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1. 发明授权

US07794961B2 Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity 失效
标题翻译：用于改变caspase活性的凋亡抑制剂（IAP）蛋白调节剂的筛选试验
公开(公告)号：US07794961B2
公开(公告)日：2010-09-14
申请号：US11651651
申请日：2007-01-09
申请人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
发明人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
IPC分类号： G01N33/574
CPC分类号： G01N33/5011 , C12Q1/37 , G01N33/573 , G01N2333/96466 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells.
摘要翻译：本发明涉及凋亡抑制剂（IAP）蛋白和细胞死亡蛋白酶半胱天冬酶家族的成员之间的作用，例如，X染色体连接的IAP（XIAP）和半胱天冬酶-3的相互作用，半胱天冬酶-7或胱天蛋白酶-9，其中IAP调节胱天蛋白酶的活性。本发明提供用于鉴定改变IAP（诸如XIAP，c-IAP-1或c-IAP-2）和半胱天冬酶（例如半胱天冬酶-3或半胱天冬酶-7）的IAP的特异性缔合的试剂的筛选试验。本发明还提供用于鉴定改变IAP如XIAP，c-IAP-1或c-IAP-2和前半胱天冬酶如前半胱天冬酶-9的特异性关联的试剂的筛选试验。此外，本发明还提供了鉴定在IAP存在下调节半胱天冬酶的活性并且通过IAP调节前半胱天冬酶的活化的试剂的方法。本发明还提供了通过向个体施用改变IAP的半胱天冬酶抑制活性的试剂来降低个体病理状况的严重性的方法。此外，本发明提供了通过使细胞与改变细胞中IAP的半胱天冬酶抑制活性的试剂接触来调节细胞群体离体存活的能力的方法。

2. 发明授权

US07192728B2 Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity 失效
标题翻译：用于改变caspase活性的凋亡抑制剂（IAP）蛋白调节剂的筛选试验
公开(公告)号：US07192728B2
公开(公告)日：2007-03-20
申请号：US09799994
申请日：2001-03-05
申请人： John C Reed , Quinn Deveraux , Guy S Salvesen , Ryosuke Takahashi , Natalie Roy
发明人： John C Reed , Quinn Deveraux , Guy S Salvesen , Ryosuke Takahashi , Natalie Roy
IPC分类号： C12Q1/34 , G01N33/53
CPC分类号： G01N33/5011 , C12Q1/37 , G01N33/573 , G01N2333/96466 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells.
摘要翻译：本发明涉及凋亡抑制剂（IAP）蛋白和细胞死亡蛋白酶半胱天冬酶家族的成员之间的作用，例如，X染色体连接的IAP（XIAP）和半胱天冬酶-3的相互作用，半胱天冬酶-7或胱天蛋白酶-9，其中IAP调节胱天蛋白酶的活性。本发明提供用于鉴定改变IAP（诸如XIAP，c-IAP-1或c-IAP-2）和半胱天冬酶（例如半胱天冬酶-3或半胱天冬酶-7）的IAP的特异性缔合的试剂的筛选试验。本发明还提供用于鉴定改变IAP如XIAP，c-IAP-1或c-IAP-2和前半胱天冬酶如前半胱天冬酶-9的特异性关联的试剂的筛选试验。此外，本发明还提供了鉴定在IAP存在下调节半胱天冬酶的活性并且通过IAP调节前半胱天冬酶的活化的试剂的方法。本发明还提供了通过向个体施用改变IAP的半胱天冬酶抑制活性的试剂来降低个体病理状况的严重性的方法。此外，本发明提供了通过使细胞与改变细胞中IAP的半胱天冬酶抑制活性的试剂接触来调节细胞群体离体存活的能力的方法。

3. 发明授权

US06027896A Methods of detecting Alzheimer's disease 失效
标题翻译：检测阿尔茨海默病的方法
公开(公告)号：US06027896A
公开(公告)日：2000-02-22
申请号：US60459
申请日：1998-04-15
申请人： Allen D. Roses , Warren J. Strittmatter , Guy S. Salvesen , Jan Enghild , Donald E. Schmechel
发明人： Allen D. Roses , Warren J. Strittmatter , Guy S. Salvesen , Jan Enghild , Donald E. Schmechel
IPC分类号： G01N33/53 , A61K39/395 , C07K1/28 , C07K14/755 , C07K14/775 , C07K16/00 , C07K16/18 , C12N15/09 , C12P21/08 , C12Q1/68 , C07H21/02 , C12P19/34
CPC分类号： C07K14/755 , C07K14/775 , C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , Y10S435/81
摘要： Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
摘要翻译：公开了在受试者中诊断或预测阿尔茨海默氏病的方法。所述方法包括直接或间接检测受试者中载脂蛋白E型4型（ApoE4）同种型或编码ApoE4的DNA的存在或不存在。 ApoE4的存在表明受试者患有阿尔茨海默氏病或患阿尔茨海默氏病的风险。还公开了用于检测受试者中载脂蛋白E（ApoE）E4等位基因的存在或不存在的新型免疫化学测定法。

