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1. 发明公开

EP1398326A2 Monoclonal antibodies against recombinant stratum corneum chymotryptic enzyme (SCCE) 失效
标题翻译：针对重组角质层胰凝乳蛋白酶（SCCE）的单克隆抗体
公开(公告)号：EP1398326A2
公开(公告)日：2004-03-17
申请号：EP03078393.0
申请日：1994-06-20
申请人： Egelrud, Torbjörn , Hansson, Lennart
发明人： Egelrud, Torbjörn , Hansson, Lennart
IPC分类号： C07K16/40 , C07K16/18 , A61K39/395
CPC分类号： A61Q19/10 , A61K8/64 , A61K38/00 , A61K2800/86 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/007 , C07K16/40 , C07K2319/00 , C12N9/6424
摘要： The present invention relates to a monoclonal antibody which recognizes a polypeptide which in its active form is capable of decomposing the substrate MeO-Suc-Arg-Pro-Tyr-pNA (S-2586), the decomposition by the polypeptide being inhibited by aprotinin, chymostatin and zinc sulphate, and which polypeptide:

a) has an amino acid sequence which has a homology of at least 80% with the amino acid sequence 1-224 in SEQ ID NO:2;
b) has an amino acid sequence from which a constitutive string of 20 amino acids is homologous to a degree of at least 95% with a string of amino acids of the same length selected from the amino acid sequence shown in SEQ ID NO:2; or
c) is a subsequence of the polypeptide in a) comprising from 50 to 250 amino acids.

The invention further relates to a monoclonal antibody as defined above for the treatment of disease conditions in animals and humans and to pharmaceutical compositions comprising an antibody as defined above or a functional derivative thereof and a pharmaceutically acceptable excipient.
摘要翻译：本发明涉及识别活性形式能够分解底物MeO-Suc-Arg-Pro-Tyr-pNA（S-2586）的多肽的单克隆抗体，通过抑肽酶抑制多肽的分解，胰凝乳蛋白酶抑制剂和硫酸锌，并且该多肽：a）具有与SEQ ID NO：2中的氨基酸序列1-224具有至少80％同源性的氨基酸序列; b）具有一个氨基酸序列，20个氨基酸的组成型序列与选自SEQ ID NO：2中所示的氨基酸序列的具有相同长度的氨基酸序列至少95％同源; 或c）是a）中的多肽的子序列，其包含50至250个氨基酸。本发明进一步涉及如上定义的用于治疗动物和人类疾病状况的单克隆抗体，以及包含如上定义的抗体或其功能衍生物和药学上可接受的赋形剂的药物组合物。

2. 发明公开

EP1398326A3 Monoclonal antibodies against recombinant stratum corneum chymotryptic enzyme (SCCE) 失效
标题翻译：对角质层胰凝乳酶的重组单克隆抗体（SCCE）
公开(公告)号：EP1398326A3
公开(公告)日：2004-03-31
申请号：EP03078393.0
申请日：1994-06-20
申请人： Egelrud, Torbjörn , Hansson, Lennart
发明人： Egelrud, Torbjörn , Hansson, Lennart
IPC分类号： C07K16/40 , C07K16/18 , A61K39/395
CPC分类号： A61Q19/10 , A61K8/64 , A61K38/00 , A61K2800/86 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/007 , C07K16/40 , C07K2319/00 , C12N9/6424
摘要： The present invention relates to a monoclonal antibody which recognizes a polypeptide which in its active form is capable of decomposing the substrate MeO-Suc-Arg-Pro-Tyr-pNA (S-2586), the decomposition by the polypeptide being inhibited by aprotinin, chymostatin and zinc sulphate, and which polypeptide: a) has an amino acid sequence which has a homology of at least 80% with the amino acid sequence 1-224 in SEQ ID NO:2; b) has an amino acid sequence from which a constitutive string of 20 amino acids is homologous to a degree of at least 95% with a string of amino acids of the same length selected from the amino acid sequence shown in SEQ ID NO:2; or c) is a subsequence of the polypeptide in a) comprising from 50 to 250 amino acids. The invention further relates to a monoclonal antibody as defined above for the treatment of disease conditions in animals and humans and to pharmaceutical compositions comprising an antibody as defined above or a functional derivative thereof and a pharmaceutically acceptable excipient.

