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1. 发明申请

WO2003015618A1 DEVICE AND METHOD FOR ASSESSING THE GEOMETRY OF A HEART VALVE 审中-公开
标题翻译：用于评估心脏瓣膜几何形状的装置和方法
公开(公告)号：WO2003015618A1
公开(公告)日：2003-02-27
申请号：PCT/US2002/025796
申请日：2002-08-13
申请人： CARDIOMEND, LLC , LOVE, Jack, W. , HANLON, James, G.
发明人： LOVE, Jack, W. , HANLON, James, G.
IPC分类号： A61B1/00
CPC分类号： A61F2/2496 , A61B5/1076 , A61F2/2427 , A61F2250/0097
摘要： A sizer for assessing the geometry of a heart valve annulus including a handle portion (10) for holding the sizer and a sizing portion (12). The sizing portion (12) is preferably in the shape of an arch having an apex (14) and two legs (16 and 18), each of which has a base (20 and 22) adjoining the handle portion. The legs of the arched sizing portion are separated from each other by a predetermined distance that corresponds to the expected separation of commissures of a normal heart valve annulus. The height of the arch (measured from the base of each leg to the apex) corresponds to a predetermined leaflet height that approximates the expected height of a leaflet of a normal heart valve . For aortic valve reconstruction, the instrument is inserted into the opened aortic root following removal of the native valve tissue and is used to assess the distance between the commissures, the leaflet height and the symmetry of the commissures of the exposed valve annulus.
摘要翻译：一种用于评估心脏瓣膜环的几何形状的分级器，包括用于保持分级器的手柄部分（10）和上浆部分（12）。上模部分（12）优选地具有顶点（14）和两个支脚（16和18）的拱形，每个支脚具有邻接手柄部分的基座（20和22）。拱形施胶部分的腿彼此分开预定距离，该预定距离对应于正常心脏瓣膜环的预期分离。拱的高度（从每个腿的基部到顶点测量）对应于接近正常心脏瓣膜的小叶的预期高度的预定小叶高度。对于主动脉瓣重建，在移除天然瓣膜组织后，将仪器插入打开的主动脉根部，并用于评估接合之间的距离，瓣叶高度和暴露的瓣膜环的连合的对称性。

2. 发明申请

WO2008036935A2 SAFETY CONNECTOR ASSEMBLY 审中-公开
标题翻译：安全连接器总成
公开(公告)号：WO2008036935A2
公开(公告)日：2008-03-27
申请号：PCT/US2007079214
申请日：2007-09-21
申请人： COVIDIEN AG , HANLON JAMES G , SWISHER DAVID R , MEYER ANN P , BOCK MALCOLM G
发明人： HANLON JAMES G , SWISHER DAVID R , MEYER ANN P , BOCK MALCOLM G
IPC分类号： A61M39/10
CPC分类号： A61B17/135 , A61H9/0078 , A61H2205/12 , A61M39/10 , A61M39/1011 , A61M2039/1027 , A61M2039/1094 , A61M2205/6045 , F16B7/0413 , F16B7/0426 , F16B9/02 , F16L25/00 , F16L2201/20 , Y10T137/9029 , Y10T403/30 , Y10T403/70
摘要： A connector assembly includes first and second mating connectors that can be joined to make a fluid connection. The connectors are constructed to discriminate improper connectors so that no fluid tight connection can be formed with improper connectors. The connector assembly can be used with a system for compression therapy to prevent deep vein thrombosis.
摘要翻译：连接器组件包括能够连接以形成流体连接的第一和第二配合连接器。连接器被构造为区分不适当的连接器，使得不能用不适当的连接器形成流体紧密连接。连接器组件可用于压缩治疗系统以防止深静脉血栓形成。

