生产非人类哺乳动物
公开(公告)号：WO2009157771A3
公开(公告)日：2010-02-18
申请号：PCT/NL2009050381
申请日：2009-06-29
申请人： MERUS B V , HOUTZAGER ERWIN , PINTO RUI DANIEL , LOGTENBERG TON , THROSBY MARK , KRAMER ROBERT ARJEN , DE KRUIF CORNELIS ADRIAAN
发明人： HOUTZAGER ERWIN , PINTO RUI DANIEL , LOGTENBERG TON , THROSBY MARK , KRAMER ROBERT ARJEN , DE KRUIF CORNELIS ADRIAAN
IPC分类号： A01K67/027 , C07K16/00 , C12N5/10 , C12N15/85
CPC分类号： A01K67/0276 , A01K67/0275 , A01K2217/052 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K2317/21 , C07K2317/24 , C12N15/8509 , C12N2800/30
摘要： The invention provides transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. The invention further provides methods for producing an immunoglobulin from the transgenic, non-human animal.
摘要翻译：本发明提供了包含编码免疫球蛋白轻链的核酸的转基因非人动物，其中免疫球蛋白轻链是人类，人类样或人源化的。为核酸提供了使其对DNA重排和/或体细胞超突变有抗性的手段。在一个实施方案中，所述核酸包含用于在发育成熟B细胞的细胞的某一发育阶段期间在细胞中表达所需分子的表达盒。本发明还提供从转基因非人动物中产生免疫球蛋白的方法。

5. 发明申请

WO2005111192A1 BIOREACTOR ASSEMBLY COMPRISING AT LEAST ONE TRAY-LIKE ROCKING PLATFORM 审中-公开
标题翻译：至少包含一个类似托盘的摇摆平台的生物反馈装置
公开(公告)号：WO2005111192A1
公开(公告)日：2005-11-24
申请号：PCT/EP2005/007094
申请日：2005-07-01
申请人： CATCHMABS BV , HOUTZAGER, Erwin , HUURMAN, Sander
发明人： HOUTZAGER, Erwin , HUURMAN, Sander
IPC分类号： C12M1/02
CPC分类号： B01F11/0017 , C12M23/14 , C12M23/28 , C12M23/48 , C12M27/16
摘要： The present invention relates to a bioreactor assembly comprising a reactor frame that permits linear upscaling under identical conditions of culture volumes from two liters to thousands of liters. The bioreactor comprises at least one rocking platforms being capable of holding at least one disposable bag adapted for receiving a total volume of at least 2 liters. Said at least one platforms have a tray-like shape, that induces the fluid in the bag to move and form a wave-like motion. Said at least one platforms are attached to the reactor frame and are positioned on top of each other along a vertical axis. In particular, the weight distribution of the rocking platforms is approximately in balance during rocking. The present invention further relates to methods using the bioreactor assembly.
摘要翻译：本发明涉及一种生物反应器组件，其包括反应器框架，该反应器框架允许在从两升到几千升的相同培养体积条件下进行线性升高。生物反应器包括至少一个摆动平台，其能够容纳至少一个适于接收至少2升的总体积的一次性袋。所述至少一个平台具有托盘状形状，其引导袋中的流体移动并形成波状运动。所述至少一个平台连接到反应器框架并且沿垂直轴线彼此定位在顶部。特别地，在摇摆过程中摇摆平台的重量分布近似平衡。本发明还涉及使用生物反应器组件的方法。

