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1. 发明公开

KR20070102429A USING A REVERSE GENETIC ENGINEERING PLATFORM TO PRODUCE PROTEIN VACCINE AND PROTEIN VACCINE OF AVIAN INFLUENZA VIRUS 审中-公开
标题翻译：使用逆向遗传工程平台生产AVIAN流感病毒的蛋白疫苗和蛋白疫苗
公开(公告)号：KR20070102429A
公开(公告)日：2007-10-18
申请号：KR20070036530
申请日：2007-04-13
申请人： HEALTHBANKS BIOTECH CO LTD
发明人： LIAO CHAO WEI , CHANG HSIU KANG , HWANG KIN KAI
IPC分类号： A61K39/145 , A61P31/12 , A61P37/00
CPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151
摘要： A protein vaccine of avian influenza virus produced by using a reverse genetic engineering platform is provided to prevent virus diseases caused by various types of viruses by containing a conserved general immunogen, so that it is not necessary to develop a new vaccine when the virus type is changed by mutation. A method for preparing the protein vaccine of avian influenza virus comprises the steps of: (a) providing an amino acid sequence of at least one epitope peptide of a target antigen protein and converting the amino acid sequence into the corresponding wild type nucleotide sequence; (b) mutating the wild type nucleotide sequence of the epitope into the mutated nucleotide sequence which is recognizable by a host cell and encodes the epitope peptide; (c) synthesizing primers of the mutated nucleotide sequence; (d) synthesizing the mutated nucleic acid by using the primers in vitro; (e) linking the synthesized nucleic acid fragment to a plasmid and a nucleotide sequence having translocation and binding functions to produce the mutated plasmid; (f) transforming a host cell with the mutated plasmid to produce the epitope peptide encoded by the mutated nucleic acid; and (g) collecting and purifying the epitope peptide.
摘要翻译：提供使用反向遗传工程平台产生的禽流感病毒蛋白疫苗，通过含有保守的一般免疫原来防止各种病毒引起的病毒病毒，因此当病毒类型为变异发生变化制备禽流感病毒蛋白疫苗的方法包括以下步骤：（a）提供靶抗原蛋白的至少一种表位肽的氨基酸序列，并将氨基酸序列转化成相应的野生型核苷酸序列; （b）将表位的野生型核苷酸序列突变为宿主细胞可识别并编码表位肽的突变核苷酸序列; （c）合成突变核苷酸序列的引物; （d）通过体外使用引物合成突变的核酸; （e）将合成的核酸片段与质粒和具有易位和结合功能的核苷酸序列连接以产生突变的质粒; （f）用突变的质粒转化宿主细胞以产生由突变的核酸编码的表位肽; 和（g）收集和纯化表位肽。

2. 发明申请

WO2009099777A3 CHIMERIC HIV FUSION PROTEINS AS VACCINES 审中-公开
标题翻译：作为疫苗的嵌合HIV融合蛋白
公开(公告)号：WO2009099777A3
公开(公告)日：2009-10-22
申请号：PCT/US2009031859
申请日：2009-01-23
申请人： HEALTHBANKS USA INC , HEALTHBANKS BIOTECH CO LTD , LIAO CHAO-WEI , CHANG HSIU-KANG
发明人： LIAO CHAO-WEI , CHANG HSIU-KANG
IPC分类号： A61K38/16 , A61P31/18 , C07K19/00
CPC分类号： C07K14/21 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/54 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , C07K14/005 , C07K2319/00 , C07K2319/10 , C07K2319/40 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334
摘要： A chimeric fusion protein useful as an immunogen for inducing HIV antigen-specific immune responses contains a first polypeptidyl region and a second polypeptidyl region. The first polypeptidyl region includes a Psedomonas Exotoxin A (PE) binding domain and a PE translocation domain. The second polypeptidyl region includes (i) a first peptidyl segment containing a fragment of gp120 C1 domain, located at the N-terminus of the second peptidyl region; (ii) a second peptidyl segment containing a fragment of gp120 C5 domain, located at the C-terminus of the first peptidyl segment; and (iii) a third peptidyl segment containing a fragment of gp41, located at the C-terminus of the second peptidyl segment. The second polypeptidyl region contains an antigenic determinant specific to one subtype of HIV. An intermediate polypeptide containing a non-Env, HIV antigenic determinant selected from Gag24, Nef, Tat and Rev may be included.
摘要翻译：可用作诱导HIV抗原特异性免疫应答的免疫原的嵌合融合蛋白含有第一多肽基区和第二多肽基区。第一个多肽基区域包括Psedomonas外毒素A（PE）结合结构域和PE易位结构域。第二多肽区域包括（i）位于第二肽基区域的N端的含有gp120C1结构域片段的第一肽片段; （ii）位于第一肽片段的C端的含有gp120C5结构域片段的第二肽片段; 和（iii）位于第二肽片段的C端的含有gp41片段的第三肽片段。第二个多肽区含有特异于HIV一种亚型的抗原决定簇。可以包括含有选自Gag24，Nef，Tat和Rev的非Env HIV抗原决定簇的中间多肽。

