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1. 发明申请

WO2011150332A1 MICRONEEDLE ELECTRODE 审中-公开
标题翻译： MICRONEEDLE电极
公开(公告)号：WO2011150332A1
公开(公告)日：2011-12-01
申请号：PCT/US2011/038339
申请日：2011-05-27
申请人： EMKINETICS, INC. , HEGDE, Anant V. , RAJGURU, Amit , BURNETT, Daniel R. , HERMANSON, Christopher
发明人： HEGDE, Anant V. , RAJGURU, Amit , BURNETT, Daniel R. , HERMANSON, Christopher
IPC分类号： A61B5/0408
CPC分类号： A61B5/0478 , A61B5/0408 , A61B5/0492
摘要： In certain variations, methods, systems and/or devices for enhancing conductivity of an electrical signal through a subjects skin using one or more microneedle electrodes are provided. A microneedle electrode may be applied to the subjects skin by placing the microneedle electrode in direct contact with the subjects skin. The microneedles of the microneedle electrode may be inserted into the skin such that the microneedles pierce stratum corneum of the skin up to or through dermis of the skin. An electrical signal passes or is conducted through or across the microneedle electrode and the subjects skin, where impedance of the microneedle electrode is minimal and greatly reduced compared to existing technologies.
摘要翻译：在一些变型中，提供了用于通过使用一个或多个微针电极通过受试者皮肤增强电信号的导电性的方法，系统和/或装置。可以通过将微针电极与受试者皮肤直接接触来将微针电极施加到受试者皮肤。微针电极的微针可以插入皮肤中，使得微针刺穿皮肤的角质层直到皮肤或通过真皮皮肤。电信号通过或穿过微针电极和受试者皮肤，其中微针电极的阻抗最小并且与现有技术相比大大降低。

2. 发明申请

WO2010005900A1 CAVITATION DEPTH, PERFORATION CONFIRMATION AND IMPLANT DELIVERY TOOL 审中-公开
标题翻译：密封深度，执行确认和嵌入式交付工具
公开(公告)号：WO2010005900A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/049698
申请日：2009-07-06
申请人： PAVAD MEDICAL, INC. , HEGDE, Anant V. , MCVICKER, Adrian , CHOE, Jerry Sung Woo , ROSS, James B.
发明人： HEGDE, Anant V. , MCVICKER, Adrian , CHOE, Jerry Sung Woo
IPC分类号： A61F2/02
CPC分类号： A61F5/566
摘要： Methods and tools that insert implants for the treatment of snoring and sleep apnea in a cavity created in the patient's tissue are disclosed Some tools and methods can additionally venfy that the cavity has proper cavitation depth and does not have unwanted perforations The tools include a sheath having a substantially flat portion for housing an implant, the sheath having a distal end and a proximal end, the sheath having a hollow collar on the proximal end, an insertion depth mark near the distal end, and a slit on the distal end, the slit being in fluid communication with the hollow collar, a substantially rigid pusher configured to be disposed within and in slidable engagement with the sheath, a tip on the distal end, and a lumen extending from said proximal side to said distal side of said rigid body.
摘要翻译：公开了在患者组织中产生的空腔中插入用于治疗打鼾和睡眠呼吸暂停的植入物的方法和工具。一些工具和方法可以额外地使空腔具有适当的空化深度并且不具有不期望的穿孔。这些工具包括具有用于容纳植入物的基本上平坦的部分，所述护套具有远端和近端，所述护套在近端具有中空的环，在远端附近具有插入深度标记，在远端具有狭缝，狭缝与所述中空轴环流体连通，构造成设置在所述护套内并与所述护套滑动接合的基本刚性的推动器，所述远端上的尖端以及从所述刚体的所述近侧延伸到所述远侧的内腔。