3. 发明授权

EP1367886B1 SCCE TRANSGENIC MICE AND THEIR USE AS MODELS OF HUMAN DISEASE 有权
标题翻译： SCCE转基因小鼠和它们作为一款型号为人类疾病
公开(公告)号：EP1367886B1
公开(公告)日：2011-07-13
申请号：EP02720389.2
申请日：2002-02-08
申请人： Egelrud, Torbjörn , Hansson, Lennart
发明人： Egelrud, Torbjörn , Hansson, Lennart
IPC分类号： A01K67/027 , C12N9/64 , A61K49/00 , A61K31/58 , A61P17/04
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0331 , C12N9/6424 , G01N33/6881 , G01N2800/20
摘要： Genetic evidence that an imbalance in the activity of serine proteases can cause severe skin disease has recently been presented. The serine protease SCCE is preferentially expressed in cornifying epithelia. Increased expression of SCCE in psoriasis has previously been reported. Increased SCCE expression also in chronic lesions of atopic dermatitis is described herein. Transgenic mice expressing human SCCE in suprabasal epidermal keratinocytes were found to develop pathological skin changes with increased epidermal thickness, hyperkeratosis, dermal inflammation, and severe pruritus. The results strengthen the idea that SCCE may be involved in the pathogenesis of inflammatory skin diseases, and may offer a new therapeutic target.

4. 发明公开

EP1367886A2 SCCE MODIFIED TRANSGENIC MAMMALS AND THEIR USE AS MODELS OF HUMAN DISEASE 有权
标题翻译： SCCE TRANSGENEMÄUSEUND DEREN VERWENDUNG ALS MODELLFÜRMENSCHLICHE KRANKHEITEN
公开(公告)号：EP1367886A2
公开(公告)日：2003-12-10
申请号：EP02720389.2
申请日：2002-02-08
申请人： Egelrud, Torbjörn , Hansson, Lennart
发明人： Egelrud, Torbjörn , Hansson, Lennart
IPC分类号： A01K67/027 , C12N9/64 , A61K49/00 , A61K31/58 , A61K7/48 , A61P17/04
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0331 , C12N9/6424 , G01N33/6881 , G01N2800/20
摘要： Genetic evidence that an imbalance in the activity of serine proteases can cause severe skin disease has recently been presented. The serine protease SCCE is preferentially expressed in cornifying epithelia. Increased expression of SCCE in psoriasis has previously been reported. Increased SCCE expression also in chronic lesions of atopic dermatitis is described herein. Transgenic mice expressing human SCCE in suprabasal epidermal keratinocytes were found to develop pathological skin changes with increased epidermal thickness, hyperkeratosis, dermal inflammation, and severe pruritus. The results strengthen the idea that SCCE may be involved in the pathogenesis of inflammatory skin diseases, and may offer a new therapeutic target.
摘要翻译：最近已经提出了丝氨酸蛋白酶活性不平衡可导致严重皮肤病的遗传证据。丝氨酸蛋白酶SCCE优先在角化上皮细胞中表达。之前已经报道了SCCE在牛皮癣中的表达增加。本文描述了在特应性皮炎的慢性损伤中也增加的SCCE表达。发现在上皮表皮角化细胞中表达人SCCE的转基因小鼠发生病理皮肤变化，表皮厚度增加，角化过度，皮肤炎症和严重瘙痒。结果加强了SCCE可能参与炎症性皮肤病发病的思路，可能提供新的治疗靶点。

