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1. 发明申请

US20100113435A1 INHIBITORS OF 11-BETA-HYDROXY STERIOD DEHYDROGENASE TYPE 1 审中-公开
标题翻译： 11-羟基异丁酸脱氢酶1型抑制剂
公开(公告)号：US20100113435A1
公开(公告)日：2010-05-06
申请号：US12619216
申请日：2009-11-16
申请人： Tjeerd BARF , Rikard Emond , Guido Kurz , Jerk Vallgarda , Marianne Nilsson
发明人： Tjeerd BARF , Rikard Emond , Guido Kurz , Jerk Vallgarda , Marianne Nilsson
IPC分类号： A61K31/541 , C07D277/20 , A61K31/426 , C07D417/14 , A61K31/506 , C07D271/12 , A61K31/4245 , C07D417/02 , A61K31/454 , C07D217/22 , A61K31/47 , C07D413/02 , A61K31/5377 , C07D413/14 , A61K31/496 , A61P3/10 , A61P3/00 , A61P25/00 , A61P29/00 , A61P31/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/52 , C07D277/56 , C07D277/84 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/08 , C07D513/04
摘要： The present invention relates to compounds with the formula (II) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译：本发明涉及具有式（II）的化合物以及包含该化合物的药物组合物，其制备方法以及该化合物在医药中的用途和用于制备作用于人的药物 11-＆bgr-羟基类固醇脱氢酶1型酶。

2. 发明授权

US07671051B2 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 失效
标题翻译： 11-和β-羟基类固醇脱氢酶1型抑制剂
公开(公告)号：US07671051B2
公开(公告)日：2010-03-02
申请号：US11179507
申请日：2005-07-13
申请人： Tjeerd Barf , Rikard Emond , Jerk Vallgarda , Guido Kurz , Marianne Nilsson , Lian Zhang
发明人： Tjeerd Barf , Rikard Emond , Jerk Vallgarda , Guido Kurz , Marianne Nilsson , Lian Zhang
IPC分类号： A61K31/535 , C07D417/12
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/52 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译：本发明涉及具有式（I）的化合物以及包含该化合物的药物组合物，以及该化合物在医药中的用途以及用于制备作用于人类11-羟基类固醇的药物脱氢酶1型酶。

3. 发明申请

US20050250776A1 Inhibitors of 11-beta-hydroxy steriod dehydrogenase type 1 失效
标题翻译： 11-β-羟基甾体脱氢酶抑制剂1型
公开(公告)号：US20050250776A1
公开(公告)日：2005-11-10
申请号：US11179507
申请日：2005-07-13
申请人： Tjeerd Barf , Rikard Emond , Guido Kurz , Marianne Nilsson , Jerk Vallgarda , Lian Zhang
发明人： Tjeerd Barf , Rikard Emond , Guido Kurz , Marianne Nilsson , Jerk Vallgarda , Lian Zhang
IPC分类号： C07D20060101 , C07D277/38 , C07D277/52 , C07D417/06 , C07D417/12 , C07D417/14 , C07D521/00 , C07D417/02 , A61K31/427 , A61K31/4439 , A61K31/5377
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/52 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译：本发明涉及具有式（I）的化合物以及包含该化合物的药物组合物，以及该化合物在医药中的用途以及制备作用于人类11-β-羟基类固醇脱氢酶 1型酶。

4. 发明申请

US20050239853A1 New compounds 审中-公开
标题翻译：新化合物
公开(公告)号：US20050239853A1
公开(公告)日：2005-10-27
申请号：US11050178
申请日：2005-02-03
申请人： Tjeerd Barf , Guido Kurz , Sofia Nordin , Lars Tedenborg , Jerk Vallgarda , Meredith Williams
发明人： Tjeerd Barf , Guido Kurz , Sofia Nordin , Lars Tedenborg , Jerk Vallgarda , Meredith Williams
IPC分类号： A61K31/427 , C07D277/54 , C07D417/02 , C07D417/04 , C07D417/06 , C07D417/12
CPC分类号： C07D277/54 , C07D417/04 , C07D417/06 , C07D417/12
摘要： The present invention relates to compounds with the formula (I) wherein R1, R2, R3, X, and Y are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译：本发明涉及具有式（I）的化合物，其中R 1，R 2，R 3，X和Y如上定义并且还涉及包含该化合物的药物组合物，以及该化合物在医药中的用途以及制备作用于人类11-羟类固醇脱氢酶1型酶的药物。

5. 发明授权

US08815918B2 Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives 有权
标题翻译：咪唑并[2,1-B] [1,3,4]噻二唑衍生物
公开(公告)号：US08815918B2
公开(公告)日：2014-08-26
申请号：US13262183
申请日：2010-04-01
申请人： Joaquin Pastor Fernández , Guido Kurz , Sonia Martinez Gonzalez
发明人： Joaquin Pastor Fernández , Guido Kurz , Sonia Martinez Gonzalez
IPC分类号： A61K31/433 , A61K31/4188 , C07D285/02 , C07D235/00
CPC分类号： C07D513/04
摘要： There is provided compounds of formula (I): wherein R1, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K) is desired and/or required, and particularly in the treatment of cancer.
摘要翻译：提供式（I）化合物：其中R 1，R 2和R 3具有本说明书中给出的含义及其药学上可接受的酯，酰胺，溶剂化物或其盐，该化合物可用于治疗其中抑制蛋白质或脂质激酶（例如PI3-K，特别是I型PI3K）是期望和/或需要的，特别是在治疗癌症中。