3. 发明申请

WO1998004681A2 CHONDROCYTE MEDIA FORMULATIONS AND CULTURE PROCEDURES 审中-公开
标题翻译： CHONDROCYTE媒体制定和文化程序
公开(公告)号：WO1998004681A2
公开(公告)日：1998-02-05
申请号：PCT/US1997013140
申请日：1997-07-25
申请人： GENZYME CORPORATION , MCPHERSON, John, M. , YAEGER, Peter, C. , BROWN, Marie, E. , HANLON, James, G. , BINETTE, Francois
发明人： GENZYME CORPORATION
IPC分类号： C12N05/00
CPC分类号： C12N5/0655 , C12N2500/20 , C12N2500/25 , C12N2500/32 , C12N2500/34 , C12N2500/36 , C12N2500/38 , C12N2500/46 , C12N2500/90 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/39 , C12N2501/58
摘要： One object of the present invention is based upon the development and use of a serum-free defined cell culture medium comprising a supplement mixture, a component mixture, a vitamin mixture, an inorganic salt mixture and amino acid mixture that avoids the problems inherent in the use of serum. In particular, the defined medium is useful in culturing fibroblasts, especially chondrocytes. Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes and enhancing the synthesis of a cartilage specific matrix using tumor growth factor beta (TGF- beta ). Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes using the combination of TGF- beta and IGF.
摘要翻译：本发明的一个目的是基于开发和使用无血清定义的细胞培养基，其包含补充混合物，组分混合物，维生素混合物，无机盐混合物和氨基酸混合物，其避免了使用血清。特别地，所定义的培养基可用于培养成纤维细胞，特别是软骨细胞。本发明的另一个目的是要求一种增强软骨细胞分化和增强使用肿瘤生长因子β（TGF-β）的软骨特异性基质的合成的方法。本发明的另一个目的是要求使用TGF-β和IGF的组合增强软骨细胞分化的方法。

4. 发明申请

WO2008036935A3 SAFETY CONNECTOR ASSEMBLY 审中-公开
公开(公告)号：WO2008036935A3
公开(公告)日：2008-03-27
申请号：PCT/US2007/079214
申请日：2007-09-21
申请人： COVIDIEN AG , HANLON, James, G. , SWISHER, David, R. , MEYER, Ann, P. , BOCK, Malcolm, G.
发明人： HANLON, James, G. , SWISHER, David, R. , MEYER, Ann, P. , BOCK, Malcolm, G.
IPC分类号： A61M39/10
摘要： A connector assembly includes first and second mating connectors that can be joined to make a fluid connection. The connectors are constructed to discriminate improper connectors so that no fluid tight connection can be formed with improper connectors. The connector assembly can be used with a system for compression therapy to prevent deep vein thrombosis.

5. 发明申请

WO9804681A3 Chondrocyte media formulations and culture procedures 审中-公开
标题翻译：软骨细胞介质制剂和培养程序
公开(公告)号：WO9804681A3
公开(公告)日：1998-06-18
申请号：PCT/US9713140
申请日：1997-07-25
申请人： GENZYME CORP , MCPHERSON JOHN M , YAEGER PETER C , BROWN MARIE E , HANLON JAMES G , BINETTE FRANCOIS
发明人： MCPHERSON JOHN M , YAEGER PETER C , BROWN MARIE E , HANLON JAMES G , BINETTE FRANCOIS
IPC分类号： C12N5/00 , C12N5/077 , C12N5/08
CPC分类号： C12N5/0655 , C12N2500/20 , C12N2500/25 , C12N2500/32 , C12N2500/34 , C12N2500/36 , C12N2500/38 , C12N2500/46 , C12N2500/90 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/39 , C12N2501/58
摘要： One object of the present invention is based upon the development and use of a serum-free defined cell culture medium comprising a supplement mixture, a component mixture, a vitamin mixture, an inorganic salt mixture and amino acid mixture that avoids the problems inherent in the use of serum. In particular, the defined medium is useful in culturing fibroblasts, especially chondrocytes. Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes and enhancing the synthesis of a cartilage specific matrix using tumor growth factor beta (TGF-β). Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes using the combination of TGF-β and IGF.

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