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1. 发明专利

CA2136148C LIQUID SEPARATION APPARATUS AND METHOD 未知
公开(公告)号：CA2136148C
公开(公告)日：2006-05-09
申请号：CA2136148
申请日：1994-11-18
申请人： HOLM NIELS-ERIK
发明人： HOLM NIELS-ERIK
IPC分类号： B04B7/00 , G01N1/10 , A61J3/00 , A61K35/14 , A61L24/10 , A61M1/02 , B01D17/038 , B01L3/14 , B04B1/00 , B04B1/02 , B04B1/06 , B04B5/04 , C12S3/22 , G01N33/48 , G01N33/49
摘要： In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical walls defining a longitudinal axis and a top wall and further a piston body constituting a bottom wall of the housing. The piston body defines together with the outer cylindrical wall, the inner cylindrical wall and the top wall, an annular chamber for receiving the liquid sample. The piston body is displaceable within the annular chamber for draining a phase portion separated from the liquid sample through a drain conduit means communicating with the annular chamber. The phase separation chamber further comprises a reaction chamber to which the phase portions exposed from the annular chamber is processed. The apparatus further includes a liquid supply means for supplying the liquid sample to the annular chamber, a motor means for rotating the phase separation container round its longitudinal axis at a rotational speed causing a separation of the liquid sample into the phase portions, and an actuator means for displacing the piston body within the annular chamber.

2. 发明专利

CA2136148A1 LIQUID SEPARATION APPARATUS AND METHOD 未知
公开(公告)号：CA2136148A1
公开(公告)日：1995-05-20
申请号：CA2136148
申请日：1994-11-18
申请人： HOLM NIELS ERIK
发明人： HOLM NIELS-ERIK
IPC分类号： G01N1/10 , A61J3/00 , A61M1/02 , B01D17/038 , B01L3/14 , B04B1/00 , B04B1/02 , B04B1/06 , B04B5/04 , B04B7/00 , G01N33/48 , G01N33/49 , A61L24/10 , A61K35/14 , C12S3/22
摘要： LIQUID SEPARATION APPARATUS AND METHOD In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical walls defining a longitudinal axis and a top wall and further a piston body constituting a bottom wall of the housing. The piston body defines together with the outer cylindrical wall, the inner cylindrical wall and the top wall, an annular chamber for receiving the liquid sample. The piston body is displaceable within the annular chamber for draining a phase portion separated from the liquid sample through a drain conduit means communicating with the annular chamber. The phase separation chamber further comprises a reaction chamber to which the phase portions exposed from the annular chamber is processed. The apparatus further includes a liquid supply means for supplying the liquid sample to the annular chamber, a motor means for rotating the phase separation container round its longitudinal axis at a rotational speed causing a separation of the liquid sample into the phase portions, and an actuator means for displacing the piston body within the annular chamber.

3. 发明申请

WO1988007874A1 A DOSAGE UNIT FOR DOSING A NUMBER OF MEASURED QUANTITIES OF A LIQUID, SUCH AS AN INSULIN PREPARATION, FROM A CONTAINER, PREFERABLY A CARTRIDGE 审中-公开
标题翻译：用于计量液体量测量数量的剂量单位，例如胰岛素制备，来自容器，优先选择一个盒子
公开(公告)号：WO1988007874A1
公开(公告)日：1988-10-20
申请号：PCT/DK1988000064
申请日：1988-04-07
申请人： D.C.P. AF 1988 A/S , BONNICHSEN, Fritz, Frydendal , SIMON, Bernd , HOLM, Niels, Erik
发明人： D.C.P. AF 1988 A/S
IPC分类号： A61M05/315
CPC分类号： A61M5/3158 , A61M5/31551 , A61M5/31563 , A61M5/31593 , G01F11/023
摘要： A syringe, having means for adjustment of the dosage of liquid to be injected, comprises a piston rod (18) which is slidable in a cylindrical casing (1). A first ratchet means (17) is provided between the casing (1) and the piston rod (13) allowing the piston rod (13) to be displaced only in the expelling direction. The adjustment means (20) comprises an inner thread (21) in engagement with an outer thread (19) provided on the outside of the casing (1), so that the adjustment means (20) will be longitudinally displaced in relation to the casing (1), when rotated in relation thereto. One end of the adjustment means (20) forms a stop, against which a head (22) on the piston rod (13) will abut, when the rod (13) is displaced. Thus, the stroke of the piston rod (13) is limited by the adjustment means (20). A second ratchet means (32) is provided between the adjustment means (20) and the casing (1), so that the adjustment means (20) can be rotated and longitudinally displaced only in one direction relatively to the casing (1). The syringe enables precise adjustment of a desired dosage and is prevented from being inadvertently reused when empty.