3. 发明申请

WO2009059114A1 ON-OFF IMPLANT FOR SUPPORTING THE TONGUE 审中-公开
标题翻译：用于支持TONGUE的ON-OFF植入物
公开(公告)号：WO2009059114A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/081966
申请日：2008-10-31
申请人： PAVAD MEDICAL, INC. , BHAT, Nikhil D. , HEGDE, Anant V. , LI, Kasey , GOEBEL, Matthew , WANG, Hongpeng
发明人： BHAT, Nikhil D. , HEGDE, Anant V. , LI, Kasey , GOEBEL, Matthew , WANG, Hongpeng
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： The present invention provides an implant for stabilizing the tongue, including a first anchoring portion for securing a first end of the implant with the mandibula, a control portion connected with the anchoring portion, configured for selectively activating the implant, a flexible portion connected at its proximal end with the control portion, the flexible portion having three-dimensional flexibility in a non- energized state and the flexible portion having a lesser three-dimensional flexibility in a energized state, the flexible portion being selectively switchable between the non-energized and energized states by the control portion, wherein the flexible portion can be an electroactive polymer element, and a second anchoring portion connected with the flexible portion, the second anchoring portion being configured for connecting the implant with the base of the tongue.
摘要翻译：本发明提供了一种用于稳定舌头的植入物，包括用于固定具有下颌骨的植入物的第一端的第一锚定部分，与锚定部分连接的控制部分，构造成用于选择性地启动植入物，在其上连接的柔性部分近端具有控制部分，柔性部分具有处于非激励状态的三维柔性，并且柔性部分在通电状态下具有较小的三维柔性，柔性部分可选择地在非激励和通电之间切换通过所述控制部分的状态，其中所述柔性部分可以是电活性聚合物元件，以及与所述柔性部分连接的第二锚定部分，所述第二锚定部分构造成用于将所述植入物与所述舌头的基部连接。

4. 发明申请

WO2008079700A2 IMPLANT FOR TREATMENT OF SLEEP DISORDERS 审中-公开
标题翻译：用于治疗睡眠障碍的植入物
公开(公告)号：WO2008079700A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/087298
申请日：2007-12-12
申请人： PAVAD MEDICAL, INC. , HEGDE, Anant, V. , HALLSTEN, Casidy , YUNG, Charisse , BHAT, Nikhil, D. , CHOI, George, Yoseung
发明人： HEGDE, Anant, V. , HALLSTEN, Casidy , YUNG, Charisse , BHAT, Nikhil, D. , CHOI, George, Yoseung
IPC分类号： A61F5/56
CPC分类号： A61F2/02 , A61F5/566
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The airway implant device comprises an actuator element to control the opening of an air passageway. Preferably the actuator element is an electroactive polymer element. Energizing of the elctroactive polymer element provides support for the walls in order to prevent the collapse of an air passageway. Some embodiments of the invention include a sensor capable of sensing the possible occurrence of an apneic event and activating the actuator element of the airway implant device. Some embodiments include a housing designed to conform to the shape of the palate. Some embodiments include an attachment element to secure the device to tissue. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译：公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。还公开了使用该装置的方法。气道植入装置包括用于控制空气通道的开口的致动器元件。优选地，致动器元件是电活性聚合物元件。为了防止空气通道的塌陷，激发聚合物元件的通电为壁提供支撑。本发明的一些实施例包括能够感测呼吸暂停事件的可能发生并激活气道植入装置的致动器元件的传感器。一些实施例包括设计成符合腭形状的外壳。一些实施例包括用于将装置固定到组织的附接元件。本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

5. 发明申请

WO2008014028A2 TETHERED AIRWAY IMPLANTS AND METHODS OF USING THE SAME 审中-公开
标题翻译：专用气道植入物及其使用方法
公开(公告)号：WO2008014028A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/067130
申请日：2007-04-20
申请人： PAVAD MEDICAL , HEGDE, Anant, V , LI, Kasey, Kai-Chi , BHAT, Nikhil, D. , KIM, Doyeon , CHOI, George, Y.
发明人： HEGDE, Anant, V , LI, Kasey, Kai-Chi , BHAT, Nikhil, D. , KIM, Doyeon , CHOI, George, Y.
IPC分类号： G01B3/30
CPC分类号： A61F5/56 , A61B2017/248 , A61F5/566 , G02B26/0841 , H02N1/008 , Y10S602/902
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The airway implant device includes a deformable element to control the opening of an air passageway and a tether. Preferably the deformable element is an electroactive polymer element. Energizing of the electroactive polymer element provides support for the walls of an air passageway, when the walls collapse, and thus, completely or partially opens the air passageway. Also disclosed is an implant for stabilizing the tongue, the implant having an anchoring portion for securing a first end of the implant with the mandibula; a control portion connected with the anchoring portion, configured for selectively activating the implant; a flexible portion connected at its proximal end with the control portion, where the flexible portion has three-dimensional flexibility in a first state and where the flexible portion has a lesser three-dimensional flexibility in a second state, and where the flexible portion is selectively switchable between the first and second state by the control portion; and an anchoring portion for connecting the implant with the base of the tongue connected with the distal end of the flexible portion. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译：公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。还公开了使用该装置的方法。气道植入装置包括可变形元件以控制空气通道和系绳的开口。优选地，可变形元件是电活性聚合物元件。电活性聚合物元件的通电为空气通道的壁提供支撑，当壁崩溃时，从而完全或部分地打开空气通道。还公开了一种用于稳定舌头的植入物，植入物具有用于固定植入物的第一端与下颌骨的锚固部分; 与所述锚定部分连接的控制部分，被配置为选择性地启动所述植入物; 其柔性部分在其近端连接有控制部分，其中柔性部分在第一状态下具有三维柔性，并且柔性部分在第二状态下具有较小的三维柔性，并且其中柔性部分是选择性的通过控制部在第一状态和第二状态之间切换; 以及用于将植入物与与柔性部分的远端连接的舌头的基部连接的锚固部分。本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

