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1. 发明公开

EP1713456A1 RECTAL COMPOSITION 审中-公开
标题翻译：直肠组成
公开(公告)号：EP1713456A1
公开(公告)日：2006-10-25
申请号：EP05704798.7
申请日：2005-02-04
申请人： LTP Lipid Technologies Provider AB , Herslöf, Bengt
发明人： CARLSSON, Anders , BOGENTOFT, Conny
IPC分类号： A61K31/00 , A61P1/00
CPC分类号： A61K9/0031 , A61K31/047 , A61K31/485 , A61K31/5513 , A61K31/60 , A61K31/655 , A61K2300/00
摘要： A viscous or gellous pharmaceutical composition for the treatment of constipation by rectal administration comprises a polar lipid component, a polyvalent alcohol component, water, and optionally an oily triglyceride. Also disclosed is a compressible device filled with a single dose of the composition and a method for its manufacture; a method of treating constipation, comprising rectal administration of a constipation-dissolving amount of the composition; and a method of manufacture of a medicament for treating constipation comprising the composition of the invention.

2. 发明申请

WO2007032727A1 PARTICULATE LIPID PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：颗粒脂肪制药组合物
公开(公告)号：WO2007032727A1
公开(公告)日：2007-03-22
申请号：PCT/SE2006/001033
申请日：2006-09-11
申请人： GALENICA TECHNOLOGY AB , HERSLÖF, Bengt , TINGVALL, Per , KORNFELDT, Anna
发明人： HERSLÖF, Bengt , TINGVALL, Per , KORNFELDT, Anna
IPC分类号： A61K47/44 , A61K9/107 , A61K47/04 , A61K47/36 , A61K9/20 , A61K9/48
CPC分类号： A61K9/1617 , A61K9/0095 , A61K9/107 , A61K9/1075 , A61K9/1611 , A61K9/1652
摘要： A particulate lipid pharmaceutical composition comprises a particulate solid non-lipid carrier and an oil-in-water emulsion on the carrier. The emulsion comprises a dissolved or dispersed pharmacologically active agent. The oil-in-water emulsion is released from the carrier on contact with an aqueous media to form an oil-in-water emulsion in the media. Also disclosed is a method of producing the composition and a tablet containing it; sachets and capsules filled with the composition; use of the composition and the tablet as a medicine; a method of administering the composition to a patient.
摘要翻译：颗粒状脂质药物组合物包含载体上的颗粒固体非脂质载体和水包油乳剂。乳液包含溶解或分散的药理活性剂。水包油乳液在与水性介质接触时从载体中释放，以在介质中形成水包油乳液。还公开了制备该组合物的方法和含有它的片剂; 小袋和胶囊充满组成; 使用组合物和片剂作为药物; 将组合物给予患者的方法。

3. 发明申请

WO1995020943A1 OIL-IN-WATER EMULSIONS 审中-公开
标题翻译：水包油乳液
公开(公告)号：WO1995020943A1
公开(公告)日：1995-08-10
申请号：PCT/SE1995000115
申请日：1995-02-06
申请人： KARLSHAMNS LIPIDTEKNIK AB , CARLSSON, Anders , DELOGU, Marina , HERSLÖF, Bengt
发明人： KARLSHAMNS LIPIDTEKNIK AB
IPC分类号： A61K09/127
CPC分类号： A61K47/26 , A23D7/0053 , A23L33/12 , A23L35/00 , A61K8/062 , A61K8/14 , A61K8/60 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1272 , A61Q19/00 , Y10S436/829 , Y10S514/963 , Y10S514/965 , Y10S514/966 , Y10S514/974 , Y10T428/2984
摘要： The invention relates to an oil-in-water emulsion comprising 0.01-50 % by weight of the total preparation, preferably 0.1-10 %, of a galactolipid material as an emulsifier. The galactolipid material consists of at least 50 % digalactosyldiacylglycerols, the remainder being other polar lipids. The said emulsion is suitable as a carrier for one or more active substances in a pharmaceutical composition, but also in nutritional, cosmetical, food and agricultural products.
摘要翻译：本发明涉及包含0.01-50重量％的总制剂，优选0.1-10％的作为乳化剂的半乳糖脂材料的水包油乳液。半乳糖脂材料由至少50％的半乳糖基二酰基甘油组成，其余为其它极性脂质。所述乳液适合作为药物组合物中一种或多种活性物质的载体，也适用于营养，美容，食品和农产品中。

