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1. 发明公开

EP3442479A1 BIORESORBABLE OCULAR DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：EP3442479A1
公开(公告)日：2019-02-20
申请号：EP17722243.7
申请日：2017-04-20
申请人： Heitzmann, Harold, Alexander , Curry, Kenneth, Martin , Haffner, David, Steven , Burns, Thomas, W.
发明人： Heitzmann, Harold, Alexander , Curry, Kenneth, Martin , Haffner, David, Steven , Burns, Thomas, W.
IPC分类号： A61F9/00

2. 发明申请

WO2017184881A1 BIORESORBABLE OCULAR DRUG DELIVERY DEVICE 审中-公开
标题翻译：生物可吸收眼镜药物递送装置
公开(公告)号：WO2017184881A1
公开(公告)日：2017-10-26
申请号：PCT/US2017/028665
申请日：2017-04-20
申请人： HEITZMANN, Harold, Alexander , CURRY, Kenneth, Martin , HAFFNER, David, Steven , BURNS, Thomas, W.
发明人： HEITZMANN, Harold, Alexander , CURRY, Kenneth, Martin , HAFFNER, David, Steven , BURNS, Thomas, W.
IPC分类号： A61F9/00
摘要： An ocular implant configured for implantation into the eye of a subject comprising an elongate outer shell (54), an internal plug (210) including a hydrogel and a drug reservoir including a drug (62) wherein the drug is configured to pass through at least a portion of the internal plug to control elution of the drug through the outer shell. The implant is made of biodegradable materials.
摘要翻译：（54），包括水凝胶的内塞（210）和包括药物（62）的药物储存器，其中所述药物储存器药物被配置为穿过内塞的至少一部分以控制药物通过外壳的洗脱。植入物由可生物降解材料制成。

3. 发明申请

WO2004014218A3 IMPLANTABLE OCULAR PUMP TO REDUCE INTRAOCULAR PRESSURE 审中-公开
公开(公告)号：WO2004014218A3
公开(公告)日：2004-02-19
申请号：PCT/US2003/024890
申请日：2003-08-07
申请人： GLAUKOS CORPORATION , SMEDLEY, Gregory , HAFFNER, David , TU, Hosheng , GHARIB, Morteza
发明人： SMEDLEY, Gregory , HAFFNER, David , TU, Hosheng , GHARIB, Morteza
IPC分类号： A61M5/00
摘要： A trabecular pump (40) is implantable in the eye to reduce intraocular pressure. The pump drains aqueous humor from the anterior chamber into outflow pathways, such as Schlemm's canal. A feedback system includes an intraocular pump (54) and a pressure sensor (43/61) in communication with the pump, for regulating intraocular pressure.

4. 发明专利

CA3022830A1 BIORESORBABLE OCULAR DRUG DELIVERY DEVICE 未知
公开(公告)号：CA3022830A1
公开(公告)日：2017-10-26
申请号：CA3022830
申请日：2017-04-20
申请人： HEITZMANN HAROLD ALEXANDER , CURRY KENNETH MARTIN , HAFFNER DAVID STEVEN , BURNS THOMAS W
发明人： HEITZMANN HAROLD ALEXANDER , CURRY KENNETH MARTIN , HAFFNER DAVID STEVEN , BURNS THOMAS W
IPC分类号： A61F9/00
摘要： An ocular implant configured for implantation into the eye of a subject comprising an elongate outer shell (54), an internal plug (210) including a hydrogel and a drug reservoir including a drug (62) wherein the drug is configured to pass through at least a portion of the internal plug to control elution of the drug through the outer shell. The implant is made of biodegradable materials.