5. 发明授权

EP0703985B1 RECOMBINANT STRATUM CORNEUM CHYMOTRYPTIC ENZYME (SCCE) 失效
标题翻译：重组角质层CHYMOTYPISCHES酶（SCCE）
公开(公告)号：EP0703985B1
公开(公告)日：2003-10-29
申请号：EP94917764.6
申请日：1994-06-20
申请人： Egelrud, Torbjörn , Hansson, Lennart
发明人： Egelrud, Torbjörn , Hansson, Lennart
IPC分类号： A61K7/48 , C12Q1/37 , C12N15/00 , C12N15/62 , C12N15/57 , C12N9/64 , C12P21/08 , C07K14/00
CPC分类号： A61Q19/10 , A61K8/64 , A61K38/00 , A61K2800/86 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/007 , C07K16/40 , C07K2319/00 , C12N9/6424
摘要： The present invention relates to a polypeptide having the amino acid sequence SEQ ID NO:2 or an analogue or variant thereof having SCCE activity as defined in the present application, such as a polypeptide having a subsequence of the amino acid sequence SEQ ID NO:2. Furthermore, the present invention relates to nucleotide sequences encoding polypeptides having SCCE activity as well as to expression systems, expression vectors, plasmids and non-human organisms comprising said nucleotide sequences. Important aspects of the present invention relate to pharmaceutical, cosmetic and skin care compositions comprising a polypeptide having SCCE activity, and the use of a polypeptide having SCCE activity for the treatment or prophylaxis of various diseases such as acne, xeroderma or other hyperkeratotic conditions such as callosities and keratosis pilaris as well as the various ichthyoses, psoriasis and other inflammatory skin diseases such as eczemas. Moreover, the present invention relates to the use of a compound which has an inhibitory effect on the enzymatic activity of native SCCE for the manufacture of a pharmaceutical composition for treatment or prophylaxis of autoimmune pemphigus diseases or acantholytic diseases such as familiar pemphigus and Darier's disease.

6. 发明授权

EP1398326B1 Monoclonal antibodies against recombinant stratum corneum chymotryptic enzyme (SCCE) 失效
标题翻译：对角质层胰凝乳酶的重组单克隆抗体（SCCE）
公开(公告)号：EP1398326B1
公开(公告)日：2006-01-11
申请号：EP03078393.0
申请日：1994-06-20
申请人： Thorbjörn, Egelrud , Hansson, Lennart
发明人： Thorbjörn, Egelrud , Hansson, Lennart
IPC分类号： C07K16/40 , C07K16/18 , A61K39/395
CPC分类号： A61Q19/10 , A61K8/64 , A61K38/00 , A61K2800/86 , A61Q5/02 , A61Q5/12 , A61Q19/00 , A61Q19/007 , C07K16/40 , C07K2319/00 , C12N9/6424

7. 发明公开

EP0295232A1 Tool for breaking, cutting or working of solid materials 失效
标题翻译： Werkzeug zum Brechen，Schneiden oder Bearbeiten von festen Materialien。
公开(公告)号：EP0295232A1
公开(公告)日：1988-12-14
申请号：EP88850201.0
申请日：1988-06-06
申请人： SANDVIK AKTIEBOLAG , Hansson, Lennart , Norman, Hans-Olav
发明人： Hedlund, Jan-Gunnar , Hansson, Lennart , Norman, Hans-Oloav
IPC分类号： E21C35/18
CPC分类号： E21C35/197
摘要： The present invention refers to a tool for breaking, cutting or working of solid materials, said tool (13) being intended to be rotatably mounted in a holder (16) and being provided with a hard material cutting insert (15) and a generally cylindrical shaft (14), that is intended to be received in the holder (16), and that a clip (10;10a;10b;10c;10d) is mounted on the shaft (14), said clip (10-10d) being generally cylindrical and having a slot (11) that extends between the ends of the clip, and that the shaft (14) has a tangentially extending groove (17;17a;17b;17c;17d).
The aim of the invention is to present a clip (10-10d) that decreases the wearing of the shaft (14) of the tool (13) and the holder (16). Also the rotation of the tool (13) in the holder (16) is improved.
The characterizing features of the tool (13) are that the shaft (14) has essentially the same diameter on both sidesof the groove (17-17d) and that the clip (10-10d) has engagement means (12-12d) for cooperation with the groove (17-17d).
摘要翻译：本发明涉及一种用于破碎，切割或加工固体材料的工具，所述工具（13）旨在可旋转地安装在保持器（16）中，并且设置有硬质材料切削刀片（15）和大致圆柱形轴（14），其被容纳在保持器（16）中，并且夹子（10; 10a; 10b; 10c; 10d）安装在轴（14）上，所述夹子（10-10d）为大致圆柱形并且具有在夹子的端部之间延伸的槽（11），并且轴（14）具有切向延伸的凹槽（17; 17a; 17b; 17c; 17d）。本发明的目的是提供减少工具（13）和保持器（16）的轴（14）的磨损的夹子（10-10d）。此外，工具（13）在保持器（16）中的旋转也得到改善。工具（13）的特征在于，所述轴（14）在所述凹槽（17-17d）的两侧具有基本相同的直径，并且所述夹子（10-10d）具有用于配合的接合装置（12-12d）与凹槽（17-17d）。

