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1. 发明申请

WO0032205A8 IMMUNOMODULATORY METHODS USING CARBOHYDRATE ANTIGENS 审中-公开
标题翻译：使用碳水化合物抗原的免疫组织化学方法
公开(公告)号：WO0032205A8
公开(公告)日：2000-08-24
申请号：PCT/US9928308
申请日：1999-12-01
申请人： HARVARD COLLEGE , HARN DONALD A , OKANO MITSUHIRO
发明人： HARN DONALD A , OKANO MITSUHIRO
IPC分类号： A61K31/702 , A61K39/00 , A61K47/48 , A61P37/00 , A61P37/02 , A61K39/385
CPC分类号： A61K39/0003 , A61K47/61 , A61K47/646 , A61K2039/57 , A61K2039/6081
摘要： Methods for modulating immune responses, in particular IgE responses, are provided. The methods involve contacting an cell with an agent comprising multivalent lacto-N-neotetraose (LNnT), which modulates an immune response. The methods are useful for enhancing production of non-specific polyclonal IgE, inhibiting production of antigen-specific IgE responses, inducing cytokine production, and stimulating proliferation of splenocytes. In a preferred embodiment, the invention provides methods for modulating an immune response to an antigen (e.g., an allergen) in vivo. Pharmaceutical compositions for modulating immune responses comprising the agents of the invention are also provided.
摘要翻译：提供调节免疫应答，特别是IgE反应的方法。所述方法包括使细胞与包含调节免疫应答的多价乳-N-新四糖（LNnT）的试剂接触。该方法可用于增强非特异性多克隆IgE的产生，抑制抗原特异性IgE应答的产生，诱导细胞因子产生和刺激脾细胞增殖。在优选的实施方案中，本发明提供了在体内调节对抗原（例如变应原）的免疫应答的方法。还提供了用于调节包含本发明的药剂的免疫应答的药物组合物。

2. 发明申请

WO2012138377A3 THE USE OF LISTERIA VACCINE VECTORS TO REVERSE VACCINE UNRESPONSIVENESS IN PARASITICALLY INFECTED INDIVIDUALS 审中-公开
标题翻译：在异常感染的个体中使用赖克菌素疫苗反向疫苗不受欢迎
公开(公告)号：WO2012138377A3
公开(公告)日：2013-07-11
申请号：PCT/US2011054613
申请日：2011-10-03
申请人： UNIV PENNSYLVANIA , UNIV GEORGIA , HARN DONALD A JR , PATERSON YVONNE , MCEWEN LISA
发明人： HARN DONALD A JR , PATERSON YVONNE , MCEWEN LISA
IPC分类号： A61K39/02
CPC分类号： A61K39/21 , A61K39/00 , A61K39/0003 , A61K39/12 , A61K2039/523 , A61K2039/54 , A61K2039/577 , C12N2710/20034 , C12N2740/16034
摘要： This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
摘要翻译：本发明涉及使用利斯特氏菌疫苗载体在具有持续性Th2免疫应答谱的受试者中诱导Th1免疫应答的方法。

3. 发明申请

WO0032205A9 IMMUNOMODULATORY METHODS USING CARBOHYDRATE ANTIGENS 审中-公开
标题翻译：使用碳水化合物抗原的免疫组织化学方法
公开(公告)号：WO0032205A9
公开(公告)日：2001-07-12
申请号：PCT/US9928308
申请日：1999-12-01
申请人： HARVARD COLLEGE , HARN DONALD A , OKANO MITSUHIRO
发明人： HARN DONALD A , OKANO MITSUHIRO
IPC分类号： A61K31/702 , A61K39/00 , A61K47/48 , A61P37/00 , A61P37/02 , A61K39/385
CPC分类号： A61K39/0003 , A61K47/61 , A61K47/646 , A61K2039/57 , A61K2039/6081
摘要： Methods for modulating immune responses, in particular IgE responses, are provided. The methods involve contacting an cell with an agent comprising multivalent lacto-N-neotetraose (LNnT), which modulates an immune response. The methods are useful for enhancing production of non-specific polyclonal IgE, inhibiting production of antigen-specific IgE responses, inducing cytokine production, and stimulating proliferation of splenocytes. In a preferred embodiment, the invention provides methods for modulating an immune response to an antigen (e.g., an allergen) in vivo. Pharmaceutical compositions for modulating immune responses comprising the agents of the invention are also provided.
摘要翻译：提供调节免疫应答，特别是IgE反应的方法。所述方法包括使细胞与包含调节免疫应答的多价乳-N-新四糖（LNnT）的试剂接触。该方法可用于增强非特异性多克隆IgE的产生，抑制抗原特异性IgE应答的产生，诱导细胞因子产生和刺激脾细胞增殖。在优选的实施方案中，本发明提供了在体内调节对抗原（例如变应原）的免疫应答的方法。还提供了用于调节包含本发明的药剂的免疫应答的药物组合物。

