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1. 发明专利

IL228607D0 Lyophilized preparation of botulinum toxin 未知
公开(公告)号：IL228607D0
公开(公告)日：2013-12-31
申请号：IL22860713
申请日：2013-09-29
申请人： MEDY TOX INC , HYUN HO JUNG , GI HYEOK YANG , CHANG HOON RHEE , HACK WOO KIM , SUNG BUM KIM , SEUNG HWAN BAEK
IPC分类号： A61K20060101
摘要： There are provided a lyophilized preparation of botulinum toxin without a protein stabilizer derived from animals. The lyophilized preparation of botulinum toxin according to the present invention can maintain an activity of botulinum toxin, and also exhibit excellent long-term storage stability even under conditions of high temperature, which may occur when botulinum toxin is stored, delivered, and processed.

2. 发明专利

IL228607A Lyophilized preparation of botulinum toxin 未知
公开(公告)号：IL228607A
公开(公告)日：2018-10-31
申请号：IL22860713
申请日：2013-09-29
申请人： MEDY TOX INC , HYUN HO JUNG , GI HYEOK YANG , CHANG HOON RHEE , HACK WOO KIM , SUNG BUM KIM , SEUNG HWAN BAEK
发明人： HYUN HO JUNG , GI HYEOK YANG , CHANG HOON RHEE , HACK WOO KIM , SUNG BUM KIM , SEUNG HWAN BAEK
IPC分类号： A61K20060101
摘要： There are provided a lyophilized preparation of botulinum toxin without a protein stabilizer derived from animals. The lyophilized preparation of botulinum toxin according to the present invention can maintain an activity of botulinum toxin, and also exhibit excellent long-term storage stability even under conditions of high temperature, which may occur when botulinum toxin is stored, delivered, and processed.

3. 发明授权

US08617568B2 Pharmaceutical liquid composition of botulinum toxin with improved stability 有权
标题翻译：肉毒杆菌毒素的药物液体组合物具有改善的稳定性
公开(公告)号：US08617568B2
公开(公告)日：2013-12-31
申请号：US12666592
申请日：2008-05-28
申请人： Hyun Ho Jung , Gi Hyeok Yang , Hack Woo Kim , Hee Dong Woo , Chang Hoon Rhee
发明人： Hyun Ho Jung , Gi Hyeok Yang , Hack Woo Kim , Hee Dong Woo , Chang Hoon Rhee
IPC分类号： A61K39/08
CPC分类号： A61K38/4893 , A61K8/447 , A61K8/46 , A61K8/4993 , A61K8/64 , A61K8/66 , A61K9/0019 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/64 , A61K2800/52 , A61Q15/00 , A61Q19/08
摘要： Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine as botulinum toxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability of botulinum toxin at 25˜370C as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storing botulinum toxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without a lyophilization process.
摘要翻译：本文公开了一种稳定性提高的肉毒杆菌毒素的液体药物组合物。它包括肉毒杆菌毒素，聚山梨醇酯20，甲硫氨酸和任选的异亮氨酸。采用代替动物来源的蛋白质白蛋白或明胶，聚山梨醇酯20与甲硫氨酸和任选的异亮氨酸作为肉毒杆菌毒素稳定剂的组合，液体药物组合物消除了用血清衍生的病原体或微生物污染身体的风险，并且可以施用安全地到身体。此外，该组合物可方便地用作患者的直接注射剂。对于在25〜370℃以及在冷藏温度下肉毒杆菌毒素的储存稳定性方面使用洗涤剂或氨基酸的常规组合物，优选本发明的液体药物组合物在紧急情况下储存肉毒杆菌毒素非常有用，作为不保持低温的环境。液体药物组合物可以容易地制备，因为它使用洗涤剂和氨基酸而没有冷冻干燥过程。