4. 发明申请

WO1992005771A1 LIPID FORMULATION SYSTEM 审中-公开
标题翻译：脂质配方体系
公开(公告)号：WO1992005771A1
公开(公告)日：1992-04-16
申请号：PCT/SE1991000639
申请日：1991-09-24
申请人： KABI PHARMACIA AB , HERSLÖF, Bengt , NICKLASSON, Martin
发明人： KABI PHARMACIA AB
IPC分类号： A61K09/127
CPC分类号： A61K9/1272 , A61K8/14 , A61K8/375 , A61K8/553 , A61K9/1271 , A61K9/1274 , A61K9/1617 , A61Q19/00
摘要： The invention relates to a lipid particle forming matrix, characterized by, that from a defined system of at least two lipid components chosen from classes of different polarity, in which at least one of the lipid components is bilayer forming, discrete lipid particles are formed spontaneously when interacting with aqueous systems. Preferably at least one of the lipid components is amphiphatic and polar and one is nonpolar. These discrete particles are formed spontaneously from the matrix without any chemical or physical treatment or initiation. The lipid particle forming matrix can contain bioactive materials, chosen from the group of drugs, herbicides, pesticides, fertilizers, food and cosmetic ingredients or additives. The invention also relates to a process for the production of the matrix, the use of the lipid particle forming matrix as a carrier system for bioactive materials and pharmaceutical composition such as oral, rectal, nasal, vaginal, ocular or parenteral vehicles, creams, ointments, capsules and tablets containing the said lipid particle forming matrix and a drug.
摘要翻译：本发明涉及形成脂质颗粒的基质，其特征在于，从至少两种选自不同极性类别的脂质组分的确定体系中，其中至少一种脂质组分是双层形成的，离散的脂质颗粒自发形成当与含水体系相互作用时。优选地，脂质组分中的至少一种是双脂族和极性的，一个是非极性的。这些离散的颗粒是从基质自发形成的，没有任何化学或物理的处理或引发。脂质颗粒形成基质可以含有选自药物，除草剂，杀虫剂，肥料，食品和化妆品成分或添加剂的生物活性物质。本发明还涉及生产基质的方法，使用脂质形成基质作为生物活性物质的载体体系和药物组合物如口服，直肠，鼻，阴道，眼或肠胃外的赋形剂，霜剂，软膏，含有所述脂质形成基质的胶囊和片剂和药物。

5. 发明申请

WO2012150892A1 TREATMENT OF PSORIASIS 审中-公开
标题翻译：治疗PSORIASIS
公开(公告)号：WO2012150892A1
公开(公告)日：2012-11-08
申请号：PCT/SE2012/000061
申请日：2012-04-30
申请人： LIPIDOR AB , CARLSSON, Anders , HERSLÖF, Bengt , HOLMBÄCK, Jan
发明人： CARLSSON, Anders , HERSLÖF, Bengt , HOLMBÄCK, Jan
IPC分类号： A61K47/24 , A61K31/573 , A61K31/593 , A61P17/06 , A61K8/58
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/12 , A61K9/7015 , A61K31/56 , A61K31/573 , A61K31/575 , A61K31/593
摘要： A lipid layer forming composition for topical treatment of psoriasis comprises volatile silicone oil, polar lipid, C 2 - C 4 aliphatic alcohol, and a pharmacologically effective amount of an agent for the treatment of psoriasis, wherein the silicone oil has a boiling point above 180 °C, in particular above 200 °C. The composition does not comprise polymer silicone. Also disclosed are corresponding methods of treatment and of manufacture of the composition.
摘要翻译：用于局部治疗牛皮癣的脂质层形成组合物包括挥发性硅油，极性脂质，C 2 -C 4脂族醇和药理学有效量的用于治疗牛皮癣的药剂，其中所述硅油的沸点高于180℃ ，特别是高于200℃。组合物不包含聚合物硅氧烷。还公开了相应的组合物的处理和制造方法。

