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1. 发明申请

WO2011094027A1 BACTERIOTHERAPY FOR CLOSTRIDIUM DIFFICILE COLITIS 审中-公开
标题翻译：细菌性病毒的特异性
公开(公告)号：WO2011094027A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/000184
申请日：2011-02-01
申请人： HLAVKA, Edwin J.
发明人： HLAVKA, Edwin J.
IPC分类号： C12N1/12
CPC分类号： A61K35/741 , A61K9/20 , A61K35/74 , C12N1/04 , C12N1/20 , G01N33/56911 , G01N2333/33 , G01N2800/52
摘要： This document discusses, among other things, receiving a plurality of donor fecal samples from a plurality of donors and storing and indexing each respective donor fecal samples using at least one characteristic of the respective donor fecal sample. In an example, the donor fecal sample can be screened and processed for subsequent use in fecal bacteriotherapy to displace pathogenic or undesired organisms in the digestive track of a patient with healthy or desirable gut micriobiota.
摘要翻译：本文件尤其讨论了从多个供体接收多个供体粪便样品，并使用相应的供体粪便样品的至少一个特征来存储和索引每个相应的供体粪便样品。在一个实例中，供体粪便样品可以筛选和处理，以便随后用于粪便细菌治疗以置换具有健康或期望的肠道微生物的患者的消化道中的病原体或不需要的生物体。

2. 发明申请

WO2008063464A3 METHODS AND DEVICES FOR DEPLOYING AN IMPLANT IN CURVED ANATOMY 审中-公开
标题翻译：用于在弯曲解剖中部署植入物的方法和装置
公开(公告)号：WO2008063464A3
公开(公告)日：2008-08-28
申请号：PCT/US2007023752
申请日：2007-11-13
申请人： SAGE MEDICAL TECHNOLOGIES INC , HLAVKA EDWIN J , PETERSON ALEX ALDEN
发明人： HLAVKA EDWIN J , PETERSON ALEX ALDEN
IPC分类号： A61F2/90
CPC分类号： A61F2/95 , A61F2/90 , A61F2002/9511
摘要： Methods and devices for deploying an endoluminal implant in a curved vessel. The devices include steerable catheters having a control member that extends to the distal end and operates to bend the catheter. In other cases, the stent includes a longitudinal adjustment member attached near the leading edge of the stent and operates to shorten or lengthen the stent and thereby induce a curvature. The stent is carried in a distal region of the catheter that is advanced into a curved region of a vessel. The catheter is bent and/or the stent is curved using the longitudinal adjustment member, and the stent is deployed to achieve uniform wall contact with the endoluminal surface of the vessel at the lesser curvature.
摘要翻译：用于在弯曲血管中部署腔内植入物的方法和装置。该装置包括具有控制构件的可转向导管，该控制构件延伸至远端并操作以弯曲导管。在其他情况下，支架包括附接在支架前缘附近的纵向调节构件，并且用于缩短或延长支架并由此引起弯曲。支架被携带在推进到血管的弯曲区域的导管的远侧区域中。使用纵向调整构件弯曲导管和/或使支架弯曲，并且展开支架以实现与小容器的腔内表面在较小曲率处均匀的壁接触。

3. 发明申请

WO2002085251A1 METHOD AND APPARATUS FOR PERFORMING CATHETER-BASED ANNULOPLASTY 审中-公开
标题翻译：用于实施基于导管的神经生长的方法和装置
公开(公告)号：WO2002085251A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/010952
申请日：2002-04-09
申请人： DHC SYSTEMS, INC. , HLAVKA, Edwin, J. , SPENCE, Paul
发明人： HLAVKA, Edwin, J. , SPENCE, Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2445 , A61B2017/00243 , A61B2017/048 , A61F2/2448 , A61F2/2466 , Y10S623/904
摘要： The present invention relates to a minimally invasive method of performing annuloplasty. According to one aspect of the present invention, a method for performing a procedure on a mitral valve (728) of a heart includes inserting an implant (924) into a left ventricle and orienting the implant in the left ventricle substantially below the mitral valve. The implant (924) and tissue (970) around the mitral valve (728) are connected and tension is provided to the implant, in one embodiment, in order to substantially reduce an arc length associated with the mitral valve (728). In another embodiment, the implant (924) is inserted into the left ventricle through the aorta and the aortic valve.
摘要翻译：本发明涉及执行瓣环成形术的微创方法。根据本发明的一个方面，一种用于在心脏的二尖瓣（728）上执行手术的方法包括将植入物（924）插入左心室并将植入物定向在基本上在二尖瓣下方的左心室中。在一个实施例中，围绕二尖瓣（728）的植入物（924）和组织（970）被连接并且在植入物中提供张力，以便基本上减小与二尖瓣（728）相关联的电弧长度。在另一个实施例中，通过主动脉和主动脉瓣将植入物（924）插入左心室。

