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1. 发明授权

US07678776B2 Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof 有权
标题翻译：丁基苯酞与环糊精或其衍生物的包合物，其制备方法及其应用
公开(公告)号：US07678776B2
公开(公告)日：2010-03-16
申请号：US12200130
申请日：2008-08-28
申请人： Zhan-qi Niu , Kai Zhao , Wen-juan Liu , Gui-rong Zhou , Chao Liu , Rong-duan Wang , Hong-zhong Yuan , Wen-min Guo , Sui-chao Yan , Min Bai
发明人： Zhan-qi Niu , Kai Zhao , Wen-juan Liu , Gui-rong Zhou , Chao Liu , Rong-duan Wang , Hong-zhong Yuan , Wen-min Guo , Sui-chao Yan , Min Bai
IPC分类号： A61K31/724 , A61K31/715 , C08B37/16
CPC分类号： C08B37/0015 , A61K31/343 , A61K47/6951 , B82Y5/00 , C07D307/88
摘要： The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-β-cyclodextrin in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.
摘要翻译：本发明涉及丁基苯酞（其为D，L-混合或左旋）与环糊精或环糊精衍生物的包合络合物，其制备方法及其应用。在本发明中，丁基苯酞与环糊精或环糊精衍生物络合，优选与羟丙基 - 环糊精复合，以提高丁基苯酞的水溶性，开发临床固体或液体制剂，提高丁基苯酞的治疗效果。丁基苯酞与环糊精或环糊精衍生物的摩尔比在1：1-10范围内的包合络合物可用于制备输注，注射，可注射粉末，口服液体，糖浆，片剂，颗粒剂，分散片等。

2. 发明申请

US20090052653A1 TELEPHONE DEVICE, TELEPHONE LINE MONITORING DEVICE AND METHOD 失效
标题翻译：电话设备，电话线路监控设备和方法
公开(公告)号：US20090052653A1
公开(公告)日：2009-02-26
申请号：US12099172
申请日：2008-04-08
申请人： Lin-Kun DING , Shih-Fang WONG , Xiang-Ping ZHOU , Jiang-Feng SHAN , Gui-Rong ZHOU
发明人： Lin-Kun DING , Shih-Fang WONG , Xiang-Ping ZHOU , Jiang-Feng SHAN , Gui-Rong ZHOU
IPC分类号： H04M1/00
CPC分类号： H04M1/66
摘要： A telephone line monitoring device is connected to a telephone line and adjacent to a telephone device using the telephone line. The telephone line monitoring device includes a rectifying circuit for generating a corresponding direct current voltage according to an effective voltage of the telephone line; a first controller for generating a first control signal when the direct current voltage is lower than a predetermined voltage; a second controller for detecting an operating state of the telephone device and generating a second control signal when the telephone device is operated; a load booster for pulling down the effective voltage of the telephone line when enabled; and a first switch circuit for disabling the load booster whenever receiving the second control signal, and enabling the load booster when receiving the first control signal while not receiving the second control signal. A monitoring method and a telephone device are also provided.
摘要翻译：电话线监视装置使用电话线连接到电话线并且与电话装置相邻。电话线监视装置包括：整流电路，用于根据电话线的有效电压产生相应的直流电压; 第一控制器，用于当直流电压低于预定电压时产生第一控制信号; 第二控制器，用于在电话设备操作时检测电话设备的操作状态并产生第二控制信号; 用于在启用时拉低电话线的有效电压的负载增强器; 以及第一开关电路，用于在接收到所述第二控制信号时禁用所述负载增强器，以及在接收到所述第一控制信号而不接收所述第二控制信号的情况下使能所述负载增强器。还提供监视方法和电话装置。