4. 发明专利

HRP930507A2 A DOSAGE UNIT FOR DOSING A NUMBER OF MEASURED TITIES OF A LIQUID, SUCH AS AN INSULIN PREPARATION, FROM A RIDGE 未知
公开(公告)号：HRP930507A2
公开(公告)日：1995-04-30
申请号：HRP930507
申请日：1993-03-24
申请人： HOLM, NIELS ERIK , SPORK, ALLAN , THOGERSEN, KLAUS , BRESSENDORFF, ANDERS
发明人： HOLM NIELS ERIK , SPORK ALLAN , THOGERSEN KLAUS , BRESSENDORFF ANDERS
IPC分类号： A61M5/24 , A61M5/315

5. 发明专利

GB2256075A DISPLAY SYSTEM. 未知
公开(公告)号：GB2256075A
公开(公告)日：1992-11-25
申请号：GB9210410
申请日：1992-05-15
申请人： HOLM NIELS ERIK , THOMAS COLIN
发明人： HOLM NIELS ERIK , THOMAS COLIN
IPC分类号： G09F11/18
摘要： A display system 4 comprising a frame 1; an active and a passive receiving station 34, 36 mounted in the frame; an image carrier 50, bearing a plurality of images 52, connected between the active and passive receiving stations; a display window (65 Figure 6) disposed between the active and passive receiving stations; a first passive tensioning means 5 associated with the passive receiving station and operable to maintain a predetermined tension in the image carrier 50; and driving means 10 associated with the active receiving station and operable to drive the image carrier 50 between the active and passive receiving stations so that a selected one of said plurality of images is brought into register with the display window 65. The image carrier may be detachable from the receiving station, and, suitably this station may be a removable cassette for storing the image carrier. A second tensioning means may be associated with the active receiving station, and, such means may take the form of a spring motor. The driving means may be an electric, suitably a stepper, motor. A plurality of display means may be provided in an adjacent relationship.

6. 发明申请

WO2010020254A1 MULTILAYERED BLOOD PRODUCT 审中-公开
标题翻译：多层血液制品
公开(公告)号：WO2010020254A1
公开(公告)日：2010-02-25
申请号：PCT/DK2009/050209
申请日：2009-08-24
申请人： REAPPLIX APS , LUNDQUIST, Rasmus , HOLM, Niels, Erik
发明人： LUNDQUIST, Rasmus , HOLM, Niels, Erik
IPC分类号： A61K35/14 , A61K38/36 , A61L24/10 , B01L3/14
CPC分类号： A61K35/19 , A61K35/15 , A61K35/33 , A61K38/15 , A61K38/17 , A61K38/36 , A61K38/363 , A61L24/106 , A61L26/0042 , B04B5/04 , B04B2005/0485 , C12N5/0642 , C12N5/0644 , C12N2501/905 , A61K2300/00
摘要： A blood product (10), a method for preparing the blood product, a blood product obtainable by the method and a blood product preparing container means. The blood product comprises components from whole blood, especially fibrin, thrombocytes and leukocytes. The blood product (10) comprises a first layer (21), a second layer (22) and a third layer (23). The second layer (22) is adjacent to the first layer (21) and the third layer (23). The first layer (21) defines a first outer surface (24) of the blood product (10) and the third layer (23) defining a second outer surface (25) of the blood product (10). The first layer (21) comprises a majority of fibrin, the second layer (22) comprises a majority of thrombocytes and the third layer (23) comprises a majority of leukocytes.
摘要翻译：血液制品（10），制备血液制品的方法，通过该方法获得的血液制品和血液制品制备容器装置。血液制品包括来自全血，特别是纤维蛋白，凝血细胞和白细胞的组分。血液制品（10）包括第一层（21），第二层（22）和第三层（23）。第二层（22）与第一层（21）和第三层（23）相邻。第一层（21）限定血液制品（10）的第一外表面（24）和限定血液制品（10）的第二外表面（25）的第三层（23）。第一层（21）包含大多数纤维蛋白，第二层（22）包含大多数血小板，第三层（23）包含白细胞的大部分。