3. 发明专利

JP2006025782A Super-antigen fusion protein and application method of the same 审中-公开
标题翻译：超抗原蛋白及其应用方法
公开(公告)号：JP2006025782A
公开(公告)日：2006-02-02
申请号：JP2004327802
申请日：2004-11-11
申请人： Healthbanks Biotech Co Ltd , 生寶生物科技股▲ふん▼有限公司
发明人： JANG SHIOU-GANG , LIAO CHAO-WE , CHENG WEN-FANG
IPC分类号： C12N15/09 , A61K39/12 , A61K39/39 , C07K14/005 , C07K14/21 , C07K19/00
CPC分类号： C07K14/005 , A61K38/00 , C07K14/21 , C07K2319/55 , C12N2770/20022
摘要： PROBLEM TO BE SOLVED: To provide a super-antigen fusion protein, and to provide an application method of the same. SOLUTION: This super-antigen fusion protein has a peptide fragment which encodes a part of SARS E2 spike protein and a peptide fragment which is used for transporting the protein into a cell and translocating the protein in a cylosol, wherein the peptide fragment which encodes the part of the SARS E2 spike protein includes SEQ.ID.NO.1, SEQ.ID.NO.2, SEQ.ID.NO.3, or SEQ.ID.NO.4. Further, a DNA sequence which encodes the part of the SARS E2 spike protein and includes the SEQ.ID.NO.1, the SEQ.ID.NO.2, the SEQ.ID.NO.3, or the SEQ.ID.NO.4 is provided, wherein the DNA sequence expresses a corresponding specific protein in a coli bacillus expression system. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供超抗原融合蛋白，并提供其应用方法。解决方案：该超抗原融合蛋白具有编码SARS E2尖峰蛋白的一部分的肽片段和用于将蛋白质输送到细胞中并将该蛋白质转移到胞质中的肽片段，其中肽片段其编码SARS E2尖峰蛋白的部分包括SEQ.ID.NO.1，SEQ.ID.NO.2，SEQ.ID.NO.3或SEQ.ID.NO.4。此外，编码部分SARS E2尖峰蛋白的DNA序列包括SEQ.ID.NO.1，SEQ.ID.NO.2，SEQ.ID.NO.3或SEQ.ID. NO.4，其中DNA序列在大肠杆菌表达系统中表达相应的特异性蛋白质。版权所有（C）2006，JPO＆NCIPI

4. 发明专利

JP2010240384A Storage apparatus for storing product 有权
标题翻译：存储产品存储设备
公开(公告)号：JP2010240384A
公开(公告)日：2010-10-28
申请号：JP2009293651
申请日：2009-12-25
申请人： Healthbanks Biotech Co Ltd , ヘルスバンクスバイオテックカンパニーリミテッド
发明人： LI YU-CHING , LIN SHANG-CHIH , CHEN JIA-YOU
IPC分类号： A61J3/00 , A01N1/02 , B65G1/00 , B65G1/04
CPC分类号： B65G1/045 , A01N1/0242 , A01N1/0252 , A01N1/0257 , B65G1/0464 , G01N1/42 , G01N35/025 , G01N2035/0425
摘要： PROBLEM TO BE SOLVED: To provide a storage apparatus in which independent storage-access operation, raising storage-access accuracy and lowering cost can be achieved.
SOLUTION: The apparatus includes: an axis unit 301, supported on a base 101; a first storage-access unit 401 and a plurality of first storage units 402 arranged in a first circle; a plurality of second storage units 403 arranged in a second circle; a first rotating unit 501 connected with the tops of the first storage units 402; a first cover unit 502 connected with the tops of the second storage units 403; and a plurality of first rolling units 601 connected with the first rotating unit 501, wherein the first storage-access unit 401 and the first storage units 402 can rotate relative to the second storage units 403.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种可以实现独立的存储访问操作，提高存储访问精度和降低成本的存储装置。解决方案：该装置包括：轴单元301，支撑在基座101上; 第一存储单元401和布置在第一圆中的多个第一存储单元402; 布置在第二圈中的多个第二存储单元403; 与第一存储单元402的顶部连接的第一旋转单元501; 与第二存储单元403的顶部连接的第一盖单元502; 以及与第一旋转单元501连接的多个第一滚动单元601，其中第一存储单元401和第一存储单元402可相对于第二存储单元403旋转。版权所有（C）2011， JPO＆INPIT