6. 发明申请

WO2009157771A2 ANTIBODY PRODUCING NON-HUMAN MAMMALS 审中-公开
标题翻译：抗生素生产非人类哺乳动物
公开(公告)号：WO2009157771A2
公开(公告)日：2009-12-30
申请号：PCT/NL2009/050381
申请日：2009-06-29
申请人： MERUS B.V. , HOUTZAGER, Erwin , PINTO, Rui Daniel , LOGTENBERG, Ton , THROSBY, Mark , KRAMER, Robert, Arjen , DE KRUIF, Cornelis, Adriaan
发明人： HOUTZAGER, Erwin , PINTO, Rui Daniel , LOGTENBERG, Ton , THROSBY, Mark , KRAMER, Robert, Arjen , DE KRUIF, Cornelis, Adriaan
IPC分类号： A01K67/027 , C12N15/85 , C07K16/00 , C12N5/10
CPC分类号： A01K67/0276 , A01K67/0275 , A01K2217/052 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K2317/21 , C07K2317/24 , C12N15/8509 , C12N2800/30
摘要： The invention provides transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. The invention further provides methods for producing an immunoglobulin from the transgenic, non-human animal.
摘要翻译：本发明提供了包含编码免疫球蛋白轻链的核酸的转基因非人动物，其中免疫球蛋白轻链是人类，人类样或人源化的。为核酸提供了使其对DNA重排和/或体细胞超突变有抗性的手段。在一个实施方案中，所述核酸包含用于在发育成熟B细胞的细胞的某一发育阶段期间在细胞中表达所需分子的表达盒。本发明还提供从转基因非人动物中产生免疫球蛋白的方法。

7. 发明申请

WO2004108749A2 NOVEL BINDING PEPTIDES, METHODS FOR THEIR GENERATION AND USE 审中-公开
标题翻译：新型结合肽，其生成和使用方法
公开(公告)号：WO2004108749A2
公开(公告)日：2004-12-16
申请号：PCT/NL2004/000407
申请日：2004-06-09
申请人： CATCHMABS B.V. , HOUTZAGER, Erwin , WILLEBRANDS, Wietse , DE ROO, Guy , FRANCOIJS, KeesJan , VIJN, Irma, Maria, Caecilia
发明人： HOUTZAGER, Erwin , WILLEBRANDS, Wietse , DE ROO, Guy , FRANCOIJS, KeesJan , VIJN, Irma, Maria, Caecilia
IPC分类号： C07K1/00
CPC分类号： C07K1/107 , G01N33/5375
摘要： Provided are means, methods for generating binding peptide associated with a suitable core region, the resulting proteinaceous molecule and uses thereof. The invention provides a solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of use such as extreme temperatures or pH. Alternatively, binding molecules can be designed to respond to very subtle changes in the environment.
摘要翻译：提供了用于产生与合适的核心区域相关联的结合肽的方法，所得到的蛋白质分子及其用途。本发明提供了在整个使用范围内与使用结合分子相关的问题的解决方案。结合分子可以设计成适应极端的使用条件，如极端的温度或pH值。或者，可以设计结合分子以响应环境中非常微妙的变化。

8. 发明申请

WO2002103012A1 CHIMAERIC PHAGES 审中-公开
公开(公告)号：WO2002103012A1
公开(公告)日：2002-12-27
申请号：PCT/NL2002/000391
申请日：2002-06-14
申请人： CRUCELL HOLLAND B.V. , HOUTZAGER, Erwin , LOGTENBERG, Ton , DE KRUIF, Cornelis, Adriaan
发明人： HOUTZAGER, Erwin , LOGTENBERG, Ton , DE KRUIF, Cornelis, Adriaan
IPC分类号： C12N15/10
CPC分类号： C40B40/02 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N15/1037 , C12N2795/10021 , C12N2795/10022
摘要： The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provides chimaeric phages having a coat comprising a protein mixture comprising a fusion protein wherein a proteinaceous molecule is fused to a functional form of a phage coat protein and a mutant form of the phage coat protein, the mutant form being impaired in binding to a host cell receptor. The invention further provides new phage collections, novel helper phages and methods and means for producing chimaeric phages, infectious phages and helper phages according to the invention.
摘要翻译：本发明涉及产生辅助噬菌体和用于鉴定结合分子的噬菌体展示文库的领域。本发明提供了具有包含蛋白质混合物的外壳的嵌合噬菌体，所述蛋白质混合物包含融合蛋白，其中蛋白质分子与噬菌体外壳蛋白的功能形式和噬菌体外壳蛋白的突变形式融合，所述突变体形式在与宿主细胞受体。本发明还提供了新的噬菌体集合，新颖的辅助噬菌体以及用于生产根据本发明的嵌合噬菌体，感染性噬菌体和辅助噬菌体的方法和方法。