6. 发明申请

WO2012144943A1 LIQUID CARRIER FOR ORAL DELIVERY OF A PHARMACOLOGICALLY ACTIVE AGENT 审中-公开
标题翻译：液体载体用于口服递送药物活性剂
公开(公告)号：WO2012144943A1
公开(公告)日：2012-10-26
申请号：PCT/SE2012/000054
申请日：2012-04-20
申请人： LIPIDOR AB , CARLSSON, Anders , HERSLÖF, Bengt , HOLMBÄCK, Jan
发明人： CARLSSON, Anders , HERSLÖF, Bengt , HOLMBÄCK, Jan
IPC分类号： A61K47/44 , A61K9/10
CPC分类号： A61K47/44 , A61K9/10 , A61K9/2013 , A61K9/2036 , A61K9/4858 , A61K9/4866
摘要： A fluid carrier comprises first and second substantially immiscible liquids. The first liquid is an open-chain silicone oil of the formula [(CH 3 ) 3 Si-O]-[(CH 2 ) 2 Si-O] n -[Si(CH 3 ) 3 ]. The second liquid is a polar lipid material. The first and second liquids are capable of forming an unstable dispersion. The unstable dispersion can be stabilized by adding a powderous solid insoluble in the liquids. The powderous solid is selected from pharmacologically active agent, pharmaceutical excipient, and their mixtures. The stabilized dispersion is of a creamy or ointment-like or mouldable form, and can be filled into capsules or moulded into tablets so as to be fit for peroral administration.
摘要翻译：流体载体包括第一和第二基本上不混溶的液体。第一种液体是式[（CH3）3Si-O] - [（CH2）2Si-O] n- [Si（CH3）3]的开链硅油。第二种液体是极性脂质物质。第一和第二液体能够形成不稳定的分散体。通过添加不溶于液体的粉末状固体可以稳定不稳定的分散体。粉状固体选自药理活性剂，药物赋形剂及其混合物。稳定的分散体是乳状或软膏状或可模制的形式，并且可以填充到胶囊中或模制成片剂以适合于口服给药。

7. 发明申请

WO2009144268A1 COMPOSITION FOR INCREASING GASTROINTESTINAL TRANSIT TIME 审中-公开
标题翻译：用于增加气体运输时间的组合物
公开(公告)号：WO2009144268A1
公开(公告)日：2009-12-03
申请号：PCT/EP2009/056523
申请日：2009-05-28
申请人： DSM IP Assets B.V. , VIBERG, Annika , HERSLÖF, Bengt
发明人： VIBERG, Annika , HERSLÖF, Bengt
IPC分类号： A61K31/23 , A61K31/231 , A61K31/7032 , A23L1/30 , A61K45/06 , A61P3/04
CPC分类号： A23D7/011 , A23L33/115 , A23L33/40 , A23V2002/00 , A23V2200/332 , A23V2250/186
摘要： Use of a mixture comprising a triglyceride oil and an emulsifier for increasing the transit time of a foodstuff through the gastro-intestinal tract of an individual, which foodstuff is consumed concomitantly with or subsequent to administration of the mixture.
摘要翻译：使用包含甘油三酯油和乳化剂的混合物用于增加食物通过个体的胃肠道的通过时间，该食物与该混合物的施用相伴或随后消耗。

8. 发明申请

WO1995020945A1 LIPOPHILIC CARRIER PREPARATIONS 审中-公开
标题翻译：离子载体制备
公开(公告)号：WO1995020945A1
公开(公告)日：1995-08-10
申请号：PCT/SE1995000117
申请日：1995-02-06
申请人： KARLSHAMNS LIPIDTEKNIK AB , CARLSSON, Anders , HERSLÖF, Bengt
发明人： KARLSHAMNS LIPIDTEKNIK AB
IPC分类号： A61K09/127
CPC分类号： A61K8/064 , A23D7/0053 , A23L33/12 , A23L35/00 , A61K8/14 , A61K8/60 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1272 , A61K47/26 , A61Q19/00
摘要： The invention relates to a lipophilic carrier preparation having a continuous lipid phase, comprising a polar lipid material in combination with a non-polar lipid, and optionally a polar solvent, wherein the polar lipid material is a galacto-lipid material. The invention also relates to the use of said lipophilic carrier preparation as a carrier for an active substance in a pharmaceutical composition, but also in nutritional, cosmetical and food products, as well as to a pharmaceutical composition.
摘要翻译：本发明涉及具有连续脂质相的亲脂性载体制剂，其包含与非极性脂质和任选的极性溶剂组合的极性脂质材料，其中极性脂质材料是半乳糖 - 脂质材料。本发明还涉及所述亲脂性载体制剂作为药物组合物中的活性物质的载体，还涉及营养，化妆品和食品以及药物组合物的用途。

