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    • 2. 发明申请
    • APPARATUS AND METHODS FOR PHOTO-ELECTRIC MEASUREMENT
    • 用于照相电测量的装置和方法
    • WO2004106874A1
    • 2004-12-09
    • PCT/EP2003/005758
    • 2003-06-02
    • SENSOVATION AGHING, Paul, Anthony
    • HING, Paul, Anthony
    • G01J3/28
    • G01J3/2803G01N21/31
    • The invention relates to an apparatus and a method for photo-electric measurement. The apparatus comprises a single or a plurality of photo-electric conversion devices, preferably array sensor(s) such as CCD, CMOS, CID and the like, an optical system which is modularly expandable in one axis or a plurality of axes in order to acquire electromagnetic radiation from a line or area of any desired size on an object, with any desired resolution, wherein the said optical system preferably separates the said electromagnetic radiation modularly into a plurality of smaller segments, and projects electromagnetic radiation corresponding to the said smaller segments onto said single or a plurality of individual photo-electric conversion devices and sensor electronics related to said photo-electric conversion device(s) which enable the operating mode and functionality of said photo-electric conversion device(s) to be defined and changed in real-time, whereby functions such as the readout sequence of pixels and unlimited flexibility of pixel binning in two dimensions are fully programmable, and said photo-electric conversion device(s) may operate and/or be controlled independently and/or simultaneously.
    • 本发明涉及光电测量的装置和方法。 该装置包括单个或多个光电转换装置,优选地诸如CCD,CMOS,CID等的阵列传感器,可以在一个轴或多个轴上模块地展开的光学系统,以便 以任何期望的分辨率从物体上的任何所需尺寸的线或区域获取电磁辐射,其中所述光学系统优选地将所述电磁辐射模块化地分离成多个较小的部分,并且投射对应于所述较小部分的电磁辐射 在与所述光电转换装置相关的所述单个或多个单独的光电转换装置和传感器电子装置上,使得所述光电转换装置的操作模式和功能能够被定义和改变 实时的,像素的读出顺序和二维像素分档的无限灵活性等功能完全是专业的 并且所述光电转换装置可以独立地和/或同时地操作和/或被控制。
    • 4. 发明申请
    • AUTOFOKUSVERFAHREN UND AUTOFOKUSEINRICHTUNG
    • 自动对焦方法及装置自动聚焦
    • WO2010103389A1
    • 2010-09-16
    • PCT/IB2010/000518
    • 2010-03-11
    • SENSOVATION AGHING, PaulHENSLER, Sven
    • HING, PaulHENSLER, Sven
    • G02B21/24
    • G02B21/365G02B7/09G02B21/08G02B21/18G02B21/247
    • Die Erfindung geht aus von einem Autofokus verfahren, bei dem Licht aus einer Lichtquelle (12) in einem Messlichtfokus (52) in einer Probe (6) fokussïert und von dort zurückgeworfen wird und das zurückgeworfene Licht durch ein optisches System (22) in zwei Lichtpfaden (48, 50) auf zumindest zwei Detektorelemente (72, 74) geführt wird. Um eine schnelle und genaue automatische Fokussierung auf die Probe zu erreichen, wird vorgeschlagen, dass der Messlichtfokus (52) in unterschiedlich stark Licht zurückwerfenden Schichten der Probe (6) bewegt wird und die Detektorelemente (72, 74) so angeordnet sind, dass hierbei Verläufe einer von den Detektorelementen (72, 74) registrierten Strahlungseigenschaft unterschiedlich sind und eine Fokusposition in Abhängigkeit von den Verläufen eingestellt wird.
