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    • 4. 发明申请
    • COMMUNICATION METHOD AND DEVICES FOR THE INFIRM
    • 通讯方法及其设备
    • WO2013134504A1
    • 2013-09-12
    • PCT/US2013/029604
    • 2013-03-07
    • MURPHY, Kent A.COUCH, Philip R.GUNTHER, Michael F.GAUSE, Charles B.
    • MURPHY, Kent A.COUCH, Philip R.GUNTHER, Michael F.GAUSE, Charles B.
    • H04W88/02
    • H04M1/026H04M1/0202H04M1/2474H04M1/6775
    • The telephone handset for the infirm includes a housing, wherein the housing has the appearance of an old-style telephone handset, internal electronics including a microphone, a speaker, wireless communication circuitry, and signal processing circuitry for processing signals received by the wireless communications circuitry to drive the speaker and for processing signals received from the microphone to transmit a signal representative of the received microphone signal wireless to one or more remote audio communication devices. The telephone handset also includes a simplified user interface which includes a predetermined number of keys less than ten, where the keys are programmed to cause the internal electronics to initiate contact with at least one specific remote audio communication device upon actuation. The telephone handset also has a multifunction user interface with at least a full numeric keypad and other keys sufficient to program the keys of the simplified user interface.
    • 用于体弱的电话听筒包括外壳,其中外壳具有旧式电话听筒的外观,包括麦克风的内部电子装置,扬声器,无线通信电路和用于处理由无线通信电路接收的信号的信号处理电路 以驱动扬声器并处理从麦克风接收的信号,以将表示所接收的麦克风信号的信号无线传送到一个或多个远程音频通信设备。 电话听筒还包括简化的用户界面,其包括小于十的预定数量的键,其中键被编程为使得内部电子装置在致动时启动与至少一个特定远程音频通信装置的接触。 电话听筒还具有多功能用户界面,至少具有一个完整的数字小键盘和其他足以对简化的用户界面的键进行编程的键。
    • 5. 发明申请
    • INTEGRATED OPTICS REFLECTOMETER
    • 集成光学反射计
    • WO2013138653A1
    • 2013-09-19
    • PCT/US2013/031657
    • 2013-03-14
    • COUCH, Philip R.MURPHY, Kent A.GUNTHER, Michael F.GAUSE, Charles B.
    • COUCH, Philip R.MURPHY, Kent A.GUNTHER, Michael F.GAUSE, Charles B.
    • H01S3/10H01S3/086G01J9/00
    • G01J9/00G01D5/35316G01D5/35354G01M11/3172H01S5/0687
    • An apparatus includes a laser source configured to output laser light at a target frequency, and a measurement unit configured to measure a deviation between an actual frequency outputted by the laser source at a current period of time and the target frequency of the laser source. The apparatus includes a feedback control unit configured to, based on the measured deviation between the actual and target frequencies, control the laser source to maintain a constant frequency of laser output from the laser source so that the frequency of laser light transmitted from the laser source is adjusted to the target frequency. The feedback control unit can control the laser source to maintain a linear rate of change in the frequency of its laser light output, and compensate for characteristics of the measurement unit utilized for frequency measurement. A method is provided for performing the feedback control of the laser source.
    • 一种装置,包括:被配置为以目标频率输出激光的激光源;以及测量单元,被配置为测量在当前时间段由激光源输出的实际频率与激光源的目​​标频率之间的偏差。 该装置包括反馈控制单元,其被配置为基于实测频率和目标频率之间的测量偏差,控制激光源以保持来自激光源的激光输出的恒定频率,使得从激光源发射的激光的频率 被调整到目标频率。 反馈控制单元可以控制激光源维持其激光输出频率的线性变化率,并补偿用于频率测量的测量单元的特性。 提供了一种用于执行激光源的反馈控制的方法。
    • 7. 发明申请
    • VIRAL MUTANTS, MANIPULATED IN THE FURIN CLEAVAGE SITES OF GLYCOPROTEINS
    • 葡萄糖酵母蛋白酶切位点的病毒
    • WO2003083095A1
    • 2003-10-09
    • PCT/EP2003/002520
    • 2003-03-12
    • AKZO NOBEL N.V.KEIL, Gunther, Michael
    • KEIL, Gunther, Michael
    • C12N7/00
    • C07K14/005A61K39/12A61K39/155A61K2039/552C12N2760/18522C12N2760/18534
    • The present invention relates to viruses containing glycoproteins with furin binding sites. For BRSV it has been found that the 27AA IFCSP is not essential for cell fusion activity of the F protein and the deletion or replacement of at least part of the IFCSP does not destroy F function for productive BRSV replication. Removal of Gly110 to Arg 136 and transient expression of the resulting protein (F ins ) resulted in formation of syncitia which were slightly smaller that those induced by wt F. thus, it has been found that oligopeptides, or bioactive proteins, can be integrated between 2 furin cleavage sites of a carrier glycoprotein, such as the furin cleavage sites of an F protein of an RSV. Due to the processing of the precursor protein, resulting in the cleavage at the furin cleavage sites, the heterologous sequence may be excised and consequently be secreted by a virus-infected cell. This concept can be applied likewise to other glycoproteins containing two furin cleavage sites, where the original sequence between the cleavage sites may replaced (in part) by a heterologous sequence or may simply be deleted. In proteins with one furin cleavage site, heterologous sequences may be inserted together with the sequence for a second cleavage site, thus creating a situation where the heterologous sequence is again flanked by two furin cleavage sites in the recombinant protein. Processing of the mutated protein will than also result in the excision of the heterologous sequence which may be secreted by virus infected cells. Viruses wherein glycoproteins are modified in one of the above-described ways, can be used for, for example vaccine purposes.
    • 本发明涉及含有蛋白质结合位点的糖蛋白的病毒。 对于BRSV,已经发现27AA IFCSP对于F蛋白的细胞融合活性不是必需的,并且至少部分IFCSP的缺失或替换不会破坏生产性BRSV复制的F功能。 Gly110去除Arg 136和所得蛋白质(Fins)的瞬时表达导致形成的synitia,其略小于由wt F诱导的那些。因此,已经发现寡肽或生物活性蛋白可以整合在2 载体糖蛋白的弗林蛋白酶切割位点,例如RSV的F蛋白的弗林蛋白酶切割位点。 由于前体蛋白的加工,导致弗林蛋白酶切割位点处的切割,可以切除异源序列,因此由病毒感染的细胞分泌。 该概念可以同样应用于含有两个弗林蛋白酶切割位点的其他糖蛋白,其中切割位点之间的原始序列可以通过异源序列替换(部分地)或可以简单地被删除。 在具有一个弗林蛋白酶切割位点的蛋白质中,异源序列可与该序列一起插入第二切割位点,从而产生异源序列再次侧接于重组蛋白中的两个弗林蛋白酶切割位点的情况。 突变蛋白的加工也将导致可被病毒感染的细胞分泌的异源序列的切除。 其中糖蛋白以上述方法之一修饰的病毒可用于例如疫苗目的。