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1. 发明专利

IL293911A Non-viral vectors comprising polypropyleneimine 未知
公开(公告)号：IL293911A
公开(公告)日：2022-08-01
申请号：IL29391122
申请日：2022-06-13
申请人： UNIV GENT , HOOGENBOOM RICHARD , SANDERS NIEK
发明人： HOOGENBOOM RICHARD , SANDERS NIEK
摘要： The present invention relates to the field of non-viral vectors and pharmaceutical compositions comprising polypropyleneimine and a nucleic acid, and their use in human or veterinary medicine. More precisely, the present invention relates to pharmaceutical compositions comprising a polymer or co-polymer of polypropyleneimine for delivery or transfection of a nucleic acid, e.g. RNA. The pharmaceutical compositions described herein are particularly useful for (nucleic acid) vaccination, nucleic acid-based protein therapy, nucleic-acid based protein replacement therapy, gene editing, base editing, cell therapy, immunotherapy, stem cell therapy, regenerative medicine, gene silencing, nucleic acid inhibition or protein inhibition.

2. 发明申请

WO2012057628A3 CROSS-LINKED POLYMERS AND IMPLANTS DERIVED FROM ELECTROPHILICALLY ACTIVATED POLYOXAZOLINE 审中-公开
标题翻译：交联聚合物和从电活性聚酰胺衍生的嵌入物
公开(公告)号：WO2012057628A3
公开(公告)日：2012-06-28
申请号：PCT/NL2012050001
申请日：2012-01-02
申请人： BENDER ANALYTICAL HOLDING BV , HOOGENBOOM RICHARD , BENDER JOHANNES CASPAR MATHIAS ELIZABETH , VAN HEST JAN CORNELIS MARIA
发明人： HOOGENBOOM RICHARD , BENDER JOHANNES CASPAR MATHIAS ELIZABETH , VAN HEST JAN CORNELIS MARIA
IPC分类号： A61K47/48 , A61L27/18 , A61L31/06 , A61L31/14 , C08G73/02 , C08J3/24 , C08L79/02
CPC分类号： A61L24/046 , A61L24/06 , A61L27/18 , A61L31/06 , C08G73/0233 , C08J3/246 , C08J2300/10 , C08J2379/02 , C08L79/02
摘要： One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m=2, n=2 and m+n =5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m=3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.
摘要翻译：本发明的一个方面涉及通过使亲电子活化的聚恶唑啉（EL-POX）与亲核交联剂反应而获得的生物相容的，共价交联的聚合物，所述亲电活化的POX包含m个亲电基团; 并且所述亲核交联剂包含n个亲核基团，其中m个亲电基团能够与n个亲核基团反应形成共价键; 其中m = 2，n = 2和m + n = 5; 其中所述m亲电子基团中的至少一个是侧链亲电子基团和/或其中m = 3; 并且其中所述EL-POX相对于所述亲核交联剂中所含的亲核基团的量包含过量的亲电子基团。本发明还涉及包含这种交联的POX-聚合物的生物相容性医疗产品。还提供了用于生产生物相容的交联POX-聚合物的试剂盒。本发明还提供了包含至少1重量％的EL-POX的干物质的组织粘合剂医疗产品，所述EL-POX包含至少2个亲电子基团，包括至少一个侧链亲电子基团。根据本发明的聚合物具有优异的植入物和/或密封特性。