4. 发明申请

WO2013016590A1 APPARATUS AND METHODS TO MODULATE PELVIC NERVOUS TISSUE 审中-公开
标题翻译：调节神经组织的装置和方法
公开(公告)号：WO2013016590A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/048419
申请日：2012-07-26
申请人： SACHS, Dan , HLAVKA, Edwin J.
发明人： SACHS, Dan , HLAVKA, Edwin J.
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/04 , A61B18/1477 , A61B18/1485 , A61B18/18 , A61B18/1815 , A61B18/24 , A61B2018/00023 , A61B2018/00083 , A61B2018/0022 , A61B2018/00267 , A61B2018/00517 , A61B2018/00523 , A61B2018/00577 , A61B2018/143 , A61B2018/183 , A61B2018/1861 , A61F7/12
摘要： Apparatus and methods are provided to position an energy delivery element at a desired position within a bladder and to deliver energy to non-superficial target tissue within or proximate to a bladder wall to modulate bladder function while retaining a mucosal surface of the bladder wall superficial to the non-superficial target tissue substantially intact. The apparatus can include an elongated shaft having a distal region configured to position the energy delivery element at the desired position within the bladder.
摘要翻译：提供了设备和方法以将能量递送元件定位在膀胱内的期望位置，并将能量传递到膀胱壁内或附近的膀胱壁内的非表面靶组织，以调节膀胱功能，同时将膀胱壁的粘膜表面保持在表面至非表面靶组织基本上完好无损。该装置可以包括细长轴，其具有构造成将能量输送元件定位在膀胱内所需位置的远侧区域。

5. 发明申请

WO2010019481A1 SYSTEMS AND METHODS FOR TREATING DYSPNEA, INCLUDING VIA ELECTRICAL AFFERENT SIGNAL BLOCKING 审中-公开
标题翻译：用于处理电子束的系统和方法，包括通过电气感应信号阻塞
公开(公告)号：WO2010019481A1
公开(公告)日：2010-02-18
申请号：PCT/US2009/053190
申请日：2009-08-07
申请人： CONCEPTX MEDICAL, INC. , HLAVKA, Edwin, J. , ELLIOTT, Lynn
发明人： HLAVKA, Edwin, J. , ELLIOTT, Lynn
IPC分类号： A61N1/372
CPC分类号： A61N1/3601 , A61N1/0556
摘要： Systems and methods for treating a patient with dyspnea are disclosed. A method in accordance with a particular embodiment includes identifying the patient as suffering from dyspnea, and, based at least in part on identifying the patient as suffering from dyspnea, implanting an electrical signal delivery element within the patient in signal communication with an afferent neural pathway of a carotid body chemoreceptor. The method can further include at least reducing dyspneic sensations in the patient by directing an electrical signal from the electrical signal delivery element to the neural pathway to at least partially block afferent signals from the chemoreceptor.
摘要翻译：公开了治疗呼吸困难患者的系统和方法。根据特定实施例的方法包括将患者识别为患有呼吸困难，并且至少部分地基于将患者识别为患有呼吸困难，将患者中的电信号传递元件植入与传入神经通路的信号通信的颈动脉体化学感受器。该方法可以进一步包括通过将电信号从电信号传递元件引导到神经通路来至少部分地阻止来自化学感受器的传入信号来减少患者的呼吸困难感。

