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1. 发明专利

JPH01139329A DECORATIVE SEAL ATTACHING METHOD FOR USE IN PACKAGED FOODS 失效
公开(公告)号：JPH01139329A
公开(公告)日：1989-05-31
申请号：JP29038787
申请日：1987-11-17
申请人： HAYASHI JUN
发明人： HAYASHI JUN
IPC分类号： B65C9/18
摘要： PURPOSE:To ensure an accurate attachment of labels on a film-wrapped tray in given position and direction, by wrapping the tray, in which foods are received, with a film material, and attaching a decorative seal supplied from a continuous decorative band disposed above the tray, onto an upper surface thereof. CONSTITUTION:Intended foods are received in the inside space 3 of a tray 1 having approximate rectangular configuration in plane view. Then, the tray is wholly wrapped with synthetic-resin wrapping film 5 to form a package 6 which is thereafter transported to a decorative seal attaching position P. On the other hand, the decorative seal 7 having a one-side-up direction is provided as a continuous decorative band 8 on a peelable continuous substrate sheet 10 in spaced relation. The decorative seal, which is selected depending on the foods to be wrapped, is allowed to contact the package from above, and attached to the corner thereof in the predetermined direction. This inclined attachment method assures the positioning of the decorative seal in an accurate direction on the package.

2. 发明申请

WO1991009534A1 PROCESSED HEMOGLOBIN AND PRODUCTION THEREOF 审中-公开
标题翻译：加工HEMOGLOBIN及其生产
公开(公告)号：WO1991009534A1
公开(公告)日：1991-07-11
申请号：PCT/JP1990001642
申请日：1990-12-17
申请人： OGAWA & CO., LTD. , IZUMI, Kenjiro , NONAKA, Takehiko , HAYASHI, Jun
发明人： OGAWA & CO., LTD.
IPC分类号： A23J01/06
CPC分类号： A23J3/12 , A23J1/06
摘要： A water-soluble, deodorized and decolorized processed hemoglobin which is produced by washing starting hemoglobin with water, dispersing in water under an alkaline condition of at least pH 9 for dissolution and treating with hydrogen peroxide, and which is suitable as the raw material of food.
摘要翻译：通过用水洗涤起始血红蛋白而产生的水溶性，除臭和脱色的加工血红蛋白，在至少pH9的碱性条件下分散在水中以溶解和用过氧化氢处理，并且适合作为食物的原料。

3. 发明申请

WO2009026239A1 SMALL MOLECULE INHIBITORS OF LCK SH2 DOMAIN BINDING 审中-公开
标题翻译： LCK SH2域绑定小分子抑制剂
公开(公告)号：WO2009026239A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/073498
申请日：2008-08-18
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , HAYASHI, Jun , MACKERELL, Alexander, Jr. , MIA, Younus , XIA, Guanjun
发明人： HAYASHI, Jun , MACKERELL, Alexander, Jr. , MIA, Younus , XIA, Guanjun
IPC分类号： A01N43/56 , A61K31/415
CPC分类号： A61K31/415
摘要： The present invention provides, materials and methods for modulating an immune response. The materials and methods may be used to treat diseases associated with an aberrant immune response. In some embodiments, materials and methods of the invention may be used to treat autoimmune diseases, for example, rheumatoid arthritis.
摘要翻译：本发明提供了调节免疫应答的材料和方法。材料和方法可用于治疗与异常免疫应答相关的疾病。在一些实施方案中，本发明的材料和方法可用于治疗自身免疫性疾病，例如类风湿性关节炎。

4. 发明申请

WO2005060956A1 IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN 审中-公开
标题翻译：免疫组织化学物质，目标和抑制TYYOSENE KINASE p56 LCK SH2的pY + 3结合位点
公开(公告)号：WO2005060956A1
公开(公告)日：2005-07-07
申请号：PCT/US2003/039501
申请日：2003-12-12
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , MACKERELL, Alexander, D., Jr. , HAYASHI, Jun , NAGARSEKAR, Ashish , HUANG, Niu , MACIAS, Alba
发明人： MACKERELL, Alexander, D., Jr. , HAYASHI, Jun , NAGARSEKAR, Ashish , HUANG, Niu , MACIAS, Alba
IPC分类号： A61K31/33
CPC分类号： A61K31/33
摘要： Small molecular-weight non-peptidic compounds block Lck SH2 domain-dependent interactions. The inhibitors omit phosphotyrosine (pY) or related moieties.
摘要翻译：小分子量非肽化合物阻断Lck SH2结构域依赖性相互作用。抑制剂省略磷酸酪氨酸（pY）或相关部分。