    • 从自动聚焦的方法,其中从样品中的测量光的焦点(52)的光源(12)的光(6)聚焦,并从那里反射,通过光学系统(22)分成两个光路的反射光的本发明进行 (48,50)上的至少两个检测器元件(72,74)中被引导。 为了实现一个快速,准确的自动聚焦到样品上,因此建议测量光焦(52)被移动到不同的程度的光反射回掷样品(6)和所述检测器元件的层(72,74)被布置成使得在此情况下的历史 检测器元件(72,74)中的一个注册辐射特性是不同的,并且响应于该调节级数的焦点位置。
    • 5. 发明申请
    • VERFAHREN ZUM ERFASSEN EINER EIGENSCHAFT MINDESTENS EINES GEGENSTANDS
    • 方法检测性质的至少一个对象
    • WO2004049258A1
    • 2004-06-10
    • PCT/EP2003/012612
    • 2003-11-12
    • SENSOVATION AGBICKERT, StefanGÜNTHER, UlrichHING, PaulWIESER, Jürgen
    • BICKERT, StefanGÜNTHER, UlrichHING, PaulWIESER, Jürgen
    • G06T7/00
    • G06T7/0012G06T7/73G06T2207/30041
    • Die Erfindung geht aus von einem Verfahren zum Erfassen einer Eigenschaft mindestens eines Gegenstands (28, 56, 68,). Es wird vorgeschlagen, dass a) vom Gegenstand (28, 56, 68,) beeinflusste Lichtstrahlung einem Bildsensor (6) zugefüzhrt wird, b) mindestens zwei unterschiedliche aus Pixeln (26) bestehende Teilbilder (32, 34, 36, 48, 78, 90, 94, T 1 , T 2 ) nacheinander aus dem Bildsensor ausgelesen (A ll , A 12 , A 13 , A 21 ) werden und den Pixeln (26) zugeordnete Werte einer Auswerteeinheit (10) zugeführt werden, c) aus den Werten, die einem Teilbild (32, 34, 36, 48, 78, 90, 94, T 1 , T 2 zugeordnet sind, jeweils die Eigenschaft des Gegenstands ermittelt (E 11 , E 12 , E 13 , E 21 ) wird, die Teilbilder (32, 34, 36, 48, 78, 90, 94, T 1 , T 2 ) zu einem Gesamtbild (38) zusammengesetzt werden, das zur weiteren Verarbeitung ausgegeben wird.
    • 本发明涉及一种方法,用于检测至少一个对象(28,56,68)的属性。 建议将一)(从受影响的光辐射下的对象28,56,68,)是zugefüzhrt的图像传感器(6),b)至少两个不同的由像素(26)的子图像(32,34,36,48,78的, 90,94,T1,T2)在从图像传感器连续读出(全部,A12,A13,A21)是与像素(26)分配的值,以评估单元(10)被供给,c)从所述的值(一个图32的部分 ,34,36,48,78,90,94,T1,T2与各测定(E11,E12,E13,E21),则局部图像(32,34,36,48,78,90中的对象的属性的相关联的 是用于进一步处理输出,T2)被放在一起以形成整体图像(38)94,T1 ,.
    • 6. 发明申请
    • IMAGE SENSOR DEVICE, APPARATUS AND METHOD FOR OPTICAL MEASUREMENTS
    • 图像传感器装置,用于光学测量的装置和方法
    • WO0225934A3
    • 2002-12-12
    • PCT/EP0111027
    • 2001-09-24
    • SENSOVATION AGHING PAUL ANTHONY
    • HING PAUL ANTHONY
    • G01J3/02G01J3/28H04N5/335H04N3/15
    • G01J3/02G01J3/0286G01J3/2803H04N5/341H04N5/374H04N5/3765
    • The invention relates to an apparatus and processes for optical measurement and detection with real-time closed-loop controls, which enable higher levels of performance. The invention is especially suitable for applications such as spectroscopy; microscopy; biochemical assays; processes and reactions on miniaturized formats (such as those involving micro-/nano-plates, micro-formats & micro-arrays, chemistry-on-chip, lab-on-chip, micro-channels and micro-fluidics, where dimensions are on micron scale and columes are in the sub-nanoliter range). Such "intelligent sensing" allows higher data quality and reliability, higher measurement and analysis throughput and lower cost. The invention uses fast real-time adaptive digital signal processing and controls directly at the point where data is sensed. Through real-time adaptive control of sensors, chemical/opto-mechanical/opto-electronic processes and other components during the measurement process, consistently higher quality results and higher reliability are achieved. This invention furthermore includes an improved image sensor architecture that enables very intra-array dynamic range at fast frame rates and low noise performance.
