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1. 发明专利

JP2007530438A Anti-cr1 antibody and compositions to reduce the immunogenicity and treatment method based on it 审中-公开
公开(公告)号：JP2007530438A
公开(公告)日：2007-11-01
申请号：JP2006532353
申请日：2004-03-29
申请人：ヒマワン, ジェフHimawan, Jeff
发明人：フランシス，ジェイ．カー， , アニタ，エー．ハミルトン， , ジェフヒマワン，
IPC分类号： C07K16/18 , A61K20060101 , A61K39/395 , A61P7/08 , A61P39/02 , C07K16/28 , C07K16/46 , C12N5/10 , C12N15/09 , C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/31
摘要：本発明は、ヒトCR1受容体に結合する免疫原性を低下させた抗体又は抗体フラグメントを提供するものである。本発明の免疫原性を低下させた抗CR1抗体は、当該の免疫原性を低下させた抗体がヒトにとって非免疫原性であるか、又は免疫原性が低くなるように、一つ以上のアミノ酸置換を含むように改変された一つ以上の非ヒト配列を含む。更に、本発明は、このような免疫原性を低下させた抗CR1抗体と、病原体に結合する抗原認識部分とを含む二重特異的分子も提供するものである。更に本発明は、血液由来免疫原性病原体により引き起こされる疾患又は異常の、本発明の二重特異的分子を用いた治療のための方法及び組成物も提供するものである。

2. 发明专利

CA2520224A1 IMMUNOGENICITY-REDUCED ANTI-CR1 ANTIBODY AND COMPOSITIONS AND METHODS OF TREATMENT BASED THEREON 未知
公开(公告)号：CA2520224A1
公开(公告)日：2005-01-13
申请号：CA2520224
申请日：2004-03-29
申请人： HIMAWAN JEFF
发明人： CARR FRANCIS J , HAMILTON ANITA A , HIMAWAN JEFF
IPC分类号： A61K20060101 , C07K16/28 , C12P21/08
摘要： The invention provides immunogenicity-reduced antibodies or antibody fragmen ts that bind a human CR1 receptor. The immunogenicity-reduced anti-CR1 antibody of the invention comprises one or more non-human sequences modified to comprise one or more amino acid substitutions so that the immunogenicity- reduced antibody id non-immunogenic or less immunogenic to a human. The invention also provides bispecific molecules comprising such an immunogenici ty- reduced anti-CR1 antibody and an antigen-recognition portion that binds a pathogen. The invention further provides methods and compositions for the treatment of diseases or disorders caused by a blood-borne immunogenic pathogen using the bispecific molecule of the invention.

3. 发明公开

EP1616020A2 IMMUNOGENICITY-REDUCED ANTI-CR1 ANTIBODY AND COMPOSITIONS AND METHODS OF TREATMENT BASED THEREON 审中-公开
标题翻译：免疫原性降低和基于事实的组合物和治疗方法的抗CR1抗体
公开(公告)号：EP1616020A2
公开(公告)日：2006-01-18
申请号：EP04775855.2
申请日：2004-03-29
申请人： HIMAWAN, Jeff
发明人： HIMAWAN, Jeff , HAMILTON, Anita, A. , CARR, Francis J.
IPC分类号： C12P21/08 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/31
摘要： The invention provides immunogenicity-reduced antibodies or antibody fragments that bind a human CR1 receptor. The immunogenicity-reduced anti-CR1 antibody of the invention comprises one or more non-human sequences modified to comprise one or more amino acid substitutions so that the immunogenicity-reduced antibody id non-immunogenic or less immunogenic to a human. The invention also provides bispecific molecules comprising such an immunogenicity-reduced anti-CR1 antibody and an antigen-recognition portion that binds a pathogen. The invention further provides methods and compositions for the treatment of diseases or disorders caused by a blood-borne immunogenic pathogen using the bispecific molecule of the invention.

4. 发明公开

EP1616020A4 IMMUNOGENICITY-REDUCED ANTI-CR1 ANTIBODY AND COMPOSITIONS AND METHODS OF TREATMENT BASED THEREON 审中-公开
标题翻译：具有降低的免疫原性的抗CR1抗体和组合物以及基于它们的治疗方法
公开(公告)号：EP1616020A4
公开(公告)日：2006-12-27
申请号：EP04775855
申请日：2004-03-29
申请人： HIMAWAN JEFF
发明人： HIMAWAN JEFF , HAMILTON ANITA A , CARR FRANCIS J
IPC分类号： C07K16/28 , A61K20060101 , C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/31

