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1. 发明申请

WO2006020231A3 MEDICAL DEVICES AND METHODS FOR REDUCING LOCALIZED FIBROSIS 审中-公开
标题翻译：用于减少局部化纤维化的医疗装置和方法
公开(公告)号：WO2006020231A3
公开(公告)日：2006-04-27
申请号：PCT/US2005025437
申请日：2005-07-18
申请人： MEDTRONIC INC , HENDRIKS MARC
发明人： HENDRIKS MARC
IPC分类号： A61L27/54 , A61L31/16
CPC分类号： A61L27/54 , A61K31/513 , A61L31/16 , A61L2300/236 , A61L2300/258 , A61L2300/434 , Y10S977/931
摘要： Medical devices and methods for reducing localized fibrosis at the site of the medical device.
摘要翻译：用于在医疗装置的部位减少局部纤维化的医疗装置和方法。

2. 发明申请

WO2005042043A3 METHODS OF PREPARING CROSSLINKED MATERIALS AND BIOPROSTHETIC DEVICES 审中-公开
标题翻译：制备交联材料和生物医学装置的方法
公开(公告)号：WO2005042043A3
公开(公告)日：2005-07-21
申请号：PCT/US2004035687
申请日：2004-10-27
申请人： MEDTRONIC INC , HENDRIKS MARC , EVERAERTS FRANK , GILLISSEN MIRIAN , VERHOEVEN MICHEL , TORRIANNI MARK W
发明人： HENDRIKS MARC , EVERAERTS FRANK , GILLISSEN MIRIAN , VERHOEVEN MICHEL , TORRIANNI MARK W
IPC分类号： A61L27/24 , A61L27/36
CPC分类号： A61L27/3687 , A61L27/24
摘要： Methods for making crosslinked material, such as collagen-based material, and bioprosthetic devices. The crosslinked material includes hydroxyl groups, carboxyl groups, and amine groups prior to crosslinking. The methods include removing at least a portion of the zero-length ester crosslinks in a crosslinked material and/or blocking at least a portion of the amine groups that are reactive with carboxyl groups and form zero-length crosslinks.
摘要翻译：制造交联材料（例如胶原基材料）和生物假体装置的方法。交联的材料在交联之前包括羟基，羧基和胺基。该方法包括除去交联材料中的至少一部分零长度酯交联和/或封闭至少一部分与羧基反应并形成零长度交联的胺基。

3. 发明申请

WO2004020062A1 HOISTING DEVICE AND HOISTING ELEMENT 审中-公开
标题翻译：装置装置和装置元件
公开(公告)号：WO2004020062A1
公开(公告)日：2004-03-11
申请号：PCT/NL2003/000597
申请日：2003-08-25
申请人： PROLYTE VASTGOED B.V. , HENDRIKS, Marc
发明人： HENDRIKS, Marc
IPC分类号： A63J1/02
CPC分类号： A63J1/028
摘要： A hoisting device comprises lifting means for taking in and paying out at least one group of lines (5) with an elongate hoisting element (10) on a free outer end. The hoisting element (10) serves to receive at least one stage fixture thereon. The hoisting element comprises a profile assembly of at least two elongate profiles (11, 12) which are substantially parallel to each other and which are mutually connected by at least one rigid intermediate body (13). The profiles (11, 12) are adapted on their outer end for coupling to a corresponding profile of a further profile assembly.
摘要翻译：提升装置包括提升装置，用于在自由外端上带有细长提升元件（10）的至少一组线（5）。提升元件（10）用于在其上容纳至少一个平台固定件。提升元件包括至少两个细长轮廓（11,12）的轮廓组件，其基本上彼此平行并且由至少一个刚性中间体（13）相互连接。型材（11,12）在其外端上适配，以连接到另一型材组件的相应轮廓。

