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1. 发明申请

US20110183425A1 Protein Complexes and Screening Methods 审中-公开
标题翻译：蛋白质复合物和筛选方法
公开(公告)号：US20110183425A1
公开(公告)日：2011-07-28
申请号：US12997375
申请日：2009-06-10
申请人： André Xavier de Carvalho Negräo Valente , Yuan Gao , Gregory A. Buck , Seth Roberts
发明人： André Xavier de Carvalho Negräo Valente , Yuan Gao , Gregory A. Buck , Seth Roberts
IPC分类号： G01N33/68 , C07K14/47
CPC分类号： C07K14/395 , C07K14/47
摘要： The application concerns an isolated protein complex comprising polypeptide components: (i) UTP20 HUMAN or a fragment, variant or homologue thereof; (ii) PWP2 HUMAN or a fragment, variant or homologue thereof; (iii) WDR46_HUMAN or a fragment, variant or homologue thereof; (iv) UTP18 HUMAN or a fragment, variant or homologue thereof; (v) MPPIO HUMAN or a fragment, variant or homologue thereof; (vi) WDR3_HUMAN or a fragment, variant or homologue thereof; (vii) TBL3 HUMAN or a fragment, variant or homologue thereof; (viii) WDR36_HUMAN or a fragment, variant or homologue thereof; and (ix) N0C4L HUMAN or a fragment, variant or homologue thereof. The application further concerns a method of identifying an agent that modulates the amount, function, activity, composition and/or formation of said protein complex; a method for the prevention or treatment of an eye disorder comprising administering to a subject in need thereof a suitable quantity of an agent that modulates the amount, function, activity, composition and/or formation of said protein complex; and a method of assessing whether a subject has or is likely to develop an eye disorder comprising determining whether the subject has an altered amount, function, activity, composition and/or formation of a protein complex.
摘要翻译：该应用涉及包含多肽组分的分离的蛋白质复合物：（i）UTP20Human或其片段，变体或同源物; （ii）PWP2人类或其片段，变体或同源物; （iii）WDR46_HUMAN或其片段，变体或同源物; （iv）UTP18人类或其片段，变体或同源物; （v）MPPIO HUMAN或其片段，变体或同源物; （vi）WDR3_HUMAN或其片段，变体或同源物; （vii）TBL3人类或其片段，变体或同源物; （viii）WDR36_HUMAN或其片段，变体或同源物; 和（ix）N0C4L HUMAN或其片段，变体或同源物。本申请还涉及鉴定调节所述蛋白质复合物的量，功能，活性，组成和/或形成的试剂的方法; 一种用于预防或治疗眼病的方法，其包括向有需要的受试者施用适量的调节所述蛋白质复合物的量，功能，活性，组成和/或形成的试剂; 以及评估受试者是否具有或可能发展眼病的方法，包括确定受试者是否具有改变的蛋白质复合物的量，功能，活性，组成和/或形成。

2. 发明申请

US20110093211A1 Method for Processing Protein Data 审中-公开
标题翻译：蛋白质数据处理方法
公开(公告)号：US20110093211A1
公开(公告)日：2011-04-21
申请号：US12997441
申请日：2009-06-10
申请人： Andre' Xavier de Carvalho Negrão Valente , Yuan Gao , Gregory A. Buck , Seth Roberts
发明人： Andre' Xavier de Carvalho Negrão Valente , Yuan Gao , Gregory A. Buck , Seth Roberts
IPC分类号： G06F19/00 , G01N33/68
CPC分类号： G16B5/00
摘要： A method of generating data indicating whether a set of proteins is a protein complex. The method comprises receiving as input experimental data indicating experimentally observed relationships, each experimentally observed relationship being between a first protein and zero or more second proteins and generating data indicating whether the set of proteins is a protein complex. The experimental data is processed to determine a first data value indicating a number of proteins having a relationship with one or more second proteins and a second data value indicating a number of proteins having a relationship with a selected protein.
摘要翻译：产生指示蛋白质是否是蛋白质复合物的数据的方法。该方法包括接收表示实验观察到的关系的输入实验数据，每个实验观察到的关系在第一蛋白质和零个或更多个第二蛋白质之间，并产生指示蛋白质组是否是蛋白质复合物的数据。处理实验数据以确定指示与一个或多个第二蛋白质具有关系的蛋白质数量的第一数据值和指示与所选蛋白质具有关系的蛋白质数量的第二数据值。

3. 发明授权

US6110683A Automated DNA Sequencer loading dye which contains a lane tracking aid 有权
标题翻译：自动DNA测序仪加载染料，其中包含车道追踪辅助
公开(公告)号：US6110683A
公开(公告)日：2000-08-29
申请号：US239826
申请日：1999-01-29
申请人： Thomas R. Reynolds , Gregory A. Meyers , Gregory A. Buck , Joshua Rameaka
发明人： Thomas R. Reynolds , Gregory A. Meyers , Gregory A. Buck , Joshua Rameaka
IPC分类号： C12Q1/68 , G01N27/447
CPC分类号： C12Q1/6869 , C12Q1/68 , G01N27/44726
摘要： The present invention provides a reagent which can be used as a marker to identify individual lanes on an electrophoresis gel which is run on an Automated DNA Sequencer. This reagent is may be included in the loading dye for samples in DNA sequencing, DNA fragment analysis, or linkage mapping analysis. Inclusion of the reagent aids in the identification of the lane in which each sample is individually loaded on the acrylamide gel, such that the data read from each lane by the instrument is correctly applied to the appropriate sample.
摘要翻译：本发明提供了一种试剂，其可用作识别在自动DNA测序仪上运行的电泳凝胶上的个体泳道的标记物。该试剂可以包含在DNA测序，DNA片段分析或连锁作图分析中的样品的加载染料中。试剂的包含有助于将每个样品分别装载在丙烯酰胺凝胶上的泳道的鉴定，使得通过仪器从每个泳道读取的数据被正确地应用于适当的样品。

4. 发明申请

US20110008392A1 VACCINE TARGETS AND DELIVERY SYSTEMS FOR CRYPTOSPORIDIUM 审中-公开
标题翻译：疫苗目标和交付系统
公开(公告)号：US20110008392A1
公开(公告)日：2011-01-13
申请号：US12739810
申请日：2008-10-24
申请人： Gregory A Buck , Patricio A. Manque , Fernando Tenjo , Myna Garcia Serrano , Joao Marcelo Pereira Alves , Ping Xu
发明人： Gregory A Buck , Patricio A. Manque , Fernando Tenjo , Myna Garcia Serrano , Joao Marcelo Pereira Alves , Ping Xu
IPC分类号： A61K39/002 , A61K38/16 , A61K31/7052 , A61P37/04 , A61P33/02
CPC分类号： A61K39/002 , A61K2039/523 , A61K2039/53 , A61K2039/543 , Y02A50/488 , Y02A50/489
摘要： Compositions comprising the Cryptosporidium sporozoite antigens such as SRK (‘similar to riken’), CP15 and profilin are used in vaccines against the protozoan parasite Cryptosporidim.
摘要翻译：包含隐孢子虫子孢子抗原如SRK（“类似于riken”），CP15和profilin的组合物用于针对原生动物寄生虫隐孢菌素的疫苗中。

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