6. 发明申请

WO2007095582A2 AIRWAY IMPLANT SENSORS AND METHODS OF MAKING AND USING SAME 审中-公开
标题翻译： AIRWAY植入式传感器及其制造和使用方法
公开(公告)号：WO2007095582A2
公开(公告)日：2007-08-23
申请号：PCT/US2007062149
申请日：2007-02-14
申请人： PAVAD MEDICAL , BHAT NIKHIL D , HEGDE ANANT V , CHOI GEORGE YOSEUNG
发明人： BHAT NIKHIL D , HEGDE ANANT V , CHOI GEORGE YOSEUNG
CPC分类号： A61F5/566 , A61B5/0031 , A61B5/1076 , A61B5/4818 , A61C7/00 , A61F2/00 , A61F5/56 , A61N1/0519 , A61N1/0546 , A61N1/0548 , A61N1/3601
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The airway implant device includes a deformable element to control the opening of an air passageway. Preferably the deformable element is an electroactive polymer element. Energizing of the electroactive polymer element provides support for the walls of an air passageway, when the walls collapse, and thus, completely or partially opens the air passageway. Some embodiments of the invention include a sensor capable of sensing the possible occurrence of an apneic event and activating the deformable element of the airway implant device. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译：公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。还公开了使用该装置的方法。气道植入装置包括可变形元件以控制空气通道的开口。优选地，可变形元件是电活性聚合物元件。电活性聚合物元件的通电为空气通道的壁提供支撑，当壁崩溃时，从而完全或部分地打开空气通道。本发明的一些实施例包括能够感测呼吸暂停事件的可能发生并激活气道植入装置的可变形元件的传感器。本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

7. 发明申请

WO2006034434A3 AIRWAY IMPLANT AND METHODS OF MAKING AND USING 审中-公开
公开(公告)号：WO2006034434A3
公开(公告)日：2007-03-08
申请号：PCT/US2005034111
申请日：2005-09-21
申请人： PAVAD MEDICAL INC , HEGDE ANANT V , CHOI GEORGE YOSEUNG , BUCH WALLY S , LI KASEY KAI-CHI
发明人： HEGDE ANANT V , CHOI GEORGE YOSEUNG , BUCH WALLY S , LI KASEY KAI-CHI
IPC分类号： A61F5/56 , A61N1/18
CPC分类号： A61L31/125 , A61B2017/248 , A61C7/00 , A61F2/00 , A61F5/56 , A61F5/566 , A61F2210/0023 , A61L31/14 , A61N1/0517 , A61N1/0519 , A61N1/0548 , A61N1/3601 , Y10S602/902
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The airway implant device comprises a deformable element to control the opening of an air passageway. Preferably the deformable element is an electroactive polymer element. Energizing of the electroactive polymer element provides support for the walls of an air passageway, when the walls collapse, and thus, completely or partially opens the air passageway. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译：公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。还公开了使用该装置的方法。气道植入装置包括可变形元件以控制空气通道的开口。优选地，可变形元件是电活性聚合物元件。电活性聚合物元件的通电为空气通道的壁提供支撑，当壁崩溃时，从而完全或部分地打开空气通道。本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

8. 发明申请

WO2006034434A8 AIRWAY IMPLANT AND METHODS OF MAKING AND USING 审中-公开
公开(公告)号：WO2006034434A8
公开(公告)日：2006-06-01
申请号：PCT/US2005034111
申请日：2005-09-21
申请人： PAVAD MEDICAL INC , HEGDE ANANT V , CHOI GEORGE YOSEUNG , BUCH WALLY S , LI KASEY KAI-CHI
发明人： HEGDE ANANT V , CHOI GEORGE YOSEUNG , BUCH WALLY S , LI KASEY KAI-CHI
IPC分类号： A61F5/56
CPC分类号： A61L31/125 , A61B2017/248 , A61C7/00 , A61F2/00 , A61F5/56 , A61F5/566 , A61F2210/0023 , A61L31/14 , A61N1/0517 , A61N1/0519 , A61N1/0548 , A61N1/3601 , Y10S602/902
摘要： An airway implant device for maintaining and/or creating an opening in air passageways is disclosed. Methods of using the device are also disclosed. The airway implant device comprises a deformable element to control the opening of an air passageway. Preferably the deformable element is an electroactive polymer element. Energizing of the electroactive polymer element provides support for the walls of an air passageway, when the walls collapse, and thus, completely or partially opens the air passageway. Methods of treating airway disorders such as sleep apnea and snoring with the airway implant device are disclosed herein.
摘要翻译：公开了一种用于在空气通道中保持和/或形成开口的气道植入装置。还公开了使用该装置的方法。气道植入装置包括可变形元件以控制空气通道的开口。优选地，可变形元件是电活性聚合物元件。电活性聚合物元件的通电为空气通道的壁提供支撑，当壁崩溃时，从而完全或部分地打开空气通道。本文公开了用气道植入装置处理呼吸道疾病如睡眠呼吸暂停和打鼾的方法。

