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1. 发明申请

WO2010127108A2 COMPOSITIONS COMPRISING AN ANTIHISTAMINE, ANTITUSSIVE AND DECONGESTANT IN EXTENDED RELEASE FORMULATIONS 审中-公开
标题翻译：包含抗组胺剂，抗老化剂和去势组合物在延长释放制剂中的组合物
公开(公告)号：WO2010127108A2
公开(公告)日：2010-11-04
申请号：PCT/US2010/032958
申请日：2010-04-29
申请人： ATLEY PHARMACEUTICALS, INC. , MCDERMOTT, James, Joseph , HOLLENBECK, R., Gary , ATTKISSON, Craig, Linwood
发明人： MCDERMOTT, James, Joseph , HOLLENBECK, R., Gary , ATTKISSON, Craig, Linwood
IPC分类号： A61K31/485 , A61P11/00 , A61P11/02 , A61P11/14
CPC分类号： A61K9/0095 , A61K9/1623 , A61K9/1652 , A61K9/5026 , A61K31/137 , A61K31/4402 , A61K31/485 , A61K2300/00
摘要： The invention provides oral formulations for the treatment of cold and allergy symptoms. Each formulation combines an antihistamine, an antitussive, and/or a decongestant into one extended release composition. The invention further provides for methods of making and using such formulations, as well as for methods for preventing abuse or extraction of a single drug present in an oral extended release composition comprising two or more of an antihistamine, antitussive, and/or decongestant.
摘要翻译：本发明提供了用于治疗感冒和过敏症状的口服制剂。每种制剂将抗组胺药，镇咳药和/或减充血剂组合成一种缓释组合物。本发明进一步提供制备和使用所述制剂的方法，以及用于预防存在于包含两种或更多种抗组胺药，镇咳药和/或减充血剂的口服延长释放组合物中的单一药物滥用或提取的方法。 / p>

2. 发明申请

WO2006135362A9 AQUEOUS SUSTAINED-RELEASE DRUG DELIVERY SYSTEM FOR HIGHLY WATER-SOLUBLE ELECTROLYTIC DRUGS 审中-公开
公开(公告)号：WO2006135362A9
公开(公告)日：2006-12-21
申请号：PCT/US2005/020534
申请日：2005-06-09
申请人： UPM PHARMACEUTICALS, INC. , HOLLENBECK, R., Gary
发明人： HOLLENBECK, R., Gary
IPC分类号： A61K9/10 , A61K47/36 , A61K47/48 , A61K31/135
摘要： The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex comprising a pharmaceutically acceptable a ion-exchange matrix and a water-soluble electrolytic drug associated with the ion-exchange matrix, wherein the surface charge of the ion-exchange matrix is opposite that of the electrolytic drug wherein the dispersed phase further comprises a non-electrolytic, soluble component having low molecular weight and a diffusion controlling membrane and a dispersion medium substantially free of diffusible counterions, further comprising an excipient capable of associating with water and impeding water activity such that drug dissolution is inhibited prior to administration. The invention also provides methods for preparing such compositions and methods of treatment.

3. 发明申请

WO2010127108A3 COMPOSITIONS COMPRISING AN ANTIHISTAMINE, ANTITUSSIVE AND DECONGESTANT IN EXTENDED RELEASE FORMULATIONS 审中-公开
标题翻译：包含抗菌素，抗菌药物和延缓释放配方中组合物的组合物
公开(公告)号：WO2010127108A3
公开(公告)日：2014-03-27
申请号：PCT/US2010032958
申请日：2010-04-29
申请人： ATLEY PHARMACEUTICALS INC , MCDERMOTT JAMES JOSEPH , HOLLENBECK R GARY , ATTKISSON CRAIG LINWOOD
发明人： MCDERMOTT JAMES JOSEPH , HOLLENBECK R GARY , ATTKISSON CRAIG LINWOOD
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K9/0095 , A61K9/1623 , A61K9/1652 , A61K9/5026 , A61K31/137 , A61K31/4402 , A61K31/485 , A61K2300/00
摘要： The invention provides oral formulations for the treatment of cold and allergy symptoms. Each formulation combines an antihistamine, an antitussive, and/or a decongestant into one extended release composition. The invention further provides for methods of making and using such formulations, as well as for methods for preventing abuse or extraction of a single drug present in an oral extended release composition comprising two or more of an antihistamine, antitussive, and/or decongestant.
摘要翻译：本发明提供用于治疗感冒和过敏症状的口服制剂。每种制剂将抗组胺药，镇咳药和/或减充血剂组合成一种延长释放组合物。本发明还提供制备和使用这些制剂的方法，以及用于预防滥用或提取口服延长释放组合物中包含两种或多种抗组胺剂，止咳剂和/或减充血剂的单一药物的方法。