9. 发明申请

WO2012150891A1 COMPOSITION FOR ADMINISTRATION OF A PHARMACOLOGICALLY OR COSMETICALLY ACTIVE AGENT ONTO A SURFACE OF A LIVING ORGANISM 审中-公开
标题翻译：将药物或化学活性剂施用于生活有机体的表面的组合物
公开(公告)号：WO2012150891A1
公开(公告)日：2012-11-08
申请号：PCT/SE2012/000060
申请日：2012-04-30
申请人： LIPIDOR AB , CARLSSON, Anders , HERSLÖF, Bengt , HOLMBÄCK, Jan
发明人： CARLSSON, Anders , HERSLÖF, Bengt , HOLMBÄCK, Jan
IPC分类号： A61K47/24 , A01N25/02 , A61K8/58
CPC分类号： A61K47/24 , A01N25/02 , A61K8/34 , A61K8/585 , A61K9/0014 , A61K9/08 , A61Q17/02 , A01N37/18
摘要： A composition for topical administration comprises a volatile silicone oil of a boiling point above 180 °C, a pharmacologically or cosmetically active agent, and optionally a C 2 - C 4 aliphatic alcohol but which neither comprises lipid nor polymer silicone. The composition can be applied to a biological surface by spraying, dipping or brushing to form a layer of active agent on the surface. Also disclosed is a method of manufacture of the composition.
摘要翻译：用于局部给药的组合物包含沸点高于180℃的挥发性硅油，药理学或化妆品活性剂和任选的C 2 -C 4脂族醇，但其既不包含脂质也不包含聚合物硅氧烷。组合物可以通过喷涂，浸涂或刷涂施用于生物表面，以在表面上形成一层活性剂。还公开了制备该组合物的方法。

10. 发明申请

WO2007075142A1 LONG TERM WEIGHT MAINTENANCE 审中-公开
标题翻译：长期重量维护
公开(公告)号：WO2007075142A1
公开(公告)日：2007-07-05
申请号：PCT/SE2006/050599
申请日：2006-12-20
申请人： DSM IP ASSETS B.V. , STEIJNS, Jan , ZUURENDONK, Peter , HERSLÖF, Bengt , VIBERG, Annika
发明人： STEIJNS, Jan , ZUURENDONK, Peter , HERSLÖF, Bengt , VIBERG, Annika
IPC分类号： A61K31/23 , A23D7/00 , A23L1/035 , A23L1/30 , A61K9/107 , A61P3/04
CPC分类号： A23D7/011 , A21D13/80 , A23L29/10 , A23L33/10 , A61K9/0056 , A61K31/23
摘要： This invention is in the field of weight maintenance, more in particular in the field of long term weight maintenance of humans. The invention relates to the use of a mixture of a triglyceride oil having a solid fat content at ambient to body temperature and an emulsifier for maintaining weight after weight loss. The invention also relates to the use of a mixture of a triglyceride oil having a solid fat content at ambient to body temperature and an emulsifier for obtaining a thermogenic effect. The invention also relates to the use of a mixture of a triglyceride oil having a solid fat content at ambient to body temperature and an emulsifier for increasing the energy expenditure such as resting energy expenditure.
摘要翻译：本发明在体重维持领域，特别是在人类的长期体重维持领域。本发明涉及在环境温度下具有固体脂肪含量的甘油三酯油与乳化剂在减肥后维持体重的混合物的用途。本发明还涉及在环境温度下具有固体脂肪含量的甘油三酯油与乳化剂的混合物用于获得发热效果的用途。本发明还涉及在环境温度下具有固体脂肪含量的甘油三酯油与乳化剂的混合物的用途，用于增加诸如静息能量消耗的能量消耗。

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