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1. 发明申请

WO0191629A3 METHODS FOR DETECTING DNA DAMAGE AND SCREENING FOR CANCER THERAPEUTICS 审中-公开
标题翻译：检测DNA损伤和筛查癌症治疗方法
公开(公告)号：WO0191629A3
公开(公告)日：2002-04-11
申请号：PCT/US0117471
申请日：2001-05-30
申请人： WISTAR INST , HALAZONETIS THANOS , SCHULTZ LINDA B
发明人： HALAZONETIS THANOS , SCHULTZ LINDA B
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/574 , C07K16/18 , C12N9/96 , G01N33/53
CPC分类号： G01N33/5014 , G01N33/5011 , G01N33/5047 , G01N33/5748
摘要： A method for detecting DNA damage in a tissue sample involves contacting an immobilized biological sample with a labeled ligand which binds to human 53Bp1, and examining the immobilized sample for the presence of a label generated-detectable signal concentrated in foci in said sample. The presence of concentrated foci is indicative of DNA damage and the presence of diffuse signal is indicative of a normal sample. Diagnostic reagents contain a ligand that binds to human 53Bpl associated with a detectable label. Diagnostic kits for detecting DNA damage in a biological sample contain such diagnostic reagents and signal detection components. Compositions that inhibit or antagonize the biological activity of 53Bpl are identified by suitable assays, and are employed in methods of reatarding the growth of a cancer cell.
摘要翻译：用于检测组织样本中的DNA损伤的方法包括使固定的生物样品与结合人53Bp1的标记配体接触，并检查固定化样品中是否存在集中在所述样品中焦点的标记产生的可检测信号。浓缩灶的存在表明DNA损伤，扩散信号的存在表明正常样品。诊断试剂含有与可检测标记物相关的人类53Bpl结合的配体。用于检测生物样品中DNA损伤的诊断试剂盒含有这样的诊断试剂和信号检测组分。抑制或拮抗53Bpl生物活性的组合物通过合适的测定法鉴定，并用于重新植入癌细胞生长的方法中。

2. 发明申请

WO1996025434A1 PEPTIDES AND PEPTIDOMIMETICS WITH STRUCTURAL SIMILARITY TO HUMAN p53 THAT ACTIVATE p53 FUNCTION 审中-公开
标题翻译：具有结构相似性的pPTIDES和PEPTIMOMTITICS与激活p53功能的人p53
公开(公告)号：WO1996025434A1
公开(公告)日：1996-08-22
申请号：PCT/US1996001535
申请日：1996-02-16
申请人： THE WISTAR INSTITUTE , BAYER CORPORATION , HALAZONETIS, Thanos , HARTWIG, Wolfgang
发明人： THE WISTAR INSTITUTE , BAYER CORPORATION
IPC分类号： C07K14/82
CPC分类号： A61K38/1709 , C07K14/4746 , C07K14/82
摘要： The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and to select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.
摘要翻译：本发明提供了对应于人p53的残基360-386所包含的部分或整个区域的肽和肽模拟物，所述肽和肽模拟物的特征在于活化野生型p53的DNA结合的能力并选择肿瘤衍生的 p53突变体。还提供本发明化合物的药物组合物和治疗性使用这些组合物的方法。

3. 发明专利

GB2419945A Interactions between 53BP1 and histone H3 未知
公开(公告)号：GB2419945A
公开(公告)日：2006-05-10
申请号：GB0521166
申请日：2005-10-18
申请人： HALAZONETIS THANOS DEMETRIOS
发明人： HALAZONETIS THANOS DEMETRIOS
IPC分类号： G01N33/68 , C07K14/47
摘要： The present invention relates to methods of identifying modulators of an interaction between 53BP1 and histone H3 (H3). The present invention also relates to methods of use of inhibitors of an interaction between 53BP1 and H3. The present invention further relates to fragments of 53BP1 and H3, as well as other methods and uses.

4. 发明专利

GB0521166D0 Methods of identifying an agent that modulates an interaction between 53BP1 and histone H3, and uses thereof 未知
公开(公告)号：GB0521166D0
公开(公告)日：2005-11-23
申请号：GB0521166
申请日：2005-10-18
申请人： HALAZONETIS THANOS D
IPC分类号： G01N33/68
摘要： The present invention relates to methods of identifying modulators of an interaction between 53BP1 and histone H3 (H3). The present invention also relates to methods of use of inhibitors of an interaction between 53BP1 and H3. The present invention further relates to fragments of 53BP1 and H3, as well as other methods and uses.

5. 发明申请

WO2006105142A3 METHOD OF DETECTING PRECANCEROUS LESIONS 审中-公开
标题翻译：检测前列腺炎的方法
公开(公告)号：WO2006105142A3
公开(公告)日：2009-04-16
申请号：PCT/US2006011377
申请日：2006-03-30
申请人： HALAZONETIS THANOS D
发明人： HALAZONETIS THANOS D
IPC分类号： G01N33/53
CPC分类号： G01N33/57407
摘要： The present invention relates to methods of detection of precancerous lesions and/or cancer. The present invention also relates to the presence of DNA replication stress in precancerous lesions. The present invention further relates to the detection of loss of heterozygosity at common fragile sites and phosphorylated substrates of DNA damage activated kinases.
摘要翻译：本发明涉及癌前病变和/或癌症的检测方法。本发明还涉及在癌前病变中DNA复制应力的存在。本发明还涉及在DNA损伤激活的激酶的常见脆弱位点和磷酸化底物上检测杂合性的丧失。