    • 本发明涉及一种用于实时闭环控制的光学测量和检测的装置和方法,其实现更高水平的性能。 本发明特别适用于光谱学; 显微镜; 生化测定; 微型化格式的过程和反应(如涉及微/纳米板,微格式和微阵列,片上化学,片上实验室,微通道和微流体学的方法和反应,其尺寸在 微米级和串联在亚纳升范围内)。 这种“智能感应”可以提供更高的数据质量和可靠性,更高的测量和分析吞吐量以及更低的成本。 本发明使用快速实时自适应数字信号处理和直接在数据被感测的位置进行控制。 通过在测量过程中通过传感器,化学/光电机械/光电子工艺和其他部件的实时自适应控制,实现了更高质量的结果和更高的可靠性。 本发明还包括改进的图像传感器架构,其能够以快速帧速率和低噪声性能实现非常阵列内的动态范围。
    • 8. 发明申请
    • DIGITAL MICROSCOPE
    • 数字显微镜
    • WO2012024627A1
    • 2012-02-23
    • PCT/US2011/048488
    • 2011-08-19
    • SAKURA FINETEK U.S.A., INC.HING, PaulROMER, ChristianHENSLER, Sven
    • HING, PaulROMER, ChristianHENSLER, Sven
    • G02B21/36
    • G02B21/367G02B21/361G02B21/365
    • A method and a computer-readable medium containing instructions to perform a method including sensing an image without magnification of a portion of a tissue sample on a substrate with a sensor; displaying the sensed image on a display at a sensor to display pixel ratio greater than one to one; and performing at least one of the following: refreshing the sensed image at a predetermined rate, storing the sensed image, modifying the sensor to display pixel ratio, and sensing a magnified view of an area of the portion of the tissue sample. An apparatus including a digital microscope (150) comprising: at least one image sensor (160); a stage (180) configured to support at least one microscope slide (210); a first optic (168) configured to project an image with a magnification of one or less; a second optic (170) disposed between the at least one sensor and the stage, the second optic configured to project an image with a magnification greater than one; and a light source (195, 196); and a computer (110) coupled to the digital microscope (150) and operable to direct an image capture by the at least one image sensor of a portion of a microslide on the stage projected through the first optic or the second optic.
    • 一种方法和计算机可读介质,其包含用于执行方法的指令,所述方法包括:在传感器的基板上不使组织样本的一部分放大的情况下感测图像; 在传感器的显示器上显示感测图像以显示大于1比1的像素比; 并且执行以下中的至少一个:以预定速率刷新感测到的图像,存储感测图像,修改传感器以显示像素比,以及感测组织样本的该部分区域的放大视图。 一种包括数字显微镜(150)的设备,包括:至少一个图像传感器(160); 构造成支撑至少一个显微镜载玻片(210)的平台(180); 第一光学器件(168),被配置为以一个或更小的放大率投影图像; 设置在所述至少一个传感器和所述台之间的第二光学器件(170),所述第二光学器件被配置为以大于1的倍率投影图像; 和光源(195,196); 以及联接到数字显微镜(150)的计算机(110),并且可操作以将所述至少一个图像传感器引导到通过所述第一光学器件或所述第二光学器件投射的所述台上的微滑块的一部分的图像捕获。
    • 9. 发明申请
    • MICROSCOPE
    • 显微镜
    • WO2006133899A3
    • 2007-03-22
    • PCT/EP2006005665
    • 2006-06-13
    • SENSOVATION AGHING PAULVOGEL MARTINBICKERT STEFAN
    • HING PAULVOGEL MARTINBICKERT STEFAN
    • G02B21/06G01N21/64G02B21/00
    • G02B21/0076G01N21/6458G02B21/06
    • The invention relates to a microscope (2), in particular, a fluorescence analysis microscope, with an illumination support (20) and illumination units (22a, 22b) arranged thereon, for the illumination of a sample region (10), at least two illumination units (22a, 22b) forming a double unit the illumination beams (50a, 50b) of which run together trough a coupling mirror (52). According to the invention, a sample region (10) may be evenly illuminated with a compact device in a simple manner, whereby at least three illumination units (22a, 22b) are arranged on the illumination support (20) for the simultaneous illumination of the sample region (10) from different directions. The microscope has an optical controller (96, 98), comprising optical means (102, 104), the controller comprising at least one optical means provided for reducing a beam spread in the dispersion unit. The optical means has an essentially cylindrical, cylindrical segment, conical or frustum form.
    • 本发明涉及一种显微镜(2),特别是与照明光束(20),进行荧光分析显微镜和布置在其上的照明单元(22A,22B),用于一个样本区域(10)的入射光照明,其特征在于,至少两个照明单元(22A,22B)形成双重单元 其照明光束路径(50A,50B)通过一个耦合镜(52)被合并。 到一个样本区域(10)与以简单的方式紧凑的装置均匀地照射,所以建议至少三个照明单元(22A,22B)被布置用于从所述照明载体(20)上的不同方向上的样品区(10)的同时入射照明。 该显微镜具有光散射单元(96,98),所述光学装置(102,104),其中所述漫射单元包括包含至少,因为它意在减少散射单元的扩束器的光学装置。 该光学装置是大致圆柱形的,气缸段状,圆锥状和/或锥形段形。