4. 发明申请

WO2011098473A1 ORTHOPEDIC IMPLANT 审中-公开
标题翻译：手术植入
公开(公告)号：WO2011098473A1
公开(公告)日：2011-08-18
申请号：PCT/EP2011/051875
申请日：2011-02-09
申请人： DSM IP ASSETS B.V. , HENDRIKS, Marc , SCHUMANN, Detlef Olaf Alexander , WISSE, Eva
发明人： HENDRIKS, Marc , SCHUMANN, Detlef Olaf Alexander , WISSE, Eva
IPC分类号： A61F2/38 , A61F2/44 , A61L27/18
CPC分类号： A61F2/28 , A61F2/3094 , A61F2/30965 , A61F2/38 , A61F2/3872 , A61F2/44 , A61F2/442 , A61F2002/30004 , A61F2002/30014 , A61F2002/30016 , A61F2002/30069 , A61F2002/3008 , A61F2002/30329 , A61F2002/30448 , A61F2002/30451 , A61F2002/30673 , A61F2002/30945 , A61F2002/30957 , A61F2002/3096 , A61F2002/30968 , A61F2002/3097 , A61F2002/30971 , A61F2002/30976 , A61F2002/30985 , A61F2220/0025 , A61F2220/005 , A61F2220/0058 , A61F2240/001 , A61F2250/0014 , A61F2250/0018 , A61F2250/0019 , A61F2250/0098 , A61L27/18 , A61L2400/10 , A61L2430/06 , A61L2430/24 , A61L2430/38 , C08L75/04
摘要： The invention is directed to an orthopedic implant comprising different distinct sections, wherein each section comprises a different polymeric material and the polymeric materials are at the contact surfaces of the sections attached to each other by chemical bonds and/or physical interaction and to a method for the production of an orthopedic implant wherein multi-component molding is used.
摘要翻译：本发明涉及包括不同不同部分的矫形植入物，其中每个部分包括不同的聚合物材料，并且聚合物材料位于通过化学键和/或物理相互作用彼此连接的部分的接触表面上，制造使用多组分成型的矫形植入物。

5. 发明申请

WO2008021831A1 STENT GRAFT WITH STRIPS TO PROMOTE LOCALIZED HEALING 审中-公开
标题翻译：具有促进局部化治疗的STEG GRAFT
公开(公告)号：WO2008021831A1
公开(公告)日：2008-02-21
申请号：PCT/US2007/075372
申请日：2007-08-07
申请人： MEDTRONIC VASCULAR, INC. , KWITKIN, Brian , BILLY, Didier , HENDRIKS, Marc
发明人： KWITKIN, Brian , BILLY, Didier , HENDRIKS, Marc
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/064 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2250/006 , A61F2250/0067
摘要： An endoluminal stent graft (100) includes segments (116A, 116B) of a healing promoter to promote the "healing in" of the distal and/or proximal neck(s) of the endoluminal stent graft in a vessel, thus reducing the risk of migration and the occurrence of endoleaks that can formed at the side of the neck(s) and the consequent feeding of the aneurysm sac. In some applications, the segments of the healing promoter are located within a proximal anchor region located near the proximal neck opening of the endoluminal stent graft and, optionally, within one or more distal anchor regions located near one or more distal neck openings of the endoluminal stent graft. In other applications, the segments of the healing promoter are located within the proximal anchor region, but not the distal anchor region.
摘要翻译：腔内支架移植物（100）包括愈合促进剂的段（116A，116B），以促进血管内腔内支架移植物的远端和/或近端颈部的“愈合”，从而降低迁移和可能形成在颈部侧面的内漏的发生以及随之而来的动脉瘤囊的供给。在一些应用中，愈合促进剂的部分位于位于内腔支架移植物的近端颈部开口附近的近端锚定区域中，并且可选地位于位于内腔内的一个或多个远端颈部开口附近的一个或多个远侧锚定区域内支架移植在其他应用中，愈合促进剂的区段位于近端锚定区域内，但不位于远端锚定区域。

6. 发明申请

WO2007047426A2 BIOACTIVE DELIVERY MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：生物活性递送基质组合物和方法
公开(公告)号：WO2007047426A2
公开(公告)日：2007-04-26
申请号：PCT/US2006/040056
申请日：2006-10-12
申请人： MEDTRONIC, INC. , EVERAERTS, Frank , HENDRIKS, Marc , GILLSISSEN, Mirian
发明人： EVERAERTS, Frank , HENDRIKS, Marc , GILLSISSEN, Mirian
CPC分类号： A61L24/0084 , A61K9/0024 , A61L24/0015 , A61L27/46 , A61L27/54 , A61L2300/112 , A61L2300/414 , C08L101/02
摘要： Bioactive delivery matrix compositions and methods of making and using such compositions.
摘要翻译：生物活性递送基质组合物以及制备和使用这种组合物的方法。