9. 发明申请

WO2006026509A2 ARTIFICIAL SPHINCTER 审中-公开
标题翻译：人工神经
公开(公告)号：WO2006026509A2
公开(公告)日：2006-03-09
申请号：PCT/US2005/030564
申请日：2005-08-25
申请人： PAVAD MEDICAL, INC. , HEGDE, Anant, V. , CHOI, George, Yoseung , BUCH, Wally, S.
发明人： HEGDE, Anant, V. , CHOI, George, Yoseung , BUCH, Wally, S.
IPC分类号： A61F2/02
CPC分类号： A61F2/0036 , A61F2/0004 , A61F2/0022 , A61F2/0031 , A61L27/14 , A61L27/50 , A61N1/0512 , A61N1/36007
摘要： A biologically implantable artificial sphincter system and methods of using the same is disclosed. The artificial sphincter system disclosed herein comprises a support and an electroactive polymer element, both of which are adapted and configured to open and/or close a body cavity. The artificial sphincter systems are useful in the treatment of urinary incontinence, fecal incontinence, and reflux disorders. The implanted artificial sphincter can also provide a signal to the recipient to urinate or defecate.
摘要翻译：公开了生物可植入人造括约肌系统及其使用方法。本文公开的人造括约肌系统包括支撑件和电活性聚合物元件，两者都适合于并构造成打开和/或闭合体腔。人造括约肌系统可用于治疗尿失禁，大便失禁和返流性疾病。植入的人造括约肌还可以向接受者提供排尿或排便的信号。

10. 发明申请

WO2010138593A1 IMPLANT SYSTEM FOR CONTROLLING AIRWAY PASSAGE 审中-公开
标题翻译：用于控制空中通行的植入系统
公开(公告)号：WO2010138593A1
公开(公告)日：2010-12-02
申请号：PCT/US2010/036204
申请日：2010-05-26
申请人： PAVAD MEDICAL, INC. , SHARKAWY, Adam , SAHIN, Koray , MCVICKER, Adrian , MOSS, Jon, F. , DOMINGO, Casidy , BHAT, Nikhil D. , BAGLEY, Christopher , HEGDE, Anant, V. , FARBARIK, John M. , CHOI, George, Y. , LI, Kasey Kai-Chi
发明人： SHARKAWY, Adam , SAHIN, Koray , MCVICKER, Adrian , MOSS, Jon, F. , DOMINGO, Casidy , BHAT, Nikhil D. , BAGLEY, Christopher , HEGDE, Anant, V. , FARBARIK, John M. , CHOI, George, Y. , LI, Kasey Kai-Chi
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F5/56
摘要： Techniques for operating a subcutaneous implant device are disclosed. The implant device can be formed of a non-magnetic material that is compatible with diagnostics such as magnetic resonance imaging (MRI) and can include a rotor element that rotates under the influence of an external magnetic field. The implant device includes a tension relief mechanism for relieving excessive force applied between the implant device and a portion of a patient's tongue. A non-implanted device can include a stator and drive circuitry for generating the external magnetic field. The non-implanted device can receive a user command and can vary the external magnetic field based on the command. When activated by the magnetic field, the implant device can change its operating state to interact with the patient's body.
摘要翻译：公开了用于操作皮下植入装置的技术。植入装置可以由与诸如磁共振成像（MRI）的诊断相兼容的非磁性材料形成，并且可以包括在外部磁场的影响下旋转的转子元件。植入装置包括用于减轻施加在植入装置与患者舌头的一部分之间的过大力的张力释放机构。非植入装置可以包括用于产生外部磁场的定子和驱动电路。非植入装置可以接收用户命令并且可以基于命令改变外部磁场。当由磁场激活时，植入装置可以改变其操作状态以与患者的身体相互作用。

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