4. 发明授权

US08993268B2 Method of producing Clostridium botulinum toxin using media containing plant-derived components and flexible closed container 有权
标题翻译：使用含有植物衍生成分和柔性密闭容器的培养基生产肉毒杆菌毒素的方法
公开(公告)号：US08993268B2
公开(公告)日：2015-03-31
申请号：US12993332
申请日：2008-07-02
申请人： Hyun-Ho Jung , Gi-Hyeok Yang , Hack-Woo Kim , Byung-Kook Lee , Young-suk Yoon , Hyung-Pyo Hong
发明人： Hyun-Ho Jung , Gi-Hyeok Yang , Hack-Woo Kim , Byung-Kook Lee , Young-suk Yoon , Hyung-Pyo Hong
IPC分类号： C12P21/04 , C07K14/33 , C12N1/20 , C12N9/52
CPC分类号： C07K14/33 , C12N1/20 , C12N9/52 , C12Y304/24069
摘要： Provided are a method of producing Clostridium botulinum toxin by using a media containing plant-derived components, and a method of producing Clostridium botulinum toxin by using a flexible closed container.
摘要翻译：提供了通过使用含有植物衍生成分的培养基来产生肉毒杆菌毒素的方法，以及通过使用柔性密闭容器来生产肉毒杆菌毒素的方法。

5. 发明授权

US08920795B2 Lyophilized preparation of botulinum toxin 有权
标题翻译：肉毒杆菌毒素的冻干制剂
公开(公告)号：US08920795B2
公开(公告)日：2014-12-30
申请号：US14008326
申请日：2012-03-30
申请人： Hyun Ho Jung , Gi Hyeok Yang , Chang Hoon Rhee , Hack Woo Kim , Sung Bum Kim , Seung Hwan Baek
发明人： Hyun Ho Jung , Gi Hyeok Yang , Chang Hoon Rhee , Hack Woo Kim , Sung Bum Kim , Seung Hwan Baek
IPC分类号： A61K38/46 , A61K47/26 , A61K47/02 , A61K9/19 , A61K38/48 , A61K47/18 , A61K47/00 , A61K47/22
CPC分类号： A61K47/26 , A61K9/19 , A61K38/4893 , A61K47/00 , A61K47/02 , A61K47/183 , A61K47/20 , A61K47/22 , C12Y304/24069
摘要： There are provided a lyophilized preparation of botulinum toxin without a protein stabilizer derived from animals. The lyophilized preparation of botulinum toxin according to the present invention can maintain an activity of botulinum toxin, and also exhibit excellent long-term storage stability even under conditions of high temperature, which may occur when botulinum toxin is stored, delivered, and processed.
摘要翻译：提供了没有衍生自动物的蛋白质稳定剂的肉毒杆菌毒素的冻干制剂。根据本发明的肉毒杆菌毒素的冻干制剂可以保持肉毒杆菌毒素的活性，并且即使在高温下也能表现出优异的长期保存稳定性，当肉毒杆菌毒素被储存，输送和加工时可能发生。

6. 发明申请

US20110091937A1 Method of Producing Clostridium Botulinum Toxin Using Media Containing Plant-Derived Components and Flexible Closed Container 有权
标题翻译：使用包含植物来源的组分和柔性封闭容器的培养基生产肉毒杆菌毒素的方法
公开(公告)号：US20110091937A1
公开(公告)日：2011-04-21
申请号：US12993332
申请日：2008-07-02
申请人： Hyun-Ho Jung , Gi-Hyeok Yang , Hack-Woo Kim , Byung-Kook Lee , Young-suk Yoon , Hyung-Pyo Hong
发明人： Hyun-Ho Jung , Gi-Hyeok Yang , Hack-Woo Kim , Byung-Kook Lee , Young-suk Yoon , Hyung-Pyo Hong
IPC分类号： C12P21/02
CPC分类号： C07K14/33 , C12N1/20 , C12N9/52 , C12Y304/24069
摘要： Provided are a method of producing Clostridium botulinum toxin by using a media containing plant-derived components, and a method of producing Clostridium botulinum toxin by using a flexible closed container.
摘要翻译：提供了通过使用含有植物衍生成分的培养基来产生肉毒杆菌毒素的方法，以及通过使用柔性密闭容器来生产肉毒杆菌毒素的方法。