5. 发明专利

JP2008013537A Fusion protein of swine breeding/respiratory disorder syndrome virus as prrs vaccine 审中-公开
标题翻译：作为PRRS疫苗的猪育种/呼吸系统疾病综合症病毒的融合蛋白
公开(公告)号：JP2008013537A
公开(公告)日：2008-01-24
申请号：JP2006287430
申请日：2006-10-23
申请人： Healthbanks Biotech Co Ltd , ヘルスバンクスバイオテックカンパニーリミテッド
发明人： CHANG HSIU-KANG , LIAO CHAO-WEI
IPC分类号： C07K19/00 , A61K39/21 , A61P11/00 , A61P15/00 , A61P31/14 , C07K7/08 , C07K14/08 , C07K14/21 , C12N15/09
CPC分类号： C07K14/21 , A61K39/12 , A61K39/385 , A61K2039/552 , A61K2039/55566 , A61K2039/6037 , C07K14/005 , C07K2319/02 , C07K2319/04 , C12N2770/10022 , C12N2770/10034
摘要： PROBLEM TO BE SOLVED: To provide a fusion protein as a PRRSV subunit vaccine inducing PRRSV neutralization value in swine. SOLUTION: The PRRSV subunit vaccine is provided, comprising PE-PQGAB-K3 as the fusion protein that induces the neutralization value in swine and comprises a chimeric polypeptide containing the N-terminal part of PRRSV ORF5 and ORF6 structural protein, part of a Pseudomonas aeruginosa exotoxin A-bound and rearranged domain, and a carbonyl-terminated domain comprising a sequence KDEL-KDEL-KDEL(K3). Reduction of inflammation owing to a group of PE-PQGAB-K3 vaccines in the lung of a swine infected with PRRSV indicates that there is no antigen-specific allergic effect in PQGAB. Importantly, in a swine infection test, the PE-PQGAB-K3 vaccine is better in defence against PRRSV infection than a control group. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供融合蛋白作为在猪中诱导PRRSV中和值的PRRSV亚单位疫苗。解决方案：提供PRRSV亚单位疫苗，其包含PE-PQGAB-K3作为诱导猪中和值的融合蛋白，并且包含含有PRRSV ORF5和ORF6结构蛋白的N-末端部分的嵌合多肽，其部分铜绿假单胞菌外毒素A结合和重排域，以及包含序列KDEL-KDEL-KDEL（K3）的羰基封端结构域。在PRRSV感染猪的肺中由于一组PE-PQGAB-K3疫苗引起的炎症减少表明在PQGAB中没有抗原特异性过敏作用。重要的是，在猪感染检测中，与对照组相比，PE-PQGAB-K3疫苗在防御PRRSV感染方面更好。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2007282636A Method for developing protein vaccines and vaccines for avian influenza using reverse genetic method 审中-公开
标题翻译：使用反向遗传方法开发AVIAN INFLUENZA的蛋白疫苗和疫苗的方法
公开(公告)号：JP2007282636A
公开(公告)日：2007-11-01
申请号：JP2007129826
申请日：2007-04-13
申请人： Healthbanks Biotech Co Ltd , 生寶生物科技股▲ふん▼有限公司
发明人： LIAO CHAO-WEI , JANG SHIOU-GANG , HWANG KINKAI
IPC分类号： C12N7/00 , A61K39/00 , A61K39/145 , C12N15/09
CPC分类号： A61K39/145 , A61K39/12 , C07K14/005 , C07K2319/55 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151
摘要： PROBLEM TO BE SOLVED: To provide a method for developing protein vaccines and vaccines for avian influenza using a reverse genetic method. SOLUTION: The present invention relates to a preparation method of protein vaccines, and comprises the steps of: (a) providing at least one amino acid sequence of an epitope peptide of a target antigen protein; (b) modifying a wild-type nucleic acid sequence of the epitope peptide; (c) synthesizing a plurality of primers of the modified nucleic acid sequence; (d) synthesizing the modified nucleic acid in vitro; (e) binding the modified nucleic acid to form a plasmid; (f) transforming the plasmid into a host cell to produce a synthesized nucleic acid encoded with the epitope peptide; and (g) collecting and purifying the epitope peptide. Vaccines with high safety and antibody-inducing effect against diseases with high risk are rapidly produced by the reverse genetic method. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供使用反向遗传方法开发用于禽流感的蛋白疫苗和疫苗的方法。解决方案：本发明涉及蛋白疫苗的制备方法，包括以下步骤：（a）提供靶抗原蛋白的表位肽的至少一个氨基酸序列; （b）修饰表位肽的野生型核酸序列; （c）合成修饰的核酸序列的多个引物; （d）体外合成修饰的核酸; （e）结合修饰的核酸以形成质粒; （f）将质粒转化到宿主细胞中以产生用表位肽编码的合成核酸; 和（g）收集和纯化表位肽。通过反向遗传方法快速产生具有高安全性和抗高血压疾病抗体诱导作用的疫苗。版权所有（C）2008，JPO＆INPIT

