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1. 发明申请

WO2006130470A3 METHODS AND COMPOSITIONS COMPRISING CHIMERIC AND FULL-LENGTH HUMAN ACETYL-COA CARBOXYLASE 审中-公开
公开(公告)号：WO2006130470A3
公开(公告)日：2006-12-07
申请号：PCT/US2006/020461
申请日：2006-05-26
申请人： UNIVERSITY OF CHICAGO , HASELKORN, Robert , GORNICKI, Piotr
发明人： HASELKORN, Robert , GORNICKI, Piotr
IPC分类号： C12N15/82
摘要： Disclosed are isolated nucleic acid sequences encoding and conjugates comprising a non-human acetyl-CoA carboxylase (ACC) amino acid sequence and a human ACC amino acid sequence. Yeast cells comprising a nucleic acid sequence encoding a non-human ACC amino acid sequence and a human ACC amino acid sequence are also disclosed. Also disclosed are methods that involve (a) obtaining a candidate substance; (b) preparing a first and second yeast cell, wherein the first and second yeast cells each comprise a nucleic acid sequence encoding a non-human ACC amino acid sequence and a human ACC amino acid sequence; (c) contacting the first yeast cell with the candidate substance; and (d) assaying for growth inhibition of the first yeast cell by comparing the growth of the first yeast cell in the presence of the candidate substance to growth of the second yeast cell in the absence of the candidate substance. These methods can be applied, for example, in the identification of modulators of human ACC which can be directed to the treatment and prevention of diseases such as obesity, cardiovascular disease, diabetes, insulin resistance, hyperproliferative disease, and metabolic disease.

2. 发明申请

WO1998003637A1 BACTERIAL SUCROSE SYNTHASE COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：细菌枯草芽孢杆菌合成酶及其使用方法
公开(公告)号：WO1998003637A1
公开(公告)日：1998-01-29
申请号：PCT/US1997012736
申请日：1997-07-21
申请人： ARCH DEVELOPMENT CORPORATION , HASELKORN, Robert , BUIKEMA, William, J. , BAUER, Christopher, C.
发明人： ARCH DEVELOPMENT CORPORATION
IPC分类号： C12N09/10
CPC分类号： C12N9/1062 , C12N15/8245 , C12N15/8261 , Y02A40/146
摘要： The present invention provides isolated and purified polynucleotides that encode bacterial polypeptides that participate in the utilization of sucrose. Isolated bacterial sucrose synthase compositions and methods of use are provided. Processes for altering sucrose synthase activity, altering the starch and/or sucrose content of bacterial and/or plant cells, methods of identifying sucrose synthase-encoding nucleic acid segments, and compositions comprising sucrose synthase peptides and antibodies are also disclosed.
摘要翻译：本发明提供编码参与蔗糖利用的细菌多肽的分离和纯化的多核苷酸。提供了分离的细菌蔗糖合成酶组合物和使用方法。还公开了改变蔗糖合酶活性，改变细菌和/或植物细胞的淀粉和/或蔗糖含量，鉴定蔗糖合酶编码核酸片段的方法，以及包含蔗糖合成酶和抗体的组合物的方法。

3. 发明申请

WO2008103382A1 METHOD FOR ASSEMBLING HIGH-PURITY CHEMICAL LIBRARIES, COMPOUNDS SUPPRESSING ACETYL COENZYME A CARBOXYLASE ACTIVITIES DISCOVERED BY SAME 审中-公开
标题翻译：组装高纯度化学文库的方法，抑制乙酰胆碱酯化合物发现的羧酸酶活性
公开(公告)号：WO2008103382A1
公开(公告)日：2008-08-28
申请号：PCT/US2008/002240
申请日：2008-02-20
申请人： KOZMIN, Sergey , CUI, Jiayue , HASELKORN, Robert , GORNICKI, Piotr
发明人： KOZMIN, Sergey , CUI, Jiayue , HASELKORN, Robert , GORNICKI, Piotr
IPC分类号： A01P15/00
CPC分类号： C07D405/14 , C07D209/14 , C07D209/34 , C07D209/52 , C07D211/78 , C07D403/12 , C07D409/14 , C07D471/04
摘要： The present disclosure provides novel compounds of the formula (I): wherein R 0 , R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined in the detailed description. Two preferred compounds of formulae (IX) and (X) are disclosed.
摘要翻译：本公开提供了新的式（I）化合物：其中R 0，R 1，R 2，R 3， R 4，R 5，R 5和R 6如在详细描述中所定义。公开了两种优选的式（IX）和（X）化合物。