3. 发明授权

US08180033B2 Telephone device, telephone line monitoring device and method 失效
标题翻译：电话设备，电话线路监控设备及方法
公开(公告)号：US08180033B2
公开(公告)日：2012-05-15
申请号：US12099172
申请日：2008-04-08
申请人： Lin-Kun Ding , Shih-Fang Wong , Xiang-Ping Zhou , Jiang-Feng Shan , Gui-Rong Zhou
发明人： Lin-Kun Ding , Shih-Fang Wong , Xiang-Ping Zhou , Jiang-Feng Shan , Gui-Rong Zhou
IPC分类号： H04M3/00
CPC分类号： H04M1/66
摘要： A telephone line monitoring device is connected to a telephone line and adjacent to a telephone device using the telephone line. The telephone line monitoring device includes a rectifying circuit for generating a corresponding direct current voltage according to an effective voltage of the telephone line; a first controller for generating a first control signal when the direct current voltage is lower than a predetermined voltage; a second controller for detecting an operating state of the telephone device and generating a second control signal when the telephone device is operated; a load booster for pulling down the effective voltage of the telephone line when enabled; and a first switch circuit for disabling the load booster whenever receiving the second control signal, and enabling the load booster when receiving the first control signal while not receiving the second control signal. A monitoring method and a telephone device are also provided.
摘要翻译：电话线监视装置使用电话线连接到电话线并且与电话装置相邻。电话线监视装置包括：整流电路，用于根据电话线的有效电压产生相应的直流电压; 第一控制器，用于当直流电压低于预定电压时产生第一控制信号; 第二控制器，用于在电话设备操作时检测电话设备的操作状态并产生第二控制信号; 用于在启用时拉低电话线的有效电压的负载增强器; 以及第一开关电路，用于在接收到所述第二控制信号时禁用所述负载增强器，以及在接收到所述第一控制信号而不接收所述第二控制信号的情况下使能所述负载增强器。还提供监视方法和电话装置。

4. 发明申请

US20060166931A1 Clathrates of butylphtualide with cyclodextrin or its derivatives, a process for their preparation and the use thereof 审中-公开
标题翻译：丁基水杨酸与环糊精或其衍生物的包合物，其制备方法及其应用
公开(公告)号：US20060166931A1
公开(公告)日：2006-07-27
申请号：US10524653
申请日：2002-08-21
申请人： Zhan-qi Niu , Kai Zhao , Wen-juan Liu , Gui-rong Zhou , Chao Liu , Rong-duan Wang , Hong-zhong Yuan , Wen-min Guo , Sui-chao Yan , Min Bai
发明人： Zhan-qi Niu , Kai Zhao , Wen-juan Liu , Gui-rong Zhou , Chao Liu , Rong-duan Wang , Hong-zhong Yuan , Wen-min Guo , Sui-chao Yan , Min Bai
IPC分类号： A61K31/724 , C08B5/10
CPC分类号： C08B37/0015 , A61K31/343 , A61K47/6951 , B82Y5/00 , C07D307/88
摘要： The present invention relates to the inclusion complexes of butylphthalide, which is D,L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-β-cyclodextrin, in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.
摘要翻译：本发明涉及丁基苯酞（其为D，L-混合或左旋）与环糊精或环糊精衍生物的包合络合物，其制备方法及其应用。在本发明中，丁基苯酞与环糊精或环糊精衍生物，优选与羟丙基-β-环糊精复合，以提高丁基苯酞的水溶性，开发临床固体或液体制剂，并提高丁基苯酞的治疗效果。丁基苯酞与环糊精或环糊精衍生物的摩尔比在1：1-10范围内的包合络合物可用于制备输注，注射，可注射粉末，口服液体，糖浆，片剂，颗粒剂，分散片等。

5. 发明申请

US20080267415A1 PORTABLE ELECTRONIC DEVICE 失效
标题翻译：便携式电子设备
公开(公告)号：US20080267415A1
公开(公告)日：2008-10-30
申请号：US11960713
申请日：2007-12-20
申请人： XIANG-PING ZHOU , GUI-RONG ZHOU , LIN-KUN DING , SHIH-FANG WONG
发明人： XIANG-PING ZHOU , GUI-RONG ZHOU , LIN-KUN DING , SHIH-FANG WONG
IPC分类号： H04R29/00
CPC分类号： H04R3/007 , H04R2430/01 , H04R2499/11 , H04S7/30
摘要： A portable electronic device includes a player, a speaker, a control circuit, a switch circuit, and a current limiter. The player is for outputting analog audio signals. The speaker is for transforming the analog audio signals into sound. The control circuit is for generating a first control signal when ambient light intensity is lower than a predetermined value. The switch circuit is for turning on and transmitting the analog audio signals to the speaker when receiving the first control signal. The current limiter is for transmitting the analog audio signals to the speaker when the switch circuit turns off, and for limiting a current flowing through the speaker.
摘要翻译：便携式电子设备包括播放器，扬声器，控制电路，开关电路和限流器。播放器用于输出模拟音频信号。扬声器用于将模拟音频信号转换为声音。控制电路用于当环境光强度低于预定值时产生第一控制信号。开关电路用于在接收到第一控制信号时接通并将模拟音频信号发送到扬声器。电流限制器用于在开关电路关断时将模拟音频信号传输到扬声器，并限制流过扬声器的电流。