7. 发明申请

US20180163177A1 SERUM-FREE CULTURE MEDIUM AND METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS 审中-公开
公开(公告)号：US20180163177A1
公开(公告)日：2018-06-14
申请号：US15832774
申请日：2017-12-06
申请人： HealthBanks Biotech Co. Ltd.
发明人： Wei-Yu Lo , Pei-Chi Tseng , Chao-Hsun Yu
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , C12N5/0665 , C12N2500/38 , C12N2500/90 , C12N2501/125 , C12N2501/145 , C12N2501/22 , C12N2501/2303 , C12N2501/2306 , C12N2501/26 , C12N2501/392 , C12N2502/1388
摘要： A serum-free culture medium for hematopoietic stem cell (HSC) expansion is provided. The serum-free culture medium includes a serum-free base medium, cytokines, an umbilical cord mesenchymal stem cell conditioned medium and supplemental components. The cytokines comprise stem cell factor, thrombopoietin and hematopoietic growth factor Flt3 ligand. The umbilical cord mesenchymal stern cell conditioned medium is derived from culturing human umbilical cord mesenchymal stem cells. The supplemental components comprise vitamin C, vitamin E or a combination of vitamin C and vitamin E.

8. 发明申请

US20160066566A1 CRYOPRESERVATION OF UMBILICAL CORD TISSUE STRIPS FOR CORD TISSUE-DERIVED STEM CELLS 有权
标题翻译：骨组织衍生干细胞的脐带组织条的CRYOPRE
公开(公告)号：US20160066566A1
公开(公告)日：2016-03-10
申请号：US14850810
申请日：2015-09-10
申请人： Healthbanks Biotech Co., Ltd.
发明人： Hsiu-Kang Chang , Pei-Chi Tseng , Xiang-Rui Xu , Chi-Hsuan Huang , Wei-Yu Lo
IPC分类号： A01N1/02 , C12N5/073
CPC分类号： A01N1/0236 , A61K35/51 , C12N5/0665
摘要： A method for cryopreserving an umbilical cord tissue strip includes the steps of: (a) applying tension to a segment of an umbilical cord to expand spaces between umbilical cord vessels; (b) cutting the segment of the umbilical cord, at the spaces between the umbilical cord vessels in a longitudinal direction that parallels a length of the umbilical cord vessels, to obtain the umbilical cord tissue strip, wherein the umbilical cord tissue strip contains Wharton's jelly from a perivascular region, a intervascular region, and a subamnion region; (c) incubating the umbilical cord tissue strip with a cryogenic composition; and (d) cryopreserving the umbilical cord tissue strip containing the Wharton's jelly and the cryogenic composition.
摘要翻译：用于冷冻保存脐带组织条的方法包括以下步骤：（a）向脐带的一段施加张力以扩展脐带血管之间的空间; （b）在与脐带血管长度方向的纵向方向上的脐带血管之间的间隔切割脐带的部分，以获得脐带组织带，其中脐带组织条含有沃顿的果冻来自血管周围区域，血管内区域和亚氨酸盐区域; （c）用低温组合物孵育脐带组织条; 和（d）冷冻保存含有沃顿的果冻和低温组合物的脐带组织条。