7. 发明申请

WO2006047289A2 ANGIOTENSIN-(1-7) ELUTING POLYMER-COATED MEDICAL DEVICE TO REDUCE RESTENOSIS AND IMPROVE ENDOTHELIAL CELL FUNCTION 审中-公开
标题翻译： ANGIOTENSIN-（1-7）涂覆聚合物涂层医疗器械以减少内源性和改善内皮细胞功能
公开(公告)号：WO2006047289A2
公开(公告)日：2006-05-04
申请号：PCT/US2005037895
申请日：2005-10-21
申请人： MEDTRONIC INC , TIJSMA EDZE JAN , DRIESSEN-LEVELS ANITA , HENDRIKS MARC
发明人： TIJSMA EDZE JAN , DRIESSEN-LEVELS ANITA , HENDRIKS MARC
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/25 , A61L2300/416 , A61L2300/608 , A61L2420/08 , C08L71/02
摘要： Medical devices with polymer coatings designed to control the release of angiotensin-(1-7) receptor agonist from medical devices are disclosed. The present application also discloses providing vascular stents with angiotesin-(1-7) receptor angonist-containing controlled-release coatings. Methods for treating or inhibiting post-stent implantation restenosis as well as improving vascular endothelial function in patients are also provided.
摘要翻译：公开了具有设计用于控制来自医疗装置的血管紧张素（1-7）受体激动剂的释放的聚合物涂层的医疗装置。本申请还公开了向血管支架提供含有血管刺激素（1-7）受体负离子的控释药物。还提供了治疗或抑制支架内植入再狭窄以及改善患者血管内皮功能的方法。

8. 发明申请

WO2006020230A2 METHODS FOR REDUCING OR PREVENTING LOCALIZED FIBROSIS USING SiRNA 审中-公开
标题翻译：使用SiRNA减少或预防局部化纤维化的方法
公开(公告)号：WO2006020230A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/025435
申请日：2005-07-18
申请人： MEDTRONIC, INC. , HENDRIKS, Marc
发明人： HENDRIKS, Marc
IPC分类号： C12N15/113
CPC分类号： C12N15/1137 , C12N2310/111 , C12N2310/14 , C12Y114/11004
摘要： Methods for reducing or preventing localized fibrosis in a localized tissue region using SiRNA technology.
摘要翻译：使用SiRNA技术减少或预防局部组织区域局部纤维化的方法。

9. 发明申请

WO2004073768A3 OCCLUSION RESISTANT HYDROCEPHALIC SHUNT 审中-公开
公开(公告)号：WO2004073768A3
公开(公告)日：2004-09-02
申请号：PCT/US2004/004925
申请日：2004-02-18
申请人： MEDTRONIC, INC. , KOULLICK, Edouard , HENDRIKS, Marc , BERTRAND, William, J.
发明人： KOULLICK, Edouard , HENDRIKS, Marc , BERTRAND, William, J.
IPC分类号： A61L31/16
摘要： An occlusion resistant medical shunt, particularly a hydrocephalic shunt, is provided for implantation into a mammal. The shunt has an elongate wall structure configured as a tube having a lumen therethrough and a proximal end for receipt of bodily fluids. The bodily fluids, such as cerebrospinal fluid, flows through the shunt to a distal end for discharge of the bodily fluids. The wall structure of the shunt generally includes a biocompatible medical device material. The shunts of the present invention further include one or more occlusion resistant materials to resist occlusion of the lumenal passage in the shunt.

10. 发明申请

WO2004073768A2 OCCLUSION RESISTANT HYDROCEPHALIC SHUNT 审中-公开
标题翻译：防止水污染
公开(公告)号：WO2004073768A2
公开(公告)日：2004-09-02
申请号：PCT/US2004004925
申请日：2004-02-18
申请人： MEDTRONIC INC , KOULLICK EDOUARD , HENDRIKS MARC , BERTRAND WILLIAM J
发明人： KOULLICK EDOUARD , HENDRIKS MARC , BERTRAND WILLIAM J
IPC分类号： A61K9/50 , A61L31/06 , A61L31/16 , A61M20060101 , A61M5/00 , A61M27/00 , A61M29/00 , A61M
CPC分类号： A61L31/16 , A61L31/06 , A61L2300/00 , A61M1/3655 , A61M27/006 , C08L83/04 , C08L75/04
摘要： An occlusion resistant medical shunt, particularly a hydrocephalic shunt, is provided for implantation into a mammal. The shunt has an elongate wall structure configured as a tube having a lumen therethrough and a proximal end for receipt of bodily fluids. The bodily fluids, such as cerebrospinal fluid, flows through the shunt to a distal end for discharge of the bodily fluids. The wall structure of the shunt generally includes a biocompatible medical device material. The shunts of the present invention further include one or more occlusion resistant materials to resist occlusion of the lumenal passage in the shunt.
摘要翻译：提供阻塞性医疗分路，特别是脑积水分流器，用于植入哺乳动物。分流器具有细长的壁结构，其构造为具有通过其的内腔的管，以及用于接收体液的近端。体液如脑脊液通过分流器流到远端以排出体液。分流器的壁结构通常包括生物相容的医疗装置材料。本发明的分流器还包括一种或多种抗阻塞材料，以阻止分路中的内腔通道的阻塞。

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