9. 发明申请

WO2004069211A3 AFFINITY PROTEINS FOR CONTROLLED APPLICATION OF COSMETIC SUBSTANCES 审中-公开
标题翻译：用于控制化妆品应用的亲和性蛋白质
公开(公告)号：WO2004069211A3
公开(公告)日：2004-12-02
申请号：PCT/NL0300876
申请日：2003-12-10
申请人： MABS B V L , HOUTZAGER ERWIN , VIJN IRMA MARIA CAECILIA , SIJMONS PETER CHRISTIAAN , VALINOTTI TONY , MUDGE GRANT , FADEL ADDI
发明人： HOUTZAGER ERWIN , VIJN IRMA MARIA CAECILIA , SIJMONS PETER CHRISTIAAN , VALINOTTI TONY , MUDGE GRANT , FADEL ADDI
IPC分类号： A61K8/64 , A61K8/65 , A61K47/48 , A61Q1/02 , A61Q1/06 , A61Q5/10 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q19/00 , C07K16/18
CPC分类号： A61Q19/00 , A61K8/64 , A61K8/65 , A61K47/6435 , A61K47/6803 , A61K2800/57 , A61Q1/02 , A61Q1/06 , A61Q5/10 , A61Q11/00 , A61Q13/00 , A61Q15/00
摘要： Provided are means and methods for applying cosmetic substance to a desired target. The method comprising providing a conjugate of a proteinaceous substance having a specific affinity for said target molecule linked to a cosmetic substance, whereby the resulting connection between cosmetic substance and target molecule can be disrupted upon the presence of a chemical and/or physical signal.
摘要翻译：提供了将化妆品物质应用于所需目标的方法和方法。所述方法包括提供与化妆品物质连接的所述靶分子具有特异性亲和性的蛋白质物质的缀合物，由此在化学和/或物理信号的存在下，化妆品物质和靶分子之间的所得连接可能被破坏。

10. 发明申请

WO2004069211A2 AFFINITY PROTEINS FOR CONTROLLED APPLICATION OF COSMETIC SUBSTANCES 审中-公开
标题翻译：用于控制化妆品应用的亲和蛋白
公开(公告)号：WO2004069211A2
公开(公告)日：2004-08-19
申请号：PCT/NL2003/000876
申请日：2003-12-10
申请人： L-MABS B.V. , HOUTZAGER, Erwin , VIJN, Irma, Maria, Caecilia , SIJMONS, Peter, Christiaan , VALINOTTI, Tony , MUDGE, Grant , FADEL, Addi
发明人： HOUTZAGER, Erwin , VIJN, Irma, Maria, Caecilia , SIJMONS, Peter, Christiaan , VALINOTTI, Tony , MUDGE, Grant , FADEL, Addi
IPC分类号： A61K7/00
CPC分类号： A61Q19/00 , A61K8/64 , A61K8/65 , A61K47/6435 , A61K47/6803 , A61K2800/57 , A61Q1/02 , A61Q1/06 , A61Q5/10 , A61Q11/00 , A61Q13/00 , A61Q15/00
摘要： Provided are means and methods for applying cosmetic substance to a desired target. The method comprising providing a conjugate of a proteinaceous substance having a specific affinity for said target molecule linked to a cosmetic substance, whereby the resulting connection between cosmetic substance and target molecule can be disrupted upon the presence of a chemical and/or physical signal.
摘要翻译：提供用于将化妆品物质施加到期望的目标的手段和方法。所述方法包括提供对与化妆品物质连接的所述目标分子具有特异性亲和力的蛋白质物质的偶联物，由此在化学物质和/或物理信号的存在下可以破坏化妆品物质与目标分子之间的所得连接。 / p>

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