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1. 发明专利

AU2014290028B2 Self-expanding cannula 未知
公开(公告)号：AU2014290028B2
公开(公告)日：2019-04-18
申请号：AU2014290028
申请日：2014-07-17
申请人： DING JUN , GRIFFITH BARTLEY P , UNIV MARYLAND , UNIVERSITY OF MARYLAND BALTIMORE COUNTY , WU ZHONGJUN
发明人： WU ZHONGJUN , GRIFFITH BARTLEY P , DING JUN
IPC分类号： A61M29/00
摘要： Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (SLC) configurations and double lumen cannula (DLC) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patients body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patients blood vessel or a portion of the system inserted into the patients blood vessel) from collapsing as fluid is drained from the patient.

2. 发明专利

AU2014290028A1 Self-expanding cannula 未知
公开(公告)号：AU2014290028A1
公开(公告)日：2016-02-04
申请号：AU2014290028
申请日：2014-07-17
申请人： GRIFFITH BARTLEY , UNIV MARYLAND , DING JUN , WU ZHONGJUN , UNIV MARYLAND
发明人： WU ZHONGJUN , GRIFFITH BARTLEY P , DING JUN
IPC分类号： A61M29/00
摘要： Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (SLC) configurations and double lumen cannula (DLC) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patients body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patients blood vessel or a portion of the system inserted into the patients blood vessel) from collapsing as fluid is drained from the patient.

3. 发明申请

WO2022217139A1 IMPROVED CENTRIFUGAL BLOOD PUMP 审中-公开
公开(公告)号：WO2022217139A1
公开(公告)日：2022-10-13
申请号：PCT/US2022/024233
申请日：2022-04-11
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , BREETHE, INC. , WU, Zhongjun , GRIFFITH, Bartley P. , ZHANG, Jiafeng , LUDDY, Charles
发明人： WU, Zhongjun , GRIFFITH, Bartley P. , ZHANG, Jiafeng , LUDDY, Charles
IPC分类号： A61M60/232 , A61M60/818 , A61M60/205
摘要： A blood flow pump device includes a centrifugal pump having a single ball-and-cup hybrid magnetic/blood immersed bearing-supported shrouded impeller driven by a magnetically coupled motor drive. The device further includes a housing, an impeller, and a shroud, thus forming a pump chamber. The impeller is a shrouded impeller having extended blades from a hub of the impeller and the shroud. The system and method employ a blood flow pump device having a housing with a blood inlet and a blood outlet, the housing defining a fluid pathway between the inlet and the outlet, and the housing containing an impeller comprising a base, a base lid, two blades, and a shroud, with the housing positioned on a motor. A controller communicates with the motor and controls rotational speed of the impeller in response to the blood flow through the blood outlet.

4. 发明申请

WO2006031858A1 BLOOD PUMP-OXYGENATOR SYSTEM 审中-公开
标题翻译：血液泵氧系统
公开(公告)号：WO2006031858A1
公开(公告)日：2006-03-23
申请号：PCT/US2005/032675
申请日：2005-09-13
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , WU, Zhongjun , ANTAKI, James, F. , GRIFFITH, Bartley, P.
发明人： WU, Zhongjun , ANTAKI, James, F. , GRIFFITH, Bartley, P.
IPC分类号： A61M37/00
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1017 , A61M1/1029 , A61M1/1031 , A61M1/122 , A61M1/1678 , A61M1/262 , A61M1/267
摘要： A blood pump-oxygenator system including a housing, an impeller, a fiber bed, and a bypass channel that provides a path for blood to be recirculated through the fiber bed; a system comprising a housing, a means for drawing blood into the housing, a means for removing carbon dioxide from the blood, a means for adding oxygen to the blood, and a means for recirculating the blood back through the removing means and the adding means; and a method for oxygenating blood comprising drawing blood into a housing comprising a fiber bed, propelling blood principally in a radial direction through the fiber bed, adding oxygen to the blood as it moves through the fiber bed, and repeating the forcing and adding steps for at least a portion of the blood.
摘要翻译：一种血泵 - 氧合器系统，包括壳体，叶轮，纤维床和旁路通道，其提供血液通过纤维床再循环的路径; 一种系统，包括壳体，用于将血液吸入壳体的装置，用于从血液中除去二氧化碳的装置，用于向血液添加氧气的装置以及用于使血液再循环通过除去装置和加法装置的装置 ; 以及用于对血液进行氧合的方法，包括将血液抽入包含纤维床的壳体中，主要沿径向推动血液穿过纤维床，当血液通过纤维床时向血液中加入氧气，并且重复强制和添加步骤至少一部分血液。

