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1. 发明申请

WO2010006326A2 METHODS AND COMPOSITIONS FOR SPORE-BASED VACCINES 审中-公开
标题翻译：用于基于细胞的疫苗的方法和组合物
公开(公告)号：WO2010006326A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/050356
申请日：2009-07-13
申请人： TUFTS UNIVERSITY , HERRMANN, John, E. , BELITSKY, Boris, R. , SONENSHEIN, Abraham, L. , TZIPORI, Saul
发明人： HERRMANN, John, E. , BELITSKY, Boris, R. , SONENSHEIN, Abraham, L. , TZIPORI, Saul
IPC分类号： A61K39/12 , A61K39/02 , A61K39/39 , A61P37/00
CPC分类号： A61K39/15 , A61K39/0016 , A61K39/12 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , C12N2720/12334 , C12N2830/007 , C12N2830/55
摘要： Methods for immunizing a subject to an infectious agent are provided, using vegetative cytoplasmic expression of an antigen encoding an infectious agent or spore surface display of the antigen, and contacting the subject with a composition including a spore or a vegetative cell or both with or without an adjuvant. Also included are a thermally- stable vaccine composition using the method described above and a kit for its use.
摘要翻译：提供了将受试者免疫感染剂的方法，使用编码感染性抗原或抗原的孢子表面展示的抗原的营养细胞质表达，并使受试者与包含孢子或营养细胞的组合物或有或没有佐剂。还包括使用上述方法的热稳定疫苗组合物及其用途的试剂盒。

2. 发明申请

WO2009023733A1 METHODS AND MICROARRAYS FOR DETECTING ENTERIC VIRUSES 审中-公开
标题翻译：检测肠道病毒的方法和微观
公开(公告)号：WO2009023733A1
公开(公告)日：2009-02-19
申请号：PCT/US2008/073058
申请日：2008-08-13
申请人： TRUSTEES OF TUFTS COLLEGE , BROWN, David, W. , HERRMANN, John, E. , TZIPORI, Saul , GUNNING, Kerry, B.
发明人： BROWN, David, W. , HERRMANN, John, E. , TZIPORI, Saul , GUNNING, Kerry, B.
IPC分类号： C12Q1/70 , C12Q1/68 , G01N33/569
CPC分类号： C12Q1/701 , B01J2219/00387 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , C12Q1/6881 , C12Q2531/107
摘要： The present invention relates to methods, microarrays and kits for detecting one or more human astrovirus serotypes in a sample (e.g., a fecal sample) from an individual. The method includes amplifying nucleic acid molecules of the sample with one or more primers, to thereby obtain an amplified nucleic acid product; contacting the amplified nucleic acid product with one or more serotype specific probes having a nucleic acid sequence that is specific for only one astrovirus serotype in the group of astroviruses being assessed, wherein the nucleic acid sequence includes between about 9 and 25 nucleic acid bases (e.g., SEQ ID NO: 5-24); and detecting the hybridization complex. The presence of hybridization complexes with a serotype specific probe indicates the presence of one or more specific astrovirus serotypes, and the absence of hybridization complexes with a serotype specific probe indicates the absence of the specific astrovirus serotype. Identification of the astrovirus serotypes allows for one to diagnose an individual infected with the serotype. The present invention further includes microarrays having any one of the astrovirus specific probe, or kits having microarrays and reagents for carrying out the assay.
摘要翻译：本发明涉及用于检测来自个体的样品（例如，粪便样品）中的一种或多种人星状病毒血清型的方法，微阵列和试剂盒。该方法包括用一个或多个引物扩增样品的核酸分子，从而获得扩增的核酸产物; 使所述扩增的核酸产物与一种或多种血清型特异性探针接触，所述探针具有在所评估的星状病毒组中仅具有一种星状病毒血清型的核酸序列，其中所述核酸序列包含约9至25个核酸碱基（例如，SEQ ID NO：5-24）; 并检测杂交复合物。与血清型特异性探针的杂交复合物的存在表明存在一种或多种特异性星状病毒血清型，并且与血清型特异性探针不存在杂交复合物表明不存在特异性星状病毒血清型。识别星状病毒血清型允许一个诊断感染血清型的个体。本发明还包括具有任何一种星状病毒特异性探针或具有微阵列的试剂盒和用于进行测定的试剂的微阵列。

