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1. 发明公开

EP4232062A1 BIFUNCTIONAL ANTAGONISTS OF ACTIVIN AND TUMOR NECROSIS FACTOR-ALPHA AND USES THEREOF 审中-实审
公开(公告)号：EP4232062A1
公开(公告)日：2023-08-30
申请号：EP21883996.7
申请日：2021-10-22
申请人： HAN, Hq , Zhou, Xiaolan
发明人： HAN, Hq , Zhou, Xiaolan
IPC分类号： A61K38/16 , A61K38/18 , A61K38/21 , A61K39/00 , A61K39/395

2. 发明公开

EP4240388A1 NOVEL BIFUNCTIONAL MULTISPECIFIC ANTAGONISTS CAPABLE OF INHIBITING MULTIPLE LIGANDS OF TGF-BETA FAMILY AND USES THEREOF 审中-实审
公开(公告)号：EP4240388A1
公开(公告)日：2023-09-13
申请号：EP21889869.0
申请日：2021-10-29
申请人： HAN, Hq , Zhou, Xiaolan
发明人： HAN, Hq , Zhou, Xiaolan
IPC分类号： A61K38/00 , C07K14/71 , C07K16/22 , C07K16/46 , C07K19/00

3. 发明公开

EP4232063A1 BIFUNCTIONAL ANTAGONISTS OF TUMOR NECROSIS FACTOR-ALPHA AND TRANSFORMING GROWTH FACTOR-BETA AND USES THEREOF 审中-实审
公开(公告)号：EP4232063A1
公开(公告)日：2023-08-30
申请号：EP21884002.3
申请日：2021-10-22
申请人： HAN, Hq , Zhou, Xiaolan
发明人： HAN, Hq , Zhou, Xiaolan
IPC分类号： A61K38/16 , A61K38/18 , A61K38/21 , A61K39/00 , A61K39/395

4. 发明公开

EP4243931A1 BIFUNCTIONAL ANTAGONISTS OF ACTIVIN/TGF-BETA AND RANKL AND USES THEREOF 审中-实审
公开(公告)号：EP4243931A1
公开(公告)日：2023-09-20
申请号：EP21892613.7
申请日：2021-11-05
申请人： HAN, Hq , Zhou, Xiaolan
发明人： HAN, Hq , Zhou, Xiaolan
IPC分类号： A61P19/08 , A61P19/10 , A61P35/00

5. 发明申请

WO2007067616A3 USES OF MYOSTATIN ANTAGONISTS 审中-公开
标题翻译：肌营养拮抗剂的使用
公开(公告)号：WO2007067616A3
公开(公告)日：2008-10-09
申请号：PCT/US2006046546
申请日：2006-12-06
申请人： AMGEN INC , HAN HQ , DEPAOLI ALEXANDER , LU JOHN ZHAO-NIAN , WANG JIN LIN
发明人： HAN HQ , DEPAOLI ALEXANDER , LU JOHN ZHAO-NIAN , WANG JIN LIN
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/435 , A61K38/08 , A61K38/10 , C07K14/475 , C07K16/22
摘要： The present invention provides methods for treating disorders arising from hypogonadism, rheumatoid cachexia, cachexia due to burns, cachexia due to administration of chemical agents, cachexia due to diabetes, diabetic nephropathy, Prader Willi syndrome, excessive TNF-a, and other muscle-related, metabolic and inflammatory disorders by administering myostatin antagonists to subjects suffering from such disorders.
摘要翻译：本发明提供治疗由性腺功能减退症，类风湿性恶病质，由于灼伤引起的恶病质，由于施用化学试剂引起的恶病质，由于糖尿病引起的恶病质，糖尿病性肾病，Prader Willi综合征，过度TNF-α等肌肉相关性疾病，代谢和炎性疾病，通过将肌生长抑素拮抗剂施用于患有这种疾病的受试者。

6. 发明申请

WO2022087426A1 BIFUNCTIONAL ANTAGONISTS OF ACTIVIN AND TUMOR NECROSIS FACTOR-ALPHA AND USES THEREOF 审中-公开
公开(公告)号：WO2022087426A1
公开(公告)日：2022-04-28
申请号：PCT/US2021/056272
申请日：2021-10-22
申请人： HAN, Hq , ZHOU, Xiaolan
发明人： HAN, Hq , ZHOU, Xiaolan
IPC分类号： A61K38/16 , A61K38/18 , A61K38/21 , A61K39/00 , A61K39/395
摘要： This invention disclosure provides novel bifunctional antagonistic polypeptides comprising at least one TNF-cs binding domain and at least one Activin-binding domain, which are highly capable of sequestering TNF-a and Activin or Activin -related ligand in parallel. Also provided are pharmaceutical compositions of such bifunctional polypeptide antagonists and their uses to treat various complex disease conditions, whose pathogenesis involve the activation of both TNF-α-mediated NF-KB signaling pathway and Activin-mediated Smad2/3 signaling pathway.