6. 发明授权

US08363857B2 Portable electronic device 失效
标题翻译：便携式电子设备
公开(公告)号：US08363857B2
公开(公告)日：2013-01-29
申请号：US11960713
申请日：2007-12-20
申请人： Xiang-Ping Zhou , Gui-Rong Zhou , Lin-Kun Ding , Shih-Fang Wong
发明人： Xiang-Ping Zhou , Gui-Rong Zhou , Lin-Kun Ding , Shih-Fang Wong
IPC分类号： H04R3/00
CPC分类号： H04R3/007 , H04R2430/01 , H04R2499/11 , H04S7/30
摘要： A portable electronic device includes a player, a speaker, a control circuit, a switch circuit, and a current limiter. The player is for outputting analog audio signals. The speaker is for transforming the analog audio signals into sound. The control circuit is for generating a first control signal when ambient light intensity is lower than a predetermined value. The switch circuit is for turning on and transmitting the analog audio signals to the speaker when receiving the first control signal. The current limiter is for transmitting the analog audio signals to the speaker when the switch circuit turns off, and for limiting a current flowing through the speaker.
摘要翻译：便携式电子设备包括播放器，扬声器，控制电路，开关电路和限流器。播放器用于输出模拟音频信号。扬声器用于将模拟音频信号转换为声音。控制电路用于当环境光强度低于预定值时产生第一控制信号。开关电路用于在接收到第一控制信号时接通并将模拟音频信号发送到扬声器。电流限制器用于在开关电路关断时将模拟音频信号传输到扬声器，并限制流过扬声器的电流。

7. 发明申请

US20080318898A1 INCLUSION COMPLEXES OF BUTYLPHTHALIDE WITH CYCLODEXTRIN OR ITS DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THE USE THEREOF 有权
标题翻译：包括丁二酸与环糊精或其衍生物的复合物，其制备方法及其用途
公开(公告)号：US20080318898A1
公开(公告)日：2008-12-25
申请号：US12200130
申请日：2008-08-28
申请人： Zhan-qi Niu , Kai Zhao , Wen-juan Liu , Gui-rong Zhou , Chao Liu , Rong-duan Wang , Hong-zhong Yuan , Wen-min Guo , Sui-chao Yan , Min Bai
发明人： Zhan-qi Niu , Kai Zhao , Wen-juan Liu , Gui-rong Zhou , Chao Liu , Rong-duan Wang , Hong-zhong Yuan , Wen-min Guo , Sui-chao Yan , Min Bai
IPC分类号： A61K31/724 , C08B37/16
CPC分类号： C08B37/0015 , A61K31/343 , A61K47/6951 , B82Y5/00 , C07D307/88
摘要： The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed with cyclodextrin or cyclodextrin derivatives, preferably with hydroxypropyl-β-cyclodextrin in order to increase the water-solubility of butylphthalide, develop clinical solid or liquid formulations and improve the therapeutic effect of butylphthalide. The inclusion complex, in which the molar ratio of butylphthalide to cyclodextrin or cyclodextrin derivatives is in the range of 1:1-10, can be used to prepare infusion, injection, injectable powder, liquids for oral administration, syrup, tablets, granules, dispersible tablets and others.
摘要翻译：本发明涉及丁基苯酞（其为D，L-混合或左旋）与环糊精或环糊精衍生物的包合络合物，其制备方法及其应用。在本发明中，丁基苯酞与环糊精或环糊精衍生物，优选与羟丙基-β-环糊精复合，以提高丁基苯酞的水溶性，开发临床固体或液体制剂，提高丁基苯酞的治疗效果。丁基苯酞与环糊精或环糊精衍生物的摩尔比在1：1-10范围内的包合络合物可用于制备输注，注射，可注射粉末，口服液体，糖浆，片剂，颗粒剂，分散片等。

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