4. 发明授权

US5508167A Methods of screening for Alzheimer's disease 失效
标题翻译：筛查阿尔茨海默氏病的方法
公开(公告)号：US5508167A
公开(公告)日：1996-04-16
申请号：US227044
申请日：1994-04-13
申请人： Allen D. Roses , Warren J. Strittmatter , Guy S. Salvesen , Jan Enghild , Donald E. Schmechel
发明人： Allen D. Roses , Warren J. Strittmatter , Guy S. Salvesen , Jan Enghild , Donald E. Schmechel
IPC分类号： G01N33/53 , A61K39/395 , C07K1/28 , C07K14/755 , C07K14/775 , C07K16/00 , C07K16/18 , C12N15/09 , C12P21/08 , C12Q1/68 , C12P19/34 , C12Q1/00
CPC分类号： C07K14/755 , C07K14/775 , C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , Y10S435/81
摘要： Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA, encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
摘要翻译：公开了在受试者中诊断或预测阿尔茨海默氏病的方法。所述方法包括直接或间接检测在受试者中编码ApoE4的载脂蛋白E型4型（ApoE4）同种型或DNA的存在或不存在。 ApoE4的存在表明受试者患有阿尔茨海默氏病或患阿尔茨海默氏病的风险。还公开了用于检测受试者中载脂蛋白E（ApoE）E4等位基因的存在或不存在的新型免疫化学测定法。

5. 发明授权

US08071327B2 Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity 失效
标题翻译：用于改变caspase活性的凋亡抑制剂（IAP）蛋白调节剂的筛选试验
公开(公告)号：US08071327B2
公开(公告)日：2011-12-06
申请号：US12848936
申请日：2010-08-02
申请人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
发明人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
IPC分类号： C12Q1/34
CPC分类号： G01N33/5011 , C12Q1/37 , G01N33/573 , G01N2333/96466 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells.
摘要翻译：本发明涉及凋亡抑制剂（IAP）蛋白和细胞死亡蛋白酶半胱天冬酶家族的成员之间的作用，例如，X染色体连接的IAP（XIAP）和半胱天冬酶-3的相互作用，半胱天冬酶-7或胱天蛋白酶-9，其中IAP调节胱天蛋白酶的活性。本发明提供用于鉴定改变IAP（诸如XIAP，c-IAP-1或c-IAP-2）和半胱天冬酶（例如半胱天冬酶-3或半胱天冬酶-7）的IAP的特异性缔合的试剂的筛选试验。本发明还提供用于鉴定改变IAP如XIAP，c-IAP-1或c-IAP-2和前半胱天冬酶如前半胱天冬酶-9的特异性关联的试剂的筛选试验。此外，本发明还提供了鉴定在IAP存在下调节半胱天冬酶的活性并且通过IAP调节前半胱天冬酶的活化的试剂的方法。本发明还提供了通过向个体施用改变IAP的半胱天冬酶抑制活性的试剂来降低个体病理状况的严重性的方法。此外，本发明提供了通过使细胞与改变细胞中IAP的半胱天冬酶抑制活性的试剂接触来调节细胞群体离体存活的能力的方法。