3. 发明申请

WO2012057628A2 CROSS-LINKED POLYMERS AND IMPLANTS DERIVED FROM ELECTROPHILICALLY ACTIVATED POLYOXAZOLINE 审中-公开
标题翻译：交联聚合物和来自电泳激活的聚恶唑啉的植入物
公开(公告)号：WO2012057628A2
公开(公告)日：2012-05-03
申请号：PCT/NL2012/050001
申请日：2012-01-02
申请人： BENDER ANALYTICAL HOLDING B.V. , HOOGENBOOM, Richard , BENDER, Johannes Caspar Mathias Elizabeth , VAN HEST, Jan Cornelis Maria
发明人： HOOGENBOOM, Richard , BENDER, Johannes Caspar Mathias Elizabeth , VAN HEST, Jan Cornelis Maria
IPC分类号： A61K47/48 , A61L27/18 , A61L31/06 , A61L31/14 , C08G73/02 , C08J3/24
CPC分类号： A61L24/046 , A61K47/50 , A61L24/06 , A61L27/18 , A61L31/06 , C08G73/0233 , C08J3/246 , C08J2300/10 , C08J2379/02 , C08L79/02
摘要： One aspect of the invention relates to a biocompatible, covalently cross-linked, polymer that is obtained by reacting an electrophilically activated polyoxazoline (EL-POX) with a nucleophilic cross-linking agent, said electrophilically activated POX comprising m electrophilic groups; and said nucleophilic cross-linking agent comprising n nucleophilic groups, wherein the m electrophilic groups are capable of reaction with the n nucleophilic groups to form covalent bonds; wherein m≥2, n≥2 and m+n ≥5; wherein at least one of the m electrophilic groups is a pendant electrophilic group and/or wherein m≥3; and wherein the EL-POX comprises an excess amount of electrophilic groups relative to the amount of nucleophilic groups contained in the nucleophilic cross-linking agent. The invention further relates to biocompatible medical products comprising such a cross-linked POX-polymer. Also provided is a kit for producing a biocompatible, cross-linked POX-polymer. The invention further provides a tissue adhesive medical product comprising at least 1% by weight of dry matter of EL-POX, said EL-POX comprising at least 2 electrophilic groups, including at least one pendant electrophilic group. The polymers according to the invention have excellent implant and/or sealing characteristics.
摘要翻译：本发明的一个方面涉及通过使亲电活化的聚恶唑啉（EL-POX）与亲核性交联剂反应获得的生物相容性共价交联聚合物，所述亲电活化的POX 包含m个亲电子基团; 并且所述亲核交联剂包含n个亲核基团，其中所述m个亲电子基团能够与所述n个亲核基团反应以形成共价键; 其中m≥2，n≥2且m +n≥5; 其中所述m个亲电子基团中的至少一个是侧基亲电子基团和/或其中m≥3; 并且其中相对于亲核交联剂中所含的亲核基团的量，EL-POX包含过量的亲电子基团。本发明进一步涉及包含这种交联的POX-聚合物的生物相容性医疗产品。还提供了用于生产生物相容性交联POX聚合物的试剂盒。本发明还提供了包含至少1重量％干物质EL-POX的组织粘附医药产品，所述EL-POX包含至少2个亲电子基团，包括至少一个侧挂亲电子基团。根据本发明的聚合物具有优异的植入和/或密封特性。

4. 发明申请

WO2011002285A1 DRUG DELIVERY SYSTEM COMPRISING POLYOXAZOLINE AND A BIOACTIVE AGENT 审中-公开
标题翻译：包含聚氧杂环丁烷和生物活性剂的药物递送系统
公开(公告)号：WO2011002285A1
公开(公告)日：2011-01-06
申请号：PCT/NL2010/050403
申请日：2010-06-28
申请人： BENDER ANALYTICAL HOLDING B.V. , BENDER, Johannes Caspar Mathias Elizabeth , HOOGENBOOM, Richard , VAN VLIET, Patrick Andreas Anton
发明人： BENDER, Johannes Caspar Mathias Elizabeth , HOOGENBOOM, Richard , VAN VLIET, Patrick Andreas Anton
IPC分类号： A61K9/70 , A61K9/16 , A61K9/20 , A61K9/40
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/1641 , A61K9/1694 , A61K9/2031 , A61K9/4816 , A61K9/7007
摘要： The invention relates to drug delivery systems comprising a water-soluble polymer matrix and a bioactive agent entrained therein, said water soluble polymer matrix containing at least 50 wt. % of polyoxazoline having a molar mass of at least 5 40,000 g/mol. The drug delivery systems of the present invention offer the advantage that the bioactive agent is readily released when the drug delivery system is contacted with water. The drug delivery system can be in the form of a solid dispersion, a mucoadhesive sheet, a tablet, a powder, a capsule.
摘要翻译：本发明涉及包含水溶性聚合物基质和夹带在其中的生物活性剂的药物递送系统，所述水溶性聚合物基质含有至少50wt。摩尔质量为至少5 40,000g / mol的聚恶唑啉的％。本发明的药物递送系统提供了当药物递送系统与水接触时生物活性剂容易释放的优点。药物递送系统可以是固体分散体，粘膜粘附片，片剂，粉末，胶囊的形式。

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