6. 发明申请

WO2008063464A2 METHODS AND DEVICES FOR DEPLOYING AN IMPLANT IN CURVED ANATOMY 审中-公开
标题翻译：用于在弯曲解剖中分配植入物的方法和装置
公开(公告)号：WO2008063464A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/023752
申请日：2007-11-13
申请人： SAGE MEDICAL TECHNOLOGIES, INC. , HLAVKA, Edwin, J. , PETERSON, Alex, Alden
发明人： HLAVKA, Edwin, J. , PETERSON, Alex, Alden
IPC分类号： A61F2/84
CPC分类号： A61F2/95 , A61F2/90 , A61F2002/9511
摘要： Methods and devices for deploying an endoluminal implant in a curved vessel. The devices include steerable catheters having a control member that extends to the distal end and operates to bend the catheter. In other cases, the stent includes a longitudinal adjustment member attached near the leading edge of the stent and operates to shorten or lengthen the stent and thereby induce a curvature. The stent is carried in a distal region of the catheter that is advanced into a curved region of a vessel. The catheter is bent and/or the stent is curved using the longitudinal adjustment member, and the stent is deployed to achieve uniform wall contact with the endoluminal surface of the vessel at the lesser curvature.
摘要翻译：用于在弯曲血管中部署腔内植入物的方法和装置。所述装置包括具有延伸到远端并用于弯曲导管的控制构件的可导向导管。在其他情况下，支架包括附接在支架的前缘附近的纵向调节构件，并且用于缩短或延长支架，从而引起曲率。支架被放置在导管的远端区域中，该远端区域前进到血管的弯曲区域。导管被弯曲和/或支架使用纵向调节构件弯曲，并且支架被展开以实现与较小曲率的血管内腔表面的均匀壁接触。

7. 发明申请

WO2013016588A1 APPARATUS AND METHODS TO MODULATE PELVIC NERVOUS TISSUE 审中-公开
标题翻译：调节神经组织的装置和方法
公开(公告)号：WO2013016588A1
公开(公告)日：2013-01-31
申请号：PCT/US2012/048417
申请日：2012-07-26
申请人： SACHS, Dan , HLAVKA, Edwin J.
发明人： SACHS, Dan , HLAVKA, Edwin J.
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/04 , A61B18/1477 , A61B18/1485 , A61B18/18 , A61B18/1815 , A61B18/24 , A61B2018/00023 , A61B2018/00083 , A61B2018/0022 , A61B2018/00267 , A61B2018/00517 , A61B2018/00523 , A61B2018/00577 , A61B2018/143 , A61B2018/183 , A61B2018/1861 , A61F7/12
摘要： Apparatus and methods are provided to receive a mucosal surface of a bladder, superficial to a target volume within a bladder wall, at a first surface of a distal region of a device, to insert a longitudinal portion of a therapy delivery element into the target volume at a substantially uniform distance from the first surface of the device, and to provide therapy to the target volume using the therapy delivery element.
摘要翻译：提供了装置和方法，以在装置的远侧区域的第一表面处接收膀胱的粘膜表面，在膀胱壁内的表面的目标体积，以将治疗递送元件的纵向部分插入目标体积距离装置的第一表面基本上均匀的距离，并且使用治疗递送元件向目标体积提供治疗。

8. 发明申请

WO2006044727A3 DEVICES AND METHODS FOR TISSUE REMOVAL 审中-公开
标题翻译：用于组织去除的装置和方法
公开(公告)号：WO2006044727A3
公开(公告)日：2006-11-02
申请号：PCT/US2005037136
申请日：2005-10-15
申请人： BAXANO INC , BLEICH JEFFERY L , SPISAK STEVEN A , HLAVKA EDWIN J , SAADAT VAHID , MILLER DAVID R , YURCHENCO JAMES
发明人： BLEICH JEFFERY L , SPISAK STEVEN A , HLAVKA EDWIN J , SAADAT VAHID , MILLER DAVID R , YURCHENCO JAMES
IPC分类号： A61B17/22 , A61D1/02
CPC分类号： A61B17/320758 , A61B1/3135 , A61B17/149 , A61B17/1659 , A61B17/1671 , A61B17/29 , A61B17/320016 , A61B17/32002 , A61B17/32053 , A61B17/3401 , A61B17/3403 , A61B17/3421 , A61B17/3496 , A61B18/1477 , A61B18/1487 , A61B90/04 , A61B90/361 , A61B2017/00261 , A61B2017/00287 , A61B2017/003 , A61B2017/00867 , A61B2017/00907 , A61B2017/320004 , A61B2017/320044 , A61B2017/32006 , A61B2017/3445 , A61B2017/3447 , A61B2018/1407 , A61B2018/1425 , A61B2090/061 , A61B2090/08021 , A61F2/0045 , A61N1/0551 , A61N1/36017
摘要： Methods and apparatus are provided for selective surgical removal of tissue, e.g., for enlargement of diseased spinal structures, such as impinged lateral recesses and pathologically narrowed neural foramen. In one variation, tissue may be ablated, resected, removed, or otherwise remodeled by standard small endoscopic tools delivered into the epidural space through an epidural needle. Once the sharp tip of the needle is in the epidural space, it is converted to a blunt tipped instrument for further safe advancement. A nerve stimulator optionally may be provided to reduce a risk of inadvertent neural abrasion. Additionally, safe epidural placement of the working barrier and epidural tissue modification tools may be further improved with the- use of electrical nerve- stimulation- capabilities within the invention that, when combined with neural stimulation monitors, provide neural localization capabilities to the surgeon.
摘要翻译：提供了用于选择性手术去除组织的方法和装置，例如用于扩大患病的脊柱结构，例如冲击的侧向凹陷和病理变窄的神经孔。在一个变化中，组织可以被通过硬膜外针递送到硬膜外腔的标准小内窥镜工具进行消融，切除，去除或其它改造。一旦尖锐尖端的针头在硬膜外腔中，就会被转换成钝头，以进一步安全的进行。任选地可以提供神经刺激器以减少无意神经磨损的风险。另外，通过使用本发明中的电神经刺激能力可以进一步改善工作屏障和硬膜外组织修饰工具的安全硬膜外置放，当与神经刺激监测器组合时，向外科医生提供神经定位能力。