5. 发明申请

WO2013040079A1 INTRAOCULAR PHYSIOLOGICAL SENSOR 审中-公开
标题翻译：内科生理传感器
公开(公告)号：WO2013040079A1
公开(公告)日：2013-03-21
申请号：PCT/US2012/054926
申请日：2012-09-12
申请人： DOSE MEDICAL CORPORATION , BURNS, Thomas, W. , HEITZMANN, Harold, A. , CURRY, Kenneth, Martin , HAFFNER, David, S. , APPLEGATE, David , NOGALES, Bruce
发明人： BURNS, Thomas, W. , HEITZMANN, Harold, A. , CURRY, Kenneth, Martin , HAFFNER, David, S. , APPLEGATE, David , NOGALES, Bruce
IPC分类号： A61B3/16 , A61B5/07 , A61B5/145 , A61B5/11 , A61B5/00
CPC分类号： A61B3/16 , A61B5/0031 , A61B5/076 , A61B5/1112 , A61B5/14503 , A61B5/14507 , A61B5/14532 , A61B5/1473 , A61B5/4836 , A61B5/4839 , A61B5/6821 , A61B5/6867 , A61B5/6882 , A61B5/7246 , A61B2562/0247 , H01M8/16
摘要： An implantable intraocular physiological sensor (e.g., 200) for measuring intraocular pressure, glucose concentration in the aqueous humor, and other physiological characteristics. The implantable intraocular physiological sensor (e.g., 200) may be at least partially powered by a fuel cell, such as an electrochemical glucose fuel cell (e.g., 210). The implantable intraocular physiological sensor (e.g., 200) may wirelessly transmit measurements to an external device. In addition, the implantable intraocular physiological sensor may incorporate aqueous drainage and/or drug delivery features.
摘要翻译：用于测量眼内压的可植入眼内生理传感器（例如200），房水中的葡萄糖浓度和其它生理特性。可植入的眼内生理传感器（例如，200）可以由诸如电化学葡萄糖燃料电池（例如，210）的燃料电池至少部分地供电。可植入的眼内生理传感器（例如，200）可以将测量值无线传输到外部设备。此外，可植入的眼内生理传感器可以包含水性排液和/或药物递送特征。

6. 发明申请

WO2010093945A2 UVEOSCLERAL DRUG DELIVERY IMPLANT AND METHODS FOR IMPLANTING THE SAME 审中-公开
公开(公告)号：WO2010093945A2
公开(公告)日：2010-08-19
申请号：PCT/US2010/024128
申请日：2010-02-12
申请人： GLAUKOS CORPORATION , HAFFNER, David , CURRY, Kenneth
发明人： HAFFNER, David , CURRY, Kenneth
IPC分类号： A61F9/00 , A61M37/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61K31/00 , A61L27/18 , A61L27/54 , A61L2300/604 , A61L2430/16 , A61M25/00 , A61M25/0105 , A61M27/00 , A61M37/00 , A61M2025/0286 , A61M2210/0612 , C08L67/04
摘要： Devices and methods for treating intraocular pressure are disclosed. The devices include drug delivery implants for treating ocular tissue. Optionally, the devices also include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The drug delivery implants can be implanted in ab interno or ab externo procedures.
摘要翻译：公开了用于治疗眼内压的装置和方法。该装置包括用于治疗眼组织的药物递送植入物。可选地，所述装置还包括用于将房水从前房排出至囊肿流出路径的分流器，包括上附近的空间和脉管外空间。药物输送植入物可以以内部或外部程序植入。

7. 发明申请

WO2005021406A3 PRODUCT DISPLAY AND FRONTING ASSEMBLY 审中-公开
公开(公告)号：WO2005021406A3
公开(公告)日：2005-03-10
申请号：PCT/US2004/027925
申请日：2004-08-27
申请人： L & P PROPERTY MANAGEMENT COMPANY , BUSTOS, Rafael, T. , HAFFNER, David, S. , KELLY, Francis, A.
发明人： BUSTOS, Rafael, T. , HAFFNER, David, S. , KELLY, Francis, A.
IPC分类号： A47F1/04
摘要： In some embodiments, a product fronting assembly includes a rotatable rear member and an elongated member extending to a handle at a front of the assembly. The rear member in some embodiments is rotatable to permit rear product loading in the assembly. Alternatively or in addition, the rear member is rotatable between a position in which forward handle movement fronts product and another position in which such handle movement does not front product. In some embodiments, a ratchet mechanism enables a handle to be returned to a stowed position after fronting product. A cable or strip can connect a handle to a rear member used to move the product. A portion of the cable or strip can be wound in a coil within or at least partially defining an assembly handle. Also, in some embodiments the assembly can be snap-fit upon a shelf.