7. 发明申请

WO2012024242A1 ANTIBODIES THAT BIND MYOSTATIN, COMPOSITIONS AND METHODS 审中-公开
标题翻译：包括肌营养肽，组合物和方法的抗体
公开(公告)号：WO2012024242A1
公开(公告)日：2012-02-23
申请号：PCT/US2011/047806
申请日：2011-08-15
申请人： AMGEN INC. , HAN, Hq , ARORA, Taruna , CHEN, Qing , LU, Hsieng Sen , ZHOU, Xiaolan
发明人： HAN, Hq , ARORA, Taruna , CHEN, Qing , LU, Hsieng Sen , ZHOU, Xiaolan
IPC分类号： C07K16/22 , A61P19/08 , A61P21/00
CPC分类号： C07K16/26 , A61K2039/505 , C07K16/22 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them. Neutralizing antibodies recognizing the conformational epitope near position 21 to 31 and position 50 to 60.
摘要翻译：公开了选择性肌生成抑制素拮抗剂（包括抗体），编码它们的核酸，以及制备和使用它们的方法。识别位置21至31位置50至60附近的构象表位的中和抗体。

8. 发明申请

WO2008031061A2 ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗激活素A抗体及其用途
公开(公告)号：WO2008031061A2
公开(公告)日：2008-03-13
申请号：PCT/US2007077923
申请日：2007-09-07
申请人： AMGEN INC , HAN HQ , CHEN QING , KWAK KEITH SOO-NYUNG , ZHOU XIAOLAN
发明人： HAN HQ , CHEN QING , KWAK KEITH SOO-NYUNG , ZHOU XIAOLAN
IPC分类号： C07K16/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.
摘要翻译：本公开提供了涉及或衍生自抗激活素A结合蛋白（包括抗体）的组合物和方法。在具体的实施方案中，本公开提供了结合人激活素A，激活素A结合片段和此类抗体的衍生物以及包含此类片段的激活素A结合多肽的完全人源化，人源化和嵌合抗激活素A抗体。其他实施方案提供了编码此类抗体的核酸，抗体片段和衍生物和多肽，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法治疗或诊断具有与激素A相关的病症或病症（包括与性腺癌相关的恶病质，其他癌症，类风湿性关节炎和其他疾病）的受试者。

9. 发明申请

WO2007067616A2 USES OF MYOSTATIN ANTAGONISTS 审中-公开
标题翻译：肌营养拮抗剂的使用
公开(公告)号：WO2007067616A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/046546
申请日：2006-12-06
申请人： AMGEN INC , HAN, HQ , DEPAOLI, Alexander , LU, John Zhao-Nian , WANG, Jin Lin
发明人： HAN, HQ , DEPAOLI, Alexander , LU, John Zhao-Nian , WANG, Jin Lin
CPC分类号： C07K14/435 , A61K38/08 , A61K38/10 , C07K14/475 , C07K16/22
摘要： The present invention provides methods for treating disorders arising from hypogonadism, rheumatoid cachexia, cachexia due to burns, cachexia due to administration of chemical agents, cachexia due to diabetes, diabetic nephropathy, Prader Willi syndrome, excessive TNF-α, and other muscle-related, metabolic and inflammatory disorders by administering myostatin antagonists to subjects suffering from such disorders.
摘要翻译：本发明提供治疗由性腺功能减退症，类风湿性恶病质，由于灼伤引起的恶病质，由于施用化学试剂引起的恶病质，由于糖尿病引起的恶病质，糖尿病性肾病，Prader Willi综合征，过度TNF-α等肌肉相关性疾病，代谢和炎性疾病，通过将肌生长抑素拮抗剂施用于患有这种疾病的受试者。

10. 发明申请

WO2022098570A1 NOVEL BIFUNCTIONAL MULTISPECIFIC ANTAGONISTS CAPABLE OF INHIBITING MULTIPLE LIGANDS OF TGF-BETA FAMILY AND USES THEREOF 审中-公开
公开(公告)号：WO2022098570A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/057209
申请日：2021-10-29
申请人： HAN, Hq , ZHOU, Xiaolan
发明人： HAN, Hq , ZHOU, Xiaolan
IPC分类号： A61K38/00 , C07K14/71 , C07K16/22 , C07K16/46 , C07K19/00
摘要： This invention disclosure describes novel polypeptide antagonists capable of neutralizing multiple members of TGF-β family in a selective manner. Specifically, the multispecific polypeptide antagonists disclosed herein comprise at least one Activin-binding domain and at least one TGFβ-binding domain and therefore, are capable of neutralizing TGF-β and Activin as well as Activin-related ligands in parallel. Moreover, this invention disclosure also discloses bifunctional multispecific polypeptide antagonists designed to inhibit Activin, TGF-β and T-Cell immune checkpoint (i.e., PD1, PDL1 or CTLA4) in a simultaneous manner. Specifically, the bifunctional multispecific antagonists disclosed herein comprise at least one Activin-binding domain, at least one TGFβ-binding domain and at least one PD1-, PDL1- or CTLA4-binding domain. Also provided are pharmaceutical compositions of such multispecific or bifunctional multispecific polypeptide antagonists and their therapeutic uses for treating certain disease conditions, which involve overexpression of both TGF-β and Activin, such as fibrosis and cancer.

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