5. 发明申请

WO2002075275A2 POLYCLONAL POPULATIONS OF BISPECIFIC MOLECULES AND METHODS OF PRODUCTION AND USES THEREOF 审中-公开
标题翻译：双相分子的聚合物及其生产方法及其用途
公开(公告)号：WO2002075275A2
公开(公告)日：2002-09-26
申请号：PCT/US2002/007950
申请日：2002-03-14
申请人： ELUSYS THERAPEUTICS, INC. , HIMAWAN, Jeff
发明人： HIMAWAN, Jeff
IPC分类号： G01N
CPC分类号： C07K16/1045 , A61K47/6849 , A61K47/6879 , A61K2039/505 , A61K2039/515 , C07K16/2896 , C07K2317/31
摘要： The invention relates to a polyclonal population of bispecific molecules which comprises a plurality of different bispecific molecules, each comprising a first antigen recognition portion that binds a C3b-like receptor cross-linked to a different second antigen recognition portion that binds a pathogenic antigenic molecule such that the plurality of different bispecific molecules have different second antigen recognition portions with different recognition specificities, such as with recognition specificities directed to different epitopes and/or different variants of a pathogen and/or to different pathogens. The invention also relates to methods of producing such polyclonal population of bispecific molecules. The invention further relates to methods of using such polyclonal population of bispecific molecules for the clearance of pathogens from the circulatory system of a mammal.
摘要翻译：本发明涉及双特异性分子的多克隆群体，其包含多个不同的双特异性分子，每个特异性分子包含第一抗原识别部分，其结合与结合病原性抗原分子的不同第二抗原识别部分交联的C3b样受体，多种不同的双特异性分子具有不同的识别特异性的不同的第二抗原识别部分，例如具有针对病原体和/或不同病原体的不同表位和/或不同变体的识别特异性。本发明还涉及产生双特异性分子多克隆群体的方法。本发明还涉及使用双特异性分子的多克隆群体来清除哺乳动物的循环系统的病原体的方法。

6. 发明申请

WO0246208A3 METHOD OF PRODUCING BIOSPECIFIC MOLECULES BY PROTEIN TRANS-SPLICING 审中-公开
标题翻译：通过蛋白质翻译产生生物特异性分子的方法
公开(公告)号：WO0246208A3
公开(公告)日：2002-08-08
申请号：PCT/US0145653
申请日：2001-11-01
申请人： ELUSYS THERAPEUTICS INC , HIMAWAN JEFF
发明人： HIMAWAN JEFF
IPC分类号： C12N15/09 , A61K39/395 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/18 , A61P33/00 , A61P33/02 , A61P37/06 , A61P39/02 , C07K14/35 , C07K14/735 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/62 , C12P21/02 , C12P21/08 , A61K48/00 , C12N9/00 , C12P21/06
CPC分类号： C07K14/70535 , A61K2039/505 , C07K16/283 , C07K16/2896 , C07K16/468 , C07K2317/31 , C07K2317/52 , C07K2319/22 , C07K2319/30 , C07K2319/92 , C12N15/62
摘要： The invention provides methods of using protein trans-splicing for the production of bispecific molecule which has a first antigen recognition portion that binds a C3b-like receptor and a second antigen recognition portion that binds an antigenic molecule present in the circulatory system of a mammal. The invention also provides bispecific molecules produced by protein trans-splicing. The bispecific molecules of the invention can be used for the clearance of pathogenic antigenic molecules from the circulatory system of a mammal. The invention further provides methods of using protein trans-splicing for the production of poylclonal libraries of bispecific molecules, which comprise populations of bispecific molecules with different antigen recognition specificities. Such polyclonal libraries of bispecific molecules can be used for targeting multiple epitopes of a pathogenic antigenic molecule and/or multiple variants of a pathogenic antigenic molecule.
摘要翻译：本发明提供了使用蛋白质剪接来产生双特异性分子的方法，所述双特异性分子具有结合C3b样受体的第一抗原识别部分和结合存在于哺乳动物循环系统中的抗原性分子的第二抗原识别部分。本发明还提供了通过蛋白质反式剪接产生的双特异性分子。本发明的双特异性分子可用于从哺乳动物的循环系统中清除致病抗原性分子。本发明进一步提供了使用蛋白质剪接来产生双特异性分子的多克隆文库的方法，所述多克隆文库包含具有不同抗原识别特异性的双特异性分子群体。双特异性分子的这种多克隆文库可以用于靶向致病性抗原性分子的多个表位和/或致病性抗原性分子的多个变体。

7. 发明申请

WO2005002529A2 IMMUNOGENICITY-REDUCED ANTI-CR1 ANTIBODY AND COMPOSITIONS AND METHODS OF TREATMENT BASED THEREON 审中-公开
标题翻译：免疫原性降低的抗CR1抗体及其组合物和基于其治疗的方法
公开(公告)号：WO2005002529A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/009622
申请日：2004-03-29
申请人： HIMAWAN, Jeff , HAMILTON, Anita, A. , CARR, Francis, J.
发明人： HIMAWAN, Jeff , HAMILTON, Anita, A. , CARR, Francis, J.
IPC分类号： A61K
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/31
摘要： The invention provides immunogenicity-reduced antibodies or antibody fragments that bind a human CR1 receptor. The immunogenicity-reduced anti-CR1 antibody of the invention comprises one or more non-human sequences modified to comprise one or more amino acid substitutions so that the immunogenicity-reduced antibody id non-immunogenic or less immunogenic to a human. The invention also provides bispecific molecules comprising such an immunogenicity-reduced anti-CR1 antibody and an antigen-recognition portion that binds a pathogen. The invention further provides methods and compositions for the treatment of diseases or disorders caused by a blood-borne immunogenic pathogen using the bispecific molecule of the invention.
摘要翻译：本发明提供了结合人CR1受体的免疫原性降低的抗体或抗体片段。本发明的免疫原性降低的抗CR1抗体包含经修饰以包含一个或多个氨基酸取代的一个或多个非人序列，使得免疫原性降低的抗体对人非免疫原性或免疫原性较低。本发明还提供了包含这种免疫原性降低的抗CR1抗体和结合病原体的抗原识别部分的双特异性分子。本发明进一步提供了使用本发明的双特异性分子治疗由血源免疫原性病原体引起的疾病或病症的方法和组合物。