4. 发明申请

WO2010127100A8 COMPOSITIONS COMPRISING AN ANTIHISTAMINE, ANTITUSSIVE AND DECONGESTANT IN EXTENDED RELEASE FORMULATIONS 审中-公开
标题翻译：包含抗病毒药物的组合物，延伸释放制剂中的抗生素和抗生素
公开(公告)号：WO2010127100A8
公开(公告)日：2010-12-29
申请号：PCT/US2010032949
申请日：2010-04-29
申请人： ATLEY PHARMACEUTICALS INC , MCDERMOTT JAMES JOSEPH , HOLLENBECK R GARY , ATTKISSON CRAIG LINWOOD
发明人： MCDERMOTT JAMES JOSEPH , HOLLENBECK R GARY , ATTKISSON CRAIG LINWOOD
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K9/1652 , A61K9/0095 , A61K9/5026 , A61K31/137 , A61K31/4402 , A61K31/485 , A61K2300/00
摘要： The invention provides oral formulations for the treatment of cold and allergy symptoms. Each formulation combines an antihistamine, an antitussive, and/or a decongestant into one extended release composition. The invention further provides for methods of making and using such formulations, as well as for methods for preventing abuse or extraction of a single drug present in an oral extended release composition comprising two or more of an antihistamine, antitussive, and/or decongestant.
摘要翻译：本发明提供了用于治疗感冒和过敏症状的口服制剂。每种制剂将抗组胺药，止咳剂和/或减充血剂组合成一种延长释放组合物。本发明进一步提供制备和使用这些制剂的方法，以及用于预防滥用或提取存在于口服延长释放组合物中的单一药物的方法，其包含两种或多种抗组胺剂，止咳剂和/或减充血剂。

5. 发明申请

WO2009023544A3 DOSAGE UNIT ANION-EXCHANGE POLYMER PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：剂量单位阴离子交换聚合物药物组合物
公开(公告)号：WO2009023544A3
公开(公告)日：2009-03-19
申请号：PCT/US2008072566
申请日：2008-08-08
申请人： ILYPSA INC , MANSKY PAUL , CHEN YAN , GADRE ASHWINI , HOLLENBECK R GARY , CHANG HAN TING , CHARMOT DOMINIQUE , CONNOR ERIC
发明人： MANSKY PAUL , CHEN YAN , GADRE ASHWINI , HOLLENBECK R GARY , CHANG HAN TING , CHARMOT DOMINIQUE , CONNOR ERIC
IPC分类号： A61K9/20 , A61K31/785
CPC分类号： A61K9/2018 , A61K31/785
摘要： The present invention relates to pharmaceutical compositions including impregnated polymeric materials, particularly anion-exchange polymers. Processes for producing such compositions and impregnated polymers are also disclosed herein. Examples of uses for the compositions disclosed herein include the treatment of renal diseases and ion imbalances.
摘要翻译：本发明涉及药物组合物，包括浸渍的聚合物材料，特别是阴离子交换聚合物。本文还公开了用于生产这种组合物和浸渍聚合物的方法。本文公开的组合物的用途实例包括治疗肾脏疾病和离子失衡。

6. 发明申请

WO2006135362A1 AQUEOUS SUSTAINED-RELEASE DRUG DELIVERY SYSTEM FOR HIGHLY WATER-SOLUBLE ELECTROLYTIC DRUGS 审中-公开
标题翻译：高水溶性电解液的水溶性持续释放药物输送系统
公开(公告)号：WO2006135362A1
公开(公告)日：2006-12-21
申请号：PCT/US2005/020534
申请日：2005-06-09
申请人： UPM PHARMACEUTICALS, INC. , HOLLENBECK, R., Gary
发明人： HOLLENBECK, R., Gary
IPC分类号： A61K9/10 , A61K47/36 , A61K47/48 , A61K31/135
CPC分类号： A61K9/0095 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5078 , A61K31/135 , A61K47/585
摘要： The present invention relates to liquid sustained release suspension dosage forms comprising ionized forms of water-soluble drugs. In particular, the invention encompasses a liquid form controlled release drug composition comprising a dispersed phase comprising an ion-exchange matrix drug complex comprising a pharmaceutically acceptable a ion-exchange matrix and a water-soluble electrolytic drug associated with the ion-exchange matrix, wherein the surface charge of the ion-exchange matrix is opposite that of the electrolytic drug wherein the dispersed phase further comprises a non-electrolytic, soluble component having low molecular weight and a diffusion controlling membrane and a dispersion medium substantially free of diffusible counterions, further comprising an excipient capable of associating with water and impeding water activity such that drug dissolution is inhibited prior to administration. The invention also provides methods for preparing such compositions and methods of treatment.
摘要翻译：本发明涉及包含电离形式的水溶性药物的液体缓释悬浮剂剂型。特别地，本发明包括液体形式的控释药物组合物，其包含分散相，其包含离子交换基质药物复合物，其包含药学上可接受的离子交换基质和与离子交换基质相关的水溶性电解药物，其中离子交换基质的表面电荷与电解药物的表面电荷相反，其中分散相还包含具有低分子量的非电解可溶性组分和扩散控制膜以及基本上不含可扩散抗衡离子的分散介质，还包含能够与水缔合并阻碍水分活性的赋形剂，使得在施用之前药物溶解被抑制。本发明还提供了制备这种组合物和治疗方法的方法。

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