5. 发明申请

WO2015009904A1 SELF-EXPANDING CANNULA 审中-公开
标题翻译：自我扩张肛门
公开(公告)号：WO2015009904A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/046978
申请日：2014-07-17
申请人： WU, Zhongjun , GRIFFITH, Bartley P. , DING, Jun , UNIVERSITY OF MARYLAND, BALTIMORE , UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
发明人： WU, Zhongjun , GRIFFITH, Bartley P. , DING, Jun
IPC分类号： A61M29/00
CPC分类号： A61M25/003 , A61M1/3659 , A61M25/005 , A61M25/04 , A61M2025/0024 , A61M2025/0031 , A61M2025/0035 , A61M2025/0039 , A61M2025/0059 , A61M2205/0266
摘要： Disclosed is a self-expanding cannula, systems using such cannulae, and methods of their use. The cannulae may comprise single lumen cannula (SLC) configurations and double lumen cannula (DLC) configurations, and include at least a first cannula and a self-expanding wire frame attached to the first cannula. Self-expanding wire frame is automatically expandable from a compressed state (providing a reduced cannula diameter as it is moved through a patients body to the site at which it is to be deployed) to an expanded state (which increases the diameter of the cannula to the diameter intended for its normal use). The expanded wire frame provides radial support to prevent a drainage canal (whether a patients blood vessel or a portion of the system inserted into the patients blood vessel) from collapsing as fluid is drained from the patient.
摘要翻译：公开了一种自扩张插管，使用这种插管的系统及其使用方法。套管可以包括单腔插管（SLC）构造和双腔插管（DLC）构造，并且包括至少第一插管和连接到第一插管的自扩张线框架。自膨胀线框可以从压缩状态自动扩展（将插入直径缩小到通过患者身体到其部署位置时的插管直径）扩展到扩张状态（这将套管的直径增加到直径用于其正常使用）。扩张的线框架提供径向支撑以防止排泄管（无论患者血管或插入患者血管的系统的一部分）在流体从患者排出时塌陷。

6. 发明申请

WO2014107690A1 BIOCOMPATIBLE COATING COMPOSITIONS 审中-公开
标题翻译：生物涂料组合物
公开(公告)号：WO2014107690A1
公开(公告)日：2014-07-10
申请号：PCT/US2014/010391
申请日：2014-01-06
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , GARIMELLA, Narayana , WU, Zhongjun , GRIFFITH, Bartley
发明人： GARIMELLA, Narayana , WU, Zhongjun , GRIFFITH, Bartley
IPC分类号： A61K31/14 , A61L33/10
CPC分类号： A61L33/0023 , A61L33/0011 , A61L33/0029 , A61L33/0076 , A61L33/04 , A61L33/064 , A61L2300/208 , A61L2300/236 , A61L2300/42 , A61L2300/608 , A61L2420/02 , A61L2420/06 , A61L2420/08 , C08L39/06
摘要： Hemo-compatible, anti- and non-thrombogenic, heparin-based bioactive coat a surface to be contacted with blood, such as a surface of an oxygenator device (e.g., a Hollow Fiber Membrane (HFM) surface) or an artificial lung, which coatings include a quaternary ammonium salt and heparin complex (QUAT). The surface is treated with polyvinylpyrrolidone (PVP), followed by a coating layer of said quaternary ammonium salts and heparin complex (QUAT) to form a PVP-QUAT coating. According to other example embodiments, anionic functional groups are created on the one or more surfaces of the HFM by modifying the surf ace of the HFM using ionic complexes dissolved in a solvent mixture that includes major quantity of alcohol along with a minor quantity of organic dissolving agents. Also provided are methods of making the provided coatings, methods of coating a surface, devices that have been coated, and kits that include such coatings.
摘要翻译：血液相容性，抗和非血栓形成的基于肝素的生物活性涂层与血液接触的表面，例如氧合器装置的表面（例如中空纤维膜（HFM）表面））或人造肺，其中涂层包括季铵盐和肝素复合物（QUAT）。用聚乙烯吡咯烷酮（PVP）处理表面，然后用所述季铵盐和肝素复合物（QUAT）的涂层进行处理以形成PVP-QUAT涂层。根据其他示例性实施方案，通过使用溶解在包括主要量的醇的溶剂混合物中的离子络合物以及少量有机溶解来改变HFM的一个或多个表面上的阴离子官能团代理商。还提供了制备所提供的涂层，涂覆表面的方法，已经被涂覆的装置以及包括这种涂层的试剂盒的方法。