8. 发明申请

WO2005016418A1 DEVICES AND METHODS FOR GLAUCOMA TREATMENT 审中-公开
标题翻译： GLAUCOMA治疗的装置和方法
公开(公告)号：WO2005016418A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/024988
申请日：2004-08-03
申请人： GLAUKOS CORPORATION , HAFFNER, David , SMEDLEY, Gregory, T. , TU, Hosheng
发明人： HAFFNER, David , SMEDLEY, Gregory, T. , TU, Hosheng
IPC分类号： A61M5/00
CPC分类号： A61F9/00781
摘要： Intraocular stents (229) and applicators are disclosed for treating glaucoma. The stents (229) are configured to extend between the anterior chamber of the eye and Schlemm's canal (22) for enhancing outflow of aqueous from the anterior chamber (20) so as to reduce intraocular pressure. The stents (229) can have features for anchoring the stent into Schlemm's canal (22) as well as preventing the walls of Schlemm's canal (22) from closing the outlet of the stents (229). The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.
摘要翻译：公开了用于治疗青光眼的眼内支架（229）和敷贴器。支架（229）构造成在眼睛的前房和施乐姆管（22）之间延伸，以增强从前房（20）流出的水分，以便降低眼内压。支架（229）可以具有用于将支架锚定到施莱姆管（22）中的特征，以及阻止施莱姆管（22）的壁关闭支架的出口（229）。施加器可以是可操纵的，以便使植入更容易。此外，施用器可以被配置成保持多个支架，使得可以通过一个切口植入多个支架，而不会从串联注入之间的切口移除施加器。

9. 发明申请

WO2012071476A3 DRUG ELUTING OCULAR IMPLANT 审中-公开
标题翻译：药物治疗OCOLAR IMPLANT
公开(公告)号：WO2012071476A3
公开(公告)日：2012-08-09
申请号：PCT/US2011061967
申请日：2011-11-22
申请人： HAFFNER DAVID , CURRY KEN , HEITZMANN HAROLD , APPLEGATE DAVID
发明人： HAFFNER DAVID , CURRY KEN , HEITZMANN HAROLD , APPLEGATE DAVID
IPC分类号： A61K9/00 , A61F9/00
CPC分类号： A61F9/0017 , A61F9/00781 , A61F2210/0061 , A61K9/0051 , A61K9/0092 , A61K9/2072
摘要： Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.
摘要翻译：本文公开了用于治疗眼部疾病的药物递送装置和方法，其需要靶向和受控地将药物施用于眼睛的内部以减少或预防病症的症状。这些装置能够控制释放一种或多种药物，并且还可以包括通过允许房水通过装置流出眼睛前房而允许治疗眼内压升高的结构。

10. 发明申请

WO2011163067A1 BEDDING FOUNDATION HAVING BORDER WIRE WITH GENERALLY RECTANGULAR CROSS-SECTION 审中-公开
标题翻译：具有一般矩形横截面的边界线的基座
公开(公告)号：WO2011163067A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/040800
申请日：2011-06-17
申请人： L&P PROPERTY MANAGEMENT COMPANY , HAFFNER, David, S. , HULL, John, E. , MONTAGUE, Steven, M. , RICHMOND, Darrell, A. , WELLS, Thomas, W.
发明人： HAFFNER, David, S. , HULL, John, E. , MONTAGUE, Steven, M. , RICHMOND, Darrell, A. , WELLS, Thomas, W.
IPC分类号： A47C23/00
CPC分类号： A47C23/00 , B68G1/00 , B68G2001/005
摘要： A bedding foundation (10) having a nestably stackable spring assembly (16) including a border wire (22) having a generally rectangular cross-section. The foundation's spring assembly (16) may be nestably stacked with numerous other such assemblies for transportation, thereby avoiding the need to compress and tie the assembly for shipping. Each foundation assembly (16) includes a number of corrugated support wires (28) having alternating peaks (32) and valleys (34). The border wire (22) is generally rectangular in cross-section to reduce wire costs without compromising beam strength of the border wire.
摘要翻译：一种具有可堆叠堆叠的弹簧组件（16）的寝具基座（10），包括具有大致矩形横截面的边界线（22）。基座的弹簧组件（16）可以与许多其他这样的组件可以堆叠地堆叠以便运输，从而避免压缩和捆扎组件以用于运输。每个基础组件（16）包括具有交替的峰（32）和谷（34）的多个波纹支撑线（28）。边界线（22）的横截面通常为矩形，以减少线材成本，而不损害边界线的束强度。

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