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1. 发明授权

US06786153B2 Printing rolls having wear indicators and methods for determining wear of printing and anilox rolls and sleeves 有权
公开(公告)号：US06786153B2
公开(公告)日：2004-09-07
申请号：US10247528
申请日：2002-09-19
申请人： William Burrow , Gregory Haley
发明人： William Burrow , Gregory Haley
IPC分类号： B41F3107
CPC分类号： B41F31/26 , B41F31/027 , Y10S507/906
摘要： A printing device, system and method are disclosed for measuring and displaying the amount of wear experienced by printing rolls. A wear detection mechanism is employed in connection with rolls, such as anilox-type rolls that transfer ink to a substrate in forming a printed image. A wear detection mechanism is engraved, etched, or the like into the outer circumferential surface of the roll to provide an indication of the amount of wear experienced by the roll. Portions provided in series at predetermined depths may be correlated with a depletion scale indicia to display the wear condition of a particular roll in a printing system. A depletable wear strip comprising multiple engraved portions which correlate with values upon a depletion scale may be employed.

2. 发明申请

US20080020989A1 CARBONATE AND CARBAMATE PRODRUGS OF THIAZOLO[4,5-d]PYRIMIDINES 有权
标题翻译：噻唑并[4,5-d]吡啶的碳酸盐和碳酸盐
公开(公告)号：US20080020989A1
公开(公告)日：2008-01-24
申请号：US11779007
申请日：2007-07-17
申请人： Gregory Haley , Joseph Lennox , Alan Xiang , Stephen Webber
发明人： Gregory Haley , Joseph Lennox , Alan Xiang , Stephen Webber
IPC分类号： A61K31/7068 , A61K31/519 , A61P31/12 , A61P35/00 , C07D497/04 , C07H19/24
CPC分类号： C07H19/24 , C07D513/04
摘要： The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.
摘要翻译：本发明涉及噻唑并[4,5-d]嘧啶化合物的碳酸酯和氨基甲酸酯前药，其代谢母体化合物具有免疫调节活性。本发明还涉及这些前药及其药物组合物在治疗与异常细胞生长相关的疾病状态（例如癌症）中的治疗用途。

3. 发明申请

US20050288287A1 Chiral cis-imidazolines 失效
标题翻译：手性顺式 - 咪唑啉
公开(公告)号：US20050288287A1
公开(公告)日：2005-12-29
申请号：US11129621
申请日：2005-05-13
申请人： Nader Fotouhi , Gregory Haley , Klaus Simonsen , Binh Vu , Stephen Webber
发明人： Nader Fotouhi , Gregory Haley , Klaus Simonsen , Binh Vu , Stephen Webber
IPC分类号： A61K31/4164 , A61K31/496 , A61K31/5377 , A61P35/00 , C07D233/22 , C07D233/26 , C07D403/06 , C07D413/14 , C07D43/02
CPC分类号： C07D403/06 , C07D233/22 , C07D233/26
摘要： and the pharmaceutically acceptable salts and esters thereof, wherein X1, X2, X3, Y1, Y2 and R are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
摘要翻译：及其药学上可接受的盐和酯，其中X 1，X 2，X 3，Y 1，本文描述的Y 2和R 2抑制MDM2蛋白与p53样肽的相互作用，因此具有抗增殖活性。

4. 发明申请

US20080032999A1 Prodrugs of 5-amino-3-(3'-deoxy-b-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione 有权
标题翻译： 5-氨基-3-（3'-脱氧-b-D-呋喃核糖基） - 噻唑并[4,5-d]嘧啶-2,7-二酮的前药
公开(公告)号：US20080032999A1
公开(公告)日：2008-02-07
申请号：US11766724
申请日：2007-06-21
申请人： Gregory Haley , Joseph Lennox , Alan Xiang , Stephen Webber
发明人： Gregory Haley , Joseph Lennox , Alan Xiang , Stephen Webber
IPC分类号： A61K31/519 , A61P31/12 , A61P35/00 , C07D513/04
CPC分类号： C07D513/04
摘要： The invention is directed to 5-amino-3-(3′-deoxy-β-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione prodrugs, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.
摘要翻译：本发明涉及其代谢母体化合物具有免疫调节活性的5-氨基-3-（3'-脱氧-β-D-呋喃核糖基） - 噻唑并[4,5-d]嘧啶-2,7-二酮前药。本发明还涉及这些前药及其药物组合物在治疗与异常细胞生长相关的疾病状态（例如癌症）中的治疗用途。