6. 发明申请

WO2006105142A2 METHOD OF DETECTING PRECANCEROUS LESIONS 审中-公开
标题翻译：检测前列腺炎的方法
公开(公告)号：WO2006105142A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011377
申请日：2006-03-30
申请人： HALAZONETIS, Thanos, D.
发明人： HALAZONETIS, Thanos, D.
IPC分类号： G01N33/574
CPC分类号： G01N33/57407
摘要： The present invention relates to methods of detection of precancerous lesions and/or cancer. The present invention also relates to the presence of DNA replication stress in precancerous lesions. The present invention further relates to the detection of loss of heterozygosity at common fragile sites and phosphorylated substrates of DNA damage activated kinases.
摘要翻译：本发明涉及癌前病变和/或癌症的检测方法。本发明还涉及在癌前病变中DNA复制应力的存在。本发明还涉及在DNA损伤激活的激酶的常见脆弱位点和磷酸化底物上检测杂合性的丧失。

7. 发明申请

WO0109150A3 COMPOSITIONS AND METHODS TO ENHANCE SENSITIVITY OF CANCER CELLS TO MITOTIC STRESS 审中-公开
标题翻译：组合物和提高癌细胞对MITOTIC应激敏感性的方法
公开(公告)号：WO0109150A3
公开(公告)日：2001-10-04
申请号：PCT/US0016391
申请日：2000-06-14
申请人： WISTAR INST , HALAZONETIS THANOS , SCOLNICK DANIEL
发明人： HALAZONETIS THANOS , SCOLNICK DANIEL
IPC分类号： C07K14/47 , C07H21/04 , C07K16/00
CPC分类号： C07K14/4702
摘要： An isolated nucleic acid sequence of a mitotic checkpoint gene, chfr , encodes a Chfr protein having a Forkhead-associated domain and a Ring Finger. This protein is required for regulation of the transition of cells from prophase to metaphase during mitosis. The chfr nucleic acid and Chfr polypeptide are useful in diagnosing tumorigenic cells and in screening for drugs which can inhibit the activity of Chfr in a cancer cell, thereby rendering the cell more sensitive to additional anti-tumor therapies.
摘要翻译：有丝分裂检查点基因的分离的核酸序列，编码具有叉头相关结构域和环指的Chfr蛋白。这种蛋白质是调节有丝分裂期间细胞从前期转化为中期所必需的。核酸和Chfr多肽可用于诊断致瘤细胞和筛选可抑制癌细胞中Chfr活性的药物，从而使细胞对其他抗肿瘤治疗更敏感。

8. 发明申请

WO1996016989A1 p53 PROTEINS WITH ALTERED TETRAMERIZATION DOMAINS 审中-公开
标题翻译：具有改变的TETRAMERIZATION域的p53蛋白
公开(公告)号：WO1996016989A1
公开(公告)日：1996-06-06
申请号：PCT/US1995015353
申请日：1995-11-27
申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , HALAZONETIS, Thanos, D.
发明人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
IPC分类号： C07K14/82
CPC分类号： C07K14/4746 , A61K38/00 , A61K48/00
摘要： The present invention provides p53 proteins with altered tetramerization domains that retain wild-type p53 function, and the ability to form tetramers and have at least one of the following characteristics: (1) do not hetero-oligomerize with wild-type p53 or tumor-derived p53 mutants, and (2) restricted DNA binding specificity from an alteration in the way that the tetramerization domain orients the DNA binding domains of a p53 tetramer relative to one another. The invention also provides nucleic acids encoding the above proteins and methods of enhancing the cellular response to DNA damaging agents, treating diseases characterized by abnormal cell proliferation, and inducing immune tolerance to facilitate transplants and treatment of autoimmune disease, by administration of proteins of the invention or nucleic acid sequences encoding the proteins of the invention.
摘要翻译：本发明提供具有保留野生型p53功能的改变的四聚体结构域的p53蛋白质，以及形成四聚体并具有以下特征中的至少一个的能力：（1）不与野生型p53或肿瘤 - 衍生的p53突变体，和（2）限制性的DNA结合特异性来自四聚体结构域引导p53四聚体的DNA结合结构域相对于彼此的方式的改变。本发明还提供编码上述蛋白质的核酸和通过施用本发明的蛋白质来增强对DNA损伤剂的细胞应答，治疗以异常细胞增殖为特征的疾病和诱导免疫耐受以促进移植和治疗自身免疫性疾病的方法或编码本发明蛋白质的核酸序列。

9. 发明专利

GB2442617A8 Method of detecting precancerous lesions 未知
公开(公告)号：GB2442617A8
公开(公告)日：2008-04-09
申请号：GB0721183
申请日：2006-03-30
申请人： HALAZONETIS THANOS DEMETRIOS
发明人： HALAZONETIS THANOS DEMETRIOS
IPC分类号： G01N33/00
摘要： The present invention relates to methods of detection of precancerous lesions and/or cancer. The present invention also relates to the presence of DNA replication stress in precancerous lesions. The present invention further relates to the detection of loss of heterozygosity at common fragile sites and phosphorylated substrates of DNA damage activated kinases.

10. 发明专利

GB2442617A Method of detecting precancerous lesions 未知
公开(公告)号：GB2442617A
公开(公告)日：2008-04-09
申请号：GB0721183
申请日：2006-03-30
申请人： HALAZONETIS THANOS DEMETRIOS
发明人： HALAZONETIS THANOS DEMETRIOS
IPC分类号： G01N33/574
摘要： The present invention relates to methods of detection of precancerous lesions and/or cancer. The present invention also relates to the presence of DNA replication stress in precancerous lesions. The present invention further relates to the detection of loss of heterozygosity at common fragile sites and phosphorylated substrates of DNA damage activated kinases.

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