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1. 发明申请

WO2008006373A1 SOLID-PHASE DETECTION OF TERMINAL MONOSACCHARIDES CLEAVED FROM GLYCOSYLATED SUBSTRATES 审中-公开
标题翻译：从胶体基质中清除终端单糖的固相检测
公开(公告)号：WO2008006373A1
公开(公告)日：2008-01-17
申请号：PCT/DK2007/000352
申请日：2007-07-10
申请人： CARLSBERG A/S , SØRENSEN, Mads, Detlef , MARTINS, Rita , HINDSGAUL, Ole
发明人： SØRENSEN, Mads, Detlef , MARTINS, Rita , HINDSGAUL, Ole
IPC分类号： G01N33/52 , G01N33/58
CPC分类号： C12Q1/34 , G01N33/543 , G01N33/58 , Y10T436/143333 , Y10T436/144444
摘要： The present invention relates to a novel method for analysing carbohydrates. The invention is in particular useful in detecting a terminal monosaccharide which may be released from a glycosylated substrate for example using an exoglucosidase. After relase from the glycosylated substrate the terminal monosaccharide may be captured on a solid support, incubated with a boronate detection agent and detected by aid of the boronate detection agent. The methods of the invention are useful for a variety of purposes including sequencing of carbohydrates, wherein exoglycosidases with predetermined specificity are employed for the release.
摘要翻译：本发明涉及一种分析碳水化合物的新方法。本发明特别可用于检测可以例如使用外切葡糖苷酶从糖基底物释放的末端单糖。在从糖基化的底物上脱除后，末端单糖可以捕获在固体支持物上，与硼酸盐检测剂一起孵育并通过硼酸盐检测剂的检测。本发明的方法可用于多种目的，包括碳水化合物的测序，其中使用具有预定特异性的exoglycosidases用于释放。

2. 发明授权

EP0875759B1 Methods for screening compound libraries 失效
标题翻译：一种用于筛选化学化合物文库的方法
公开(公告)号：EP0875759B1
公开(公告)日：2006-10-25
申请号：EP98401455.5
申请日：1998-06-15
申请人： Hindsgaul, Ole , Schriemer, David C.
发明人： Hindsgaul, Ole , Schriemer, David C.
IPC分类号： G01N33/68 , G01N33/543 , G01N33/538
CPC分类号： G01N33/6845 , B01J2219/00585 , B01J2219/00704 , B01J2219/00707 , B01J2219/00731 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/12 , C40B40/18 , G01N30/466 , G01N30/7266 , G01N33/538 , G01N33/54306 , G01N33/54366 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N33/6851 , G01N2030/628 , H01J49/00 , H01J49/0036 , Y10T436/24

3. 发明授权

EP0886143B1 Apparatus for screening compound libraries 失效
标题翻译：设备化合物库的研究
公开(公告)号：EP0886143B1
公开(公告)日：2002-03-27
申请号：EP98401525.5
申请日：1998-06-22
申请人： Hindsgaul, Ole , Schriemer, David C.
发明人： Hindsgaul, Ole , Schriemer, David C.
IPC分类号： G01N33/68 , G01N33/543 , G01N33/538
CPC分类号： G01N33/6845 , B01J2219/00585 , B01J2219/00704 , B01J2219/00707 , B01J2219/00731 , B01J2219/00738 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/12 , C40B40/18 , G01N30/466 , G01N30/7266 , G01N33/538 , G01N33/54306 , G01N33/54366 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2030/628 , H01J49/00

4. 发明申请

WO2003051910A2 INHIBITORS OF HEPATITIS C VIRUS PROTEASE 审中-公开
标题翻译：丙型肝炎病毒蛋白酶抑制剂
公开(公告)号：WO2003051910A2
公开(公告)日：2003-06-26
申请号：PCT/CA2002/001929
申请日：2002-12-13
申请人： JOYCE, Michael , WILLIAMS, Mark , HINDSGAUL, Ole , TYRREL, D., Lorne
发明人： JOYCE, Michael , WILLIAMS, Mark , HINDSGAUL, Ole , TYRREL, D., Lorne
IPC分类号： C07K7/04
CPC分类号： C07K7/06 , A61K38/00 , C07K14/005 , C07K14/811 , C12N2770/24222
摘要： The present invention features HCV protease inhibitors, which act by affecting the activity of the HCV protease NS3, or by preventing its activation by NS4A. The invention also features methods of use of the inhibitors of the invention in the treatment of HCV infection in a subject.
摘要翻译：本发明特征在于HCV蛋白酶抑制剂，其通过影响HCV蛋白酶NS3的活性或通过防止NS4A的活化来起作用。本发明还涉及使用本发明抑制剂治疗受试者中HCV感染的方法。