6. 发明申请

US20120094996A1 Imidazo [2, 1-B] [1, 3, 4] Thiadiazole Derivatives 有权
标题翻译：咪唑并[2,1-B] [1,3,4]噻二唑衍生物
公开(公告)号：US20120094996A1
公开(公告)日：2012-04-19
申请号：US13262183
申请日：2010-04-01
申请人： Joaquin Pastor Fernández , Guido Kurz , Sonia Martinez Gonzalez
发明人： Joaquin Pastor Fernández , Guido Kurz , Sonia Martinez Gonzalez
IPC分类号： A61K31/433 , A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/4545 , A61K31/496 , A61P35/00 , A61P37/00 , A61P9/00 , A61P31/12 , A61P29/00 , A61P3/00 , A61P25/00 , A61P17/06 , A61P9/10 , A61P3/10 , A61P25/28 , A61P35/02 , C07D513/04
CPC分类号： C07D513/04
摘要： There is provided compounds of formula (I): wherein R1, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K) is desired and/or required, and particularly in the treatment of cancer.
摘要翻译：提供式（I）化合物：其中R 1，R 2和R 3具有本说明书中给出的含义及其药学上可接受的酯，酰胺，溶剂化物或其盐，该化合物可用于治疗其中抑制蛋白质或脂质激酶（例如PI3-K，特别是I型PI3K）是期望和/或需要的，特别是在治疗癌症中。

7. 发明授权

US07618961B2 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 失效
标题翻译： 11-β-羟基类固醇脱氢酶1型抑制剂
公开(公告)号：US07618961B2
公开(公告)日：2009-11-17
申请号：US10296553
申请日：2001-05-22
申请人： Tjeerd Barf , Rikard Emond , Guido Kurz , Jerk Vallgårda , Marianne Nilsson
发明人： Tjeerd Barf , Rikard Emond , Guido Kurz , Jerk Vallgårda , Marianne Nilsson
IPC分类号： A61K31/535 , A61K31/497 , A61K31/47 , A61K31/445 , A61K31/425 , C07D413/12 , C07D413/14 , C07D413/06 , C07D453/04 , C07D277/38
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/52 , C07D277/56 , C07D277/84 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/08 , C07D513/04
摘要： The present invention relates to compounds with the formula (II) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译：本发明涉及具有式（II）的化合物以及包含该化合物的药物组合物，其制备方法以及该化合物在医药中的用途和用于制备作用于人的药物 11-β-羟基类固醇脱氢酶1型酶。

8. 发明授权

US07125900B2 Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1 失效
公开(公告)号：US07125900B2
公开(公告)日：2006-10-24
申请号：US10276954
申请日：2001-05-22
申请人： Tjeerd Barf , Marianne Nilsson , Jerk Vallgårda , Guido Kurz
发明人： Tjeerd Barf , Marianne Nilsson , Jerk Vallgårda , Guido Kurz
IPC分类号： C07D277/52 , A61K31/426
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/52 , C07D277/56 , C07D277/84 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/08 , C07D513/04
摘要： The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

9. 发明授权

US07094792B2 Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 失效
公开(公告)号：US07094792B2
公开(公告)日：2006-08-22
申请号：US10302036
申请日：2002-11-22
申请人： Tjeerd Barf , Rikard Emond , Guido Kurz , Marianne Nilsson , Jerk Vallgårda , Lian Zhang
发明人： Tjeerd Barf , Rikard Emond , Guido Kurz , Marianne Nilsson , Jerk Vallgårda , Lian Zhang
IPC分类号： A61K31/426 , C07D277/52
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/52 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

10. 发明授权

US06398416B1 Sintered friction bearing for motors and gears 失效
标题翻译：用于电机和齿轮的烧结摩擦轴承
公开(公告)号：US06398416B1
公开(公告)日：2002-06-04
申请号：US09678219
申请日：2000-10-02
申请人： Guido Kurz , Thomas Broghammer
发明人： Guido Kurz , Thomas Broghammer
IPC分类号： F16C3310
CPC分类号： F16C33/1065 , F16C17/02 , F16C33/103 , Y10S384/902
摘要： A sintered friction bearing for motors and gears with a bearing surface, which is formed by a bearing bore and can have a lubricant from lubricant depositories in the bearing. The bearing bore has alternating highly compressed, small-pored bearing surfaces distributed over the circumference and slightly compressed, open-pored lubricant depositories from one front face to the other front face of the bearing. Lubrication of the sintered friction bearing is improved because the lubricant depositories are embodied as grooved structures with at least two longitudinal grooves, which are inclined at an acute angle with respect to a center axis of the bearing bore from one front face to another front face of the bearing.
摘要翻译：一种用于电动机和齿轮的烧结摩擦轴承，其具有轴承表面，其由轴承孔形成并且可以具有来自轴承中的润滑剂储存器的润滑剂。轴承孔具有交替的高度压缩，小孔的轴承表面，其分布在圆周上，并且从轴承的一个前表面到另一个前表面分布在稍微压缩的，开放的润滑剂储存器上。烧结摩擦轴承的润滑被改善，因为润滑剂储存器被实施为具有至少两个纵向凹槽的开槽结构，所述至少两个纵向槽相对于轴承孔的中心轴线从一个前表面到另一个正面倾斜成锐角轴承。

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