9. 发明申请

WO2006044727A2 DEVICES AND METHODS FOR TISSUE REMOVAL 审中-公开
标题翻译：用于组织去除的装置和方法
公开(公告)号：WO2006044727A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/037136
申请日：2005-10-15
申请人： BAXANO, INC. , BLEICH, Jeffery, L. , SPISAK, Steven, A. , HLAVKA, Edwin, J. , SAADAT, Vahid , MILLER, David, R. , YURCHENCO, James
发明人： BLEICH, Jeffery, L. , SPISAK, Steven, A. , HLAVKA, Edwin, J. , SAADAT, Vahid , MILLER, David, R. , YURCHENCO, James
IPC分类号： A61B5/05
CPC分类号： A61B17/320758 , A61B1/3135 , A61B17/149 , A61B17/1659 , A61B17/1671 , A61B17/29 , A61B17/320016 , A61B17/32002 , A61B17/32053 , A61B17/3401 , A61B17/3403 , A61B17/3421 , A61B17/3496 , A61B18/1477 , A61B18/1487 , A61B90/04 , A61B90/361 , A61B2017/00261 , A61B2017/00287 , A61B2017/003 , A61B2017/00867 , A61B2017/00907 , A61B2017/320004 , A61B2017/320044 , A61B2017/32006 , A61B2017/3445 , A61B2017/3447 , A61B2018/1407 , A61B2018/1425 , A61B2090/061 , A61B2090/08021 , A61F2/0045 , A61N1/0551 , A61N1/36017
摘要： Methods and apparatus are provided for selective surgical removal of tissue, e.g., for enlargement of diseased spinal structures, such as impinged lateral recesses and pathologically narrowed neural foramen. In one variation, tissue may be ablated, resected, removed, or otherwise remodeled by standard small endoscopic tools delivered into the epidural space through an epidural needle. Once the sharp tip of the needle is in the epidural space, it is converted to a blunt tipped instrument for further safe advancement. A specially designed epidural catheter that is used to cover the previously sharp needle tip may also contain a fiberoptic cable. Further embodiments of the current invention include a double barreled epidural needle or other means for placement of a working channel for the placement of tools within the epidural space, beside the epidural instrument. The current invention includes specific tools that enable safe tissue modification in the epidural space, including a barrier that separates the area where tissue modification will take place from adjacent vulnerable neural and vascular structures. In one variation, a tissue abrasion device is provided including a thin belt or ribbon with an abrasive cutting surface. The device may be placed through the neural foramina of the spine and around the anterior border of a facet joint. Once properly positioned, a medical practitioner may enlarge the lateral recess and neural foramina via frictional abrasion, i.e., by sliding the abrasive surface of the ribbon across impinging tissues. A nerve stimulator optionally may be provided to reduce a risk of inadvertent neural abrasion. Additionally, safe epidural placement of the working barrier and epidural tissue modification tools may be further improved with the use of electrical nerve stimulation capabilities within the invention that, when combined with neural stimulation monitors, provide neural localization capabilities to the surgeon. The device optionally may be placed within a protective sheath that exposes the abrasive surface of the ribbon only in the area where tissue removal is desired. Furthermore, an endoscope may be incorporated into the device in order to monitor safe tissue removal. Finally, tissue remodeling within the epidural space may be ensured through the placement of compression dressings against remodeled tissue surfaces, or through the placement of tissue retention straps, belts or cables that are wrapped around and pull under tension aspects of the impinging soft tissue and bone in the posterior spinal canal.
摘要翻译：提供了用于选择性手术去除组织的方法和装置，例如用于扩大患病的脊柱结构，例如冲击的侧向凹陷和病理变窄的神经孔。在一个变化中，组织可以被通过硬膜外针递送到硬膜外腔的标准小内窥镜工具进行消融，切除，去除或其它改造。一旦尖锐尖端的针头在硬膜外腔中，就会被转换成钝头，以进一步安全的进行。用于覆盖先前锋利的针尖的特别设计的硬膜外导管还可以包含光纤电缆。本发明的另外的实施例包括双重硬膜外针或其他用于放置用于在硬膜外腔内的硬膜外腔内放置工具的工作通道的装置。本发明包括能够在硬膜外腔中进行安全组织修复的特定工具，包括将相邻的脆弱神经和血管结构发生组织修饰的区域分开的屏障。在一个实施例中，提供了一种组织磨损装置，其包括具有研磨切割表面的薄带或带。该装置可以通过脊柱的神经孔和围绕小关节的前边缘放置。一旦适当定位，医生可以通过摩擦磨损，即通过将带的研磨表面滑动穿过冲击组织来扩大横向凹部和神经孔。任选地可以提供神经刺激器以减少无意神经磨损的风险。此外，通过使用本发明中的电神经刺激能力，可以进一步改善工作屏障和硬膜外组织修饰工具的安全硬膜外放置，当与神经刺激监测器组合时，向外科医生提供神经定位能力。该装置可选择地放置在保护套内，仅在期望组织移除的区域中暴露带的研磨表面。此外，为了监视安全的组织去除，可以将内窥镜结合到装置中。最后，可以通过将压缩敷料放置在重建的组织表面上，或者通过放置组织保持带，皮带或电缆，在打入的软组织和骨骼的张力方面被缠绕和拉动来确保硬膜外腔内的组织重建在后椎管内。

