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1. 发明申请

WO2004106363A2 PURIFICATION MEANS 审中-公开
标题翻译：净化手段
公开(公告)号：WO2004106363A2
公开(公告)日：2004-12-09
申请号：PCT/GB2004/002327
申请日：2004-06-01
申请人： CSS-ALBACHEM LIMITED , HAY, Alastair , COTTON, Graham , RAMAGE, Robert
发明人： HAY, Alastair , COTTON, Graham , RAMAGE, Robert
IPC分类号： C07K1/13
CPC分类号： C07K1/13 , C07D213/38
摘要： Disclosed is a tag for purification of peptides, The tag structure facilitates the easy cleavage of a bond formed between the tag molecule and a peptide to which it is bound under conditions which minimise, indeed preferably prevent, damage to the peptide. The tag molecules of the invention may be used to separate and/or purify a peptide from a mixture of peptides and/or other components.
摘要翻译：披露了用于纯化肽的标签。标签结构有助于在最小化，实际上优选地防止对肽的损伤的条件下容易地切割标签分子与其所结合的肽之间形成的键。本发明的标签分子可用于从肽和/或其它组分的混合物分离和/或纯化肽。

2. 发明申请

WO2003035636A3 PROCESS FOR THE PREPARATION OF 3 - ISOCHROMANONE 审中-公开
公开(公告)号：WO2003035636A3
公开(公告)日：2003-05-01
申请号：PCT/GB2002/004451
申请日：2002-10-02
申请人： SYNGENTA LIMITED , WHITTON, Alan, John , JONES, Raymond, Vincent, Heavon , HAY, Alastair, Mackie
发明人： WHITTON, Alan, John , JONES, Raymond, Vincent, Heavon , HAY, Alastair, Mackie
IPC分类号： C07D311/76
摘要： A process is described for the preparation of 3-isochromanone having the general formula (I): the process comprising reacting ο-tolylacetic acid with a suitable halogenating agent to form a compound of general formula (III): wherein R is halo, reacting the compound of general formula (III) with a suitable halogenating agent to form a compound of the general formula (II): wherein X is halo; and (a) treating a compound of the general formula (II): with an aqueous base to a pH of 7 to 14 followed by acidification; or (b) adding the compound of the general formula (II) to water with the simultaneous addition of base to maintain the pH between 5 and 8; or (c) treating the compound of the general formula (II)with water or aqueous acid followed by pH adjustment to a pH between 5 and 8. Typically both R and X are chloro. 3-Isochromanone is useful, inter alia , as an intermediate in the manufacture of agricultural products, especially fungicides of the strobilurin type.

3. 发明申请

WO2003035636A2 CHEMICAL PROCESS 审中-公开
标题翻译：化学工艺
公开(公告)号：WO2003035636A2
公开(公告)日：2003-05-01
申请号：PCT/GB2002/004451
申请日：2002-10-02
申请人： SYNGENTA LIMITED , WHITTON, Alan, John , JONES, Raymond, Vincent, Heavon , HAY, Alastair, Mackie
发明人： WHITTON, Alan, John , JONES, Raymond, Vincent, Heavon , HAY, Alastair, Mackie
IPC分类号： C07D311/76
CPC分类号： C07D311/76 , C07C51/60 , C07C51/62 , C07C57/72 , C07C57/76
摘要： A process is described for the preparation of 3-isochromanone having the general formula (I): the process comprising reacting ο-tolylacetic acid with a suitable halogenating agent to form a compound of general formula (III): wherein R is halo, reacting the compound of general formula (III) with a suitable halogenating agent to form a compound of the general formula (II): wherein X is halo; and (a) treating a compound of the general formula (II): with an aqueous base to a pH of 7 to 14 followed by acidification; or (b) adding the compound of the general formula (II) to water with the simultaneous addition of base to maintain the pH between 5 and 8; or (c) treating the compound of the general formula (II)with water or aqueous acid followed by pH adjustment to a pH between 5 and 8. Typically both R and X are chloro. 3-Isochromanone is useful, inter alia , as an intermediate in the manufacture of agricultural products, especially fungicides of the strobilurin type.
摘要翻译：描述了用于制备具有通式（I）的3-异色满酮的方法：该方法包括使邻甲酰基乙酸与合适的卤化剂反应以形成通式（III）的化合物：其中R是卤素，使通式（III）的化合物与合适的卤化剂反应以形成通式（II）的化合物：其中X为卤素; 和（a）用碱水溶液处理通式（II）的化合物至pH7至14，然后酸化; 或（b）将通式（II）的化合物加入到水中同时加入碱以保持pH在5和8之间; 或（c）用水或含水酸处理通式（II）的化合物，然后pH调节至5至8之间的pH值。通常R和X均为氯。 3-异色满酮尤其可用作制造农产品，特别是嗜球果伞素类杀真菌剂的中间体。

4. 发明申请

WO2011114099A1 PURIFICATION TAGS OF SYNTHETIC PEPTIDES AND PROTEINS 审中-公开
标题翻译：合成肽和蛋白质的纯化标签
公开(公告)号：WO2011114099A1
公开(公告)日：2011-09-22
申请号：PCT/GB2011/000363
申请日：2011-03-16
申请人： ALMAC SCIENCES (SCOTLAND) LIMITED , ANDERSON, David, William , COTTON, Graham, John , HAY, Alastair, Mackie , ARMSTRONG, Paul, William , WILSON, Ian
发明人： ANDERSON, David, William , COTTON, Graham, John , HAY, Alastair, Mackie , ARMSTRONG, Paul, William , WILSON, Ian
IPC分类号： C07D215/36 , C07K1/16 , C07K1/13
CPC分类号： C07D215/36 , C07K1/13 , C07K1/22
摘要： The present invention relates to a series of compounds useful for effecting purification, in particular for use in purification of synthetic peptides and proteins. The compounds of the invention are particularly efficient at securely anchoring peptides or proteins to a surface and allowing the peptide or protein to become uniformly orientated, thus ensuring that substantially all of the peptide or protein is available for molecular binding to a substrate.
摘要翻译：本发明涉及可用于实现纯化的一系列化合物，特别是用于纯化合成肽和蛋白质。本发明的化合物在将肽或蛋白质牢固地固定在表面上并允许肽或蛋白质变得均匀取向是特别有效的，因此确保基本上所有的肽或蛋白质可用于分子结合至底物。

5. 发明申请

WO2004106363A3 A TAG FOR PURIFICATION OF PEPTIDES 审中-公开
标题翻译：用于净化肽的标签
公开(公告)号：WO2004106363A3
公开(公告)日：2005-05-26
申请号：PCT/GB2004002327
申请日：2004-06-01
申请人： CSS ALBACHEM LTD , HAY ALASTAIR , COTTON GRAHAM , RAMAGE ROBERT
发明人： HAY ALASTAIR , COTTON GRAHAM , RAMAGE ROBERT
IPC分类号： C07D213/38 , C07K1/13 , C07K1/16
CPC分类号： C07K1/13 , C07D213/38
摘要： Disclosed is a tag for purification of peptides, The tag structure facilitates the easy cleavage of a bond formed between the tag molecule and a peptide to which it is bound under conditions which minimise, indeed preferably prevent, damage to the peptide. The tag molecules of the invention may be used to separate and/or purify a peptide from a mixture of peptides and/or other components.
摘要翻译：公开了用于纯化肽的标签。标签结构有助于在最小化，实际上优选地防止对肽的损害的条件下容易地切割标签分子与其所结合的肽之间形成的键。本发明的标签分子可用于从肽和/或其它组分的混合物分离和/或纯化肽。

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