9. 发明专利

JP2009149372A Storage-access apparatus for storing products and storage system thereof 有权
标题翻译：用于存储产品和存储系统的存储访问设备
公开(公告)号：JP2009149372A
公开(公告)日：2009-07-09
申请号：JP2008296312
申请日：2008-11-20
申请人： Healthbanks Biotech Co Ltd , ヘルスバンクスバイオテックカンパニーリミテッド
发明人： LIN SHANG-CHIH , CHEN JIA-YOU
IPC分类号： B65D77/04 , B65D77/08
CPC分类号： A01N1/0236 , A01N1/0252 , A01N1/0257 , F25D3/10 , G01N1/42 , G01N35/025 , G01N2035/0425
摘要： PROBLEM TO BE SOLVED: To provide a storage-access apparatus employed in depositing and picking up products independently. SOLUTION: The storage-access apparatus 100 includes a first support device including a first base 11; at least one first storage-access device 13 and at least one first storage device 14, disposed on the first base and arranged in a first circle; a second support device including a second base 15; at least one second storage-access device 17 and at least one second storage device 18, disposed on the second base and arranged in a second circle; and a transporting device, wherein the first storage-access device, the first storage device, the second storage-access device and the at least one second storage device each has plural compartments 23, the transporting device corresponds to the compartments, and the first storage-access device and the first storage device can rotate relative to the second storage-access device and the second storage device. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于独立地存放和拾取产品的存储访问装置。解决方案：存储访问装置100包括：第一支撑装置，包括第一基座11; 至少一个第一存储存取装置13和至少一个第一存储装置14，其设置在第一基座上并且布置在第一圆中; 第二支撑装置，包括第二基座15; 至少一个第二存储访问装置17和至少一个第二存储装置18，其布置在第二基座上并且布置在第二圆圈中; 以及传送装置，其中，所述第一存储访问装置，所述第一存储装置，所述第二存储访问装置和所述至少一个第二存储装置各自具有多个隔室23，所述传送装置对应于所述隔间，并且所述第一存储所述第一存储设备可以相对于所述第二存储访问设备和所述第二存储设备旋转。版权所有（C）2009，JPO＆INPIT

10. 发明专利

JP2006056869A Fusion protein for suppressing cervical cancer 有权
标题翻译：用于抑制癌症的融合蛋白
公开(公告)号：JP2006056869A
公开(公告)日：2006-03-02
申请号：JP2004320487
申请日：2004-11-04
申请人： Healthbanks Biotech Co Ltd , 生寶生物科技股▲ふん▼有限公司
发明人： JANG SHIOU-GANG , LIAO CHAO-WE , CHENG WEN-FANG
IPC分类号： C07K19/00 , A61K38/00 , A61K39/23 , A61P35/00 , C07K14/025 , C07K14/21 , C12N15/09
CPC分类号： C07K14/005 , A01K2267/0331 , A61K38/00 , A61K39/00 , C07K2319/01 , C07K2319/04 , C12N2710/20022
摘要： PROBLEM TO BE SOLVED: To provide a fusion protein for suppressing cervical cancer to suppress the development of cancer.
SOLUTION: The fusion protein for suppressing cervical cancer contains E7 protein peptide sequence of human papiloma virus 16, a translocation peptide sequence and a peptide in the terminal fragment of carboxy group. The invention further provides an antibody composition bonded with the E7 peptide. The translocation peptide sequence is derived from a part of Pseudomonas aeruginosa exotoxin and shows a specific sequence of the E7 peptide.
COPYRIGHT: (C)2006,JPO&NCIPI

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