7. 发明申请

WO2007121748A3 IMPROVED FIBRIN SEALANT COMPOSITION AND ITS USE 审中-公开
公开(公告)号：WO2007121748A3
公开(公告)日：2007-11-01
申请号：PCT/DK2007/000188
申请日：2007-04-20
申请人： HOLM, Niels, Erik
发明人： HOLM, Niels, Erik
IPC分类号： A61L24/10 , A61L26/00
摘要： The wound healing process may be augmented by the addition of fibrin sealant. Dependent on the sealant composition and way of application the wound healing process and tissue regeneration may be further accelerated. The present invention provides for an improved sealant composition and its use.

8. 发明申请

WO1996016714A1 METHOD AND DEVICE FOR SEPARATING FIBRIN MONOMER FROM BLOOD PLASMA 审中-公开
标题翻译：用于从血浆等离子体分离纤维素单体的方法和装置
公开(公告)号：WO1996016714A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015669
申请日：1995-12-01
申请人： E.R. SQUIBB AND SONS, INC. , HOLM, Niels, Erik , EDWARDSON, Peter, Andrew, David
发明人： E.R. SQUIBB AND SONS, INC.
IPC分类号： B01D21/26
CPC分类号： G01N33/491 , A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0449 , A61M2202/045 , B01D21/01 , B01D21/08 , B01D21/20 , B01D21/2405 , B01D21/26 , B01D21/262 , B01D2221/10 , B04B5/0442 , B04B2005/0485 , Y10T436/111666 , Y10T436/25375
摘要： A device for separating components such as fibrin monomer from blood by centrifugation about a central axis comprising a first annular chamber (70) defined by an outer cylindrical wall (72) and an inner cylindrical wall (71) both walls being concentrically accommodated about an axis of rotation, and by a top wall (73) and a bottom wall (74), where the bottom wall is formed by a piston (55) displaceable within the first chamber. The device including a second chamber (75) below the first chamber and communicating with the first chamber through a first conduit (4) and being defined by said outer cylindrical wall (72), the bottom wall (74) of the first chamber, and another bottom wall (76). The device also includes a capsule (45) accommodated in the second chamber and including a plurality of compartments for receiving respective compositions promoting the separation.
摘要翻译：用于通过围绕包括由外圆柱形壁（72）和内圆柱形壁（71）限定的第一环形室（70））的中心轴离心分离诸如纤维蛋白单体的组分与血液的装置，所述两个壁围绕轴线同心地容纳的旋转，以及顶壁（73）和底壁（74），其中底壁由在第一室内可移位的活塞（55）形成。所述装置包括在第一室下方的第二室（75），并通过第一导管（4）与第一室连通并由所述外圆筒壁（72），第一室的底壁（74）限定，以及另一个底壁（76）。该装置还包括容纳在第二室中的胶囊（45），并且包括多个隔室，用于接收促进分离的相应组合物。