10. 发明申请

WO2002085252A1 METHOD AND APPARATUS FOR CATHETER-BASED ANNULOPLASTY USING LOCAL PLICATIONS 审中-公开
标题翻译：方法和装置使用基于导管的ANNOLOPLASTY使用本地化
公开(公告)号：WO2002085252A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/011375
申请日：2002-04-11
申请人： DHC SYSTEMS, INC. , HLAVKA, Edwin, J. , PODMORE, Jonathan, L. , SPENCE, Paul, A.
发明人： HLAVKA, Edwin, J. , PODMORE, Jonathan, L. , SPENCE, Paul, A.
IPC分类号： A61F2/06
CPC分类号： A61B17/0644 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/0643 , A61B17/08 , A61B2017/00004 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0406 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0464 , A61B2017/0472 , A61B2017/048 , A61B2017/0488 , A61B2017/0496 , A61B2017/081 , A61F2/2448
摘要： The present invention relates to a minimally invasive method of performing annuloplasty. According to one aspect of the present invention, a method for performing annuloplasty includes accessing a left ventricle of a heart to provide a discrete plication element (905) to the left ventricle, and engaging the plication element to tissue near a mitral valve (916) of the heart. Engaging the plication element (905) includes causing the plication element to gather a portion of the tissue to create a plication. In one embodiment, accesing the left ventricle of the heart to provide the plication element (905) includes accessing the left ventricle of the heart using a catheter arrangement.
摘要翻译：本发明涉及执行瓣环成形术的微创方法。根据本发明的一个方面，一种用于进行瓣膜成形术的方法包括进入心脏的左心室以向左心室提供离散的打孔元件（905），并将折叠元件接合到二尖瓣附近的组织（916）的心脏使折叠元件（905）接合包括使折叠元件收集组织的一部分以产生折痕。在一个实施例中，接近心脏的左心室以提供折叠元件（905）包括使用导管装置进入心脏的左心室。

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