5. 发明申请

WO0210191A3 IMMUNOMODULATORY COMPOUNDS 审中-公开
标题翻译：免疫组织化学
公开(公告)号：WO0210191A3
公开(公告)日：2002-04-25
申请号：PCT/US0141467
申请日：2001-07-31
申请人： UNIV MARYLAND , HAYASHI JUN , MACKERELL ALEXANDER D
发明人： HAYASHI JUN , MACKERELL ALEXANDER D
IPC分类号： A61K31/4406 , A61K31/16 , A61K31/17 , A61K31/192 , A61K31/195 , A61K31/205 , A61K31/21 , A61K31/222 , A61K31/265 , A61K31/4402 , A61K31/47 , A61K31/66 , A61P35/00 , A61P37/00 , A61P37/06
CPC分类号： A61K31/16 , A61K31/17 , A61K31/192 , A61K31/195 , A61K31/21 , A61K31/222 , A61K31/265 , A61K31/4402 , A61K31/47 , A61K31/66
摘要： Compounds are described which modulate the tzrosine kinase activity of p56lck and signal transduction pathways in which this enzyme is involved. The invention also relates to compounds which have immunomodulatory activity, e.g., which have immunosuppressant or immunostimulatory activity, and/or which have an antineoplastic effect. The invention further relates to compositions comprising these compounds, and methods of using them.

6. 发明申请

WO2011152142A8 METHOD FOR CULTIVATING PLANT AND PLANT CULTIVATION DEVICE 审中-公开
标题翻译：用于培育植物和植物培养装置的方法
公开(公告)号：WO2011152142A8
公开(公告)日：2012-02-23
申请号：PCT/JP2011059649
申请日：2011-04-19
申请人： SHARP KK , UNIV OSAKA , TATSUMI NAOYUKI , FUJI HIROSHI , AKAMATSU FUMITERU , KOBAYASHI AKIO , KURIMOTO SHUJI , SUDA YOSHITO , FUJIYAMA KAZUHITO , OKAZAWA ATSUSHI , HIRATA KAZUMASA , HARADA KAZUO , MACHIMURA TAKASHI , KATO SATORU , HAYASHI JUN
发明人： TATSUMI NAOYUKI , FUJI HIROSHI , AKAMATSU FUMITERU , KOBAYASHI AKIO , KURIMOTO SHUJI , SUDA YOSHITO , FUJIYAMA KAZUHITO , OKAZAWA ATSUSHI , HIRATA KAZUMASA , HARADA KAZUO , MACHIMURA TAKASHI , KATO SATORU , HAYASHI JUN
IPC分类号： A01G7/00
CPC分类号： A01G9/00 , A01G1/001 , A01G7/00 , A01G9/24 , Y02A40/264
摘要： A method for cultivating a plant which comprises placing the plant under a pressure of 1.5-10 atmospheres inclusive and cultivating the same. A plant cultivation device (1) which comprises a cultivation chamber (10) and a compressor (20) for blowing compressed air into the cultivation chamber. A carry-in entrance (30), which is formed in the side wall (16) of the cultivation chamber (10) for carrying in/out materials to/from the chamber, is provided with a semispherical cover (31) projecting toward the inside of the cultivation chamber (10). The cover (31) is in contact, via a packing (32), with the inner face of the side wall (16) surrounding the carry-in entrance (30), thereby blocking the carry-in entrance (30). When compressed air is supplied by the compressor (20) in this state, the pressure in the cultivation chamber (10) becomes higher than the atmospheric pressure. By cultivating a plant in the high-pressure environment differing from the natural environment, the growth rate of the plant can be improved. Also provided is a plant cultivation device which enables the cultivation of a plant in a high-pressure environment.
摘要翻译：一种栽培植物的方法，包括将植物放置在包含1.5-10大气压并培养植物的压力下。一种植物栽培装置（1），其包括用于将压缩空气吹入培养室的培养室（10）和压缩机（20）。形成在培养室（10）的侧壁（16）中的用于向/从室内输送材料的进入口（30）设置有半球形盖（31），其朝向在培养室（10）的内部。盖31经由密封件32与侧壁（16）的内表面围绕进入入口（30）接触，从而阻止进入入口（30）。当在这种状态下由压缩机（20）供给压缩空气时，培养室（10）中的压力变得高于大气压。通过在与自然环境不同的高压环境中种植植物，可以提高植物的生长速度。还提供了能够在高压环境下种植植物的植物栽培装置。