4. 发明申请

WO2012145355A1 VACCINE DELIVERY METHOD 审中-公开
标题翻译：疫苗递送方法
公开(公告)号：WO2012145355A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/034012
申请日：2012-04-18
申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. , HARN, Donald A. , QUEIROZ, Rafaella , MCEWEN, Lisa
发明人： HARN, Donald A. , QUEIROZ, Rafaella , MCEWEN, Lisa
IPC分类号： A61P33/12 , A61K39/00 , A61K9/00
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/06 , A61K39/00 , A61K39/0003 , A61K39/012 , A61K39/0208 , A61K39/0258 , A61K39/0275 , A61K39/04 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/092 , A61K39/099 , A61K39/102 , A61K39/104 , A61K39/1045 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/155 , A61K39/17 , A61K39/215 , A61K39/255 , A61K39/265 , A61K39/29 , A61K39/292 , A61K47/42 , A61K2039/5252 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/552 , A61K2039/55505 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/575 , C12N2710/16334 , C12N2710/16734 , C12N2710/24034 , C12N2720/10034 , C12N2720/12334 , C12N2730/10134 , C12N2750/10034 , C12N2750/14334 , C12N2760/16134 , C12N2760/16171 , C12N2760/18034 , C12N2760/18134 , C12N2770/10034 , C12N2770/20034 , C12N2770/24334 , C12N2770/32334 , Y02A50/423
摘要： The present invention includes a composition including as one component a slurry matrix that is a liquid at room temperature and a gel at physiological salt concentrations and/or physiological temperatures and as a second component one or more antigens. Also include are methods of inducing an immune response in a subject and vaccinating a subject by administering such compositions.
摘要翻译：本发明包括一种组合物，其包括在室温下为液体的浆液基质和在生理盐浓度和/或生理温度下的凝胶和作为第二组分的一种或多种抗原的浆料基质。还包括在受试者中诱导免疫应答的方法，并通过施用这样的组合物接种受试者。

5. 发明申请

WO2012138377A2 THE USE OF LISTERIA VACCINE VECTORS TO REVERSE VACCINE UNRESPONSIVENESS IN PARASITICALLY INFECTED INDIVIDUALS 审中-公开
标题翻译：在异常感染的个体中使用赖克菌素疫苗反向疫苗不受欢迎
公开(公告)号：WO2012138377A2
公开(公告)日：2012-10-11
申请号：PCT/US2011/054613
申请日：2011-10-03
申请人： TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , ADVAXIS , HARN, Donald, A., Jr. , PATERSON, Yvonne
发明人： HARN, Donald, A., Jr. , PATERSON, Yvonne
IPC分类号： A61K39/02
CPC分类号： A61K39/21 , A61K39/00 , A61K39/0003 , A61K39/12 , A61K2039/523 , A61K2039/54 , A61K2039/577 , C12N2710/20034 , C12N2740/16034 , Y02A50/41 , Y02A50/412 , Y02A50/423
摘要： This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
摘要翻译：本发明涉及使用利斯特氏菌疫苗载体在具有持续性Th2免疫应答谱的受试者中诱导Th1免疫应答的方法。