6. 发明申请

US20120094922A1 SCREENING ASSAYS FOR AGENTS THAT ALTER INHIBITOR OF APOPTOSIS (IAP) PROTEIN REGULATION OF CASPASE ACTIVITY 审中-公开
标题翻译：用于杀虫剂（IAP）蛋白抑制剂对CASPASE活性的抑制剂的筛选测定
公开(公告)号：US20120094922A1
公开(公告)日：2012-04-19
申请号：US13287979
申请日：2011-11-02
申请人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
发明人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
IPC分类号： A61K38/02 , A61P35/00 , A61P25/28 , C12Q1/37 , G01N33/573
CPC分类号： G01N33/5011 , C12Q1/37 , G01N33/573 , G01N2333/96466 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7 or a pro-caspase such as pro-caspase-9, or that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP.
摘要翻译：本发明涉及凋亡抑制剂（IAP）蛋白和细胞死亡蛋白酶半胱天冬酶家族的成员之间的作用，例如，X染色体连接的IAP（XIAP）和半胱天冬酶-3的相互作用，半胱天冬酶-7或胱天蛋白酶-9，其中IAP调节胱天蛋白酶的活性。本发明提供用于鉴定改变IAP如XIAP，c-IAP-1或c-IAP-2和胱天蛋白酶如半胱天冬酶-3或半胱天冬酶-7或前半胱天冬酶的特异性关联的筛选试验， pro-caspase-9，或者在IAP存在下调节胱天蛋白酶的活性，并且通过IAP调节前半胱天冬酶的活化。本发明还提供了通过向个体施用改变IAP的半胱天冬酶抑制活性的试剂来降低个体病理状况的严重性的方法。

7. 发明申请

US20110059465A1 SCREENING ASSAYS FOR AGENTS THAT ALTER INHIBITOR OF APOPTOSIS (IAP) PROTEIN REGULATION OF CASPASE ACTIVITY 失效
标题翻译：用于杀虫剂（IAP）蛋白抑制剂对CASPASE活性的抑制剂的筛选测定
公开(公告)号：US20110059465A1
公开(公告)日：2011-03-10
申请号：US12848936
申请日：2010-08-02
申请人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
发明人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
IPC分类号： G01N33/573 , C12Q1/37
CPC分类号： G01N33/5011 , C12Q1/37 , G01N33/573 , G01N2333/96466 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells.
摘要翻译：本发明涉及凋亡抑制剂（IAP）蛋白和细胞死亡蛋白酶半胱天冬酶家族的成员之间的作用，例如，X染色体连接的IAP（XIAP）和半胱天冬酶-3的相互作用，半胱天冬酶-7或胱天蛋白酶-9，其中IAP调节胱天蛋白酶的活性。本发明提供用于鉴定改变IAP（诸如XIAP，c-IAP-1或c-IAP-2）和半胱天冬酶（例如半胱天冬酶-3或半胱天冬酶-7）的IAP的特异性缔合的试剂的筛选试验。本发明还提供用于鉴定改变IAP如XIAP，c-IAP-1或c-IAP-2和前半胱天冬酶如前半胱天冬酶-9的特异性关联的试剂的筛选试验。此外，本发明还提供了鉴定在IAP存在下调节半胱天冬酶的活性并且通过IAP调节前半胱天冬酶的活化的试剂的方法。本发明还提供了通过向个体施用改变IAP的半胱天冬酶抑制活性的试剂来降低个体病理状况的严重性的方法。此外，本发明提供了通过使细胞与改变细胞中IAP的半胱天冬酶抑制活性的试剂接触来调节细胞群体离体存活的能力的方法。

8. 发明授权

US06228603B1 Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity 失效
标题翻译：用于改变caspase活性的凋亡抑制剂（IAP）蛋白调节剂的筛选试验
公开(公告)号：US06228603B1
公开(公告)日：2001-05-08
申请号：US09058969
申请日：1998-04-10
申请人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
发明人： John C. Reed , Quinn Deveraux , Guy S. Salvesen , Ryosuke Takahashi , Natalie Roy
IPC分类号： G01N3353
CPC分类号： G01N33/5011 , C12Q1/37 , G01N33/573 , G01N2333/96466 , G01N2500/00 , G01N2500/10 , G01N2510/00
摘要： The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The invention provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a caspase such as caspase-3 or caspase-7. The invention also provides screening assays for identifying agents that alter the specific association of an IAP such as XIAP, c-IAP-1 or c-IAP-2 and a pro-caspase such as pro-caspase-9. In addition, the invention also provides methods for identifying agents that modulate the activity of a caspase in the presence of an IAP and that regulate the activation of a pro-caspase by an IAP. The invention further provides methods of reducing the severity of a pathologic condition in an individual by administering to the individual an agent that alters the caspase inhibitory activity of an IAP. In addition, the invention provides methods of modulating the ability of a population of cells to survive ex vivo by contacting the cells with an agent that alters the caspase inhibitory activity of an IAP in the cells.
摘要翻译：本发明涉及凋亡抑制剂（IAP）蛋白和细胞死亡蛋白酶半胱天冬酶家族的成员之间的作用，例如，X染色体连接的IAP（XIAP）和半胱天冬酶-3的相互作用，半胱天冬酶-7或胱天蛋白酶-9，其中IAP调节胱天蛋白酶的活性。本发明提供用于鉴定改变IAP（诸如XIAP，c-IAP-1或c-IAP-2）和半胱天冬酶（例如半胱天冬酶-3或半胱天冬酶-7）的IAP的特异性缔合的试剂的筛选试验。本发明还提供用于鉴定改变IAP如XIAP，c-IAP-1或c-IAP-2和前半胱天冬酶如前半胱天冬酶-9的特异性关联的试剂的筛选试验。此外，本发明还提供了鉴定在IAP存在下调节半胱天冬酶的活性并且通过IAP调节前半胱天冬酶的活化的试剂的方法。本发明还提供了通过向个体施用改变IAP的半胱天冬酶抑制活性的试剂来降低个体病理状况的严重性的方法。此外，本发明提供了通过使细胞与改变细胞中IAP的半胱天冬酶抑制活性的试剂接触来调节细胞群体离体存活的能力的方法。