4. 发明申请

WO0066154A2 ANTI-MICROBIAL AGENTS, DIAGNOSTIC REAGENTS, AND VACCINES BASED ON UNIQUE APICOMPLEXAN PARASITE COMPONENTS 审中-公开
标题翻译：基于独特的APICOMPLEXAN PARASITE组件的抗微生物剂，诊断试剂和疫苗
公开(公告)号：WO0066154A2
公开(公告)日：2000-11-09
申请号：PCT/US0011478
申请日：2000-04-27
申请人： ARCH DEV CORP , MRJ TRUST , MCLEOD RIMA W , ROBERTS CRAIG , ROBERTS FIONA , JOHNSON JENNIFER , KIRISITS MICHAEL , FERGUSON DAVID , LYONS RUSSELL , MUI ERNEST , HASELKORN ROBERT , MACK DOUG , SAMUEL BENJAMIN , GORNICKI PIOTRI , ZUTHER ELLEN
发明人： MCLEOD RIMA W , ROBERTS CRAIG , ROBERTS FIONA , JOHNSON JENNIFER , KIRISITS MICHAEL , FERGUSON DAVID , LYONS RUSSELL , MUI ERNEST , HASELKORN ROBERT , MACK DOUG , SAMUEL BENJAMIN , GORNICKI PIOTRI , ZUTHER ELLEN
IPC分类号： A61K39/002 , A61P37/02 , C12N15/60 , C12Q1/18 , A61K39/00
CPC分类号： A61K39/002 , C12Q1/18
摘要： This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphorfructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors. A cDNA sequence that encodes chorismate synthase expressed at an early state of Apicomplexan development, is disclosed and may be altered to produce a "knockout" organism useful in vaccine production.
摘要翻译：本发明涉及不包括psbA或PPi磷酸果糖激酶的植物样代谢途径的组分的用途，并且通常不在动物中操作或由质体DNA编码，以开发干扰Apicomplexan生长和存活的组合物。途径的组分包括酶，转运肽和编码酶和肽的核苷酸序列，或这些核苷酸序列的启动子，其中抗体，反义分子和其它抑制剂被引导。基于组分及其抑制剂开发诊断和治疗试剂和疫苗。公开了编码在Apicomplexan发育的早期状态下表达的绒毛膜合成酶的cDNA序列，并且可以改变以产生用于疫苗生产的“敲除”生物体。

5. 发明申请

WO2006130470A2 METHODS AND COMPOSITIONS COMPRISING CHIMERIC AND FULL-LENGTH HUMAN ACETYL-COA CARBOXYLASE 审中-公开
标题翻译：包含全身和全长人乙酰辅酶A羧酸酶的方法和组合物
公开(公告)号：WO2006130470A2
公开(公告)日：2006-12-07
申请号：PCT/US2006020461
申请日：2006-05-26
申请人： UNIV CHICAGO , HASELKORN ROBERT , GORNICKI PIOTR
发明人： HASELKORN ROBERT , GORNICKI PIOTR
CPC分类号： C12Y604/01002 , C12N9/93
摘要： Disclosed are isolated nucleic acid sequences encoding and conjugates comprising a non-human acetyl-CoA carboxylase (ACC) amino acid sequence and a human ACC amino acid sequence. Yeast cells comprising a nucleic acid sequence encoding a non-human ACC amino acid sequence and a human ACC amino acid sequence are also disclosed. Also disclosed are methods that involve (a) obtaining a candidate substance; (b) preparing a first and second yeast cell, wherein the first and second yeast cells each comprise a nucleic acid sequence encoding a non-human ACC amino acid sequence and a human ACC amino acid sequence; (c) contacting the first yeast cell with the candidate substance; and (d) assaying for growth inhibition of the first yeast cell by comparing the growth of the first yeast cell in the presence of the candidate substance to growth of the second yeast cell in the absence of the candidate substance. These methods can be applied, for example, in the identification of modulators of human ACC which can be directed to the treatment and prevention of diseases such as obesity, cardiovascular disease, diabetes, insulin resistance, hyperproliferative disease, and metabolic disease.
摘要翻译：公开了编码和包含非人乙酰辅酶A羧化酶（ACC）氨基酸序列和人ACC氨基酸序列的分离的核酸序列。还公开了包含编码非人ACC氨基酸序列和人ACC氨基酸序列的核酸序列的酵母细胞。还公开了涉及（a）获得候选物质的方法; （b）制备第一和第二酵母细胞，其中所述第一和第二酵母细胞各自包含编码非人ACC氨基酸序列和人ACC氨基酸序列的核酸序列; （c）使第一酵母细胞与候选物质接触; 和（d）通过比较在不存在候选物质的条件下，在候选物质存在下第一酵母细胞的生长与第二酵母细胞的生长相比，测定第一酵母细胞的生长抑制。这些方法可以应用于例如鉴定人ACC的调节剂，其可以用于治疗和预防诸如肥胖症，心血管疾病，糖尿病，胰岛素抵抗，过度增殖性疾病和代谢疾病等疾病。

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