5. 发明申请

WO0008038A3 SOLID PHASE SYNTHESIS OF THIO-OLIGOSACCHARIDES 审中-公开
标题翻译：硫代寡糖的固相合成
公开(公告)号：WO0008038A3
公开(公告)日：2000-06-15
申请号：PCT/CA9900726
申请日：1999-08-06
申请人： SYNSORB BIOTECH INC , HINDSGAUL OLE , HUMMEL GERD
发明人： HINDSGAUL OLE , HUMMEL GERD
IPC分类号： C07H5/10 , C07H15/203
CPC分类号： C07H15/203
摘要： Solid phase synthetic methods of forming sulfur-linked disaccharides and oligosccharides are described, wherein a saccharide or oligosaccharide bearing a protected thiol-group at the anomeric carbon is immobilized onto a solid support at any position other than the anomeric carbon atom of the reducing sugar. The resultant immobilized thiol, or a derivative thereof, undergoes nucleophilic saccharide addition to provide a di- or oligosaccharide.
摘要翻译：描述了形成硫连接的二糖和寡糖的固相合成方法，其中在异头碳上带有受保护的硫醇基的糖或寡糖在除了还原糖的异头碳原子以外的任何位置固定在固体载体上。所得固定化硫醇或其衍生物经历亲核糖加成以提供二糖或寡糖。

6. 发明申请

WO9821222A3 1-GALACTOSE DERIVATIVES 审中-公开
标题翻译： 1-GALACTOSE衍生物
公开(公告)号：WO9821222A3
公开(公告)日：1998-07-16
申请号：PCT/CA9700864
申请日：1997-11-14
申请人： SYNSORB BIOTECH INC , HINDSGAUL OLE
发明人： HINDSGAUL OLE
IPC分类号： C07H15/14 , A61K31/7028 , A61K31/7034 , A61P31/04 , A61P43/00 , C07H5/10 , C07H15/18 , C07H15/20 , C07H15/203 , C07H15/22 , C40B40/12 , C07H15/00
CPC分类号： C07H5/10 , B01J2219/00731 , C07H15/18 , C07H15/203 , C40B40/12
摘要： Disclosed are novel 1-galactose derivatives which inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. Additionally disclosed are compounds which inhibit binding of enterovirulent organisms (e.g., bacteria, virus, fungi, and the like), such as Vibrio cholerae and enterotoxigenic strains of Escherichia coli, to their cell surface receptors. 00000
摘要翻译：公开了新颖的1-半乳糖衍生物，其在体外或体内抑制毒素如热不稳定肠毒素或霍乱毒素与其受体的结合。另外公开了抑制肠病毒生物体（例如细菌，病毒，真菌等）如霍乱弧菌和大肠杆菌肠毒素毒株与其细胞表面受体的结合的化合物。 00000

7. 发明申请

WO2006084461A1 SOLID-PHASE OLIGOSACCHARIDE TAGGING: A TECHNIQUE FOR MANIPULATION OF IMMOBILIZED CARBOHYDRATES 审中-公开
标题翻译：固相低密度脂蛋白标签：用于操纵固定化碳酸氢盐的技术
公开(公告)号：WO2006084461A1
公开(公告)日：2006-08-17
申请号：PCT/DK2006/000066
申请日：2006-02-08
申请人： CARLSBERG A/S , LOHSE, Anders , JØRGENSEN, Malene Ryborg , MARTINS, Rita , HINDSGAUL, Ole
发明人： LOHSE, Anders , JØRGENSEN, Malene Ryborg , MARTINS, Rita , HINDSGAUL, Ole
IPC分类号： G01N33/543
CPC分类号： G01N33/6842 , G01N33/54353 , G01N33/6803 , Y10T436/145555 , Y10T436/24
摘要： The invention relates to methods of manipulating immobilised carbohydrates by de-rivatisation. Depending on the nature of the derivatisation, the carbohydrate may thereby be more easily detected and/or identified or handled. In particular, the inven-tion relates to methods of preparing a reactive sugar comprising the steps of: i) pro-viding a sample comprising a reducing sugar; ii) providing a solid support covalently attached to a linker comprising a capture group comprising an -NH2 group, wherein said linker optionally is attached to said solid support via a spacer; iii) reacting said reducing sugar with said -NH2 group, thereby obtaining an immobilised sugar; iv) reacting free -NH2 groups with a capping agent, wherein the capping agent com-prises a reactive group capable of reacting with an -NH2 group; and v) reducing C=N bonds with a reducing agent, thereby obtaining an reactive sugar of the struc-ture SugarCHn-NH- linked to a solid support via a linker and optionally a spacer, wherein n is 1 or 2.
摘要翻译：本发明涉及通过脱核化来操作固定的碳水化合物的方法。根据衍生化的性质，可以更容易地检测和/或识别或处理碳水化合物。特别地，本发明涉及制备反应性糖的方法，包括以下步骤：i）预处理包含还原糖的样品; ii）提供共价连接到包含-NH 2基团的捕获基团的接头的固体支持物，其中所述接头任选地经由间隔子连接到所述固体支持物上; iii）使所述还原糖与所述-NH 2基团反应，从而获得固定的糖; iv）使游离-NH 2基团与封端剂反应，其中封端剂包含能够与-NH 2基团反应的反应性基团; 和v）用还原剂还原C = N键，从而通过接头和任选的间隔基获得与固体支持物连接的结构糖基-NH-的反应性糖，其中n为1或2。