8. 发明申请

WO2005002529A3 IMMUNOGENICITY-REDUCED ANTI-CR1 ANTIBODY AND COMPOSITIONS AND METHODS OF TREATMENT BASED THEREON 审中-公开
标题翻译：免疫原性降低的抗CR1抗体及其组合物及其治疗方法
公开(公告)号：WO2005002529A3
公开(公告)日：2005-06-30
申请号：PCT/US2004009622
申请日：2004-03-29
申请人： HIMAWAN JEFF , HAMILTON ANITA A , CARR FRANCIS J
发明人： HIMAWAN JEFF , HAMILTON ANITA A , CARR FRANCIS J
IPC分类号： A61K20060101 , C07K16/28 , C12P21/08
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/24 , C07K2317/31
摘要： The invention provides immunogenicity-reduced antibodies or antibody fragments that bind a human CR1 receptor. The immunogenicity-reduced anti-CR1 antibody of the invention comprises one or more non-human sequences modified to comprise one or more amino acid substitutions so that the immunogenicity-reduced antibody id non-immunogenic or less immunogenic to a human. The invention also provides bispecific molecules comprising such an immunogenicity-reduced anti-CR1 antibody and an antigen-recognition portion that binds a pathogen. The invention further provides methods and compositions for the treatment of diseases or disorders caused by a blood-borne immunogenic pathogen using the bispecific molecule of the invention.
摘要翻译：本发明提供结合人CR1受体的免疫原性降低的抗体或抗体片段。本发明的免疫原性降低的抗CR1抗体包含一个或多个修饰为包含一个或多个氨基酸取代的非人序列，使得免疫原性降低的抗体id对人免疫原性较小或免疫原性较小。本发明还提供了包含这种免疫原性降低的抗CR1抗体和结合病原体的抗原识别部分的双特异性分子。本发明还提供了用于治疗由使用本发明的双特异性分子的血源性免疫原性病原体引起的疾病或病症的方法和组合物。

9. 发明申请

WO02075275A3 POLYCLONAL POPULATIONS OF BISPECIFIC MOLECULES AND METHODS OF PRODUCTION AND USES THEREOF 审中-公开
标题翻译：双相分子的聚合物及其生产方法及其用途
公开(公告)号：WO02075275A3
公开(公告)日：2003-03-13
申请号：PCT/US0207950
申请日：2002-03-14
申请人： ELUSYS THERAPEUTICS INC , HIMAWAN JEFF
发明人： HIMAWAN JEFF
IPC分类号： C12N15/09 , A61K39/395 , A61K47/48 , C07K16/00 , C07K16/10 , C07K16/28 , C12N5/06 , C12P21/08 , A61K39/40 , A61K39/42 , A61K39/44 , C12N5/16 , C12Q1/68 , G01N33/53
CPC分类号： C07K16/1045 , A61K47/6849 , A61K47/6879 , A61K2039/505 , A61K2039/515 , C07K16/2896 , C07K2317/31
摘要： The invention relates to a polyclonal population of bispecific molecules which comprises a plurality of different bispecific molecules, each comprising a first antigen recognition portion that binds a C3b-like receptor cross-linked to a different second antigen recognition portion that binds a pathogenic antigenic molecule such that the plurality of different bispecific molecules have different second antigen recognition portions with different recognition specificities, such as with recognition specificities directed to different epitopes and/or different variants of a pathogen and/or to different pathogens. The invention also relates to methods of producing such polyclonal population of bispecific molecules. The invention further relates to methods of using such polyclonal population of bispecific molecules for the clearance of pathogens from the circulatory system of a mammal.
摘要翻译：本发明涉及双特异性分子的多克隆群体，其包含多个不同的双特异性分子，每个特异性分子包含第一抗原识别部分，其结合与结合病原性抗原分子的不同第二抗原识别部分交联的C3b样受体，多种不同的双特异性分子具有不同的识别特异性的不同的第二抗原识别部分，例如具有针对病原体和/或不同病原体的不同表位和/或不同变体的识别特异性。本发明还涉及产生双特异性分子多克隆群体的方法。本发明还涉及使用双特异性分子的多克隆群体来清除哺乳动物的循环系统的病原体的方法。

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