9. 发明申请

WO1996016713A1 CENTRIFUGE REAGENT DELIVERY SYSTEM 审中-公开
标题翻译：离心试剂递送系统
公开(公告)号：WO1996016713A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015667
申请日：1995-12-01
申请人： E.R. SQUIBB AND SONS, INC. , HOLM, Niels, Erik
发明人： E.R. SQUIBB AND SONS, INC.
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , B01D21/2405 , B01D21/2427 , B01D2221/10 , B04B1/02 , B04B5/0442 , B04B2005/0485 , Y10T137/87676 , Y10T436/111666 , Y10T436/25375
摘要： A device for separating components such as fibrin monomer from blood by centrifugation about a central axis comprising a first annular chamber (70) defined by an outer cylindrical wall (72) and an inner cylindrical wall (71) both walls being concentrically accommodated about an axis of rotation, and by a top wall (73) and a bottom wall (74), where the bottom wall is formed by a piston (55) displaceable within the first chamber. The device including a second chamber (75) below the first chamber and communicating with the first chamber through a first conduit (4) and being defined by the outer cylindrical wall (72), the bottom wall (74) of the first chamber, and another bottom wall (76). The device also includes a capsule (45) accommodated in the second chamber and including a plurality of compartments for receiving respective compositions promoting the separation.
摘要翻译：一种用于通过围绕包括由外圆柱形壁（72）和内圆柱形壁（71）限定的第一环形室（70））的中心轴离心分离诸如纤维蛋白单体的组分与血液的装置，两个壁围绕轴线同心地容纳的旋转，以及顶壁（73）和底壁（74），其中底壁由可在第一室内移位的活塞（55）形成。该装置包括在第一室下方的第二室（75），并通过第一导管（4）与第一室连通并由第二室的外圆筒壁（72），第一室的底壁（74）限定，以及另一个底壁（76）。该装置还包括容纳在第二室中的胶囊（45），并且包括多个隔室，用于接收促进分离的相应组合物。

10. 发明申请

WO1991017778A1 AN APPARATUS FOR PREPARING A CONCENTRATE OF COAGULATION FACTORS, SUCH AS FIBRINOGEN, FROM A BLOOD SAMPLE 审中-公开
标题翻译：用于制备凝血因子浓度的装置，如来自血液样品的纤维蛋白原
公开(公告)号：WO1991017778A1
公开(公告)日：1991-11-28
申请号：PCT/DK1991000131
申请日：1991-05-14
申请人： UNES A/S , WEIS-FOGH, Ulla , HERN, Soren , HOLM, Niels, Erik
发明人： UNES A/S
IPC分类号： A61M01/36
CPC分类号： A61M1/3693 , A61M1/369 , A61M2202/0449 , C07K14/75
摘要： An apparatus for preparing a concentrate of coagulation factors, such as fibrinogen, from a blood sample, comprises a first chamber (14) for collection and separation of said blood sample so as to separate a plasma fraction, and a second chamber (15) for collection of said plasma fraction through a tubing member (22, 30) and a valve (24) and for precipitation of said concentrate. The apparatus comprises furthermore a removable syringe (36) for receiving the concentrate from the second chamber (15) through a tubing member (32). The first and the second chamber (14, 15) are partially defined by the same integrally formed solid container wall (2) and comprise a common partition. The first chamber (14) is further defined by a piston (4) displaceable both in connection with the blood sample collection and the transfer of said plasma fraction to the second chamber (15) and in connection with returning said plasma fraction to the first chamber (14) upon the precipitation of the concentrate.
摘要翻译：一种用于从血液样品制备凝血因子如纤维蛋白原的浓缩物的装置包括用于收集和分离所述血液样品以分离血浆分数的第一腔室（14）和用于通过管道构件（22,30）和阀（24）收集所述血浆部分并且用于沉淀所述浓缩物。该装置还包括用于通过管道构件（32）从第二室（15）接收浓缩物的可移除注射器（36）。第一和第二室（14,15）由同一整体形成的固体容器壁（2）部分地限定，并且包括公共隔板。第一腔室（14）由活塞（4）进一步限定，活塞（4）可以与血液样品收集和所述等离子体部分转移到第二腔室（15）并且将所述血浆部分返回到第一腔室（14）浓缩物沉淀后。

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