8. 发明申请

WO1993004171A1 HUMAN BETA-CASEIN, PROCESS FOR PRODUCING IT AND USE THEREOF 审中-公开
标题翻译：人造皮肤，生产和使用它的方法
公开(公告)号：WO1993004171A1
公开(公告)日：1993-03-04
申请号：PCT/DK1991000233
申请日：1991-08-19
申请人： SYMBICOM AKTIEBOLAG , BERGSTRÖM, Sven , HERNELL, Olle , LÖNNERDAL, Bo , HJALMARSSON, Karin , HANSSON, Lennart , TÖRNELL, Jan , STRÖMQVIST, Mats
发明人： SYMBICOM AKTIEBOLAG
IPC分类号： C12N15/12
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/101 , A01K2227/105 , A01K2267/01 , C07K14/4732 , Y10S426/801
摘要： A DNA sequence encoding human beta -casein (a human milk protein) and analogues of said DNA sequence which encodes a polypeptide having the calcium binding activity of human beta -casein or opioid activity or angiotension converting enzyme (ACE) inhibitory activity. The polypeptide encoded by said DNA sequence or analogues may be used in the production of recombinant human beta -casein either by means of a prokaryotic or an eukaryotic production system, or more advantageously by means of production in transgenic non-human mammals such as cows. The recombinant human beta -casein is a useful constituent of infant formulae used for feeding infants as a substitute for human milk, i.e. maternal milk. The recombinant human beta -casein makes it possible to prepare an infant formula having a closer similarity to human milk and thus an improved nutritional and biological value.
摘要翻译：编码人β-酪蛋白（人乳蛋白）的DNA序列和所述DNA序列的类似物，其编码具有人β-酪蛋白或阿片样物质活性或血管紧张素转换酶（ACE）抑制活性的钙结合活性的多肽。由所述DNA序列或类似物编码的多肽可用于通过原核或真核生产系统生产重组人β-酪蛋白，或更有利地通过在转基因非人哺乳动物如牛中的生产来使用。重组人β-酪蛋白是用于喂养婴儿作为人乳代用品（即母乳）的婴儿配方的有用成分。重组人β-酪蛋白使得可以制备与人乳更接近相似性的婴儿配方，从而改善营养和生物学价值。