7. 发明申请

WO2010062734A1 BLOOD COAGULATION INDUCING POLYMER HYDROGEL 审中-公开
标题翻译：血液凝聚诱导聚合物水凝胶
公开(公告)号：WO2010062734A1
公开(公告)日：2010-06-03
申请号：PCT/US2009/063049
申请日：2009-11-03
申请人： UNIVERSITY OF MARYLAND, BALTIMORE , UNIVERSITY OF MARYLAND, COLLEGE PARK , CASEY, Brendan, J. , KOFINAS, Peter , BEHRENS, Adam , SNYDER, Trevor, A. , GRIFFITH, Bartley, P.
发明人： CASEY, Brendan, J. , KOFINAS, Peter , BEHRENS, Adam , SNYDER, Trevor, A. , GRIFFITH, Bartley, P.
IPC分类号： A61F13/02 , A61L15/44 , A61P7/04
CPC分类号： A61L15/24 , A61L15/44 , A61L15/60 , A61L24/0015 , A61L24/0031 , A61L24/06 , A61L2300/204 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/41 , A61L2300/418 , A61L2300/43 , C08L33/26
摘要： The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated.
摘要翻译：本申请被描述为合成的聚合物水凝胶基材料，其能够主动地诱导身体在血液或无细胞血浆中的天然止血凝血过程。本发明提供了能够诱导凝血并递送用于止血或伤口护理应用的治疗剂的含伯胺聚合物水凝胶的开发，以及形成能够诱导凝血过程的含伯胺聚合物水凝胶的方法。含伯胺聚合物水凝胶能够实现与生物基止血剂相同的最终结果，没有疾病传播或免疫应答的先天风险，并且价格仅为一小部分。此外，由于其固有的基于水凝胶的设计，该材料具有阻止失血的能力，同时以受控的方式递送治疗剂，可能彻底改变伤口的治疗方式。

8. 发明授权

US08158110B2 Use of aerosolized cyclosporine for prevention and treatment of pulmonary disease 有权
标题翻译：使用雾化环孢素预防和治疗肺部疾病
公开(公告)号：US08158110B2
公开(公告)日：2012-04-17
申请号：US12433231
申请日：2009-04-30
申请人： Aldo T. Iacono , Griffith Bartley
发明人： Aldo T. Iacono , Griffith Bartley
IPC分类号： A61K9/14 , A61K9/12 , A61K38/00 , A61K38/12
CPC分类号： A61K38/13 , A61K9/0073 , Y10T428/2982 , A61K2300/00
摘要： The present invention relates to methods and compositions for prevention of graft rejection in lung transplant recipients and for treatment of subjects with pulmonary disorders. Specifically, the methods and compositions of the invention provide a means for inhibiting immune response mediated inflammatory processes in the lungs. The method of the invention comprises the administration of aerosolized cyclosporine for prevention of acute and/or chronic refractory rejection in lung transplant patients. The invention further provides for the use of aerosolized cyclosporine to treat subjects having immunologically mediated inflammatory pulmonary disorders including, but not limited to, asthma, cystic fibrosis, idiopathic pulmonary fibrosis, chronic bronchitis and allergic rhinitis. The present invention, by enabling a method for the use of aerosolized cyclosporine for inhibiting pulmonary inflammation leading to prevention of graft rejection and treatment of pulmonary disorders, provides a safer and less toxic treatment than those methods that utilize systemic administration of cyclosporine.
摘要翻译：本发明涉及用于预防肺移植受体中的移植物排斥反应的方法和组合物以及用于治疗患有肺部疾病的受试者。具体地，本发明的方法和组合物提供了一种用于抑制肺中免疫应答介导的炎症过程的手段。本发明的方法包括施用雾化的环孢菌素以预防肺移植患者的急性和/或慢性难治性排斥反应。本发明还提供了使用雾化的环孢菌素来治疗具有免疫介导的炎症性肺病的受试者，包括但不限于哮喘，囊性纤维化，特发性肺纤维化，慢性支气管炎和过敏性鼻炎。本发明通过实现气雾化环孢菌素用于抑制肺部炎症导致预防移植物排斥反应和治疗肺部疾病的方法，提供比利用全身施用环孢菌素的那些方法更安全和更少毒性的治疗方法。

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