7. 发明申请

US20100291136A1 Pharmaceutical Liquid Composition of Botulinum Toxin With Improved Stability 有权
标题翻译：肉毒毒素药物液体组成改善稳定性
公开(公告)号：US20100291136A1
公开(公告)日：2010-11-18
申请号：US12666592
申请日：2008-05-28
申请人： Hyun Ho Jung , Gi Hyeok Yang , Hack Woo Kim , Hee Dong Woo , Chang Hoon Rhee
发明人： Hyun Ho Jung , Gi Hyeok Yang , Hack Woo Kim , Hee Dong Woo , Chang Hoon Rhee
IPC分类号： A61K39/08 , A61K39/385 , A61P25/00
CPC分类号： A61K38/4893 , A61K8/447 , A61K8/46 , A61K8/4993 , A61K8/64 , A61K8/66 , A61K9/0019 , A61K47/183 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/64 , A61K2800/52 , A61Q15/00 , A61Q19/08
摘要： Disclosed herein is a liquid pharmaceutical composition of botulinum toxin which is improved in stability. It comprises botulinum toxin, polysorbate 20, and methionine and optionally isoleucine. Employing, instead of the animal-derived protein albumin or gelatin, a combination of polysorbate 20 and methionine and optionally isoleucine as botulinum toxin stabilizers, the liquid pharmaceutical composition eliminates the risk of contaminating the body with serum-derived pathogens or microorganisms and can be administered safely to the body. Also, the composition is convenient for use as a direct injection for patients. Superior to conventional compositions employing either detergents or amino acids in terms of the storage stability of botulinum toxin at 25˜370 C as well as at refrigerated temperatures, the liquid pharmaceutical composition of the present invention is very useful for storing botulinum toxin under an emergency condition such as an environment without maintaining low temperature. The liquid pharmaceutical composition can be readily prepared because it employs a detergent and an amino acid(s) without a lyophilization process.
摘要翻译：本文公开了一种稳定性提高的肉毒杆菌毒素的液体药物组合物。它包括肉毒杆菌毒素，聚山梨醇酯20，甲硫氨酸和任选的异亮氨酸。采用代替动物来源的蛋白质白蛋白或明胶，聚山梨醇酯20与甲硫氨酸和任选的异亮氨酸作为肉毒杆菌毒素稳定剂的组合，液体药物组合物消除了用血清衍生的病原体或微生物污染身体的风险，并且可以施用安全地到身体。此外，该组合物可方便地用作患者的直接注射剂。对于在25〜370℃以及在冷藏温度下肉毒杆菌毒素的储存稳定性方面使用洗涤剂或氨基酸的常规组合物，优选本发明的液体药物组合物在紧急情况下储存肉毒杆菌毒素非常有用如不保持低温的环境。液体药物组合物可以容易地制备，因为它使用洗涤剂和氨基酸而没有冷冻干燥过程。

8. 发明申请

US20140086900A1 Lyophilized Preparation of Botulinum Toxin 有权
标题翻译：冷冻制备肉毒杆菌毒素
公开(公告)号：US20140086900A1
公开(公告)日：2014-03-27
申请号：US14008326
申请日：2012-03-30
申请人： Hyun Ho Jung , Gi Hyeok Yang , Chang Hoon Rhee , Hack Woo Kim , Sung Bum Kim , Seung Hwan Baek
发明人： Hyun Ho Jung , Gi Hyeok Yang , Chang Hoon Rhee , Hack Woo Kim , Sung Bum Kim , Seung Hwan Baek
IPC分类号： A61K9/19 , A61K47/02 , A61K47/22 , A61K47/26 , A61K38/48 , A61K47/18
CPC分类号： A61K47/26 , A61K9/19 , A61K38/4893 , A61K47/00 , A61K47/02 , A61K47/183 , A61K47/20 , A61K47/22 , C12Y304/24069
摘要： There are provided a lyophilized preparation of botulinum toxin without a protein stabilizer derived from animals. The lyophilized preparation of botulinum toxin according to the present invention can maintain an activity of botulinum toxin, and also exhibit excellent long-term storage stability even under conditions of high temperature, which may occur when botulinum toxin is stored, delivered, and processed.
摘要翻译：提供了没有衍生自动物的蛋白质稳定剂的肉毒杆菌毒素的冻干制剂。根据本发明的肉毒杆菌毒素的冻干制剂可以保持肉毒杆菌毒素的活性，并且即使在高温下也能表现出优异的长期保存稳定性，当肉毒杆菌毒素被储存，输送和加工时可能发生。

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