9. 发明申请

WO1995000637A1 TRANSGENIC PRODUCTION OF EC-SOD 审中-公开
标题翻译： EC-SOD的转基因生产
公开(公告)号：WO1995000637A1
公开(公告)日：1995-01-05
申请号：PCT/IB1994000181
申请日：1994-06-24
申请人： SYMBICOM AKTIEBOLAG , HANSSON, Lennart
发明人： SYMBICOM AKTIEBOLAG
IPC分类号： C12N15/00
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/101 , A01K2227/105 , A01K2227/107 , A01K2267/01 , A23C9/20 , C12N9/0089
摘要： The present invention relates to a mammalian expression system comprising a DNA sequence encoding a polypeptide having the amino acid sequence shown in SEQ ID NO:2 or a variant thereof which has a biological activity of human EC-SOD. The mammalian expression system is preferably expressed in a non-human mammal selected from the group consisting of rabbits, mice, rats, goats, sheep, pigs, lama, camels and bovine species. The invention includes expression systems, wherein the variant has a reduced heparin affinity as compared to human EC-SOD type C such as the variants T216, T215, T213, T209, SAT216, SRT216, SA219, SA220 and SA211-213, and expression systems wherein the variant has an increased heparin affinity as compared to human EC-SOD type C such as the variants SA216, SA216/218 and SA216/220. Within the scope of the invention is also DNA fragments, hybrid genes, expression vectors, cells, methods for producing a transgenic non-human mammal capable of expressing EC-SOD as defined above, and non-human mammals expressing EC-SOD.
摘要翻译：本发明涉及包含编码具有SEQ ID NO：2所示氨基酸序列的多肽的DNA序列或其具有人EC-SOD生物活性的变体的哺乳动物表达系统。哺乳动物表达系统优选在选自兔，小鼠，大鼠，山羊，绵羊，猪，羔羊，骆驼和牛物种的非人哺乳动物中表达。本发明包括表达系统，其中与EC-SOD C型变体相比，该变体与变体T216，T215，T213，T209，SAT216，SRT216，SA219，SA220和SA211-213等相比具有降低的肝素亲和力，以及表达系统其中所述变体与人EC-SOD C型比较，如变体SA216，SA216 / 218和SA216 / 220相比具有增加的肝素亲和力。在本发明的范围内，也是DNA片段，杂合基因，表达载体，细胞，用于产生能够表达如上定义的EC-SOD的转基因非人哺乳动物的方法和表达EC-SOD的非人哺乳动物。

10. 发明申请

WO1993004172A2 GENE ENCODING A HUMAN BETA-CASEIN PROCESS FOR OBTAINING THE PROTEIN AND USE THEREOF IN AN INFANT FORMULA 审中-公开
标题翻译：编码用于获得蛋白质的人类β-酪蛋白过程的基因及其在哺乳动物体内的用途
公开(公告)号：WO1993004172A2
公开(公告)日：1993-03-04
申请号：PCT/DK1992000246
申请日：1992-08-19
申请人： SYMBICOM AKTIEBOLAG , BERGSTRÖM, Sven , HERNELL, Olle , LÖNNERDAL, Bo , HJALMARSSON, Karin , HANSSON, Lennart , TÖRNELL, Jan , STRÖMQVIST, Mats
发明人： SYMBICOM AKTIEBOLAG
IPC分类号： C12N15/12
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/10 , A01K2227/101 , A01K2227/105 , A01K2267/01 , C07K14/4732 , Y10S426/801
摘要： The present invention relates to a DNA sequence encoding the human milk protein beta -casein or an analogue or variant thereof which has either the calcium binding activity of human beta -casein, or opioid activity, or angiotensin converting enzyme (ACE) inhibitory activity, or a combination of any two or three of these activities. The DNA sequence may optionally contain one or more intron sequences and permissive RNA splice signals. The DNA sequence is used in the production of recombinant human beta -casein, advantageously by means of production in transgenic non-human mammals such as bovine species. In one embodiment, the DNA sequence is inserted into a milk protein gene of a mammal such as a whey acidic protein (WAP) gene. The main use of the recombinant human beta -casein is as a constituent of infant formulae. It is contemplated that the recombinant human beta -casein provides a substantial improvement of the nutritional and biological value of the formulae in that a closer similarity to human milk is obtained.
摘要翻译：本发明涉及编码人乳蛋白β-酪蛋白或其类似物或变体的DNA序列，其具有人β-酪蛋白的钙结合活性或阿片样物质活性或血管紧张素转换酶（ACE）抑制活性，或任何两个或三个这些活动的组合。 DNA序列可以任选地含有一个或多个内含子序列和允许的RNA剪接信号。 DNA序列用于生产重组人β-酪蛋白，有利地通过在转基因非人哺乳动物如牛物种中的生产。在一个实施方案中，将DNA序列插入哺乳动物如乳清酸性蛋白（WAP）基因的乳蛋白基因中。重组人β-酪蛋白的主要用途是作为婴儿配方奶粉的成分。预期重组人β-酪蛋白提供了配方的营养和生物学价值的显着改善，因为获得了更接近于人乳的相似性。

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