8. 发明申请

WO9718222A9 NOVEL OLIGOSACCHARIDE GLYCOSIDES HAVING MAMMALIAN IMMUNOSUPPRESSIVE AND TOLEROGENIC PROPERTIES 审中-公开
标题翻译：具有马马里兰免疫抑制和耐热性的新型低聚糖苷
公开(公告)号：WO9718222A9
公开(公告)日：1999-07-01
申请号：PCT/US9618831
申请日：1996-11-13
申请人： GLYCOMED INC , SRIVASTAVA OM P , SRIVASTAVA GEETA , SZWEDA ROMAN , BUNDLE DAVID R , HINDSGAUL OLE , HANNA H RIZK , HOLME KEVIN , BARRESI FRANK W , MINGHUI DU
发明人： SRIVASTAVA OM P , SRIVASTAVA GEETA , SZWEDA ROMAN , BUNDLE DAVID R , HINDSGAUL OLE , HANNA H RIZK , HOLME KEVIN , BARRESI FRANK W , DU MINGHUI
IPC分类号： C07H3/04 , C07H3/06 , C07H9/02 , C07H15/00 , C07H15/04 , C07H15/18 , C07H15/203
CPC分类号： C07H3/04 , C07H3/06 , C07H9/02 , C07H15/00
摘要： Disclosed are novel oligosaccharide glycosides having mammalian immunosuppressive and tolerogenic properties, pharmaceutical compositions containing such oligosaccharide glycosides and methods of using such oligosaccharide glycosides to modulate cell-mediated immune responses in a mammal.
摘要翻译：公开了具有哺乳动物免疫抑制和耐受性的新型寡糖糖苷，含有这种寡糖糖苷的药物组合物和使用这种寡糖糖苷调节哺乳动物细胞介导的免疫应答的方法。

9. 发明申请

WO9821220A3 SACCHARIDE DERIVATIVES 审中-公开
标题翻译： SACCHARIDE衍生物
公开(公告)号：WO9821220A3
公开(公告)日：1998-08-06
申请号：PCT/CA9700862
申请日：1997-11-14
申请人： SYNSORB BIOTECH INC , HINDSGAUL OLE
发明人： HINDSGAUL OLE
IPC分类号： C07H15/14 , A61K31/7028 , A61K31/7034 , A61P31/04 , A61P43/00 , C07H5/10 , C07H15/18 , C07H15/20 , C07H15/203 , C07H15/22 , C40B40/12 , C07H15/00
CPC分类号： C07H5/10 , B01J2219/00731 , C07H15/18 , C07H15/203 , C40B40/12
摘要： Disclosed are novel saccharide derivatives which inhibit binding of toxins, such as heat-labile enterotoxin or cholera toxin, to their receptors either in vitro or in vivo. Additionally, disclosed are compounds which inhibit binding of enterovirulent organisms (e.g., bacteria, virus, fungi, and the like), such as Vibrio cholerae and enterotoxigenic strains of Escherichia coli, to their cell surface receptors. 00000
摘要翻译：公开了在体外或体内抑制毒素如热不稳定肠毒素或霍乱毒素与其受体结合的新型糖衍生物。此外，公开了抑制肠病毒生物体（例如细菌，病毒，真菌等）如霍乱弧菌和大肠杆菌肠毒素毒株与其细胞表面受体的结合的化合物。 00000

10. 发明申请

WO1998022487A1 COMBINATORIAL SYNTHESIS OF CARBOHYDRATE LIBRARIES 审中-公开
标题翻译：碳水化合物库的组合合成
公开(公告)号：WO1998022487A1
公开(公告)日：1998-05-28
申请号：PCT/CA1997000866
申请日：1997-11-14
申请人： SYNSORB BIOTECH, INC. , HINDSGAUL, Ole
发明人： SYNSORB BIOTECH, INC.
IPC分类号： C07H05/10
CPC分类号： C07H5/10 , B01J2219/00731 , C07B2200/11 , C07H15/18 , C07H15/203 , C40B40/12
摘要： Disclosed are methods for synthesizing very large collections of diverse thiosaccharide derivatives optionally attached to a solid support. Also disclosed are libraries of diverse thiosaccharide derivatives.
摘要翻译：公开了用于合成非常大的不同硫代衍生物衍生物的方法，任选地连接到固体支持物上。还公开了多种硫代糖衍生物的文库。

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