6. 发明申请

WO0178748A2 IMMUNOMODULATORY METHODS USING CARBOHYDRATE ANTIGENS 审中-公开
标题翻译：使用碳水化合物抗原的免疫组织化学方法
公开(公告)号：WO0178748A2
公开(公告)日：2001-10-25
申请号：PCT/US0112365
申请日：2001-04-16
申请人： HARVARD COLLEGE , HARN DONALD A , MITSUHIRO OKANO , TERRAZAS LUIS IGNACIO
发明人： HARN DONALD A , MITSUHIRO OKANO , TERRAZAS LUIS IGNACIO
IPC分类号： A61K31/726 , A61K39/385 , A61K47/48 , A61P37/00 , A61K31/702
CPC分类号： A61K31/726 , A61K39/385 , A61K47/61 , A61K47/643 , A61K2039/57 , A61K2039/6081 , A61K2039/6087
摘要： Methods for modulating immune responses, such as IgE responses and autoimmune responses, are provided. The methods involve contacting a cell with an agent comprising multivalent lacto-N-neotetraose (LNnT), which modulates an immune response. The methods are useful for enhancing production of non-specific polyclonal IgE, inhibiting production of antigen-specific IgE responses, inducing cytokine production, and stimulating proliferation of splenocytes. In a preferred embodiment, the invention provides methods for modulating an immune response to an antigen (e.g., an allergan) in vivo . Pharmaceutical compositions for modulating immune responses comprising the agents of the invention are also provided. The invention also provides for treatment or prevention of shock in a subject using multivalent LNnT and methods for treating an autoimmune disease in a subject using multivalent LNnT. Still further the invention provides for treatment of cancer in a subject using monovalent LNnT.
摘要翻译：提供了调节免疫应答的方法，如IgE反应和自身免疫应答。所述方法包括使细胞与包含调节免疫应答的多价乳-N-新四糖（LNnT）的试剂接触。该方法可用于增强非特异性多克隆IgE的产生，抑制抗原特异性IgE应答的产生，诱导细胞因子产生和刺激脾细胞增殖。在优选的实施方案中，本发明提供了在体内调节对抗原（例如，allergan）的免疫应答的方法。还提供了用于调节包含本发明的药剂的免疫应答的药物组合物。本发明还提供使用多价LNnT治疗或预防受试者的休克以及使用多价LNnT治疗受试者的自身免疫性疾病的方法。本发明进一步提供了使用单价LNnT治疗受试者的癌症。

7. 发明申请

WO1997027872A1 IMMUNOMODULATORY METHODS USING OLIGOSACCHARIDES 审中-公开
标题翻译：使用低聚糖的免疫组织化学方法
公开(公告)号：WO1997027872A1
公开(公告)日：1997-08-07
申请号：PCT/US1997001682
申请日：1997-01-31
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HARN, Donald, A. , VELUPILLAI, Palanivel
发明人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
IPC分类号： A61K39/385
CPC分类号： A61K31/702 , A61K31/739 , A61K38/38 , A61K39/39 , A61K2039/55511 , A61K2039/57 , C07H15/00 , C07K14/5428 , Y10S530/813
摘要： Methods for modulating immune responses are provided. The methods involve contacting an immune cell with an agent that modulates interaction of a compound comprising a Lewis antigen with the immune cell such that production by the immune cell of at least one cytokine that regulates development of a T helper type 1 or T helper type 2 response is modulated. In one embodiment, the agent is a stimulatory form of a compound comprising a Lewis antigen, such as a Lewis , Lewis or Lewis oligosaccharide, or a derivative thereof. In another embodiment, the agent is an inhibitory form of a compound comprising a Lewis antigen, such as a Lewis , Lewis or Lewis oligosaccharide, or a derivative thereof. In various embodiments, the immune cell is a human immune cell, a macrophage, a T cell or a non-T, non-B spleen cell. In a preferred embodiment, the invention provides methods of stimulating a specific immune response to an antigne in vivo using a stimulatory agent of the invention. In another preferred embodiment, the invention provides methods for inhibiting allergic responses in vivo using an inhibitory agent of the invention. Pharmaceutical compositions for modulating immune responses comprising the stimulatory or inhibitory agents of the invention are also provided.
摘要翻译：提供了调节免疫应答的方法。所述方法包括使免疫细胞与调节包含Lewis抗原的化合物与免疫细胞的相互作用的试剂接触，使得由免疫细胞产生调节T型1型或T型辅助型2型的至少一种细胞因子响应被调制。在一个实施方案中，所述试剂是包含路易斯抗原如Lewis x，Lewis x或Lewis寡糖或其衍生物的化合物的刺激形式。在另一个实施方案中，所述试剂是包含路易斯抗原例如路易斯，路易斯x或路易斯寡糖或其衍生物的化合物的抑制形式。在各种实施方案中，免疫细胞是人免疫细胞，巨噬细胞，T细胞或非T，非B脾细胞。在一个优选的实施方案中，本发明提供使用本发明的刺激剂在体内刺激对于反义肽的特异性免疫应答的方法。在另一个优选的实施方案中，本发明提供使用本发明的抑制剂抑制体内过敏反应的方法。还提供了用于调节包含本发明的刺激或抑制剂的免疫应答的药物组合物。

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