9. 发明授权

US5767248A Apolipoprotein E isoform-specific monoclonal antibodies 失效
标题翻译：载脂蛋白E异构体特异性单克隆抗体
公开(公告)号：US5767248A
公开(公告)日：1998-06-16
申请号：US835503
申请日：1997-04-08
申请人： Allen D. Roses , Warren J. Strittmatter , Guy S. Salvesen , Jan Enghild , Donald E. Schmechel
发明人： Allen D. Roses , Warren J. Strittmatter , Guy S. Salvesen , Jan Enghild , Donald E. Schmechel
IPC分类号： G01N33/53 , A61K39/395 , C07K1/28 , C07K14/755 , C07K14/775 , C07K16/00 , C07K16/18 , C12N15/09 , C12P21/08 , C12Q1/68
CPC分类号： C07K14/755 , C07K14/775 , C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , Y10S435/81
摘要： Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is afflicted with Alzheimer's disease or at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
摘要翻译：公开了在受试者中诊断或预测阿尔茨海默氏病的方法。所述方法包括直接或间接检测受试者中载脂蛋白E型4型（ApoE4）同种型或编码ApoE4的DNA的存在或不存在。 ApoE4的存在表明受试者患有阿尔茨海默氏病或患阿尔茨海默氏病的风险。还公开了用于检测受试者中载脂蛋白E（ApoE）E4等位基因的存在或不存在的新型免疫化学测定法。

10. 发明授权

US5716828A Kit for detecting the ApoE4 allele, and for diagnosing the existence or risk of developing Alzheimer's disease 失效
标题翻译：用于检测ApoE4等位基因的试剂盒，用于诊断发生阿尔茨海默氏病的存在或风险
公开(公告)号：US5716828A
公开(公告)日：1998-02-10
申请号：US441001
申请日：1995-05-15
申请人： Allen D. Roses , Warren J. Strittmatter , Guy S. Salvesen , Jan Enghild , Donald E. Schmechel
发明人： Allen D. Roses , Warren J. Strittmatter , Guy S. Salvesen , Jan Enghild , Donald E. Schmechel
IPC分类号： G01N33/53 , A61K39/395 , C07K1/28 , C07K14/755 , C07K14/775 , C07K16/00 , C07K16/18 , C12N15/09 , C12P21/08 , C12Q1/68
CPC分类号： C07K14/755 , C07K14/775 , C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , Y10S435/81
摘要： Methods of diagnosing or prognosing Alzheimer's disease in a subject are disclosed. The methods involve directly or indirectly detecting the presence or absence of an apolipoprotein E type 4 (ApoE4) isoform or DNA encoding ApoE4 in the subject. The presence of ApoE4 indicates the subject is at risk of developing Alzheimer's disease. A novel immunochemical assay for detecting the presence or absence of the Apoliprotein E (ApoE) E4 allele in a subject is also disclosed.
摘要翻译：公开了在受试者中诊断或预测阿尔茨海默氏病的方法。所述方法包括直接或间接检测受试者中载脂蛋白E型4型（ApoE4）同种型或编码ApoE4的DNA的存在或不存在。 ApoE4的存在表明受试者处于发展阿尔茨海默氏病的风险中。还公开了用于检测受试者中载脂蛋白E（ApoE）E4等位基因的存在或不存在的新型免疫化学测定法。

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