5. 发明申请

US20060167264A1 Pyridine-3-sulfonyl compounds as pesticidal agents 失效
标题翻译：吡啶-3-磺酰基化合物作为杀虫剂
公开(公告)号：US20060167264A1
公开(公告)日：2006-07-27
申请号：US10495929
申请日：2002-11-22
申请人： Gregory Haley , Deborah Culbertson , Michael Treacy
发明人： Gregory Haley , Deborah Culbertson , Michael Treacy
IPC分类号： C07D213/62
CPC分类号： C07D213/70 , A01N43/40
摘要： The present invention describes novel pyridine-3-sullonyl compounds having the formula (I) wherein R1, R2, R3, R4 and R5 are as defined herein. The present invention is also directed lo pesticidal compositions that include a) compounds of formula (11) wherein R1, R2, R3, R4 and R6 are as defined herein and b) a carrier. Moreover, the present invention relates to methods for protecting crops from insect attack by contacting the crop with a pesticidally effective amount of the compound of formula (II). In addition, the present invention includes methods for controlling insects by treating the target species with a pesticidally effective amount of the compound of formula (II).
摘要翻译：本发明描述了具有式（I）的新颖的吡啶-3-磺酰基化合物，其中R 1，R 2，R 3，R 3， SUP＆gt; 4＆gt;和＆lt; 5＆gt;如本文所定义。本发明还涉及农药组合物，其包括a）式（11）的化合物，其中R 1，R 2，R 3， R 4和R 6如本文所定义，b）载体。此外，本发明涉及通过使作物与杀虫有效量的式（II）化合物接触来保护作物免受昆虫攻击的方法。此外，本发明包括通过用杀虫有效量的式（II）化合物处理目标物种来控制昆虫的方法。

6. 发明申请

US20060160830A1 3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof 有权
公开(公告)号：US20060160830A1
公开(公告)日：2006-07-20
申请号：US11304691
申请日：2005-12-16
申请人： Stephen Webber , Gregory Haley , Joseph Lennox , Alan Xiang , Erik Rueden
发明人： Stephen Webber , Gregory Haley , Joseph Lennox , Alan Xiang , Erik Rueden
IPC分类号： A61K31/519 , C07D498/02 , C07D491/02 , A61K31/655
CPC分类号： C07H19/23 , A61K31/7064 , A61K39/00 , A61K39/395 , A61K45/06 , C07D513/04 , C07H19/14 , C07H19/16 , C07H19/24
摘要： The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.

7. 发明申请

US20060211693A1 Cis-imidazolines 失效
标题翻译：顺式 - 咪唑啉
公开(公告)号：US20060211693A1
公开(公告)日：2006-09-21
申请号：US11374407
申请日：2006-03-13
申请人： Nader Fotouhi , Gregory Haley , Klaus Simonsen , Binh Vu , Stephen Webber
发明人： Nader Fotouhi , Gregory Haley , Klaus Simonsen , Binh Vu , Stephen Webber
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , C07D413/14 , C07D403/14
CPC分类号： C07D233/22 , C07D233/24 , C07D233/26 , C07D401/06 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/14
摘要： There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such the compounds will have anti-hyperproliferative cellular activity.
摘要翻译：呈现下式的化合物或其药学上可接受的盐，其中Y 1，Y 2，X 1，X 2， / SUB>，X 3和R如本申请中所述。据信这些化合物抑制MDM2-p53的相互作用，因此这些化合物将具有抗过度增殖的细胞活性。

8. 发明申请

US20050282803A1 CIS-imidazolines 失效
标题翻译：苯并咪唑
公开(公告)号：US20050282803A1
公开(公告)日：2005-12-22
申请号：US11143161
申请日：2005-06-02
申请人： Gregory Haley , Norman Kong , Emily Liu , Binh Vu
发明人： Gregory Haley , Norman Kong , Emily Liu , Binh Vu
IPC分类号： A61K31/4178 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D233/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D45/14
CPC分类号： C07D403/12 , C07D233/22 , C07D401/06 , C07D403/06
摘要： The present invention relates to compounds of the formula and the pharmaceutically acceptable salts and esters thereof, a process for their manufacture, medicaments containing them as well as the use of these compounds as pharmaceutically active agents. The compounds show antiproliferative activity and may be especially useful for the treatment of cancer.
摘要翻译：本发明涉及下式的化合物及其药学上可接受的盐和酯，其制备方法，含有它们的药物以及这些化合物作为药物活性剂的用途。这些化合物显示出抗增殖活性，并且可能特别适用于治疗癌症。

9. 发明申请

US20070167437A1 Cis-imidazolines 失效
标题翻译：顺式 - 咪唑啉
公开(公告)号：US20070167437A1
公开(公告)日：2007-07-19
申请号：US11654102
申请日：2007-01-17
申请人： Nader Fotouhi , Gregory Haley , Klaus Simonsen , Binh Vu , Stephen Webber
发明人： Nader Fotouhi , Gregory Haley , Klaus Simonsen , Binh Vu , Stephen Webber
IPC分类号： A61K31/551 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/4439 , A61K31/4178 , C07D413/14 , C07D409/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D409/04 , C07D409/14 , C07D413/14
摘要： There are provided compounds of the formula I wherein R, V1, V2 and Ring A are described herein. The compounds exhibit anticancer activity.
摘要翻译：提供式I化合物，其中本文描述了R 1，V 2，V 2和环A。该化合物具有抗癌活性。

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