3. 发明申请

WO2010006326A3 METHODS AND COMPOSITIONS FOR SPORE-BASED VACCINES 审中-公开
标题翻译：基于孢子的疫苗的方法和组合物
公开(公告)号：WO2010006326A3
公开(公告)日：2010-05-06
申请号：PCT/US2009050356
申请日：2009-07-13
申请人： UNIV TUFTS , HERRMANN JOHN E , BELITSKY BORIS R , SONENSHEIN ABRAHAM L , TZIPORI SAUL
发明人： HERRMANN JOHN E , BELITSKY BORIS R , SONENSHEIN ABRAHAM L , TZIPORI SAUL
IPC分类号： A61K39/12 , A61K39/02 , A61K39/39 , A61P37/00
CPC分类号： A61K39/15 , A61K39/0016 , A61K39/12 , A61K2039/522 , A61K2039/523 , A61K2039/542 , A61K2039/543 , A61K2039/545 , A61K2039/55544 , C12N2720/12334 , C12N2830/007 , C12N2830/55
摘要： Methods for immunizing a subject to an infectious agent are provided, using vegetative cytoplasmic expression of an antigen encoding an infectious agent or spore surface display of the antigen, and contacting the subject with a composition including a spore or a vegetative cell or both with or without an adjuvant. Also included are a thermally- stable vaccine composition using the method described above and a kit for its use.
摘要翻译：提供了使用营养细胞质表达编码感染因子或孢子表面展示抗原的细胞质表达，并使受试者与包含孢子或营养细胞或含有或不含有营养细胞的组合物接触的方法，佐剂。还包括使用上述方法的热稳定疫苗组合物及其使用的试剂盒。

4. 发明申请

WO2009073328A1 PORTABLE RADIO AND BATTERY PACK CONFIGURATION 审中-公开
标题翻译：便携式无线电和电池组配置
公开(公告)号：WO2009073328A1
公开(公告)日：2009-06-11
申请号：PCT/US2008/083271
申请日：2008-11-12
申请人： MOTOROLA, INC. , OGLESBEE, John W. , HERRMANN, John E.
发明人： OGLESBEE, John W. , HERRMANN, John E.
IPC分类号： H02H9/00
CPC分类号： H04B1/04
摘要： A portable radio and battery pack configuration favoring higher available transmit power in explosive atmosphere applications includes a radio device (302) and a battery pack (304) removably attached to the radio device. The battery pack includes at least one of an audio power amplifier (346) and a radio frequency (RF) power amplifier (356), and a battery (306) for supplying power to the radio device and to the at least one of an audio power amplifier and a RF power amplifier.
摘要翻译：在爆炸性环境应用中有利于更高可用传输功率的便携式无线电和电池组配置包括可移除地附接到无线电设备的无线电设备（302）和电池组（304）。电池组包括音频功率放大器（346）和射频（RF）功率放大器（356）中的至少一个，以及用于向无线电设备和至少一个音频提供电力的电池（306）功率放大器和RF功率放大器。

5. 发明申请

WO9961049A3 MODEL FOR INFECTION BY A PATHOGEN USING ADMINISTRATION OF NUCLEIC ACIDS 审中-公开
标题翻译：使用核酸管理感染病毒的模型
公开(公告)号：WO9961049A3
公开(公告)日：2000-02-03
申请号：PCT/US9911251
申请日：1999-05-20
申请人： UNIV MASSACHUSETTS MEDICAL , LU SHAN , HERRMANN JOHN E
发明人： LU SHAN , HERRMANN JOHN E
IPC分类号： A61K39/00 , A61P31/18 , C12N7/00 , C12N15/85 , A01K67/027
CPC分类号： C12N15/8509 , A01K2267/0337 , A61K39/00 , C12N7/00 , C12N2740/15011
摘要： Methods are described for generating a model for infection of a host by a pathogen of interest, such as an immunodeficiency virus, and for generating organisms for use in a live, attenuated vaccine against a pathogen, by administering nucleic acids from the pathogen to the host.
摘要翻译：描述了用于通过将来自病原体的核酸给予宿主来产生感兴趣的病原体（例如免疫缺陷病毒）感染宿主的模型和用于产生用于针对病原体的活的减毒疫苗的生物体的方法。

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