7. 发明申请

WO2011022394A2 MATERIALS AND METHODS FOR THE DEVELOPMENT OF AN ANTIGEN-SPECIFIC IMMUNE NON-RESPONSIVENESS STATE 审中-公开
标题翻译：用于发展抗原特异性免疫非反应性状态的材料和方法
公开(公告)号：WO2011022394A2
公开(公告)日：2011-02-24
申请号：PCT/US2010045753
申请日：2010-08-17
申请人： A & G PHARMACEUTICAL INC , HAYASHI JUN
发明人： HAYASHI JUN
IPC分类号： A61K39/395 , A61K39/38 , A61P3/10 , A61P19/02 , C07K14/715 , C07K14/725
CPC分类号： A61K39/0008 , A61K31/455 , A61K31/502 , A61K31/609
摘要： The present invention provides materials and methods for making a subject non- responsive to an antigen. Methods of the invention may comprise contacting the subject with the antigen and a compound that induces anergy. In some embodiments, the antigen may be an autoimmune antigen, examples of which include, but are not limited to acetylcholine receptor for myasthenia gravis, glutamic acid decarboxylase for type I diabetes mellitus and rheumatoid factor in rheumatoid arthritis, hi some embodiments, the present invention provides a method of transplanting an organ, tissue, or cells into a subject (e.g., a mammal such as a human).
摘要翻译：本发明提供了使受试者对抗原无反应性的材料和方法。本发明的方法可以包括使受试者与抗原和诱导无反应性的化合物接触。在一些实施方案中，抗原可以是自身免疫抗原，其实例包括但不限于重症肌无力的乙酰胆碱受体，I型糖尿病的谷氨酸脱羧酶和类风湿性关节炎中的类风湿因子。在一些实施方案中，本发明提供了将器官，组织或细胞移植到受试者（例如哺乳动物，例如人）中的方法。

8. 发明申请

WO2011022394A3 MATERIALS AND METHODS FOR THE DEVELOPMENT OF AN ANTIGEN-SPECIFIC IMMUNE NON-RESPONSIVENESS STATE 审中-公开
公开(公告)号：WO2011022394A3
公开(公告)日：2011-02-24
申请号：PCT/US2010/045753
申请日：2010-08-17
申请人： A&G PHARMACEUTICAL, INC. , HAYASHI, Jun
发明人： HAYASHI, Jun
IPC分类号： A61K39/395 , A61K39/38 , C07K14/715 , C07K14/725 , A61P3/10 , A61P19/02
摘要： The present invention provides materials and methods for making a subject non- responsive to an antigen. Methods of the invention may comprise contacting the subject with the antigen and a compound that induces anergy. In some embodiments, the antigen may be an autoimmune antigen, examples of which include, but are not limited to acetylcholine receptor for myasthenia gravis, glutamic acid decarboxylase for type I diabetes mellitus and rheumatoid factor in rheumatoid arthritis, hi some embodiments, the present invention provides a method of transplanting an organ, tissue, or cells into a subject (e.g., a mammal such as a human).

9. 发明申请

WO2008024759A3 IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE PY+3 BINDING SITE OF TYROSENE KINASE P56 LCK SH2 DOMAIN 审中-公开
标题翻译：免疫组织化学物质，目标和抑制TYYSENE KINASE P56 LCK SH2的PY + 3结合位点
公开(公告)号：WO2008024759A3
公开(公告)日：2008-10-30
申请号：PCT/US2007076402
申请日：2007-08-21
申请人： UNIV MARYLAND , MACKERELL ALEXANDER , HAYASHI JUN
发明人： MACKERELL ALEXANDER , HAYASHI JUN
IPC分类号： A61K31/33
CPC分类号： A61K31/426 , A61K31/427
摘要： Small molecular-weight non-peptidic compounds block Lck SH2 domain-dependent interactions. The inhibitors omit phosphotyrosine (pY) or related moieties.
摘要翻译：小分子量非肽化合物阻断Lck SH2结构域依赖性相互作用。抑制剂省略磷酸酪氨酸（pY）或相关部分。

10. 发明申请

WO2008024759A2 IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE PY+3 BINDING SITE OF TYROSENE KINASE P56 LCK SH2 DOMAIN 审中-公开
标题翻译：靶向和抑制TYROSENE KINASE P56 LCK SH2域PY + 3结合位点的免疫调节化合物
公开(公告)号：WO2008024759A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/076402
申请日：2007-08-21
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , MACKERELL, Alexander , HAYASHI, Jun
发明人： MACKERELL, Alexander , HAYASHI, Jun
IPC分类号： A61K31/427 , A61K31/426
CPC分类号： A61K31/426 , A61K31/427
摘要： Small molecular-weight non-peptidic compounds block Lck SH2 domain-dependent interactions. The inhibitors omit phosphotyrosine (pY) or related moieties.
摘要翻译：小分子量非肽类化合物阻断Lck SH2结构域依赖性相互作用。抑制剂不含磷酸酪氨酸（pY）或相关部分。

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